| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hood River Capital Management LLC | 0 | 1,243,545 | +1,243,545 | 0.00 | 0.76 | +0.76 | buy |
| Invesco Ltd. | 2,801,065 | 3,928,657 | +1,127,592 | 0.02 | 0.03 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,051,679 | +1,051,679 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 2,000,000 | 3,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 981,058 | +981,058 | 0.00 | 0.25 | +0.25 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 56,669 | 1,019,194 | +962,525 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 301,361 | 944,846 | +643,485 | 0.02 | 0.08 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 821,405 | 1,444,023 | +622,618 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 961,216 | 1,567,565 | +606,349 | 0.00 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 0 | 598,237 | +598,237 | 0.00 | 0.27 | +0.27 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,331,473 | 1,925,198 | +593,725 | 0.01 | 0.02 | +0.01 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 460,282 | +460,282 | 0.00 | 7.84 | +7.84 | buy |
| Bank of New York Mellon Corp | 548,207 | 927,773 | +379,566 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 16,484,985 | 16,832,059 | +347,074 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 184,767 | 493,063 | +308,296 | 0.01 | 0.02 | +0.01 | buy |
| Deep Track Capital, LP | 900,000 | 1,200,000 | +300,000 | 1.25 | 1.74 | +0.49 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 7,900,000 | 8,192,000 | +292,000 | 1.56 | 2.40 | +0.85 | buy |
| BANK OF AMERICA CORP /DE/ | 1,101,509 | 1,380,868 | +279,359 | 0.00 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 4,167 | 260,058 | +255,891 | 0.00 | 0.02 | +0.02 | buy |
| Graham Capital Management, L.P. | 24,859 | 278,128 | +253,269 | 0.03 | 0.54 | +0.50 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 252,761 | +252,761 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,030,527 | 1,267,412 | +236,885 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,681,580 | 3,909,941 | +228,361 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 439,066 | 639,264 | +200,198 | 0.01 | 0.03 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 384,231 | 584,296 | +200,065 | 0.29 | 0.50 | +0.21 | buy |
| Legal & General Group Plc | 159,573 | 339,490 | +179,917 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 23,799 | 197,365 | +173,566 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 2,081,253 | 2,252,762 | +171,509 | 0.09 | 0.09 | +0.00 | buy |
| ROYAL BANK OF CANADA | 172,669 | 338,409 | +165,740 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 271,110 | 432,082 | +160,972 | 0.08 | 0.10 | +0.02 | buy |
| BlackRock, Inc. | 14,259,479 | 14,411,203 | +151,724 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 0 | 148,986 | +148,986 | 0.00 | 0.04 | +0.04 | buy |
| FEDERATED HERMES, INC. | 277,587 | 424,695 | +147,108 | 0.02 | 0.04 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 337,880 | 479,680 | +141,800 | 0.01 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 133,832 | +133,832 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 504,342 | 633,886 | +129,544 | 0.04 | 0.04 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 535,763 | 659,633 | +123,870 | 0.21 | 0.31 | +0.09 | buy |
| Nicholas Investment Partners, LP | 159,501 | 271,630 | +112,129 | 0.61 | 1.08 | +0.47 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 109,897 | +109,897 | 0.00 | 0.04 | +0.04 | buy |
| Bank of New York Mellon Corp | 200,000 | 300,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 283,741 | 383,485 | +99,744 | 0.02 | 0.02 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 7,629 | 102,785 | +95,156 | 0.00 | 0.02 | +0.02 | buy |
| Freestone Grove Partners LP | 0 | 93,469 | +93,469 | 0.00 | 0.04 | +0.04 | buy |
| Nuveen, LLC | 411,907 | 504,110 | +92,203 | 0.00 | 0.01 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 59,061 | 148,917 | +89,856 | 0.01 | 0.03 | +0.02 | buy |
| Point72 Europe (London) LLP | 0 | 89,458 | +89,458 | 0.00 | 0.25 | +0.25 | buy |
| TD ASSET MANAGEMENT INC | 0 | 88,950 | +88,950 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 38,220 | 125,959 | +87,739 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 85,000 | +85,000 | 0.00 | 0.26 | +0.26 | buy |
