| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 1,747,000 | 4,195,000 | +2,448,000 | 0.24 | 0.61 | +0.36 | buy |
| Woodline Partners LP | 949,749 | 2,211,521 | +1,261,772 | 0.20 | 0.41 | +0.21 | buy |
| Alyeska Investment Group, L.P. | 0 | 940,415 | +940,415 | 0.00 | 0.10 | +0.10 | buy |
| Capital Research Global Investors | 2,614,308 | 3,526,747 | +912,439 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 14,198,856 | 15,077,915 | +879,059 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 12,879,510 | 13,709,646 | +830,136 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 819,162 | +819,162 | 0.00 | 0.84 | +0.84 | buy |
| UBS Group AG | 1,086,793 | 1,839,855 | +753,062 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 503,162 | 1,075,858 | +572,696 | 0.12 | 0.28 | +0.16 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 715,157 | 1,224,282 | +509,125 | 0.03 | 0.05 | +0.02 | buy |
| TORONTO DOMINION BANK | 0 | 500,000 | +500,000 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,532,224 | 1,885,794 | +353,570 | 0.03 | 0.04 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,826,000 | 5,131,000 | +305,000 | 0.01 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 290,242 | +290,242 | 0.00 | 0.61 | +0.61 | buy |
| ARISTEIA CAPITAL, L.L.C. | 136,587 | 411,927 | +275,340 | 0.12 | 0.41 | +0.29 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 270,000 | +270,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 5,962,654 | 6,182,627 | +219,973 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 185,000 | +185,000 | 0.00 | 0.06 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 810,465 | 991,238 | +180,773 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 180,400 | +180,400 | 0.00 | 0.09 | +0.09 | buy |
| Cutter Capital Management, LP | 396,388 | 560,344 | +163,956 | 2.98 | 6.30 | +3.32 | buy |
| JANE STREET GROUP, LLC | 524,361 | 664,924 | +140,563 | 0.02 | 0.03 | +0.01 | buy |
| Lighthouse Investment Partners, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.13 | +0.13 | buy |
| Cinctive Capital Management LP | 0 | 114,202 | +114,202 | 0.00 | 0.17 | +0.17 | buy |
| Hudson Bay Capital Management LP | 0 | 112,535 | +112,535 | 0.00 | 0.02 | +0.02 | buy |
| GROUP ONE TRADING LLC | 124,902 | 233,137 | +108,235 | 0.13 | 0.22 | +0.09 | buy |
| F/m Investments LLC | 0 | 97,198 | +97,198 | 0.00 | 0.10 | +0.10 | buy |
| JANUS HENDERSON GROUP PLC | 4,818,012 | 4,907,533 | +89,521 | 0.06 | 0.07 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 1,885,754 | 1,975,249 | +89,495 | 0.08 | 0.10 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 926,846 | 1,015,728 | +88,882 | 0.01 | 0.02 | +0.00 | buy |
| 683 Capital Management, LLC | 550,000 | 635,000 | +85,000 | 1.43 | 1.71 | +0.29 | buy |
| MILLENNIUM MANAGEMENT LLC | 37,472 | 111,071 | +73,599 | 0.00 | 0.00 | +0.00 | buy |
| GABELLI FUNDS LLC | 0 | 73,500 | +73,500 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 167,839 | 237,995 | +70,156 | 0.10 | 0.11 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 842,644 | 905,279 | +62,635 | 3.51 | 4.59 | +1.08 | buy |
| COMERICA BANK | 45,860 | 106,116 | +60,256 | 0.00 | 0.01 | +0.01 | buy |
| Edgestream Partners, L.P. | 0 | 56,235 | +56,235 | 0.00 | 0.07 | +0.07 | buy |
| First Turn Management, LLC | 399,781 | 452,290 | +52,509 | 1.61 | 2.22 | +0.61 | buy |
| BIT Capital GmbH | 222,421 | 274,915 | +52,494 | 0.54 | 0.66 | +0.12 | buy |
| Atle Fund Management AB | 53,432 | 103,032 | +49,600 | 0.64 | 1.34 | +0.70 | buy |
| EMERALD ADVISERS, LLC | 1,103,508 | 1,150,868 | +47,360 | 1.09 | 1.22 | +0.14 | buy |
| NORTHERN TRUST CORP | 1,279,303 | 1,323,258 | +43,955 | 0.01 | 0.01 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,760,457 | 3,800,457 | +40,000 | 3.84 | 4.33 | +0.49 | buy |
| Cetera Investment Advisers | 0 | 37,163 | +37,163 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 211,000 | 246,700 | +35,700 | 3.63 | 5.09 | +1.46 | buy |
| Invesco Ltd. | 857,457 | 893,127 | +35,670 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 226,684 | 262,141 | +35,457 | 5.16 | 6.32 | +1.16 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 34,741 | +34,741 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 112,076 | 141,972 | +29,896 | 0.09 | 0.09 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 195,963 | 223,573 | +27,610 | 0.01 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 24,582 | +24,582 | 0.00 | 0.03 | +0.03 | buy |
