| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,143,563 | 3,312,706 | +2,169,143 | 0.03 | 0.06 | 0.00 | buy |
| LORD, ABBETT & CO. LLC | 8,362,000 | 9,948,000 | +1,586,000 | 0.03 | 0.03 | +0.00 | buy |
| Capital Research Global Investors | 1,100,110 | 2,212,085 | +1,111,975 | 0.01 | 0.02 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 2,725,949 | 3,415,604 | +689,655 | 5.88 | 4.46 | -1.43 | buy |
| AMERICAN CENTURY COMPANIES INC | 471,866 | 914,111 | +442,245 | 0.01 | 0.02 | +0.00 | buy |
| Woodline Partners LP | 290,000 | 700,749 | +410,749 | 0.13 | 0.20 | +0.07 | buy |
| ADAR1 Capital Management, LLC | 185,137 | 549,804 | +364,667 | 3.34 | 4.64 | +1.30 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 282,146 | 585,956 | +303,810 | 1.83 | 2.55 | +0.71 | buy |
| TWO SIGMA INVESTMENTS, LP | 966,797 | 744,600 | +222,197 | 0.10 | 0.06 | 0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,714,168 | 2,862,845 | +148,677 | 0.01 | 0.01 | 0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 206,326 | 353,507 | +147,181 | 5.95 | 7.23 | +1.28 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 658,362 | 803,956 | +145,594 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 943,484 | 1,073,187 | +129,703 | 0.03 | 0.02 | 0.00 | buy |
| NOMURA HOLDINGS INC | 257,995 | 381,645 | +123,650 | 0.10 | 0.10 | 0.00 | buy |
| Candriam S.C.A. | 299,000 | 380,000 | +81,000 | 0.08 | 0.08 | -0.01 | buy |
| Sio Capital Management, LLC | 131,753 | 203,174 | +71,421 | 1.21 | 1.87 | +0.66 | buy |
| Granahan Investment Management, LLC | 388,302 | 456,986 | +68,684 | 0.52 | 0.50 | -0.02 | buy |
| BIT Capital GmbH | 73,490 | 138,697 | +65,207 | 0.29 | 0.32 | +0.03 | buy |
| Portman Square Capital LLP | 27,679 | 77,630 | +49,951 | 0.19 | 0.55 | +0.35 | buy |
| Rafferty Asset Management, LLC | 276,073 | 316,442 | +40,369 | 0.05 | 0.04 | -0.01 | buy |
| NEOS Investment Management LLC | 18,301 | 50,918 | +32,617 | 0.07 | 0.10 | +0.03 | buy |
| MOODY ALDRICH PARTNERS LLC | 124,984 | 149,222 | +24,238 | 0.91 | 0.78 | -0.12 | buy |
| Erste Asset Management GmbH | 84,225 | 107,225 | +23,000 | 0.05 | 0.05 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 121,653 | 144,094 | +22,441 | 0.28 | 0.24 | -0.04 | buy |
| Atle Fund Management AB | 23,985 | 37,841 | +13,856 | 0.76 | 0.71 | -0.05 | buy |
| China Universal Asset Management Co., Ltd. | 20,120 | 33,774 | +13,654 | 0.16 | 0.13 | -0.03 | buy |
| EMERALD ADVISERS, LLC | 685,539 | 699,083 | +13,544 | 1.18 | 0.87 | -0.31 | buy |
| HighVista Strategies LLC | 44,572 | 56,562 | +11,990 | 0.65 | 0.62 | -0.03 | buy |
| Diversified Trust Co | 17,636 | 27,702 | +10,066 | 0.02 | 0.03 | +0.00 | buy |
| MIZUHO MARKETS AMERICAS LLC | 64,379 | 74,309 | +9,930 | 0.08 | 0.06 | -0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 1,435,280 | 1,445,117 | +9,837 | 0.04 | 0.03 | -0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 40,828 | 50,336 | +9,508 | 0.01 | 0.01 | 0.00 | buy |
| Zimmer Partners, LP | 65,000 | 73,200 | +8,200 | 0.10 | 0.05 | -0.05 | buy |
| GILDER GAGNON HOWE & CO LLC | 40,122 | 45,299 | +5,177 | 0.02 | 0.02 | -0.00 | buy |
