| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 949,749 | 2,211,521 | +1,261,772 | 0.20 | 0.41 | +0.21 | buy |
| Capital Research Global Investors | 2,614,308 | 3,526,747 | +912,439 | 0.01 | 0.02 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 503,162 | 1,075,858 | +572,696 | 0.12 | 0.28 | +0.16 | buy |
| ARISTEIA CAPITAL, L.L.C. | 136,587 | 411,927 | +275,340 | 0.07 | 0.37 | +0.30 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 810,465 | 991,238 | +180,773 | 0.00 | 0.00 | +0.00 | buy |
| Cutter Capital Management, LP | 396,388 | 560,344 | +163,956 | 2.98 | 6.30 | +3.32 | buy |
| TWO SIGMA INVESTMENTS, LP | 381,242 | 238,536 | +142,706 | 0.02 | 0.02 | 0.00 | sell |
| ALGERT GLOBAL LLC | 136,447 | 23,600 | +112,847 | 0.09 | 0.02 | 0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,145,123 | 1,050,139 | +94,984 | 0.02 | 0.02 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,818,012 | 4,907,533 | +89,521 | 0.06 | 0.07 | 0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 926,846 | 1,015,728 | +88,882 | 0.01 | 0.02 | +0.00 | buy |
| 683 Capital Management, LLC | 550,000 | 635,000 | +85,000 | 1.06 | 1.08 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 842,644 | 905,279 | +62,635 | 3.41 | 4.49 | +1.08 | buy |
| First Turn Management, LLC | 399,781 | 452,290 | +52,509 | 1.61 | 2.22 | +0.61 | buy |
| BIT Capital GmbH | 222,421 | 274,915 | +52,494 | 0.53 | 0.60 | +0.07 | buy |
| Atle Fund Management AB | 53,432 | 103,032 | +49,600 | 0.64 | 1.34 | +0.70 | buy |
| EMERALD ADVISERS, LLC | 1,103,508 | 1,150,868 | +47,360 | 1.09 | 1.22 | +0.14 | buy |
| Frazier Life Sciences Management, L.P. | 3,760,457 | 3,800,457 | +40,000 | 3.84 | 4.33 | +0.49 | buy |
| Exome Asset Management LLC | 211,000 | 246,700 | +35,700 | 3.63 | 5.09 | +1.46 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 226,684 | 262,141 | +35,457 | 5.16 | 6.32 | +1.16 | buy |
| NEOS Investment Management LLC | 112,076 | 141,972 | +29,896 | 0.09 | 0.09 | +0.01 | buy |
| Nicholas Investment Partners, LP | 35,644 | 59,892 | +24,248 | 0.08 | 0.14 | +0.06 | buy |
| ROYCE & ASSOCIATES LP | 121,955 | 144,788 | +22,833 | 0.03 | 0.04 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 44,623 | 65,647 | +21,024 | 0.01 | 0.02 | +0.01 | buy |
| Nebula Research & Development LLC | 18,839 | 36,239 | +17,400 | 0.06 | 0.12 | +0.06 | buy |
| NOMURA HOLDINGS INC | 228,234 | 214,128 | +14,106 | 0.04 | 0.03 | 0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 13,279 | 25,980 | +12,701 | 0.02 | 0.05 | 0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 30,189 | 41,514 | +11,325 | 5.54 | 49.05 | +43.51 | buy |
| Crestline Management, LP | 33,571 | 44,740 | +11,169 | 0.04 | 0.04 | -0.00 | buy |
| ProShare Advisors LLC | 37,675 | 48,539 | +10,864 | 0.00 | 0.00 | 0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 906,724 | 915,500 | +8,776 | 0.02 | 0.02 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 61,150 | 68,700 | +7,550 | 0.12 | 0.16 | +0.04 | buy |
| Rafferty Asset Management, LLC | 243,331 | 250,242 | +6,911 | 0.02 | 0.02 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 51,001 | 44,661 | +6,340 | 0.01 | 0.01 | 0.00 | sell |
| FNY Investment Advisers, LLC | 8,650 | 13,750 | +5,100 | 0.11 | 0.20 | +0.09 | buy |
