| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 0 | 24,000,000 | +24,000,000 | 0.00 | 0.12 | +0.12 | buy |
| VANGUARD GROUP INC | 16,832,059 | 16,862,691 | +30,632 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 14,411,203 | 14,549,529 | +138,326 | 0.01 | 0.02 | +0.01 | buy |
| VIKING GLOBAL INVESTORS LP | 15,977,849 | 14,393,934 | -1,583,915 | 2.16 | 2.92 | +0.77 | sell |
| Kohlberg Kravis Roberts & Co. L.P. | 13,260,971 | 13,260,971 | 0 | 11.54 | 16.22 | +4.67 | hold |
| JANUS HENDERSON GROUP PLC | 8,741,079 | 11,000,457 | +2,259,378 | 0.21 | 0.38 | +0.17 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 8,192,000 | 8,998,463 | +806,463 | 2.40 | 3.58 | +1.17 | buy |
| Aisling Capital Management LP | 6,089,611 | 5,089,611 | -1,000,000 | 69.29 | 81.29 | +11.99 | sell |
| STATE STREET CORP | 5,606,340 | 4,962,866 | -643,474 | 0.01 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 3,928,657 | 4,831,305 | +902,648 | 0.03 | 0.05 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,909,941 | 4,412,523 | +502,582 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,567,565 | 3,828,746 | +2,261,181 | 0.01 | 0.03 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 3,845,457 | 3,545,557 | -299,900 | 5.98 | 7.28 | +1.30 | sell |
| BNP Paribas Asset Management Holding S.A. | 0 | 3,180,000 | +3,180,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 3,000,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Brooklands Fund Management Ltd | 0 | 2,750,000 | +2,750,000 | 0.00 | 1.49 | +1.49 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,500,000 | 2,500,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| FMR LLC | 1,700,747 | 2,390,362 | +689,615 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,019,194 | 2,348,731 | +1,329,537 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 2,252,762 | 2,214,031 | -38,731 | 0.09 | 0.13 | +0.03 | sell |
| FRANKLIN RESOURCES INC | 1,444,023 | 2,164,928 | +720,905 | 0.02 | 0.04 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,328,715 | 2,050,746 | -277,969 | 0.04 | 0.05 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,914,767 | 1,975,315 | +60,548 | 0.08 | 0.12 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,925,198 | 1,964,419 | +39,221 | 0.02 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,328,941 | 1,947,047 | -381,894 | 0.19 | 0.22 | +0.04 | sell |
| Capital Research Global Investors | 1,933,126 | 1,934,698 | +1,572 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 2,586,422 | 1,875,665 | -710,757 | 0.03 | 0.03 | +0.00 | sell |
| SC US (TTGP), LTD. | 1,860,364 | 1,860,364 | 0 | 0.60 | 1.02 | +0.42 | hold |
| GOLDMAN SACHS GROUP INC | 2,209,159 | 1,782,833 | -426,326 | 0.02 | 0.02 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,662,069 | 1,680,972 | +18,903 | 0.62 | 0.87 | +0.26 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 639,264 | 1,592,660 | +953,396 | 0.03 | 0.08 | +0.05 | buy |
| NORGES BANK | 0 | 1,527,028 | +1,527,028 | 0.00 | 0.01 | +0.01 | buy |
| Laurion Capital Management LP | 1,753,544 | 1,402,150 | -351,394 | 12.42 | 7.32 | -5.11 | sell |
| TWO SIGMA ADVISERS, LP | 1,662,755 | 1,401,035 | -261,720 | 0.17 | 0.21 | +0.04 | sell |
| MORGAN STANLEY | 1,054,865 | 1,399,809 | +344,944 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,402,409 | 1,346,754 | -55,655 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,859,000 | 1,343,000 | -1,516,000 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 1,267,412 | 1,314,303 | +46,891 | 0.03 | 0.05 | +0.02 | buy |
| Polar Capital Holdings Plc | 981,058 | 1,299,346 | +318,288 | 0.25 | 0.45 | +0.21 | buy |
| Pictet Asset Management Holding SA | 1,133,351 | 1,270,290 | +136,939 | 0.06 | 0.09 | +0.04 | buy |
| Ensign Peak Advisors, Inc | 1,351,579 | 1,263,484 | -88,095 | 0.12 | 0.17 | +0.06 | sell |
| Hood River Capital Management LLC | 1,243,545 | 1,255,185 | +11,640 | 0.76 | 1.05 | +0.29 | buy |
| Cormorant Asset Management, LP | 1,400,000 | 1,200,000 | -200,000 | 5.02 | 5.20 | +0.19 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,076,586 | 1,106,820 | +30,234 | 0.03 | 0.04 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,380,868 | 1,078,048 | -302,820 | 0.01 | 0.01 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 6,947 | 994,220 | +987,273 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 294,116 | 858,968 | +564,852 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 800,681 | 841,536 | +40,855 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 659,633 | 826,131 | +166,498 | 0.31 | 0.67 | +0.36 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 806,710 | 813,794 | +7,084 | 1.36 | 1.75 | +0.39 | buy |
