| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ewing Morris & Co. Investment Partners Ltd. | 0 | 2,000,000 | +2,000,000 | 0.00 | 1.10 | +1.10 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,985,000 | 4,826,000 | +1,841,000 | 0.00 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,747,000 | +1,747,000 | 0.00 | 0.24 | +0.24 | buy |
| JPMORGAN CHASE & CO | 176,079 | 1,216,116 | +1,040,037 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 30,849 | 833,236 | +802,387 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 2,156,449 | 2,942,114 | +785,665 | 0.05 | 0.08 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 4,312,531 | 4,818,012 | +505,481 | 0.06 | 0.06 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 666,344 | 1,103,508 | +437,164 | 0.71 | 1.09 | +0.38 | buy |
| AMERIPRISE FINANCIAL INC | 34,775 | 450,381 | +415,606 | 0.00 | 0.00 | +0.00 | buy |
| Beck Bode, LLC | 0 | 410,531 | +410,531 | 0.00 | 1.97 | +1.97 | buy |
| Capital Research Global Investors | 2,212,085 | 2,614,308 | +402,223 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 0 | 399,781 | +399,781 | 0.00 | 1.61 | +1.61 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,452,404 | 2,827,666 | +375,262 | 0.02 | 0.02 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 148,368 | 503,162 | +354,794 | 0.04 | 0.12 | +0.08 | buy |
| 683 Capital Management, LLC | 200,000 | 550,000 | +350,000 | 0.53 | 1.43 | +0.89 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 207,280 | 518,806 | +311,526 | 0.01 | 0.03 | +0.02 | buy |
| ELEMENT CAPITAL MANAGEMENT LLC | 0 | 310,194 | +310,194 | 0.00 | 0.36 | +0.36 | buy |
| Prosight Management, LP | 800,000 | 1,086,810 | +286,810 | 6.06 | 7.02 | +0.96 | buy |
| FMR LLC | 1,539,913 | 1,820,322 | +280,409 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 498,254 | 751,355 | +253,101 | 0.66 | 0.99 | +0.33 | buy |
| NORGES BANK | 893,729 | 1,143,432 | +249,703 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 1,646,202 | 1,885,754 | +239,552 | 0.08 | 0.08 | +0.01 | buy |
| CITIGROUP INC | 1,315,339 | 1,537,803 | +222,464 | 0.03 | 0.04 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 300,000 | +200,000 | 0.40 | 1.19 | +0.79 | buy |
| ADAR1 Capital Management, LLC | 1,264,570 | 1,448,470 | +183,900 | 6.45 | 6.18 | -0.27 | buy |
| EcoR1 Capital, LLC | 0 | 170,172 | +170,172 | 0.00 | 0.15 | +0.15 | buy |
| Pictet Asset Management Holding SA | 2,648,957 | 2,803,057 | +154,100 | 0.08 | 0.08 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,129,019 | 1,279,303 | +150,284 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 14,054,748 | 14,198,856 | +144,108 | 0.01 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 598,263 | 737,367 | +139,104 | 0.00 | 0.01 | +0.00 | buy |
| Exome Asset Management LLC | 78,907 | 211,000 | +132,093 | 1.78 | 3.63 | +1.85 | buy |
| BARCLAYS PLC | 413,265 | 545,008 | +131,743 | 0.00 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,632,604 | 3,760,457 | +127,853 | 4.30 | 3.84 | -0.47 | buy |
| GROUP ONE TRADING LLC | 0 | 124,902 | +124,902 | 0.00 | 0.13 | +0.13 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,290,409 | 3,413,949 | +123,540 | 0.01 | 0.01 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 121,955 | +121,955 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 5,854,140 | 5,962,654 | +108,514 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,189,197 | 1,284,802 | +95,605 | 0.01 | 0.01 | +0.00 | buy |
| Melqart Asset Management (UK) Ltd | 307,911 | 403,485 | +95,574 | 0.73 | 1.01 | +0.28 | buy |
| STEMPOINT CAPITAL LP | 0 | 94,885 | +94,885 | 0.00 | 0.72 | +0.72 | buy |
| LMR Partners LLP | 10,898 | 104,832 | +93,934 | 0.01 | 0.06 | +0.05 | buy |
| BIT Capital GmbH | 129,213 | 222,421 | +93,208 | 0.30 | 0.54 | +0.25 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 176,692 | 263,679 | +86,987 | 0.01 | 0.01 | +0.00 | buy |
| Cutter Capital Management, LP | 311,700 | 396,388 | +84,688 | 2.41 | 2.98 | +0.57 | buy |
| Rhenman & Partners Asset Management AB | 184,500 | 268,000 | +83,500 | 0.45 | 0.55 | +0.11 | buy |
| ALGERT GLOBAL LLC | 55,848 | 136,447 | +80,599 | 0.05 | 0.09 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 125,160 | 195,963 | +70,803 | 0.00 | 0.01 | +0.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 76,222 | 136,587 | +60,365 | 0.07 | 0.12 | +0.05 | buy |