| Quarry LP | 1,250 | 5,900 | +4,650 | 0.02 | 0.08 | 0.00 | buy |
| PROFUND ADVISORS LLC | 46,347 | 50,474 | +4,127 | 0.08 | 0.06 | 0.00 | buy |
| Knott David M Jr | 12,000 | 16,000 | +4,000 | 0.18 | 0.18 | -0.01 | buy |
| ProShare Advisors LLC | 30,072 | 33,281 | +3,209 | 0.00 | 0.00 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 12,955 | 16,105 | +3,150 | 0.23 | 0.20 | -0.03 | buy |
| Fox Hill Wealth Management | 71,000 | 74,000 | +3,000 | 0.07 | 0.05 | -0.01 | buy |
| ALGERT GLOBAL LLC | 87,576 | 89,406 | +1,830 | 0.14 | 0.11 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,084 | 10,611 | +1,527 | 0.23 | 0.17 | -0.06 | buy |
| BFSG, LLC | 150 | 450 | +300 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 14,769 | 14,711 | -58 | 0.04 | 0.03 | -0.01 | sell |
| Garden State Investment Advisory Services LLC | 11,828 | 11,688 | -140 | 0.19 | 0.13 | -0.06 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 13,400 | 12,700 | -700 | 0.01 | 0.01 | -0.00 | sell |
| CALDWELL SUTTER CAPITAL, INC. | 3,200 | 2,200 | -1,000 | 0.07 | 0.03 | -0.03 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 64,504 | 63,051 | -1,453 | 1.37 | 0.95 | -0.42 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,254 | 11,514 | -3,740 | 0.05 | 0.03 | -0.03 | sell |
| Capital Impact Advisors, LLC | 21,273 | 14,762 | -6,511 | 1.13 | 0.59 | -0.54 | sell |
| DUALITY ADVISERS, LP | 80,192 | 73,679 | -6,513 | 0.34 | 0.22 | -0.12 | sell |
| Edgestream Partners, L.P. | 50,302 | 43,115 | -7,187 | 0.15 | 0.07 | -0.08 | sell |
| Belvedere Trading LLC | 27,071 | 14,977 | -12,094 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 65,113 | 48,807 | -16,306 | 2.60 | 1.29 | -1.31 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 944,000 | 927,230 | -16,770 | 0.03 | 0.02 | -0.01 | sell |
| Octagon Capital Advisors LP | 706,800 | 690,000 | -16,800 | 4.57 | 2.59 | -1.97 | sell |
| B. Metzler seel. Sohn & Co. AG | 48,812 | 29,089 | -19,723 | 0.03 | 0.01 | -0.02 | sell |
| Bellevue Group AG | 33,300 | 12,800 | -20,500 | 0.02 | 0.01 | -0.01 | sell |
| HHLR ADVISORS, LTD. | 1,391,240 | 1,367,489 | -23,751 | 1.13 | 0.92 | -0.21 | sell |
| Affinity Asset Advisors, LLC | 80,000 | 50,000 | -30,000 | 0.59 | 0.19 | -0.40 | sell |
| Rhenman & Partners Asset Management AB | 135,000 | 104,500 | -30,500 | 0.54 | 0.31 | -0.24 | sell |
| Laurion Capital Management LP | 5,241,833 | 5,176,328 | -65,505 | 1.79 | 1.36 | -0.44 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 289,000 | 223,468 | -65,532 | 0.04 | 0.02 | -0.02 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 291,643 | 173,926 | -117,717 | 0.03 | 0.01 | -0.02 | sell |
| Cormorant Asset Management, LP | 3,344,179 | 3,203,029 | -141,150 | 6.45 | 4.34 | -2.10 | sell |
| Aberdeen Group plc | 284,993 | 142,247 | -142,746 | 0.02 | 0.01 | -0.02 | sell |
| Ikarian Capital, LLC | 473,126 | 282,013 | -191,113 | 1.79 | 0.96 | -0.83 | sell |
| PERCEPTIVE ADVISORS LLC | 1,748,933 | 1,412,033 | -336,900 | 1.58 | 0.76 | -0.81 | sell |
| LORD, ABBETT & CO. LLC | 13,396,000 | 5,499,000 | -7,897,000 | 0.06 | 0.02 | -0.04 | sell |