| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,143,563 | 3,312,706 | +2,169,143 | 0.03 | 0.06 | +0.03 | buy |
| LORD, ABBETT & CO. LLC | 8,362,000 | 9,948,000 | +1,586,000 | 0.03 | 0.03 | +0.00 | buy |
| Capital Research Global Investors | 1,100,110 | 2,212,085 | +1,111,975 | 0.01 | 0.02 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 2,725,949 | 3,415,604 | +689,655 | 5.88 | 4.46 | -1.43 | buy |
| Prosight Management, LP | 0 | 589,530 | +589,530 | 0.00 | 5.07 | +5.07 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 449,536 | +449,536 | 0.00 | 0.13 | +0.13 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,427,000 | 5,872,000 | +445,000 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 471,866 | 914,111 | +442,245 | 0.01 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 12,800,294 | 13,222,126 | +421,832 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 290,000 | 700,749 | +410,749 | 0.13 | 0.20 | +0.07 | buy |
| Ensign Peak Advisors, Inc | 745,071 | 1,139,357 | +394,286 | 0.06 | 0.06 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 424,238 | 817,742 | +393,504 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 379,006 | +379,006 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 185,137 | 549,804 | +364,667 | 3.34 | 4.64 | +1.30 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 744,132 | 1,092,724 | +348,592 | 0.02 | 0.03 | +0.01 | buy |
| BRAIDWELL LP | 0 | 344,827 | +344,827 | 0.00 | 0.34 | +0.34 | buy |
| Caption Management, LLC | 0 | 310,434 | +310,434 | 0.00 | 1.06 | +1.06 | buy |
| STATE STREET CORP | 5,086,899 | 5,392,862 | +305,963 | 0.01 | 0.01 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 282,146 | 585,956 | +303,810 | 2.11 | 2.93 | +0.82 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,105,989 | 1,396,419 | +290,430 | 0.18 | 0.16 | -0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,557,416 | 2,844,299 | +286,883 | 0.04 | 0.03 | -0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 276,000 | +276,000 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 1,557,231 | 1,790,070 | +232,839 | 0.08 | 0.06 | -0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 192,842 | 415,277 | +222,435 | 0.04 | 0.07 | +0.02 | buy |
| CITADEL ADVISORS LLC | 664,155 | 883,275 | +219,120 | 0.03 | 0.03 | -0.00 | buy |
| Matrix Capital Management Company, LP | 0 | 170,000 | +170,000 | 0.00 | 0.05 | +0.05 | buy |
| Pictet Asset Management Holding SA | 2,767,185 | 2,932,429 | +165,244 | 0.12 | 0.10 | -0.02 | buy |
| SEI INVESTMENTS CO | 0 | 156,000 | +156,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,714,168 | 2,862,845 | +148,677 | 0.01 | 0.01 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 206,326 | 353,507 | +147,181 | 5.95 | 7.23 | +1.28 | buy |
| JPMORGAN CHASE & CO | 219,919 | 366,653 | +146,734 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 658,362 | 803,956 | +145,594 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 943,484 | 1,073,187 | +129,703 | 0.02 | 0.02 | -0.00 | buy |
| NOMURA HOLDINGS INC | 257,995 | 381,645 | +123,650 | 0.09 | 0.10 | +0.00 | buy |
| UBS Group AG | 985,510 | 1,099,546 | +114,036 | 0.02 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 33,034 | 129,960 | +96,926 | 0.00 | 0.01 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 90,000 | +90,000 | 0.00 | 0.28 | +0.28 | buy |
| DEUTSCHE BANK AG\ | 246,053 | 330,209 | +84,156 | 0.01 | 0.00 | -0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 83,540 | +83,540 | 0.00 | 0.05 | +0.05 | buy |
| Candriam S.C.A. | 299,000 | 380,000 | +81,000 | 0.08 | 0.08 | -0.01 | buy |
| Sio Capital Management, LLC | 131,753 | 203,174 | +71,421 | 1.37 | 2.19 | +0.82 | buy |
| Granahan Investment Management, LLC | 388,302 | 456,986 | +68,684 | 0.52 | 0.50 | -0.02 | buy |
| Ghisallo Capital Management LLC | 0 | 67,500 | +67,500 | 0.00 | 0.24 | +0.24 | buy |
| BIT Capital GmbH | 73,490 | 138,697 | +65,207 | 0.32 | 0.38 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 55,763 | 116,602 | +60,839 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 96,965 | 156,987 | +60,022 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 60,000 | +60,000 | 0.00 | 0.22 | +0.22 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 58,697 | +58,697 | 0.00 | 0.00 | +0.00 | buy |
