| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 14,549,529 | 14,207,757 | -341,772 | 0.02 | 0.02 | -0.00 | sell |
| Kohlberg Kravis Roberts & Co. L.P. | 13,260,971 | 13,260,971 | 0 | 16.22 | 18.42 | +2.20 | hold |
| JANUS HENDERSON GROUP PLC | 11,000,457 | 13,179,013 | +2,178,556 | 0.38 | 0.47 | +0.09 | buy |
| VIKING GLOBAL INVESTORS LP | 14,393,934 | 11,842,434 | -2,551,500 | 2.92 | 2.46 | -0.46 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 8,998,463 | 9,365,463 | +367,000 | 3.58 | 4.12 | +0.55 | buy |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 6,080,000 | +6,080,000 | 0.42 | 0.47 | +0.05 | buy |
| Aisling Capital Management LP | 5,089,611 | 5,089,611 | 0 | 81.29 | 79.35 | -1.93 | hold |
| STATE STREET CORP | 4,962,866 | 4,934,320 | -28,546 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 4,412,523 | 4,918,030 | +505,507 | 0.02 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 4,831,305 | 4,592,814 | -238,491 | 0.05 | 0.04 | -0.00 | sell |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 4,134,000 | +4,134,000 | 0.00 | 0.48 | +0.48 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,828,746 | 3,801,655 | -27,091 | 0.03 | 0.03 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 3,545,557 | 3,448,139 | -97,418 | 7.28 | 6.59 | -0.70 | sell |
| CITADEL ADVISORS LLC | 698,182 | 3,173,940 | +2,475,758 | 0.04 | 0.17 | +0.13 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,947,047 | 3,120,631 | +1,173,584 | 0.22 | 0.19 | -0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 3,000,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 2,214,031 | 2,545,486 | +331,455 | 0.13 | 0.15 | +0.02 | buy |
| Polar Capital Holdings Plc | 1,299,346 | 2,519,306 | +1,219,960 | 0.45 | 0.82 | +0.36 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,500,000 | 2,500,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 2,348,731 | 2,483,953 | +135,222 | 0.03 | 0.03 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,164,928 | 2,438,925 | +273,997 | 0.04 | 0.04 | +0.00 | buy |
| FMR LLC | 2,390,362 | 2,343,754 | -46,608 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 1,875,665 | 2,026,821 | +151,156 | 0.03 | 0.03 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,975,315 | 1,977,080 | +1,765 | 0.12 | 0.13 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,964,419 | 1,976,094 | +11,675 | 0.02 | 0.02 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,050,746 | 1,908,907 | -141,839 | 0.05 | 0.05 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,782,833 | 1,897,716 | +114,883 | 0.02 | 0.02 | -0.00 | buy |
| MORGAN STANLEY | 1,399,809 | 1,877,359 | +477,550 | 0.01 | 0.01 | +0.00 | buy |
| SC US (TTGP), LTD. | 1,860,364 | 1,860,364 | 0 | 1.02 | 1.49 | +0.48 | hold |
| JANE STREET GROUP, LLC | 341,795 | 1,757,672 | +1,415,877 | 0.03 | 0.14 | +0.11 | buy |
| NORTHERN TRUST CORP | 1,346,754 | 1,403,642 | +56,888 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,270,290 | 1,381,184 | +110,894 | 0.09 | 0.11 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,314,303 | 1,330,415 | +16,112 | 0.05 | 0.05 | +0.00 | buy |
| JPMORGAN CHASE & CO | 858,968 | 1,312,259 | +453,291 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,592,660 | 1,307,176 | -285,484 | 0.08 | 0.06 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 1,078,048 | 1,285,748 | +207,700 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 1,255,185 | 1,265,080 | +9,895 | 1.05 | 0.94 | -0.11 | buy |
| Laurion Capital Management LP | 1,402,150 | 1,262,651 | -139,499 | 7.32 | 8.80 | +1.48 | sell |
| AMERIPRISE FINANCIAL INC | 841,536 | 1,248,521 | +406,985 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,680,972 | 1,146,671 | -534,301 | 0.87 | 0.63 | -0.25 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,106,820 | 1,090,326 | -16,494 | 0.04 | 0.04 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 781,345 | 1,023,341 | +241,996 | 0.18 | 0.25 | +0.06 | buy |
| Bank of New York Mellon Corp | 200,000 | 1,000,000 | +800,000 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 626,122 | 962,643 | +336,521 | 0.41 | 0.63 | +0.22 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 826,131 | 957,989 | +131,858 | 0.67 | 0.73 | +0.06 | buy |
| Clearbridge Investments, LLC | 498,329 | 951,200 | +452,871 | 0.03 | 0.06 | +0.03 | buy |
| Allspring Global Investments Holdings, LLC | 994,220 | 889,356 | -104,864 | 0.13 | 0.11 | -0.02 | sell |
| Cormorant Asset Management, LP | 1,200,000 | 850,000 | -350,000 | 5.20 | 3.18 | -2.02 | sell |
