| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,312,706 | 4,312,531 | +999,825 | 0.06 | 0.06 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 549,804 | 1,264,570 | +714,766 | 4.64 | 6.45 | +1.81 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 585,956 | 910,070 | +324,114 | 2.55 | 3.14 | +0.60 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 276,000 | 548,000 | +272,000 | 0.02 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 700,749 | 949,570 | +248,821 | 0.20 | 0.23 | +0.03 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 379,006 | 598,263 | +219,257 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,415,604 | 3,632,604 | +217,000 | 4.46 | 4.30 | -0.15 | buy |
| Prosight Management, LP | 589,530 | 800,000 | +210,470 | 5.07 | 6.06 | +0.99 | buy |
| AMERICAN CENTURY COMPANIES INC | 914,111 | 1,096,734 | +182,623 | 0.02 | 0.02 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 744,600 | 565,452 | +179,148 | 0.06 | 0.04 | 0.00 | sell |
| NOMURA HOLDINGS INC | 381,645 | 228,234 | +153,411 | 0.10 | 0.04 | 0.00 | sell |
| 683 Capital Management, LLC | 90,000 | 200,000 | +110,000 | 0.20 | 0.38 | +0.18 | buy |
| Rhenman & Partners Asset Management AB | 104,500 | 184,500 | +80,000 | 0.31 | 0.45 | +0.14 | buy |
| Matrix Capital Management Company, LP | 170,000 | 240,000 | +70,000 | 0.05 | 0.05 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,073,187 | 1,125,145 | +51,958 | 0.02 | 0.02 | 0.00 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 100,000 | +50,000 | 0.19 | 0.29 | +0.10 | buy |
| Ikarian Capital, LLC | 282,013 | 332,013 | +50,000 | 0.96 | 1.46 | +0.51 | buy |
| NEOS Investment Management LLC | 50,918 | 87,289 | +36,371 | 0.10 | 0.09 | -0.01 | buy |
| ALGERT GLOBAL LLC | 89,406 | 55,848 | +33,558 | 0.11 | 0.05 | 0.00 | sell |
| Erste Asset Management GmbH | 107,225 | 140,225 | +33,000 | 0.05 | 0.05 | +0.00 | buy |
| Exome Asset Management LLC | 48,807 | 78,907 | +30,100 | 1.29 | 1.78 | +0.49 | buy |
| HHLR ADVISORS, LTD. | 1,367,489 | 1,390,653 | +23,164 | 0.92 | 0.87 | -0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 803,956 | 824,818 | +20,862 | 0.00 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 37,841 | 53,432 | +15,591 | 0.71 | 0.83 | +0.11 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 11,514 | 23,311 | +11,797 | 0.03 | 0.05 | +0.03 | buy |
| MIZUHO MARKETS AMERICAS LLC | 74,309 | 83,982 | +9,673 | 0.06 | 0.06 | -0.00 | buy |
| Diversified Trust Co | 27,702 | 35,713 | +8,011 | 0.03 | 0.03 | -0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 7,000 | 15,000 | +8,000 | 0.28 | 0.14 | -0.15 | buy |
| ProShare Advisors LLC | 33,281 | 27,177 | +6,104 | 0.00 | 0.00 | 0.00 | sell |
| Knott David M Jr | 16,000 | 21,000 | +5,000 | 0.18 | 0.21 | +0.04 | buy |
| Alberta Investment Management Corp | 24,225 | 29,133 | +4,908 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 173,926 | 176,692 | +2,766 | 0.01 | 0.01 | -0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 12,700 | 15,200 | +2,500 | 0.01 | 0.01 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 11,540 | 13,772 | +2,232 | 0.01 | 0.01 | -0.00 | buy |
