| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Laurion Capital Management LP | 4,749,343 | 5,651,039 | +901,696 | 3.51 | 3.90 | +0.39 | buy |
| Woodline Partners LP | 290,000 | 1,125,634 | +835,634 | 0.06 | 0.35 | +0.29 | buy |
| Frazier Life Sciences Management, L.P. | 1,988,876 | 2,725,949 | +737,073 | 2.04 | 4.78 | +2.74 | buy |
| TWO SIGMA INVESTMENTS, LP | 740,391 | 1,277,084 | +536,693 | 0.04 | 0.10 | 0.00 | buy |
| Cormorant Asset Management, LP | 4,169,179 | 4,662,530 | +493,351 | 4.08 | 7.17 | +3.09 | buy |
| D. E. Shaw & Co., Inc. | 1,632,986 | 1,341,243 | +291,743 | 0.05 | 0.07 | 0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 696,092 | 938,700 | +242,608 | 0.01 | 0.02 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 479,125 | 694,000 | +214,875 | 0.36 | 0.89 | +0.53 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 395,540 | 500,254 | +104,714 | 0.37 | 0.80 | +0.43 | buy |
| Logos Global Management LP | 300,000 | 400,000 | +100,000 | 0.71 | 1.50 | +0.79 | buy |
| NOMURA HOLDINGS INC | 325,753 | 235,009 | +90,744 | 0.06 | 0.07 | 0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 79,873 | 137,512 | +57,639 | 0.27 | 0.69 | +0.42 | buy |
| Ikarian Capital, LLC | 429,686 | 473,126 | +43,440 | 2.61 | 4.63 | +2.02 | buy |
| NATIXIS | 6,000 | 31,800 | +25,800 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 39,884 | 65,564 | +25,680 | 0.03 | 0.08 | 0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 321,635 | 345,537 | +23,902 | 1.19 | 2.19 | +1.00 | buy |
| Belvedere Trading LLC | 13,679 | 29,729 | +16,050 | 0.08 | 0.10 | +0.03 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 23,359 | 15,207 | +8,152 | 0.00 | 0.00 | 0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 278,654 | 284,487 | +5,833 | 0.01 | 0.02 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 35,556 | 40,126 | +4,570 | 0.01 | 0.02 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 84,487 | 87,981 | +3,494 | 0.09 | 0.15 | +0.06 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 24,857 | 21,440 | +3,417 | 0.00 | 0.01 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,104 | 4,171 | +2,067 | 0.01 | 0.03 | +0.02 | buy |
| Edgestream Partners, L.P. | 14,442 | 15,040 | +598 | 0.02 | 0.03 | +0.01 | buy |
| Diversified Trust Co | 16,700 | 17,111 | +411 | 0.01 | 0.02 | +0.01 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 66,363 | 64,537 | -1,826 | 0.66 | 1.04 | +0.38 | sell |
| Corton Capital Inc. | 10,552 | 8,711 | -1,841 | 0.09 | 0.12 | +0.03 | sell |
| VIRTUS ADVISERS, LLC | 20,345 | 18,018 | -2,327 | 0.21 | 0.29 | +0.08 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,041 | 15,214 | -3,827 | 0.03 | 0.04 | +0.01 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 19,250 | 14,200 | -5,050 | 0.01 | 0.01 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 35,133 | 30,000 | -5,133 | 0.24 | 0.26 | +0.02 | sell |
| MIZUHO MARKETS AMERICAS LLC | 86,448 | 80,532 | -5,916 | 0.11 | 0.08 | -0.03 | sell |
| Capital Impact Advisors, LLC | 27,666 | 21,273 | -6,393 | 0.52 | 0.94 | +0.41 | sell |
| E Fund Management Co., Ltd. | 27,916 | 16,095 | -11,821 | 0.04 | 0.03 | -0.01 | sell |
| Bellevue Group AG | 96,900 | 78,700 | -18,200 | 0.02 | 0.03 | +0.01 | sell |
| JENNISON ASSOCIATES LLC | 53,890 | 20,301 | -33,589 | 0.00 | 0.00 | -0.00 | sell |
| B. Metzler seel. Sohn & Co. AG | 81,556 | 43,599 | -37,957 | 0.02 | 0.02 | -0.00 | sell |
| Candriam S.C.A. | 285,000 | 245,000 | -40,000 | 0.04 | 0.05 | +0.01 | sell |
| PROFUND ADVISORS LLC | 94,465 | 53,869 | -40,596 | 0.09 | 0.08 | -0.01 | sell |
| M28 Capital Management LP | 166,200 | 121,200 | -45,000 | 3.78 | 3.67 | -0.11 | sell |
| Informed Momentum Co LLC | 154,391 | 88,167 | -66,224 | 0.49 | 0.45 | -0.04 | sell |
| Global IMC LLC | 223,234 | 141,510 | -81,724 | 1.13 | 1.01 | -0.12 | sell |
| Rafferty Asset Management, LLC | 519,246 | 313,382 | -205,864 | 0.05 | 0.05 | -0.00 | sell |
| HHLR ADVISORS, LTD. | 2,993,447 | 2,782,750 | -210,697 | 1.10 | 1.64 | +0.54 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 941,176 | 716,927 | -224,249 | 0.27 | 0.34 | +0.07 | sell |
| Clearline Capital LP | 262,920 | 32,394 | -230,526 | 0.58 | 0.08 | -0.50 | sell |
| Octagon Capital Advisors LP | 1,219,200 | 971,639 | -247,561 | 2.93 | 4.51 | +1.58 | sell |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 5,500,000 | 4,604,000 | -896,000 | 0.48 | 0.49 | +0.01 | sell |
| VIKING GLOBAL INVESTORS LP | 26,620,991 | 25,120,991 | -1,500,000 | 1.87 | 2.69 | +0.81 | sell |