| Portman Square Capital LLP | 27,679 | 77,630 | +49,951 | 0.19 | 0.55 | +0.35 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,495,114 | 1,541,885 | +46,771 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 2,560 | 47,348 | +44,788 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 43,416 | +43,416 | 0.00 | 0.06 | +0.06 | buy |
| Rafferty Asset Management, LLC | 276,073 | 316,442 | +40,369 | 0.05 | 0.04 | -0.01 | buy |
| COMERICA BANK | 237 | 38,514 | +38,277 | 0.00 | 0.01 | +0.01 | buy |
| HAP Trading, LLC | 0 | 38,039 | +38,039 | 0.00 | 0.36 | +0.36 | buy |
| NEOS Investment Management LLC | 18,301 | 50,918 | +32,617 | 0.07 | 0.10 | +0.03 | buy |
| Swiss National Bank | 176,100 | 206,000 | +29,900 | 0.01 | 0.00 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 124,984 | 149,222 | +24,238 | 0.91 | 0.78 | -0.12 | buy |
| Alberta Investment Management Corp | 0 | 24,225 | +24,225 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 84,225 | 107,225 | +23,000 | 0.05 | 0.05 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 121,653 | 144,094 | +22,441 | 0.28 | 0.24 | -0.04 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,164 | +22,164 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 47,629 | 69,606 | +21,977 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 21,908 | +21,908 | 0.00 | 0.01 | +0.01 | buy |
| Concentric Capital Strategies, LP | 0 | 21,329 | +21,329 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 29,734 | 46,595 | +16,861 | 0.03 | 0.04 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 16,524 | +16,524 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 15,259 | +15,259 | 0.00 | 0.09 | +0.09 | buy |
| Atle Fund Management AB | 23,985 | 37,841 | +13,856 | 0.76 | 0.71 | -0.05 | buy |
| China Universal Asset Management Co., Ltd. | 20,120 | 33,774 | +13,654 | 0.16 | 0.13 | -0.03 | buy |
| EMERALD ADVISERS, LLC | 685,539 | 699,083 | +13,544 | 1.18 | 0.87 | -0.31 | buy |
| Calamos Advisors LLC | 0 | 12,222 | +12,222 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 44,572 | 56,562 | +11,990 | 0.65 | 0.62 | -0.03 | buy |
| HSBC HOLDINGS PLC | 0 | 11,849 | +11,849 | 0.00 | 0.00 | +0.00 | buy |
| Wealth Management Associates, Inc. | 0 | 11,380 | +11,380 | 0.00 | 0.14 | +0.14 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 127,260 | 137,944 | +10,684 | 0.01 | 0.01 | -0.00 | buy |
| DAVENPORT & Co LLC | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 6,278 | 16,556 | +10,278 | 0.06 | 0.07 | +0.01 | buy |
| Diversified Trust Co | 17,636 | 27,702 | +10,066 | 0.02 | 0.03 | +0.00 | buy |
| MIZUHO MARKETS AMERICAS LLC | 64,379 | 74,309 | +9,930 | 0.08 | 0.06 | -0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 1,435,280 | 1,445,117 | +9,837 | 0.04 | 0.03 | -0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 40,828 | 50,336 | +9,508 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 46,611 | 55,297 | +8,686 | 0.00 | 0.00 | -0.00 | buy |
| Zimmer Partners, LP | 65,000 | 73,200 | +8,200 | 0.10 | 0.05 | -0.05 | buy |
| First Bank & Trust | 0 | 8,031 | +8,031 | 0.00 | 0.05 | +0.05 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,443 | 105,596 | +7,153 | 0.01 | 0.00 | -0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 0 | 7,000 | +7,000 | 0.00 | 0.27 | +0.27 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 6,528 | +6,528 | 0.00 | 0.02 | +0.02 | buy |
| WOLVERINE TRADING, LLC | 11,478 | 17,526 | +6,048 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 68,297 | 74,160 | +5,863 | 0.00 | 0.00 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 40,122 | 45,299 | +5,177 | 0.02 | 0.02 | -0.00 | buy |
| Quarry LP | 1,250 | 5,900 | +4,650 | 0.03 | 0.07 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 0 | 4,549 | +4,549 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 180,830 | 185,204 | +4,374 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 46,347 | 50,474 | +4,127 | 0.08 | 0.06 | -0.02 | buy |
| Knott David M Jr | 12,000 | 16,000 | +4,000 | 0.18 | 0.18 | -0.01 | buy |
| EntryPoint Capital, LLC | 0 | 3,778 | +3,778 | 0.00 | 0.10 | +0.10 | buy |
| FNY Investment Advisers, LLC | 0 | 3,750 | +3,750 | 0.00 | 0.07 | +0.07 | buy |
| Arizona State Retirement System | 24,981 | 28,686 | +3,705 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 30,072 | 33,281 | +3,209 | 0.00 | 0.00 | -0.00 | buy |