| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 16,484,985 | 16,832,059 | +347,074 | 0.01 | 0.01 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 18,555,375 | 15,977,849 | -2,577,526 | 2.32 | 2.16 | -0.16 | sell |
| BlackRock, Inc. | 14,259,479 | 14,411,203 | +151,724 | 0.01 | 0.01 | +0.00 | buy |
| Kohlberg Kravis Roberts & Co. L.P. | 13,260,971 | 13,260,971 | 0 | 11.83 | 11.54 | -0.29 | hold |
| JANUS HENDERSON GROUP PLC | 9,276,532 | 8,741,079 | -535,453 | 0.20 | 0.21 | +0.01 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 7,900,000 | 8,192,000 | +292,000 | 1.56 | 2.40 | +0.85 | buy |
| Aisling Capital Management LP | 6,068,125 | 6,089,611 | +21,486 | 72.85 | 69.29 | -3.56 | buy |
| STATE STREET CORP | 5,896,596 | 5,606,340 | -290,256 | 0.01 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 2,801,065 | 3,928,657 | +1,127,592 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,681,580 | 3,909,941 | +228,361 | 0.01 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,800,457 | 3,845,457 | +45,000 | 6.56 | 5.98 | -0.58 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 2,000,000 | 3,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,056,000 | 2,859,000 | -197,000 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 2,812,499 | 2,586,422 | -226,077 | 0.03 | 0.03 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 2,500,000 | 2,500,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 2,339,067 | 2,328,941 | -10,126 | 0.18 | 0.19 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 2,470,558 | 2,328,715 | -141,843 | 0.03 | 0.04 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 2,081,253 | 2,252,762 | +171,509 | 0.09 | 0.09 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,621,251 | 2,209,159 | -412,092 | 0.02 | 0.02 | -0.00 | sell |
| Capital Research Global Investors | 3,988,298 | 1,933,126 | -2,055,172 | 0.03 | 0.02 | -0.02 | sell |
| MACQUARIE GROUP LTD | 2,095,235 | 1,933,096 | -162,139 | 0.11 | 0.12 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,331,473 | 1,925,198 | +593,725 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,891,578 | 1,914,767 | +23,189 | 0.07 | 0.08 | +0.01 | buy |
| SC US (TTGP), LTD. | 1,860,364 | 1,860,364 | 0 | 0.57 | 0.60 | +0.03 | hold |
| Laurion Capital Management LP | 2,411,248 | 1,753,544 | -657,704 | 12.02 | 12.42 | +0.41 | sell |
| FMR LLC | 2,027,395 | 1,700,747 | -326,648 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,684,055 | 1,662,755 | -21,300 | 0.15 | 0.17 | +0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,691,213 | 1,662,069 | -29,144 | 0.58 | 0.62 | +0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 961,216 | 1,567,565 | +606,349 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 821,405 | 1,444,023 | +622,618 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,363,683 | 1,402,409 | +38,726 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 1,600,000 | 1,400,000 | -200,000 | 5.15 | 5.02 | -0.13 | sell |
| BANK OF AMERICA CORP /DE/ | 1,101,509 | 1,380,868 | +279,359 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 1,315,979 | 1,351,579 | +35,600 | 0.10 | 0.12 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,030,527 | 1,267,412 | +236,885 | 0.02 | 0.03 | +0.01 | buy |
| Hood River Capital Management LLC | 0 | 1,243,545 | +1,243,545 | 0.00 | 0.76 | +0.76 | buy |
| Deep Track Capital, LP | 900,000 | 1,200,000 | +300,000 | 1.25 | 1.74 | +0.49 | buy |
| Pictet Asset Management Holding SA | 1,807,434 | 1,133,351 | -674,083 | 0.08 | 0.06 | -0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,090,134 | 1,076,586 | -13,548 | 0.03 | 0.03 | +0.00 | sell |
| MORGAN STANLEY | 1,342,378 | 1,054,865 | -287,513 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 1,051,679 | +1,051,679 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 56,669 | 1,019,194 | +962,525 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,641,620 | 1,014,677 | -626,943 | 0.16 | 0.11 | -0.05 | sell |
| Polar Capital Holdings Plc | 0 | 981,058 | +981,058 | 0.00 | 0.25 | +0.25 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 301,361 | 944,846 | +643,485 | 0.02 | 0.08 | +0.06 | buy |
| CITIGROUP INC | 1,248,505 | 927,951 | -320,554 | 0.04 | 0.03 | -0.00 | sell |
| Bank of New York Mellon Corp | 548,207 | 927,773 | +379,566 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 1,403,741 | 876,881 | -526,860 | 0.20 | 0.14 | -0.06 | sell |
| Sofinnova Investments, Inc. | 993,093 | 831,847 | -161,246 | 2.92 | 2.65 | -0.27 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 757,745 | 806,710 | +48,965 | 1.28 | 1.36 | +0.09 | buy |
