| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,907,533 | 7,171,399 | +2,263,866 | 0.07 | 0.14 | 0.00 | buy |
| Deep Track Capital, LP | 819,162 | 2,800,000 | +1,980,838 | 0.84 | 3.13 | +2.29 | buy |
| Capital Research Global Investors | 3,526,747 | 4,667,402 | +1,140,655 | 0.02 | 0.04 | +0.02 | buy |
| PFM Health Sciences, LP | 290,242 | 908,135 | +617,893 | 0.49 | 2.28 | +1.79 | buy |
| TWO SIGMA INVESTMENTS, LP | 238,536 | 843,321 | +604,785 | 0.02 | 0.07 | 0.00 | buy |
| Cormorant Asset Management, LP | 1,600,000 | 2,000,000 | +400,000 | 2.41 | 5.20 | +2.79 | buy |
| BIT Capital GmbH | 274,915 | 557,646 | +282,731 | 0.60 | 1.65 | +1.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 270,000 | 516,555 | +246,555 | 0.01 | 0.03 | +0.02 | buy |
| First Turn Management, LLC | 452,290 | 656,699 | +204,409 | 2.22 | 4.58 | +2.35 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 991,238 | 1,164,967 | +173,729 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 180,400 | 301,400 | +121,000 | 0.09 | 0.20 | +0.11 | buy |
| Portman Square Capital LLP | 24,527 | 139,247 | +114,720 | 0.13 | 0.66 | +0.53 | buy |
| Nicholas Investment Partners, LP | 59,892 | 166,655 | +106,763 | 0.14 | 0.59 | +0.45 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 300,000 | +100,000 | 0.86 | 1.62 | +0.77 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,050,139 | 1,148,292 | +98,153 | 0.02 | 0.02 | 0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 49,230 | 122,243 | +73,013 | 0.01 | 0.06 | +0.04 | buy |
| Catalio Capital Management, LP | 898,458 | 962,883 | +64,425 | 5.39 | 8.25 | +2.86 | buy |
| Atle Fund Management AB | 103,032 | 151,348 | +48,316 | 1.34 | 2.31 | +0.97 | buy |
| ROYCE & ASSOCIATES LP | 144,788 | 191,782 | +46,994 | 0.04 | 0.07 | +0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 61,118 | 25,492 | +35,626 | 0.13 | 0.07 | 0.00 | sell |
| NOMURA HOLDINGS INC | 214,128 | 240,814 | +26,686 | 0.03 | 0.05 | 0.00 | buy |
| CIBC WORLD MARKETS CORP | 13,155 | 31,192 | +18,037 | 0.00 | 0.01 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 41,514 | 59,061 | +17,547 | 49.05 | 1.43 | -47.62 | buy |
| Legato Capital Management LLC | 7,670 | 21,071 | +13,401 | 0.03 | 0.10 | +0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,015,728 | 1,027,488 | +11,760 | 0.02 | 0.02 | +0.01 | buy |
| ProShare Advisors LLC | 48,539 | 39,020 | +9,519 | 0.00 | 0.00 | 0.00 | sell |
| Moss Adams Wealth Advisors LLC | 7,577 | 16,202 | +8,625 | 0.02 | 0.06 | +0.04 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 65,647 | 73,524 | +7,877 | 0.02 | 0.03 | +0.01 | buy |
| NEOS Investment Management LLC | 141,972 | 149,117 | +7,145 | 0.09 | 0.10 | +0.01 | buy |
| TEMA ETFS LLC | 141,972 | 149,117 | +7,145 | 1.62 | 1.54 | -0.08 | buy |
| Diversified Trust Co | 27,827 | 34,866 | +7,039 | 0.02 | 0.03 | +0.01 | buy |
| F/m Investments LLC | 97,198 | 103,318 | +6,120 | 0.10 | 0.14 | +0.04 | buy |
| Clear Harbor Asset Management, LLC | 9,575 | 14,225 | +4,650 | 0.02 | 0.04 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 11,500 | 16,085 | +4,585 | 0.21 | 0.43 | +0.22 | buy |
| HARVEY CAPITAL MANAGEMENT INC | 12,900 | 17,000 | +4,100 | 0.08 | 0.15 | +0.07 | buy |
| MIZUHO MARKETS AMERICAS LLC | 90,175 | 94,175 | +4,000 | 0.05 | 0.07 | +0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 44,661 | 47,124 | +2,463 | 0.01 | 0.02 | 0.00 | buy |
| Wealth Management Associates, Inc. | 7,545 | 8,980 | +1,435 | 0.09 | 0.13 | +0.04 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 63,157 | 64,502 | +1,345 | 0.86 | 1.22 | +0.35 | buy |