| China Universal Asset Management Co., Ltd. | 36,165 | 40,073 | +3,908 | 0.10 | 0.10 | +0.00 | buy |
| MIZUHO MARKETS AMERICAS LLC | 87,180 | 90,175 | +2,995 | 0.05 | 0.05 | -0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 58,596 | 61,118 | +2,522 | 0.12 | 0.13 | 0.00 | buy |
| E Fund Management Co., Ltd. | 15,634 | 17,785 | +2,151 | 0.02 | 0.02 | +0.00 | buy |
| Belvedere Trading LLC | 9,411 | 11,316 | +1,905 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 11,357 | 12,637 | +1,280 | 0.14 | 0.14 | +0.01 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 17,700 | 18,975 | +1,275 | 0.01 | 0.01 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 14,240 | 14,706 | +466 | 0.01 | 0.01 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 62,819 | 63,157 | +338 | 0.78 | 0.86 | +0.08 | buy |
| PROFUND ADVISORS LLC | 48,966 | 49,091 | +125 | 0.05 | 0.05 | 0.00 | buy |
| Bell Investment Advisors, Inc | 174 | 223 | +49 | 0.00 | 0.00 | 0.00 | buy |
| Elequin Capital, LP | 288 | 303 | +15 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 49,412 | 49,230 | -182 | 0.02 | 0.01 | -0.00 | sell |
| Garden State Investment Advisory Services LLC | 11,588 | 11,368 | -220 | 0.09 | 0.10 | +0.00 | sell |
| Clear Harbor Asset Management, LLC | 9,850 | 9,575 | -275 | 0.02 | 0.02 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 38,043 | 37,659 | -384 | 0.05 | 0.05 | +0.00 | sell |
| First Bank & Trust | 8,044 | 7,471 | -573 | 0.04 | 0.04 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 263,679 | 261,944 | -1,735 | 0.01 | 0.02 | +0.00 | sell |
| Wealth Management Associates, Inc. | 9,680 | 7,545 | -2,135 | 0.11 | 0.09 | -0.02 | sell |
| SECTORAL ASSET MANAGEMENT INC | 15,085 | 11,500 | -3,585 | 0.23 | 0.21 | -0.02 | sell |
| Polar Asset Management Partners Inc. | 50,500 | 46,900 | -3,600 | 0.03 | 0.02 | -0.01 | sell |
| Lion Point Capital, LP | 49,000 | 40,300 | -8,700 | 2.78 | 5.79 | +3.01 | sell |
| Diversified Trust Co | 36,772 | 27,827 | -8,945 | 0.02 | 0.02 | -0.00 | sell |
| Brevan Howard Capital Management LP | 24,482 | 14,760 | -9,722 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 69,054 | 46,500 | -22,554 | 0.61 | 0.47 | -0.13 | sell |
| MOODY ALDRICH PARTNERS LLC | 123,509 | 99,684 | -23,825 | 0.57 | 0.51 | -0.07 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 751,355 | 724,872 | -26,483 | 0.99 | 1.21 | +0.22 | sell |
| LMR Partners LLP | 104,832 | 54,430 | -50,402 | 0.06 | 0.03 | -0.03 | sell |
| Portman Square Capital LLP | 77,287 | 24,527 | -52,760 | 0.65 | 0.13 | -0.52 | sell |
| Ikarian Capital, LLC | 285,613 | 215,713 | -69,900 | 2.26 | 1.69 | -0.57 | sell |
| Prosight Management, LP | 1,086,810 | 995,000 | -91,810 | 6.81 | 7.55 | +0.74 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 200,000 | -100,000 | 1.19 | 0.86 | -0.33 | sell |
| Octagon Capital Advisors LP | 552,000 | 441,600 | -110,400 | 2.25 | 2.06 | -0.19 | sell |
| Laurion Capital Management LP | 3,894,282 | 3,740,896 | -153,386 | 1.35 | 1.88 | +0.53 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 716,927 | 532,192 | -184,735 | 0.31 | 0.27 | -0.05 | sell |
| Cormorant Asset Management, LP | 1,858,351 | 1,600,000 | -258,351 | 2.51 | 2.41 | -0.10 | sell |
| ADAR1 Capital Management, LLC | 1,448,470 | 678,857 | -769,613 | 6.18 | 3.84 | -2.34 | sell |