| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Aberdeen Group plc | 0 | 1,727,067 | +1,727,067 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 350,240 | +350,240 | 0.00 | 0.20 | +0.20 | buy |
| Anson Funds Management LP | 0 | 183,970 | +183,970 | 0.00 | 0.08 | +0.08 | buy |
| BARCLAYS PLC | 6,153 | 57,479 | +51,326 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 82,000 | 128,500 | +46,500 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 281,956 | 318,462 | +36,506 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 35,571 | +35,571 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 221,040 | 249,788 | +28,748 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 16,813 | +16,813 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 15,025 | +15,025 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 14,145 | +14,145 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,049,831 | 1,063,970 | +14,139 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 73 | 13,631 | +13,558 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 498,254 | 505,261 | +7,007 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 14,494 | 19,018 | +4,524 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 10,197 | 14,036 | +3,839 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 504,826 | 508,570 | +3,744 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,685 | 3,709 | +1,024 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,492 | 13,254 | +762 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,525 | 2,525 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,194,777 | 4,194,777 | 0 | 0.06 | 0.04 | -0.02 | hold |
| HARBOURVEST PARTNERS LLC | 21,877 | 21,877 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Laurion Capital Management LP | 783,391 | 783,391 | 0 | 0.07 | 0.07 | -0.00 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Utah Retirement Systems | 13,240 | 13,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 3,301,603 | 3,301,603 | 0 | 14.29 | 6.36 | -7.93 | hold |
| 5AM Venture Management, LLC | 3,630,724 | 3,630,724 | 0 | 3.52 | 2.30 | -1.22 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,404,644 | 2,404,644 | 0 | 3.23 | 1.46 | -1.77 | hold |
| Canaan Partners XI LLC | 2,059,712 | 2,059,712 | 0 | 6.09 | 6.15 | +0.06 | hold |
| TPG GP A, LLC | 3,028,414 | 3,028,414 | 0 | 0.18 | 0.12 | -0.06 | hold |
| RESOURCES MANAGEMENT CORP /CT/ /ADV | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 2,946 | 2,946 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 1,700 | 1,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,018 | 77,018 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 38,769 | 38,759 | -10 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 45 | 0 | -45 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,258 | 15,197 | -61 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,533 | 10,467 | -66 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 107 | 0 | -107 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,361 | 2,195 | -166 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 90,687 | 90,278 | -409 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,399 | 0 | -1,399 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,746 | 5,032 | -1,714 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,759 | 0 | -1,759 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 32,801 | 29,643 | -3,158 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 408,180 | 404,655 | -3,525 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 12,342 | 0 | -12,342 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,144 | 0 | -13,144 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 16,979 | 0 | -16,979 | 0.00 | 0.00 | -0.00 | sell |
| Northeast Financial Consultants Inc | 18,151 | 0 | -18,151 | 0.00 | 0.00 | -0.00 | sell |
| Financial Security Advisor, Inc. | 50,278 | 0 | -50,278 | 0.08 | 0.00 | -0.08 | sell |
| VR Adviser, LLC | 268,532 | 0 | -268,532 | 0.10 | 0.00 | -0.10 | sell |
| SECTORAL ASSET MANAGEMENT INC | 375,960 | 0 | -375,960 | 0.25 | 0.00 | -0.25 | sell |
| Novo Holdings A/S | 2,187,999 | 1,767,861 | -420,138 | 0.54 | 0.26 | -0.28 | sell |
| FMR LLC | 3,246,287 | 2,535,571 | -710,716 | 0.00 | 0.00 | -0.00 | sell |