| Granahan Investment Management, LLC | 82,690 | 161,278 | +78,588 | 0.15 | 0.34 | +0.20 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 245,946 | 322,246 | +76,300 | 0.01 | 0.02 | +0.01 | buy |
| NATIXIS | 20 | 73,342 | +73,322 | 0.00 | 0.02 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 54,630 | 127,435 | +72,805 | 0.76 | 1.33 | +0.58 | buy |
| Jain Global LLC | 0 | 66,752 | +66,752 | 0.00 | 0.05 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 62,357 | +62,357 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 61,301 | +61,301 | 0.00 | 0.01 | +0.01 | buy |
| Edgestream Partners, L.P. | 44,556 | 100,786 | +56,230 | 0.05 | 0.15 | +0.10 | buy |
| SEI INVESTMENTS CO | 60,878 | 116,598 | +55,720 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 51,967 | +51,967 | 0.00 | 0.55 | +0.55 | buy |
| ALGERT GLOBAL LLC | 64,753 | 114,863 | +50,110 | 0.06 | 0.10 | +0.04 | buy |
| IEQ CAPITAL, LLC | 23,323 | 73,020 | +49,697 | 0.01 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 117,516 | 166,556 | +49,040 | 0.01 | 0.01 | +0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 757,745 | 806,710 | +48,965 | 1.28 | 1.36 | +0.09 | buy |
| CASTLEARK MANAGEMENT LLC | 77,840 | 123,707 | +45,867 | 0.10 | 0.18 | +0.08 | buy |
| Frazier Life Sciences Management, L.P. | 3,800,457 | 3,845,457 | +45,000 | 6.56 | 5.98 | -0.58 | buy |
| MIZUHO MARKETS AMERICAS LLC | 96,072 | 140,372 | +44,300 | 0.14 | 0.15 | +0.02 | buy |
| NORTHERN TRUST CORP | 1,363,683 | 1,402,409 | +38,726 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 180,289 | 218,696 | +38,407 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 551,684 | 589,729 | +38,045 | 4.44 | 4.60 | +0.16 | buy |
| Ensign Peak Advisors, Inc | 1,315,979 | 1,351,579 | +35,600 | 0.10 | 0.12 | +0.02 | buy |
| NISA INVESTMENT ADVISORS, LLC | 27,437 | 57,437 | +30,000 | 0.01 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 28,668 | +28,668 | 0.00 | 0.02 | +0.02 | buy |
| EFG Asset Management (North America) Corp. | 72,165 | 99,726 | +27,561 | 0.44 | 0.67 | +0.23 | buy |
| RAYMOND JAMES FINANCIAL INC | 82,095 | 106,499 | +24,404 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,891,578 | 1,914,767 | +23,189 | 0.07 | 0.08 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 28,390 | 50,047 | +21,657 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 254,400 | 276,000 | +21,600 | 0.01 | 0.01 | +0.00 | buy |
| Aisling Capital Management LP | 6,068,125 | 6,089,611 | +21,486 | 72.85 | 69.29 | -3.56 | buy |
| Artia Global Partners LP | 0 | 20,400 | +20,400 | 0.00 | 0.19 | +0.19 | buy |
| Blackstone Inc. | 0 | 20,361 | +20,361 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 20,317 | +20,317 | 0.00 | 0.03 | +0.03 | buy |
| CIBC WORLD MARKET INC. | 0 | 19,708 | +19,708 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 71,651 | 91,252 | +19,601 | 0.01 | 0.01 | +0.00 | buy |
| GeoWealth Management, LLC | 0 | 19,221 | +19,221 | 0.00 | 0.04 | +0.04 | buy |
| Creative Planning | 75,288 | 93,856 | +18,568 | 0.00 | 0.00 | +0.00 | buy |
| L & S Advisors Inc | 0 | 16,893 | +16,893 | 0.00 | 0.08 | +0.08 | buy |
| WOLVERINE TRADING, LLC | 33,322 | 49,886 | +16,564 | 0.04 | 0.05 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 713,491 | 729,524 | +16,033 | 0.14 | 0.15 | +0.01 | buy |
| OKABENA INVESTMENT SERVICES INC | 0 | 15,701 | +15,701 | 0.00 | 0.16 | +0.16 | buy |
| Baird Financial Group, Inc. | 42,057 | 57,595 | +15,538 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 67,499 | 81,959 | +14,460 | 1.07 | 1.04 | -0.03 | buy |
| ADAR1 Capital Management, LLC | 259,659 | 273,414 | +13,755 | 1.82 | 1.41 | -0.41 | buy |
| AMERIPRISE FINANCIAL INC | 787,044 | 800,681 | +13,637 | 0.01 | 0.01 | +0.00 | buy |
| Artisan Partners Limited Partnership | 318,287 | 331,302 | +13,015 | 0.02 | 0.02 | +0.00 | buy |
| Qsemble Capital Management, LP | 42,345 | 55,320 | +12,975 | 0.18 | 0.28 | +0.11 | buy |
| Inspire Advisors, LLC | 0 | 12,542 | +12,542 | 0.00 | 0.06 | +0.06 | buy |
| Baader Bank Aktiengesellschaft | 0 | 12,525 | +12,525 | 0.00 | 0.05 | +0.05 | buy |
| COMERICA BANK | 35,029 | 47,396 | +12,367 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 12,300 | 23,500 | +11,200 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 10,868 | +10,868 | 0.00 | 0.00 | +0.00 | buy |