| AMERIPRISE FINANCIAL INC | 787,044 | 800,681 | +13,637 | 0.01 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 713,491 | 729,524 | +16,033 | 0.14 | 0.15 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 1,021,257 | 720,343 | -300,914 | 1.62 | 1.20 | -0.42 | sell |
| BARCLAYS PLC | 933,512 | 719,448 | -214,064 | 0.02 | 0.01 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 965,764 | 684,277 | -281,487 | 1.78 | 1.05 | -0.73 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 535,763 | 659,633 | +123,870 | 0.21 | 0.31 | +0.09 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 439,066 | 639,264 | +200,198 | 0.01 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 504,342 | 633,886 | +129,544 | 0.04 | 0.04 | +0.00 | buy |
| Catalio Capital Management, LP | 927,711 | 622,729 | -304,982 | 8.40 | 5.98 | -2.42 | sell |
| GW&K Investment Management, LLC | 0 | 598,237 | +598,237 | 0.00 | 0.27 | +0.27 | buy |
| First Turn Management, LLC | 551,684 | 589,729 | +38,045 | 4.44 | 4.60 | +0.16 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 384,231 | 584,296 | +200,065 | 0.29 | 0.50 | +0.21 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 588,710 | 576,370 | -12,340 | 0.02 | 0.02 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 704,357 | 513,263 | -191,094 | 0.01 | 0.01 | -0.00 | sell |
| Nuveen, LLC | 411,907 | 504,110 | +92,203 | 0.00 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 184,767 | 493,063 | +308,296 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 337,880 | 479,680 | +141,800 | 0.01 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 468,720 | 473,496 | +4,776 | 0.02 | 0.02 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 465,401 | 462,311 | -3,090 | 0.21 | 0.24 | +0.03 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 460,282 | +460,282 | 0.00 | 7.84 | +7.84 | buy |
| NOMURA HOLDINGS INC | 271,110 | 432,082 | +160,972 | 0.08 | 0.10 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 445,526 | 426,300 | -19,226 | 0.01 | 0.01 | +0.00 | sell |
| FEDERATED HERMES, INC. | 277,587 | 424,695 | +147,108 | 0.02 | 0.04 | +0.02 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 645,745 | 411,427 | -234,318 | 1.70 | 1.10 | -0.59 | sell |
| Philosophy Capital Management LLC | 426,583 | 385,000 | -41,583 | 2.32 | 2.31 | -0.01 | sell |
| Russell Investments Group, Ltd. | 283,741 | 383,485 | +99,744 | 0.02 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 564,216 | 383,178 | -181,038 | 0.03 | 0.03 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 634,573 | 341,866 | -292,707 | 0.04 | 0.03 | -0.02 | sell |
| Legal & General Group Plc | 159,573 | 339,490 | +179,917 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 172,669 | 338,409 | +165,740 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 318,287 | 331,302 | +13,015 | 0.02 | 0.02 | +0.00 | buy |
| PFM Health Sciences, LP | 521,793 | 327,174 | -194,619 | 1.95 | 1.45 | -0.50 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 245,946 | 322,246 | +76,300 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 200,000 | 300,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 425,000 | 300,000 | -125,000 | 1.86 | 1.42 | -0.45 | sell |
| NOMURA HOLDINGS INC | 488,135 | 294,702 | -193,433 | 0.15 | 0.07 | -0.08 | sell |
| JPMORGAN CHASE & CO | 474,253 | 294,116 | -180,137 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 24,859 | 278,128 | +253,269 | 0.03 | 0.54 | +0.50 | buy |
| Swiss National Bank | 254,400 | 276,000 | +21,600 | 0.01 | 0.01 | +0.00 | buy |
| Burkehill Global Management, LP | 275,000 | 275,000 | 0 | 0.88 | 0.81 | -0.07 | hold |
| ADAR1 Capital Management, LLC | 259,659 | 273,414 | +13,755 | 1.82 | 1.41 | -0.41 | buy |
| Nicholas Investment Partners, LP | 159,501 | 271,630 | +112,129 | 0.61 | 1.08 | +0.47 | buy |
| SEI INVESTMENTS CO | 271,000 | 271,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Prosight Management, LP | 472,687 | 264,500 | -208,187 | 4.98 | 3.30 | -1.68 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 275,235 | 260,982 | -14,253 | 0.03 | 0.03 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 4,167 | 260,058 | +255,891 | 0.00 | 0.02 | +0.02 | buy |
| Eagle Health Investments LP | 259,300 | 259,300 | 0 | 2.76 | 3.54 | +0.77 | hold |
| Assenagon Asset Management S.A. | 350,411 | 258,904 | -91,507 | 0.02 | 0.02 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 252,761 | +252,761 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 263,693 | 245,525 | -18,168 | 0.01 | 0.01 | +0.00 | sell |