| Polar Asset Management Partners Inc. | 0 | 50,500 | +50,500 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 44,623 | +44,623 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 676,649 | 715,157 | +38,508 | 0.03 | 0.03 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,311 | 61,150 | +37,839 | 0.05 | 0.12 | +0.07 | buy |
| Nicholas Investment Partners, LP | 0 | 35,644 | +35,644 | 0.00 | 0.08 | +0.08 | buy |
| Crestline Management, LP | 0 | 33,571 | +33,571 | 0.00 | 0.05 | +0.05 | buy |
| COMERICA BANK | 12,795 | 45,860 | +33,065 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 32,930 | +32,930 | 0.00 | 0.01 | +0.01 | buy |
| Capula Management Ltd | 0 | 32,671 | +32,671 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 35,381 | 67,831 | +32,450 | 0.01 | 0.01 | +0.01 | buy |
| Creative Planning | 0 | 31,264 | +31,264 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 30,119 | +30,119 | 0.00 | 0.00 | +0.00 | buy |
| Portman Square Capital LLP | 48,177 | 77,287 | +29,110 | 0.41 | 0.65 | +0.24 | buy |
| WINTON GROUP Ltd | 0 | 28,091 | +28,091 | 0.00 | 0.05 | +0.05 | buy |
| NEOS Investment Management LLC | 87,289 | 112,076 | +24,787 | 0.09 | 0.09 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,301 | 38,039 | +24,738 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 44,572 | 69,054 | +24,482 | 0.41 | 0.61 | +0.19 | buy |
| HSBC HOLDINGS PLC | 0 | 23,602 | +23,602 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 36,500 | 58,596 | +22,096 | 0.03 | 0.04 | +0.01 | buy |
| HighTower Advisors, LLC | 201,254 | 223,331 | +22,077 | 0.01 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 727,963 | 748,819 | +20,856 | 0.09 | 0.09 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,125,145 | 1,145,123 | +19,978 | 0.02 | 0.02 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 278,231 | 297,081 | +18,850 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 0 | 18,839 | +18,839 | 0.00 | 0.06 | +0.06 | buy |
| NATIXIS | 0 | 18,500 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 13,324 | 31,173 | +17,849 | 0.05 | 0.07 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 68,896 | 86,513 | +17,617 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 16,709 | 32,421 | +15,712 | 0.01 | 0.03 | +0.01 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 15,263 | +15,263 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 15,029 | +15,029 | 0.00 | 0.04 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 21,984 | 36,165 | +14,181 | 0.08 | 0.10 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 13,279 | +13,279 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 12,148 | +12,148 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 13,185 | 24,482 | +11,297 | 0.02 | 0.03 | +0.01 | buy |
| CHOREO, LLC | 18,000 | 29,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 27,177 | 37,675 | +10,498 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 12,375 | 22,807 | +10,432 | 0.20 | 0.36 | +0.16 | buy |
| Clear Harbor Asset Management, LLC | 0 | 9,850 | +9,850 | 0.00 | 0.02 | +0.02 | buy |
| State of New Jersey Common Pension Fund D | 67,361 | 76,586 | +9,225 | 0.01 | 0.01 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 8,913 | +8,913 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 29,089 | 36,603 | +7,514 | 0.01 | 0.01 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 219,837 | 226,684 | +6,847 | 7.02 | 5.16 | -1.86 | buy |
| WOLVERINE TRADING, LLC | 13,010 | 19,134 | +6,124 | 0.01 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 6,034 | +6,034 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 44,302 | 49,412 | +5,110 | 0.01 | 0.02 | +0.00 | buy |
| Handelsbanken Fonder AB | 27,650 | 32,550 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 524 | 4,934 | +4,410 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 36,942 | 41,259 | +4,317 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 24,205 | 28,160 | +3,955 | 0.00 | 0.00 | -0.00 | buy |
| MIZUHO MARKETS AMERICAS LLC | 83,982 | 87,180 | +3,198 | 0.06 | 0.05 | -0.00 | buy |
| FNY Investment Advisers, LLC | 5,750 | 8,650 | +2,900 | 0.10 | 0.11 | +0.01 | buy |
| Quarry LP | 7,500 | 10,000 | +2,500 | 0.08 | 0.08 | -0.00 | buy |