| E Fund Management Co., Ltd. | 17,785 | 18,890 | +1,105 | 0.02 | 0.03 | +0.01 | buy |
| First Bank & Trust | 7,471 | 8,493 | +1,022 | 0.04 | 0.06 | +0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,968 | 4,839 | +871 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 18,975 | 19,050 | +75 | 0.01 | 0.01 | +0.00 | buy |
| CI INVESTMENTS INC. | 3,184 | 3,165 | +19 | 0.00 | 0.00 | 0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 2,500,000 | 2,499,999 | -1 | 0.01 | 0.01 | +0.00 | sell |
| SYON CAPITAL LLC | 13,200 | 13,164 | -36 | 0.03 | 0.04 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 14,706 | 14,331 | -375 | 0.01 | 0.02 | +0.00 | sell |
| Avanza Fonder AB | 6,581 | 6,121 | -460 | 0.01 | 0.01 | +0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 724,872 | 724,354 | -518 | 1.21 | 1.78 | +0.57 | sell |
| Hennion & Walsh Asset Management, Inc. | 37,659 | 36,709 | -950 | 0.05 | 0.06 | +0.01 | sell |
| BFSG, LLC | 1,240 | 240 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Kazazian Asset Management, LLC | 13,520 | 11,840 | -1,680 | 0.28 | 0.33 | +0.05 | sell |
| China Universal Asset Management Co., Ltd. | 40,073 | 38,149 | -1,924 | 0.10 | 0.12 | +0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 915,500 | 913,200 | -2,300 | 0.02 | 0.03 | +0.01 | sell |
| FNY Investment Advisers, LLC | 13,750 | 11,336 | -2,414 | 0.20 | 0.24 | +0.04 | sell |
| MOODY ALDRICH PARTNERS LLC | 99,684 | 96,915 | -2,769 | 0.51 | 0.70 | +0.19 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 261,944 | 258,102 | -3,842 | 0.02 | 0.02 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 1,150,868 | 1,145,491 | -5,377 | 1.22 | 1.78 | +0.56 | sell |
| PROFUND ADVISORS LLC | 49,091 | 42,621 | -6,470 | 0.05 | 0.06 | +0.01 | sell |
| CARY STREET PARTNERS FINANCIAL LLC | 19,360 | 7,700 | -11,660 | 0.02 | 0.01 | -0.01 | sell |
| Lion Point Capital, LP | 40,300 | 26,000 | -14,300 | 5.79 | 5.73 | -0.06 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 41,077 | 23,760 | -17,317 | 1.06 | 0.70 | -0.36 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 68,700 | 50,841 | -17,859 | 0.16 | 0.18 | +0.02 | sell |
| Nebula Research & Development LLC | 36,239 | 15,579 | -20,660 | 0.12 | 0.05 | -0.07 | sell |
| Rafferty Asset Management, LLC | 250,242 | 202,128 | -48,114 | 0.02 | 0.03 | +0.01 | sell |
| 683 Capital Management, LLC | 635,000 | 575,000 | -60,000 | 1.08 | 1.37 | +0.29 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 262,141 | 183,922 | -78,219 | 6.32 | 7.58 | +1.27 | sell |
| Exome Asset Management LLC | 246,700 | 165,496 | -81,204 | 5.09 | 5.12 | +0.03 | sell |
| Ikarian Capital, LLC | 215,713 | 90,837 | -124,876 | 1.69 | 1.02 | -0.67 | sell |
| Cutter Capital Management, LP | 560,344 | 390,644 | -169,700 | 6.30 | 5.88 | -0.42 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,075,858 | 769,301 | -306,557 | 0.28 | 0.29 | +0.01 | sell |
| ADAR1 Capital Management, LLC | 678,857 | 339,635 | -339,222 | 3.84 | 2.26 | -1.58 | sell |
| Prosight Management, LP | 995,000 | 610,000 | -385,000 | 7.55 | 6.93 | -0.62 | sell |
| ARISTEIA CAPITAL, L.L.C. | 411,927 | 23,582 | -388,345 | 0.37 | 0.02 | -0.35 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 905,279 | 366,608 | -538,671 | 4.49 | 2.92 | -1.57 | sell |
| Woodline Partners LP | 2,211,521 | 1,625,755 | -585,766 | 0.41 | 0.37 | -0.05 | sell |
| Laurion Capital Management LP | 3,740,896 | 2,978,167 | -762,729 | 1.88 | 2.59 | +0.71 | sell |
| VIKING GLOBAL INVESTORS LP | 25,120,991 | 22,055,375 | -3,065,616 | 2.23 | 2.42 | +0.19 | sell |
| Kohlberg Kravis Roberts & Co. L.P. | 25,260,971 | 19,260,971 | -6,000,000 | 18.56 | 15.04 | -3.52 | sell |