| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 2,985,000 | +2,985,000 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 883,275 | 2,156,449 | +1,273,174 | 0.03 | 0.05 | +0.03 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,089,492 | +1,089,492 | 0.00 | 1.06 | +1.06 | buy |
| JANUS HENDERSON GROUP PLC | 3,312,706 | 4,312,531 | +999,825 | 0.06 | 0.06 | +0.00 | buy |
| VANGUARD GROUP INC | 13,222,126 | 14,054,748 | +832,622 | 0.01 | 0.01 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 549,804 | 1,264,570 | +714,766 | 4.64 | 6.45 | +1.81 | buy |
| JANE STREET GROUP, LLC | 0 | 700,000 | +700,000 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,625,759 | 2,298,039 | +672,280 | 0.01 | 0.01 | +0.00 | buy |
| Man Group plc | 0 | 619,927 | +619,927 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,353 | 676,649 | +618,296 | 0.00 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 1,139,357 | 1,646,202 | +506,845 | 0.06 | 0.08 | +0.01 | buy |
| JANE STREET GROUP, LLC | 229,576 | 717,185 | +487,609 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 5,392,862 | 5,854,140 | +461,278 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,092,724 | 1,534,972 | +442,248 | 0.03 | 0.04 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,862,845 | 3,290,409 | +427,564 | 0.01 | 0.01 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 341,247 | +341,247 | 0.00 | 0.17 | +0.17 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 585,956 | 910,070 | +324,114 | 2.93 | 3.76 | +0.82 | buy |
| PANAGORA ASSET MANAGEMENT INC | 415,277 | 727,963 | +312,686 | 0.07 | 0.09 | +0.03 | buy |
| Cutter Capital Management, LP | 0 | 311,700 | +311,700 | 0.00 | 2.41 | +2.41 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 307,911 | +307,911 | 0.00 | 0.73 | +0.73 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 276,000 | 548,000 | +272,000 | 0.02 | 0.03 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 252,793 | +252,793 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 700,749 | 949,570 | +248,821 | 0.20 | 0.23 | +0.03 | buy |
| MORGAN STANLEY | 1,181,894 | 1,429,009 | +247,115 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 6,995 | 246,895 | +239,900 | 0.00 | 0.02 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 379,006 | 598,263 | +219,257 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,415,604 | 3,632,604 | +217,000 | 4.46 | 4.30 | -0.15 | buy |
| Prosight Management, LP | 589,530 | 800,000 | +210,470 | 5.07 | 6.06 | +0.99 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 207,280 | +207,280 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 914,111 | 1,096,734 | +182,623 | 0.02 | 0.02 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 167,839 | +167,839 | 0.00 | 0.10 | +0.10 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,048,037 | 1,189,197 | +141,160 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 116,602 | 241,780 | +125,178 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 512,091 | 624,769 | +112,678 | 0.00 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 90,000 | 200,000 | +110,000 | 0.28 | 0.53 | +0.25 | buy |
| Caption Management, LLC | 310,434 | 406,000 | +95,566 | 1.06 | 1.09 | +0.03 | buy |
| Invesco Ltd. | 998,625 | 1,088,720 | +90,095 | 0.01 | 0.01 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 81,232 | +81,232 | 0.00 | 0.07 | +0.07 | buy |
| Rhenman & Partners Asset Management AB | 104,500 | 184,500 | +80,000 | 0.31 | 0.45 | +0.14 | buy |
| ARISTEIA CAPITAL, L.L.C. | 0 | 76,222 | +76,222 | 0.00 | 0.07 | +0.07 | buy |
| Matrix Capital Management Company, LP | 170,000 | 240,000 | +70,000 | 0.05 | 0.05 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 641,895 | 706,127 | +64,232 | 0.01 | 0.01 | -0.00 | buy |
| Walleye Capital LLC | 21,908 | 77,613 | +55,705 | 0.01 | 0.02 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,073,187 | 1,125,145 | +51,958 | 0.02 | 0.02 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 100,000 | +50,000 | 0.25 | 0.40 | +0.15 | buy |
| Ikarian Capital, LLC | 282,013 | 332,013 | +50,000 | 2.37 | 2.62 | +0.25 | buy |
| Lion Point Capital, LP | 0 | 49,000 | +49,000 | 0.00 | 3.89 | +3.89 | buy |