| Nicholas Investment Partners, LP | 35,644 | 59,892 | +24,248 | 0.08 | 0.14 | +0.06 | buy |
| ROYCE & ASSOCIATES LP | 121,955 | 144,788 | +22,833 | 0.03 | 0.04 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,284,802 | 1,306,765 | +21,963 | 0.01 | 0.01 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 19,134 | 40,993 | +21,859 | 0.01 | 0.03 | +0.01 | buy |
| Wealthfront Advisers LLC | 0 | 21,578 | +21,578 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 44,623 | 65,647 | +21,024 | 0.01 | 0.02 | +0.00 | buy |
| Swiss National Bank | 219,300 | 240,300 | +21,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,099 | 20,778 | +18,679 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 69,678 | 88,000 | +18,322 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 18,839 | 36,239 | +17,400 | 0.06 | 0.12 | +0.06 | buy |
| State of New Jersey Common Pension Fund D | 76,586 | 93,131 | +16,545 | 0.01 | 0.01 | +0.00 | buy |
| Parallax Volatility Advisers, L.P. | 0 | 15,629 | +15,629 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 119,711 | 134,038 | +14,327 | 0.00 | 0.00 | +0.00 | buy |
| Compound Planning, Inc. | 0 | 14,302 | +14,302 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 13,329 | +13,329 | 0.00 | 0.03 | +0.03 | buy |
| SYON CAPITAL LLC | 0 | 13,200 | +13,200 | 0.00 | 0.03 | +0.03 | buy |
| CIBC WORLD MARKETS CORP | 0 | 13,155 | +13,155 | 0.00 | 0.00 | +0.00 | buy |
| HARVEY CAPITAL MANAGEMENT INC | 0 | 12,900 | +12,900 | 0.00 | 0.08 | +0.08 | buy |
| Qube Research & Technologies Ltd | 0 | 12,767 | +12,767 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 13,279 | 25,980 | +12,701 | 0.02 | 0.05 | +0.03 | buy |
| Creative Planning | 31,264 | 43,931 | +12,667 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 30,189 | 41,514 | +11,325 | 0.00 | 0.01 | +0.00 | buy |
| Crestline Management, LP | 33,571 | 44,740 | +11,169 | 0.05 | 0.04 | -0.01 | buy |
| ProShare Advisors LLC | 37,675 | 48,539 | +10,864 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 9,828 | +9,828 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 9,362 | +9,362 | 0.00 | 0.01 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 906,724 | 915,500 | +8,776 | 0.02 | 0.02 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 15,263 | 23,805 | +8,542 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 28,160 | 36,208 | +8,048 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 7,670 | +7,670 | 0.00 | 0.03 | +0.03 | buy |
| Moss Adams Wealth Advisors LLC | 0 | 7,577 | +7,577 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 61,150 | 68,700 | +7,550 | 0.12 | 0.16 | +0.04 | buy |
| First Bank & Trust | 0 | 7,471 | +7,471 | 0.00 | 0.04 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 108,267 | 115,655 | +7,388 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 243,331 | 250,242 | +6,911 | 0.02 | 0.02 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25,064 | 31,530 | +6,466 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 29,000 | 35,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 32,550 | 37,950 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,808 | 77,951 | +5,143 | 0.00 | 0.01 | +0.00 | buy |
| FNY Investment Advisers, LLC | 8,650 | 13,750 | +5,100 | 0.11 | 0.20 | +0.09 | buy |
| RHUMBLINE ADVISERS | 214,113 | 219,120 | +5,007 | 0.00 | 0.01 | +0.00 | buy |
| HighTower Advisors, LLC | 223,331 | 228,332 | +5,001 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 81,166 | 85,963 | +4,797 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 23,602 | 28,248 | +4,646 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 4,576 | 9,013 | +4,437 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 36,165 | 40,073 | +3,908 | 0.10 | 0.10 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,413,949 | 3,417,693 | +3,744 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 86,513 | 89,994 | +3,481 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 32,329 | 35,470 | +3,141 | 0.01 | 0.01 | +0.00 | buy |