| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 4,312,531 | 4,818,012 | +505,481 | 0.06 | 0.06 | 0.00 | buy |
| EMERALD ADVISERS, LLC | 666,344 | 1,103,508 | +437,164 | 0.71 | 1.09 | +0.38 | buy |
| Capital Research Global Investors | 2,212,085 | 2,614,308 | +402,223 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 148,368 | 503,162 | +354,794 | 0.04 | 0.12 | +0.08 | buy |
| 683 Capital Management, LLC | 200,000 | 550,000 | +350,000 | 0.38 | 1.06 | +0.68 | buy |
| Prosight Management, LP | 800,000 | 1,086,810 | +286,810 | 6.06 | 6.81 | +0.75 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 498,254 | 751,355 | +253,101 | 0.66 | 0.99 | +0.33 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 300,000 | +200,000 | 0.29 | 1.04 | +0.75 | buy |
| TWO SIGMA INVESTMENTS, LP | 565,452 | 381,242 | +184,210 | 0.04 | 0.02 | 0.00 | sell |
| ADAR1 Capital Management, LLC | 1,264,570 | 1,448,470 | +183,900 | 6.45 | 6.18 | -0.27 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 598,263 | 737,367 | +139,104 | 0.00 | 0.01 | +0.00 | buy |
| Exome Asset Management LLC | 78,907 | 211,000 | +132,093 | 1.78 | 3.63 | +1.85 | buy |
| Frazier Life Sciences Management, L.P. | 3,632,604 | 3,760,457 | +127,853 | 4.30 | 3.84 | -0.47 | buy |
| Melqart Asset Management (UK) Ltd | 307,911 | 403,485 | +95,574 | 0.65 | 0.93 | +0.28 | buy |
| LMR Partners LLP | 10,898 | 104,832 | +93,934 | 0.01 | 0.06 | +0.05 | buy |
| BIT Capital GmbH | 129,213 | 222,421 | +93,208 | 0.26 | 0.53 | +0.27 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 176,692 | 263,679 | +86,987 | 0.01 | 0.01 | +0.00 | buy |
| Cutter Capital Management, LP | 311,700 | 396,388 | +84,688 | 2.41 | 2.98 | +0.57 | buy |
| Rhenman & Partners Asset Management AB | 184,500 | 268,000 | +83,500 | 0.45 | 0.55 | +0.11 | buy |
| ALGERT GLOBAL LLC | 55,848 | 136,447 | +80,599 | 0.05 | 0.09 | 0.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 76,222 | 136,587 | +60,365 | 0.04 | 0.07 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,311 | 61,150 | +37,839 | 0.05 | 0.12 | +0.07 | buy |
| Portman Square Capital LLP | 48,177 | 77,287 | +29,110 | 0.41 | 0.65 | +0.24 | buy |
| NEOS Investment Management LLC | 87,289 | 112,076 | +24,787 | 0.09 | 0.09 | -0.00 | buy |
| HighVista Strategies LLC | 44,572 | 69,054 | +24,482 | 0.41 | 0.61 | +0.19 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 36,500 | 58,596 | +22,096 | 0.06 | 0.12 | 0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,125,145 | 1,145,123 | +19,978 | 0.02 | 0.02 | 0.00 | buy |
| AlphaQuest LLC | 13,324 | 31,173 | +17,849 | 0.05 | 0.07 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,984 | 36,165 | +14,181 | 0.08 | 0.10 | +0.02 | buy |
| ProShare Advisors LLC | 27,177 | 37,675 | +10,498 | 0.00 | 0.00 | 0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 29,089 | 36,603 | +7,514 | 0.01 | 0.01 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 219,837 | 226,684 | +6,847 | 7.02 | 5.16 | -1.86 | buy |
| GILDER GAGNON HOWE & CO LLC | 44,302 | 49,412 | +5,110 | 0.01 | 0.02 | +0.00 | buy |
| MIZUHO MARKETS AMERICAS LLC | 83,982 | 87,180 | +3,198 | 0.06 | 0.05 | -0.00 | buy |
| FNY Investment Advisers, LLC | 5,750 | 8,650 | +2,900 | 0.10 | 0.11 | +0.01 | buy |
| Quarry LP | 7,500 | 10,000 | +2,500 | 0.08 | 0.08 | 0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 15,200 | 17,700 | +2,500 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 51,029 | 48,966 | +2,063 | 0.05 | 0.05 | 0.00 | sell |
| Diversified Trust Co | 35,713 | 36,772 | +1,059 | 0.03 | 0.02 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 13,772 | 14,240 | +468 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 949,570 | 949,749 | +179 | 0.23 | 0.20 | -0.03 | buy |
| Bell Investment Advisors, Inc | 193 | 174 | +19 | 0.00 | 0.00 | 0.00 | sell |
| Elequin Capital, LP | 314 | 288 | -26 | 0.00 | 0.00 | -0.00 | sell |
| TRANSCEND CAPITAL ADVISORS, LLC | 13,500 | 13,350 | -150 | 0.02 | 0.02 | -0.00 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 63,004 | 62,819 | -185 | 0.85 | 0.78 | -0.07 | sell |
| Belvedere Trading LLC | 9,654 | 9,411 | -243 | 0.00 | 0.00 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 15,535 | 15,085 | -450 | 0.16 | 0.23 | +0.07 | sell |
| E Fund Management Co., Ltd. | 16,496 | 15,634 | -862 | 0.02 | 0.02 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 39,099 | 38,043 | -1,056 | 0.05 | 0.05 | -0.01 | sell |
| Wealth Management Associates, Inc. | 11,380 | 9,680 | -1,700 | 0.14 | 0.11 | -0.03 | sell |
| MOODY ALDRICH PARTNERS LLC | 125,829 | 123,509 | -2,320 | 0.62 | 0.57 | -0.05 | sell |
| Bellevue Group AG | 12,800 | 10,400 | -2,400 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 824,818 | 810,465 | -14,353 | 0.00 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 926,900 | 906,724 | -20,176 | 0.02 | 0.02 | -0.00 | sell |
| Rafferty Asset Management, LLC | 271,607 | 243,331 | -28,276 | 0.03 | 0.02 | -0.00 | sell |
| Ikarian Capital, LLC | 332,013 | 285,613 | -46,400 | 1.46 | 1.01 | -0.45 | sell |
| BRAIDWELL LP | 345,571 | 298,400 | -47,171 | 0.27 | 0.22 | -0.06 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 910,070 | 842,644 | -67,426 | 3.14 | 3.41 | +0.27 | sell |
| Granahan Investment Management, LLC | 251,525 | 183,788 | -67,737 | 0.25 | 0.18 | -0.07 | sell |
| Octagon Capital Advisors LP | 690,000 | 552,000 | -138,000 | 2.88 | 2.25 | -0.63 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,096,734 | 926,846 | -169,888 | 0.02 | 0.01 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 341,247 | 77,798 | -263,449 | 0.17 | 0.04 | -0.13 | sell |
| HHLR ADVISORS, LTD. | 1,390,653 | 1,023,950 | -366,703 | 0.87 | 0.57 | -0.30 | sell |
| Laurion Capital Management LP | 4,388,873 | 3,894,282 | -494,591 | 1.32 | 1.35 | +0.03 | sell |
| Kohlberg Kravis Roberts & Co. L.P. | 31,060,971 | 25,260,971 | -5,800,000 | 23.60 | 8.61 | -14.99 | sell |