| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kohlberg Kravis Roberts & Co. L.P. | 13,260,971 | 13,260,971 | 0 | 18.42 | 17.30 | -1.12 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 9,365,463 | 10,743,063 | +1,377,600 | 4.12 | 4.68 | +0.56 | buy |
| BlackRock, Inc. | 14,207,757 | 10,287,156 | -3,920,601 | 0.02 | 0.01 | -0.01 | sell |
| VIKING GLOBAL INVESTORS LP | 11,842,434 | 9,949,219 | -1,893,215 | 2.46 | 2.11 | -0.35 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,483,953 | 5,308,924 | +2,824,971 | 0.03 | 0.07 | +0.03 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 5,000,000 | +5,000,000 | 0.00 | 0.08 | +0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 3,120,631 | 4,722,185 | +1,601,554 | 0.19 | 0.26 | +0.07 | buy |
| Aisling Capital Management LP | 5,089,611 | 4,589,611 | -500,000 | 79.35 | 72.48 | -6.87 | sell |
| STATE STREET CORP | 4,934,320 | 4,435,932 | -498,388 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 4,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 4,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,173,940 | 3,760,028 | +586,088 | 0.17 | 0.16 | -0.01 | buy |
| Invesco Ltd. | 4,592,814 | 3,700,934 | -891,880 | 0.04 | 0.02 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 2,545,486 | 3,633,007 | +1,087,521 | 0.15 | 0.17 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,918,030 | 3,418,419 | -1,499,611 | 0.02 | 0.01 | -0.01 | sell |
| JANE STREET GROUP, LLC | 1,757,672 | 2,934,193 | +1,176,521 | 0.14 | 0.14 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,312,259 | 2,397,995 | +1,085,736 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 599,000 | 2,252,000 | +1,653,000 | 0.07 | 0.24 | +0.17 | buy |
| FRANKLIN RESOURCES INC | 2,438,925 | 2,160,173 | -278,752 | 0.04 | 0.03 | -0.01 | sell |
| Polar Capital Holdings Plc | 2,519,306 | 2,063,609 | -455,697 | 0.82 | 0.44 | -0.38 | sell |
| FMR LLC | 2,343,754 | 2,061,307 | -282,447 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,977,080 | 1,955,733 | -21,347 | 0.13 | 0.11 | -0.01 | sell |
| SC US (TTGP), LTD. | 1,860,364 | 1,860,364 | 0 | 1.49 | 0.43 | -1.06 | hold |
| GOLDMAN SACHS GROUP INC | 1,897,716 | 1,814,657 | -83,059 | 0.02 | 0.01 | -0.00 | sell |
| UBS Group AG | 2,026,821 | 1,757,152 | -269,669 | 0.03 | 0.02 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,801,655 | 1,726,383 | -2,075,272 | 0.03 | 0.01 | -0.02 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 1,709,417 | +1,709,417 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,976,094 | 1,709,417 | -266,677 | 0.02 | 0.02 | -0.01 | sell |
| NORGES BANK | 0 | 1,693,773 | +1,693,773 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,877,359 | 1,693,652 | -183,707 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 1,248,521 | 1,551,663 | +303,142 | 0.02 | 0.02 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,448,139 | 1,548,139 | -1,900,000 | 6.59 | 2.51 | -4.08 | sell |
| Point72 Asset Management, L.P. | 0 | 1,525,782 | +1,525,782 | 0.00 | 0.17 | +0.17 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,908,907 | 1,453,504 | -455,403 | 0.05 | 0.04 | -0.01 | sell |
| Pictet Asset Management Holding SA | 1,381,184 | 1,448,126 | +66,942 | 0.11 | 0.10 | -0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 957,989 | 1,373,057 | +415,068 | 0.73 | 0.95 | +0.22 | buy |
| Laurion Capital Management LP | 1,262,651 | 1,352,234 | +89,583 | 8.80 | 7.30 | -1.50 | buy |
| Hood River Capital Management LLC | 1,265,080 | 1,347,535 | +82,455 | 0.94 | 0.73 | -0.21 | buy |
| BANK OF AMERICA CORP /DE/ | 1,285,748 | 1,235,380 | -50,368 | 0.01 | 0.01 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 350,096 | 1,230,052 | +879,956 | 0.05 | 0.17 | +0.12 | buy |
| Squarepoint Ops LLC | 556,324 | 1,191,732 | +635,408 | 0.09 | 0.17 | +0.08 | buy |
| Bellevue Group AG | 25,377 | 1,189,506 | +1,164,129 | 0.04 | 1.86 | +1.82 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,307,176 | 1,155,442 | -151,734 | 0.06 | 0.04 | -0.02 | sell |
| GW&K Investment Management, LLC | 962,643 | 1,125,131 | +162,488 | 0.63 | 0.65 | +0.02 | buy |
| HRT FINANCIAL LP | 71,865 | 1,089,376 | +1,017,511 | 0.01 | 0.15 | +0.13 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,330,415 | 1,024,423 | -305,992 | 0.05 | 0.04 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 569,180 | 1,015,980 | +446,800 | 0.03 | 0.04 | +0.01 | buy |