| Deep Track Capital, LP | 810,142 | 841,445 | +31,303 | 1.41 | 1.29 | -0.12 | buy |
| Ensign Peak Advisors, Inc | 1,263,484 | 836,552 | -426,932 | 0.17 | 0.12 | -0.05 | sell |
| Capital Research Global Investors | 1,934,698 | 763,702 | -1,170,996 | 0.03 | 0.01 | -0.02 | sell |
| CITIGROUP INC | 700,251 | 746,483 | +46,232 | 0.04 | 0.04 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 738,843 | 742,117 | +3,274 | 0.20 | 0.21 | +0.01 | buy |
| First Turn Management, LLC | 595,473 | 695,718 | +100,245 | 5.20 | 5.77 | +0.57 | buy |
| MILLENNIUM MANAGEMENT LLC | 36,585 | 633,283 | +596,698 | 0.00 | 0.04 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 508,134 | 599,000 | +90,866 | 0.06 | 0.07 | +0.01 | buy |
| FEDERATED HERMES, INC. | 586,795 | 588,434 | +1,639 | 0.07 | 0.07 | -0.00 | buy |
| Bank of New York Mellon Corp | 596,403 | 577,283 | -19,120 | 0.01 | 0.01 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 569,680 | 569,180 | -500 | 0.03 | 0.03 | +0.00 | sell |
| Nuveen, LLC | 494,785 | 562,696 | +67,911 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 382,569 | 561,945 | +179,376 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 268,899 | 556,324 | +287,425 | 0.04 | 0.09 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 583,361 | 538,980 | -44,381 | 0.04 | 0.04 | -0.00 | sell |
| DIAMANT ASSET MANAGEMENT, INC. | 0 | 527,246 | +527,246 | 0.00 | 0.38 | +0.38 | buy |
| EMERALD ADVISERS, LLC | 535,764 | 515,361 | -20,403 | 1.26 | 1.21 | -0.05 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 362,130 | 437,130 | +75,000 | 0.43 | 0.54 | +0.10 | buy |
| Catalio Capital Management, LP | 410,700 | 432,014 | +21,314 | 5.55 | 6.70 | +1.15 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 638,883 | 426,583 | -212,300 | 0.17 | 0.13 | -0.04 | sell |
| BARCLAYS PLC | 622,575 | 423,888 | -198,687 | 0.02 | 0.01 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 457,977 | 420,325 | -37,652 | 0.37 | 0.37 | +0.00 | sell |
| Sofinnova Investments, Inc. | 720,448 | 409,183 | -311,265 | 2.38 | 1.52 | -0.85 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 451,016 | 402,948 | -48,068 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 487,376 | 398,943 | -88,433 | 0.05 | 0.04 | -0.01 | sell |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 398,000 | +398,000 | 0.07 | 0.05 | -0.02 | buy |
| SEI INVESTMENTS CO | 361,000 | 377,000 | +16,000 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 365,772 | +365,772 | 0.00 | 0.04 | +0.04 | buy |
| 1832 Asset Management L.P. | 45,600 | 356,400 | +310,800 | 0.00 | 0.04 | +0.03 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 813,794 | 352,831 | -460,963 | 1.75 | 1.21 | -0.54 | sell |
| Russell Investments Group, Ltd. | 415,156 | 351,719 | -63,437 | 0.03 | 0.03 | -0.01 | sell |
| Fisher Asset Management, LLC | 232,401 | 351,628 | +119,227 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 234,389 | 350,096 | +115,707 | 0.03 | 0.05 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 281,686 | 339,907 | +58,221 | 0.02 | 0.02 | +0.00 | buy |
| MARSHALL WACE, LLP | 74,686 | 334,382 | +259,696 | 0.01 | 0.03 | +0.02 | buy |
| Fiera Capital Corp | 0 | 322,690 | +322,690 | 0.00 | 0.08 | +0.08 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 316,784 | 320,211 | +3,427 | 1.18 | 1.15 | -0.03 | buy |
| NOMURA HOLDINGS INC | 309,930 | 318,563 | +8,633 | 0.07 | 0.20 | +0.13 | buy |
| RAYMOND JAMES FINANCIAL INC | 117,501 | 311,959 | +194,458 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 300,912 | 301,012 | +100 | 0.09 | 0.08 | -0.00 | buy |
| Nicholas Investment Partners, LP | 284,682 | 298,909 | +14,227 | 1.59 | 1.60 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 381,063 | 296,683 | -84,380 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 224,866 | 288,075 | +63,209 | 0.02 | 0.02 | +0.00 | buy |
| Swiss National Bank | 282,600 | 286,000 | +3,400 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 334,731 | 284,917 | -49,814 | 0.01 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 341,048 | 283,921 | -57,127 | 0.41 | 0.32 | -0.09 | sell |
| Candriam S.C.A. | 278,888 | 278,888 | 0 | 0.11 | 0.11 | +0.00 | hold |
| Integral Health Asset Management, LLC | 0 | 275,000 | +275,000 | 0.00 | 1.08 | +1.08 | buy |
| Eagle Health Investments LP | 259,300 | 267,031 | +7,731 | 4.36 | 4.16 | -0.20 | buy |
| Bridgewater Associates, LP | 43,172 | 259,459 | +216,287 | 0.01 | 0.09 | +0.07 | buy |
| PFM Health Sciences, LP | 306,506 | 257,747 | -48,759 | 2.37 | 2.01 | -0.36 | sell |