| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Almitas Capital LLC | 875,434 | 1,298,119 | +422,685 | 0.36 | 0.27 | -0.09 | buy |
| Northeast Financial Consultants Inc | 22,088 | 96,422 | +74,334 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 403,700 | 441,318 | +37,618 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 35,736 | +35,736 | 0.00 | 0.00 | +0.00 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 60,942 | 73,602 | +12,660 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 244,986 | 247,827 | +2,841 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 55 | 2,447 | +2,392 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,100 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 22,119 | 22,652 | +533 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 200,850 | 201,219 | +369 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,460 | 3,633 | +173 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 14,649 | 14,817 | +168 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 13,300 | 13,400 | +100 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 925,521 | 925,521 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,194,777 | 4,194,777 | 0 | 0.02 | 0.01 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 91,600 | 91,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hartford Financial Management Inc. | 6,500 | 6,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 735,543 | 735,543 | 0 | 0.06 | 0.04 | -0.01 | hold |
| CAPTRUST FINANCIAL ADVISORS | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Utah Retirement Systems | 13,240 | 13,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 3,301,603 | 3,301,603 | 0 | 3.97 | 4.24 | +0.27 | hold |
| Aberdeen Group plc | 1,727,067 | 1,727,067 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 3,630,724 | 3,630,724 | 0 | 0.88 | 0.83 | -0.05 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,404,644 | 2,404,644 | 0 | 1.67 | 1.56 | -0.11 | hold |
| TPG GP A, LLC | 3,028,414 | 3,028,414 | 0 | 0.06 | 0.05 | -0.01 | hold |
| JOHNSON & JOHNSON | 3,636,363 | 3,636,363 | 0 | 1.00 | 0.90 | -0.09 | hold |
| BARCLAYS PLC | 15,390 | 15,390 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 14,078 | 14,078 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 90,247 | 90,247 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 62,072 | 62,072 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 91,600 | 91,300 | -300 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 1,049 | 0 | -1,049 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 405,629 | 404,546 | -1,083 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 18,364 | 17,146 | -1,218 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 7,964 | 5,991 | -1,973 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 8,146 | 5,929 | -2,217 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 342,944 | 338,909 | -4,035 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 7,800 | 0 | -7,800 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 86,324 | 76,811 | -9,513 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 10,664 | 0 | -10,664 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 21,203 | 0 | -21,203 | 0.00 | 0.00 | -0.00 | sell |
| HARBOURVEST PARTNERS LLC | 21,877 | 0 | -21,877 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 50,300 | 0 | -50,300 | 0.00 | 0.00 | -0.00 | sell |
| Canaan Partners XI LLC | 1,910,987 | 1,697,684 | -213,303 | 1.89 | 2.11 | +0.22 | sell |
| FMR LLC | 2,315,480 | 1,766,701 | -548,779 | 0.00 | 0.00 | -0.00 | sell |