| FIL Ltd | 88 | 1,002,260 | +1,002,172 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 1,000,000 | 1,000,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearbridge Investments, LLC | 951,200 | 993,103 | +41,903 | 0.06 | 0.06 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,403,642 | 959,513 | -444,129 | 0.01 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 746,483 | 864,101 | +117,618 | 0.04 | 0.03 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 365,772 | 856,846 | +491,074 | 0.04 | 0.09 | +0.05 | buy |
| Ensign Peak Advisors, Inc | 836,552 | 760,977 | -75,575 | 0.12 | 0.09 | -0.02 | sell |
| Allspring Global Investments Holdings, LLC | 889,356 | 742,547 | -146,809 | 0.11 | 0.08 | -0.03 | sell |
| Qube Research & Technologies Ltd | 0 | 727,205 | +727,205 | 0.00 | 0.06 | +0.06 | buy |
| BARCLAYS PLC | 423,888 | 714,423 | +290,535 | 0.01 | 0.02 | +0.01 | buy |
| Capital Research Global Investors | 763,702 | 700,107 | -63,595 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 398,943 | 653,224 | +254,281 | 0.04 | 0.04 | +0.00 | buy |
| First Turn Management, LLC | 695,718 | 633,364 | -62,354 | 5.77 | 5.05 | -0.73 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,090,326 | 621,494 | -468,832 | 0.04 | 0.02 | -0.02 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 352,831 | 621,125 | +268,294 | 1.21 | 1.20 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 561,945 | 619,126 | +57,181 | 0.01 | 0.01 | -0.00 | buy |
| Nuveen, LLC | 562,696 | 572,789 | +10,093 | 0.01 | 0.01 | -0.00 | buy |
| Neuberger Berman Group LLC | 216,315 | 552,158 | +335,843 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 577,283 | 550,968 | -26,315 | 0.01 | 0.01 | -0.00 | sell |
| Cormorant Asset Management, LP | 850,000 | 550,000 | -300,000 | 3.18 | 2.10 | -1.08 | sell |
| GILDER GAGNON HOWE & CO LLC | 420,325 | 548,926 | +128,601 | 0.37 | 0.42 | +0.05 | buy |
| FEDERATED HERMES, INC. | 588,434 | 523,678 | -64,756 | 0.07 | 0.06 | -0.01 | sell |
| LORD, ABBETT & CO. LLC | 1,023,341 | 499,659 | -523,682 | 0.25 | 0.11 | -0.14 | sell |
| MILLENNIUM MANAGEMENT LLC | 633,283 | 487,594 | -145,689 | 0.04 | 0.02 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 402,948 | 479,758 | +76,810 | 0.01 | 0.01 | +0.00 | buy |
| Catalio Capital Management, LP | 432,014 | 455,041 | +23,027 | 6.70 | 6.37 | -0.33 | buy |
| Bridgewater Associates, LP | 259,459 | 448,143 | +188,684 | 0.09 | 0.14 | +0.05 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 437,130 | 437,130 | 0 | 0.54 | 0.44 | -0.10 | hold |
| SEI INVESTMENTS CO | 377,000 | 377,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 351,719 | 371,232 | +19,513 | 0.03 | 0.02 | -0.00 | buy |
| Fisher Asset Management, LLC | 351,628 | 345,351 | -6,277 | 0.01 | 0.01 | -0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 228,829 | 339,720 | +110,891 | 5.21 | 5.92 | +0.71 | buy |
| NOMURA HOLDINGS INC | 318,563 | 327,475 | +8,912 | 0.20 | 0.10 | -0.09 | buy |
| Weiss Asset Management LP | 0 | 320,184 | +320,184 | 0.00 | 0.27 | +0.27 | buy |
| Fiera Capital Corp | 322,690 | 316,101 | -6,589 | 0.08 | 0.09 | +0.00 | sell |
| Nicholas Investment Partners, LP | 298,909 | 311,494 | +12,585 | 1.60 | 1.31 | -0.30 | buy |
| Woodline Partners LP | 301,012 | 301,312 | +300 | 0.08 | 0.07 | -0.02 | buy |
| Candriam S.C.A. | 278,888 | 300,520 | +21,632 | 0.11 | 0.10 | -0.01 | buy |
| Legal & General Group Plc | 284,917 | 299,482 | +14,565 | 0.00 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 106,911 | 298,440 | +191,529 | 0.01 | 0.02 | +0.01 | buy |
| Swiss National Bank | 286,000 | 294,600 | +8,600 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 296,683 | 277,466 | -19,217 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 334,382 | 275,516 | -58,866 | 0.03 | 0.02 | -0.01 | sell |
| Integral Health Asset Management, LLC | 275,000 | 275,000 | 0 | 1.08 | 0.84 | -0.24 | hold |
| PFM Health Sciences, LP | 257,747 | 253,358 | -4,389 | 2.01 | 1.64 | -0.38 | sell |
| FIRST TRUST ADVISORS LP | 339,907 | 247,738 | -92,169 | 0.02 | 0.01 | -0.01 | sell |
| SEI INVESTMENTS CO | 288,075 | 247,678 | -40,397 | 0.02 | 0.02 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 245,246 | 245,346 | +100 | 3.13 | 2.61 | -0.52 | buy |
| ROYAL BANK OF CANADA | 142,407 | 237,832 | +95,425 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 7,159 | 226,869 | +219,710 | 0.01 | 0.27 | +0.26 | buy |
| ExodusPoint Capital Management, LP | 0 | 224,927 | +224,927 | 0.00 | 0.16 | +0.16 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 162,001 | 222,417 | +60,416 | 0.02 | 0.02 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 219,215 | 219,215 | 0 | 1.79 | 1.61 | -0.18 | hold |