| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 794,401 | 3,098,082 | +2,303,681 | 0.08 | 0.44 | +0.36 | buy |
| T. Rowe Price Investment Management, Inc. | 995,632 | 1,435,280 | +439,648 | 0.02 | 0.04 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 1,341,243 | 924,865 | +416,378 | 0.07 | 0.06 | 0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,277,084 | 966,797 | +310,287 | 0.10 | 0.10 | 0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 5,000 | 289,000 | +284,000 | 0.00 | 0.04 | +0.04 | buy |
| Granahan Investment Management, LLC | 108,821 | 388,302 | +279,481 | 0.10 | 0.52 | +0.42 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 745,666 | 943,484 | +197,818 | 0.01 | 0.03 | 0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 313,381 | 440,845 | +127,464 | 2.61 | 4.15 | +1.55 | buy |
| BIT Capital GmbH | 6,357 | 73,490 | +67,133 | 0.02 | 0.29 | +0.27 | buy |
| Candriam S.C.A. | 245,000 | 299,000 | +54,000 | 0.05 | 0.08 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 30,000 | 80,000 | +50,000 | 0.26 | 0.64 | +0.39 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 57,300 | 14,318 | +42,982 | 0.04 | 0.04 | 0.00 | sell |
| Edgestream Partners, L.P. | 15,040 | 50,302 | +35,262 | 0.03 | 0.15 | +0.11 | buy |
| Hennion & Walsh Asset Management, Inc. | 87,981 | 121,653 | +33,672 | 0.15 | 0.28 | +0.13 | buy |
| DUALITY ADVISERS, LP | 49,156 | 80,192 | +31,036 | 0.16 | 0.34 | +0.19 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 435,413 | 459,569 | +24,156 | 0.01 | 0.02 | +0.01 | buy |
| NOMURA HOLDINGS INC | 235,009 | 257,995 | +22,986 | 0.07 | 0.10 | 0.00 | buy |
| ALGERT GLOBAL LLC | 65,564 | 87,576 | +22,012 | 0.08 | 0.14 | 0.00 | buy |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 4,604,000 | 4,622,000 | +18,000 | 0.49 | 0.57 | +0.08 | buy |
| Erste Asset Management GmbH | 68,225 | 84,225 | +16,000 | 0.03 | 0.05 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 4,171 | 20,120 | +15,949 | 0.03 | 0.16 | +0.13 | buy |
| Y-Intercept (Hong Kong) Ltd | 14,204 | 26,192 | +11,988 | 0.04 | 0.10 | 0.00 | buy |
| PROFUND ADVISORS LLC | 53,869 | 46,347 | +7,522 | 0.08 | 0.08 | 0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 284,487 | 291,643 | +7,156 | 0.02 | 0.03 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 15,207 | 9,436 | +5,771 | 0.00 | 0.00 | 0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 938,700 | 944,000 | +5,300 | 0.02 | 0.03 | +0.01 | buy |
| B. Metzler seel. Sohn & Co. AG | 43,599 | 48,812 | +5,213 | 0.02 | 0.03 | +0.01 | buy |
| ProShare Advisors LLC | 25,503 | 30,072 | +4,569 | 0.00 | 0.00 | 0.00 | buy |
| Knott David M Jr | 9,000 | 12,000 | +3,000 | 0.09 | 0.18 | +0.09 | buy |
| Parkman Healthcare Partners LLC | 100,000 | 100,734 | +734 | 0.48 | 0.58 | +0.09 | buy |
| Diversified Trust Co | 17,111 | 17,636 | +525 | 0.02 | 0.02 | +0.01 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 21,440 | 20,990 | +450 | 0.01 | 0.01 | 0.00 | sell |
| Ameritas Investment Partners, Inc. | 11,379 | 11,540 | +161 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 1,143,613 | 1,143,563 | +50 | 0.02 | 0.03 | 0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,214 | 15,254 | +40 | 0.04 | 0.05 | +0.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 40,126 | 40,122 | -4 | 0.02 | 0.02 | +0.01 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 64,537 | 64,504 | -33 | 1.04 | 1.37 | +0.33 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 14,200 | 13,400 | -800 | 0.01 | 0.01 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 20,301 | 19,357 | -944 | 0.00 | 0.00 | +0.00 | sell |
| E Fund Management Co., Ltd. | 16,095 | 14,769 | -1,326 | 0.03 | 0.04 | +0.01 | sell |
| Belvedere Trading LLC | 29,729 | 27,071 | -2,658 | 0.00 | 0.00 | +0.00 | sell |
| Informed Momentum Co LLC | 88,167 | 84,679 | -3,488 | 0.45 | 0.61 | +0.16 | sell |
| EMERALD ADVISERS, LLC | 694,000 | 685,539 | -8,461 | 0.89 | 1.18 | +0.30 | sell |
| FRED ALGER MANAGEMENT, LLC | 131,623 | 122,797 | -8,826 | 0.02 | 0.03 | +0.01 | sell |
| VIRTUS ADVISERS, LLC | 18,018 | 9,084 | -8,934 | 0.29 | 0.23 | -0.06 | sell |
| Zimmer Partners, LP | 75,000 | 65,000 | -10,000 | 0.05 | 0.10 | +0.05 | sell |
| MOODY ALDRICH PARTNERS LLC | 137,512 | 124,984 | -12,528 | 0.69 | 0.91 | +0.22 | sell |
| MIZUHO MARKETS AMERICAS LLC | 80,532 | 64,379 | -16,153 | 0.08 | 0.08 | -0.00 | sell |
| Global IMC LLC | 141,510 | 118,138 | -23,372 | 1.01 | 1.15 | +0.14 | sell |
| Rafferty Asset Management, LLC | 313,382 | 276,073 | -37,309 | 0.05 | 0.05 | -0.00 | sell |
| Bellevue Group AG | 78,700 | 33,300 | -45,400 | 0.03 | 0.02 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 345,537 | 282,146 | -63,391 | 1.66 | 1.83 | +0.17 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 113,110 | 42,029 | -71,081 | 0.19 | 1.72 | +1.52 | sell |
| Sio Capital Management, LLC | 222,947 | 131,753 | -91,194 | 1.82 | 1.21 | -0.61 | sell |
| SECTORAL ASSET MANAGEMENT INC | 180,195 | 12,955 | -167,240 | 0.93 | 0.23 | -0.70 | sell |
| Portman Square Capital LLP | 220,597 | 27,679 | -192,918 | 0.80 | 0.19 | -0.61 | sell |
| Octagon Capital Advisors LP | 971,639 | 706,800 | -264,839 | 4.51 | 4.57 | +0.05 | sell |
| Laurion Capital Management LP | 5,651,039 | 5,241,833 | -409,206 | 0.91 | 1.79 | +0.88 | sell |
| Woodline Partners LP | 1,125,634 | 290,000 | -835,634 | 0.35 | 0.13 | -0.22 | sell |
| Cormorant Asset Management, LP | 4,662,530 | 3,344,179 | -1,318,351 | 7.17 | 6.45 | -0.72 | sell |
| HHLR ADVISORS, LTD. | 2,782,750 | 1,391,240 | -1,391,510 | 1.64 | 1.13 | -0.51 | sell |