| FNY Investment Advisers, LLC | 3,750 | 5,750 | +2,000 | 0.07 | 0.10 | +0.03 | buy |
| E Fund Management Co., Ltd. | 14,711 | 16,496 | +1,785 | 0.03 | 0.02 | -0.01 | buy |
| Quarry LP | 5,900 | 7,500 | +1,600 | 0.08 | 0.08 | 0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 11,710 | 13,116 | +1,406 | 0.00 | 0.00 | -0.00 | buy |
| BFSG, LLC | 450 | 1,240 | +790 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 10,611 | 11,357 | +746 | 0.17 | 0.14 | -0.03 | buy |
| BRAIDWELL LP | 344,827 | 345,571 | +744 | 0.34 | 0.27 | -0.07 | buy |
| PROFUND ADVISORS LLC | 50,474 | 51,029 | +555 | 0.06 | 0.05 | 0.00 | buy |
| First Bank & Trust | 8,031 | 8,044 | +13 | 0.05 | 0.04 | -0.01 | buy |
| Elequin Capital, LP | 322 | 314 | -8 | 0.00 | 0.00 | +0.00 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 63,051 | 63,004 | -47 | 0.95 | 0.85 | -0.10 | sell |
| Garden State Investment Advisory Services LLC | 11,688 | 11,588 | -100 | 0.13 | 0.10 | -0.03 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 927,230 | 926,900 | -330 | 0.02 | 0.02 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 16,105 | 15,535 | -570 | 0.20 | 0.16 | -0.04 | sell |
| Capital Impact Advisors, LLC | 14,762 | 13,925 | -837 | 0.59 | 0.99 | +0.40 | sell |
| GILDER GAGNON HOWE & CO LLC | 45,299 | 44,302 | -997 | 0.02 | 0.01 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 500,254 | 498,254 | -2,000 | 0.81 | 0.66 | -0.14 | sell |
| Belvedere Trading LLC | 14,977 | 9,654 | -5,323 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 138,697 | 129,213 | -9,484 | 0.32 | 0.26 | -0.06 | sell |
| China Universal Asset Management Co., Ltd. | 33,774 | 21,984 | -11,790 | 0.13 | 0.08 | -0.05 | sell |
| HighVista Strategies LLC | 56,562 | 44,572 | -11,990 | 0.62 | 0.41 | -0.21 | sell |
| MOODY ALDRICH PARTNERS LLC | 149,222 | 125,829 | -23,393 | 0.78 | 0.62 | -0.16 | sell |
| Portman Square Capital LLP | 77,630 | 48,177 | -29,453 | 0.55 | 0.41 | -0.14 | sell |
| EMERALD ADVISERS, LLC | 699,083 | 666,344 | -32,739 | 0.87 | 0.71 | -0.16 | sell |
| Ghisallo Capital Management LLC | 67,500 | 33,750 | -33,750 | 0.24 | 0.07 | -0.16 | sell |
| Rafferty Asset Management, LLC | 316,442 | 271,607 | -44,835 | 0.04 | 0.03 | -0.01 | sell |
| Sio Capital Management, LLC | 203,174 | 125,174 | -78,000 | 1.87 | 0.86 | -1.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 144,094 | 39,099 | -104,995 | 0.24 | 0.05 | -0.19 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 353,507 | 219,837 | -133,670 | 7.23 | 7.02 | -0.21 | sell |
| PERCEPTIVE ADVISORS LLC | 1,412,033 | 1,215,346 | -196,687 | 0.76 | 0.74 | -0.02 | sell |
| Granahan Investment Management, LLC | 456,986 | 251,525 | -205,461 | 0.50 | 0.25 | -0.24 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 449,536 | 148,368 | -301,168 | 0.13 | 0.04 | -0.09 | sell |
| Laurion Capital Management LP | 5,176,328 | 4,388,873 | -787,455 | 1.36 | 1.32 | -0.04 | sell |
| T. Rowe Price Investment Management, Inc. | 1,445,117 | 276,369 | -1,168,748 | 0.03 | 0.00 | -0.02 | sell |
| Cormorant Asset Management, LP | 3,203,029 | 1,858,351 | -1,344,678 | 4.34 | 2.72 | -1.63 | sell |