| SG Americas Securities, LLC | 6,287 | 53,865 | +47,578 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 38,946 | +38,946 | 0.00 | 0.01 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 36,500 | +36,500 | 0.00 | 0.03 | +0.03 | buy |
| NEOS Investment Management LLC | 50,918 | 87,289 | +36,371 | 0.10 | 0.09 | -0.01 | buy |
| RHUMBLINE ADVISERS | 185,204 | 221,403 | +36,199 | 0.01 | 0.01 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 35,381 | +35,381 | 0.00 | 0.01 | +0.01 | buy |
| Daiwa Securities Group Inc. | 650 | 35,709 | +35,059 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 348,357 | 382,717 | +34,360 | 0.01 | 0.01 | -0.00 | buy |
| Erste Asset Management GmbH | 107,225 | 140,225 | +33,000 | 0.05 | 0.05 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,305 | 33,633 | +32,328 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 30,849 | +30,849 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 48,807 | 78,907 | +30,100 | 1.29 | 1.78 | +0.49 | buy |
| Bayesian Capital Management, LP | 0 | 28,200 | +28,200 | 0.00 | 0.08 | +0.08 | buy |
| Alpine Global Management, LLC | 0 | 26,634 | +26,634 | 0.00 | 0.12 | +0.12 | buy |
| Engineers Gate Manager LP | 46,595 | 71,505 | +24,910 | 0.04 | 0.04 | +0.00 | buy |
| CHOREO, LLC | 0 | 24,000 | +24,000 | 0.00 | 0.00 | +0.00 | buy |
| HHLR ADVISORS, LTD. | 1,367,489 | 1,390,653 | +23,164 | 0.92 | 0.87 | -0.05 | buy |
| MetLife Investment Management, LLC | 59,178 | 81,166 | +21,988 | 0.01 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 21,421 | +21,421 | 0.00 | 0.04 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 803,956 | 824,818 | +20,862 | 0.00 | 0.00 | -0.00 | buy |
| CHOREO, LLC | 0 | 18,000 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 67,641 | 84,996 | +17,355 | 0.06 | 0.07 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 16,709 | +16,709 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 55,297 | 71,708 | +16,411 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 37,841 | 53,432 | +15,591 | 0.71 | 0.83 | +0.11 | buy |
| ExodusPoint Capital Management, LP | 0 | 14,890 | +14,890 | 0.00 | 0.00 | +0.00 | buy |
| TRANSCEND CAPITAL ADVISORS, LLC | 0 | 13,500 | +13,500 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 0 | 13,324 | +13,324 | 0.00 | 0.05 | +0.05 | buy |
| Brevan Howard Capital Management LP | 0 | 13,185 | +13,185 | 0.00 | 0.02 | +0.02 | buy |
| Diametric Capital, LP | 0 | 12,076 | +12,076 | 0.00 | 0.17 | +0.17 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 11,514 | 23,311 | +11,797 | 0.02 | 0.05 | +0.03 | buy |
| ROYAL BANK OF CANADA | 7,128 | 18,692 | +11,564 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 11,200 | +11,200 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 11,029 | +11,029 | 0.00 | 0.15 | +0.15 | buy |
| Swiss National Bank | 206,000 | 216,900 | +10,900 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 0 | 10,898 | +10,898 | 0.00 | 0.01 | +0.01 | buy |
| MIZUHO MARKETS AMERICAS LLC | 74,309 | 83,982 | +9,673 | 0.06 | 0.06 | -0.00 | buy |
| BARCLAYS PLC | 405,168 | 413,265 | +8,097 | 0.01 | 0.00 | -0.00 | buy |
| Diversified Trust Co | 27,702 | 35,713 | +8,011 | 0.03 | 0.03 | -0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 7,000 | 15,000 | +8,000 | 0.27 | 0.14 | -0.14 | buy |
| CSS LLC/IL | 0 | 6,481 | +6,481 | 0.00 | 0.01 | +0.01 | buy |
| Knott David M Jr | 16,000 | 21,000 | +5,000 | 0.18 | 0.21 | +0.04 | buy |
| Alberta Investment Management Corp | 24,225 | 29,133 | +4,908 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,596 | 109,817 | +4,221 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 3,905 | +3,905 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 8,657 | 12,375 | +3,718 | 0.17 | 0.20 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 69,606 | 73,230 | +3,624 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,950 | 25,072 | +3,122 | 0.00 | 0.00 | -0.00 | buy |
| Advisors Asset Management, Inc. | 0 | 2,931 | +2,931 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 173,926 | 176,692 | +2,766 | 0.01 | 0.01 | -0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 12,700 | 15,200 | +2,500 | 0.01 | 0.01 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 4,549 | 6,900 | +2,351 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 100 | 2,338 | +2,238 | 0.00 | 0.00 | +0.00 | buy |