| Deep Track Capital, LP | 1,200,000 | 810,142 | -389,858 | 1.74 | 1.41 | -0.33 | sell |
| LORD, ABBETT & CO. LLC | 876,881 | 781,345 | -95,536 | 0.14 | 0.18 | +0.05 | sell |
| PANAGORA ASSET MANAGEMENT INC | 729,524 | 738,843 | +9,319 | 0.15 | 0.20 | +0.05 | buy |
| Sofinnova Investments, Inc. | 831,847 | 720,448 | -111,399 | 2.65 | 2.38 | -0.27 | sell |
| CITIGROUP INC | 927,951 | 700,251 | -227,700 | 0.03 | 0.04 | +0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 698,182 | +698,182 | 0.00 | 0.04 | +0.04 | buy |
| Paradigm Biocapital Advisors LP | 684,277 | 684,277 | 0 | 1.05 | 1.40 | +0.35 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 133,832 | 638,883 | +505,051 | 0.02 | 0.17 | +0.15 | buy |
| GW&K Investment Management, LLC | 598,237 | 626,122 | +27,885 | 0.27 | 0.41 | +0.14 | buy |
| BARCLAYS PLC | 719,448 | 622,575 | -96,873 | 0.01 | 0.02 | +0.01 | sell |
| Bank of New York Mellon Corp | 927,773 | 596,403 | -331,370 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 589,729 | 595,473 | +5,744 | 4.60 | 5.20 | +0.60 | buy |
| FEDERATED HERMES, INC. | 424,695 | 586,795 | +162,100 | 0.04 | 0.07 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 473,496 | 583,361 | +109,865 | 0.02 | 0.04 | +0.02 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 576,370 | 569,680 | -6,690 | 0.02 | 0.03 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 720,343 | 535,764 | -184,579 | 1.20 | 1.26 | +0.06 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 944,846 | 508,134 | -436,712 | 0.08 | 0.06 | -0.02 | sell |
| Clearbridge Investments, LLC | 493,063 | 498,329 | +5,266 | 0.02 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 504,110 | 494,785 | -9,325 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,866 | 487,376 | +145,510 | 0.03 | 0.05 | +0.03 | buy |
| GILDER GAGNON HOWE & CO LLC | 462,311 | 457,977 | -4,334 | 0.24 | 0.37 | +0.13 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 513,263 | 451,016 | -62,247 | 0.01 | 0.01 | +0.00 | sell |
| Russell Investments Group, Ltd. | 383,485 | 415,156 | +31,671 | 0.02 | 0.03 | +0.01 | buy |
| Catalio Capital Management, LP | 622,729 | 410,700 | -212,029 | 5.98 | 5.55 | -0.43 | sell |
| DIMENSIONAL FUND ADVISORS LP | 68,253 | 382,569 | +314,316 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 426,300 | 381,063 | -45,237 | 0.01 | 0.01 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 584,296 | 362,130 | -222,166 | 0.50 | 0.43 | -0.07 | sell |
| SEI INVESTMENTS CO | 271,000 | 361,000 | +90,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 633,886 | 341,795 | -292,091 | 0.04 | 0.03 | -0.01 | sell |
| ALGERT GLOBAL LLC | 114,863 | 341,048 | +226,185 | 0.10 | 0.41 | +0.31 | buy |
| Legal & General Group Plc | 339,490 | 334,731 | -4,759 | 0.00 | 0.01 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 65,000 | 320,000 | +255,000 | 0.31 | 1.76 | +1.44 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 411,427 | 316,784 | -94,643 | 1.10 | 1.18 | +0.08 | sell |
| NOMURA HOLDINGS INC | 432,082 | 309,930 | -122,152 | 0.10 | 0.07 | -0.03 | sell |
| PFM Health Sciences, LP | 327,174 | 306,506 | -20,668 | 1.45 | 2.37 | +0.92 | sell |
| Woodline Partners LP | 198,318 | 300,912 | +102,594 | 0.05 | 0.09 | +0.04 | buy |
| Bank of New York Mellon Corp | 300,000 | 300,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nicholas Investment Partners, LP | 271,630 | 284,682 | +13,052 | 1.08 | 1.59 | +0.51 | buy |
| Swiss National Bank | 276,000 | 282,600 | +6,600 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 245,525 | 281,686 | +36,161 | 0.01 | 0.02 | +0.01 | buy |
| Artisan Partners Limited Partnership | 331,302 | 279,067 | -52,235 | 0.02 | 0.03 | +0.01 | sell |
| Candriam S.C.A. | 148,986 | 278,888 | +129,902 | 0.04 | 0.11 | +0.07 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 479,680 | 277,081 | -202,599 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 268,899 | +268,899 | 0.00 | 0.04 | +0.04 | buy |
| Eagle Health Investments LP | 259,300 | 259,300 | 0 | 3.54 | 4.36 | +0.82 | hold |
| OSAIC HOLDINGS, INC. | 260,058 | 252,145 | -7,913 | 0.02 | 0.03 | +0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 148,917 | 237,791 | +88,874 | 0.03 | 0.07 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,014,677 | 234,389 | -780,288 | 0.11 | 0.03 | -0.07 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,316 | 233,936 | +11,620 | 0.02 | 0.03 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 232,923 | 232,923 | 0 | 0.12 | 0.18 | +0.06 | hold |