| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 0 | 2,119,598 | +2,119,598 | 0.00 | 9.32 | +9.32 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,490 | 1,246,189 | +1,207,699 | 0.00 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 694,821 | 1,193,121 | +498,300 | 0.29 | 0.60 | +0.31 | buy |
| Redmile Group, LLC | 1,429,783 | 1,879,617 | +449,834 | 1.39 | 2.28 | +0.89 | buy |
| VANGUARD GROUP INC | 7,164,876 | 7,578,768 | +413,892 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,105,753 | 4,511,753 | +406,000 | 0.70 | 0.88 | +0.18 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 358,798 | +358,798 | 0.00 | 0.03 | +0.03 | buy |
| NORGES BANK | 12,887 | 294,691 | +281,804 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 162,692 | +162,692 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 148,200 | +148,200 | 0.00 | 0.01 | +0.01 | buy |
| Casdin Capital, LLC | 528,000 | 675,000 | +147,000 | 1.42 | 1.66 | +0.24 | buy |
| BANK OF AMERICA CORP /DE/ | 194,328 | 321,052 | +126,724 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 98,055 | +98,055 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 97,737 | +97,737 | 0.00 | 0.04 | +0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 158,248 | 236,387 | +78,139 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 566,858 | 641,861 | +75,003 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 8,499 | 81,220 | +72,721 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 187,588 | 259,186 | +71,598 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34,624 | 104,810 | +70,186 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 484,150 | 552,212 | +68,062 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,575,279 | 1,636,722 | +61,443 | 0.00 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 166,375 | 223,929 | +57,554 | 0.01 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 0 | 55,649 | +55,649 | 0.00 | 0.17 | +0.17 | buy |
| Point72 Hong Kong Ltd | 0 | 48,325 | +48,325 | 0.00 | 0.08 | +0.08 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 47,845 | +47,845 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 111,430 | 147,510 | +36,080 | 0.07 | 0.12 | +0.05 | buy |
| TWINBEECH CAPITAL LP | 0 | 34,641 | +34,641 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 75,709 | 107,187 | +31,478 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 11,445 | 39,513 | +28,068 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 9,981 | 37,955 | +27,974 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 26,486 | +26,486 | 0.00 | 0.07 | +0.07 | buy |
| Schonfeld Strategic Advisors LLC | 25,505 | 48,698 | +23,193 | 0.01 | 0.01 | +0.01 | buy |
| Capula Management Ltd | 0 | 18,853 | +18,853 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 36,378 | 54,999 | +18,621 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 48,161 | 65,369 | +17,208 | 0.00 | 0.00 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 98,215 | 114,786 | +16,571 | 0.14 | 0.16 | +0.03 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 16,189 | +16,189 | 0.00 | 0.01 | +0.01 | buy |
| Teza Capital Management LLC | 0 | 16,102 | +16,102 | 0.00 | 0.07 | +0.07 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 15,496 | +15,496 | 0.00 | 0.13 | +0.13 | buy |
| Pearl River Capital, LLC | 0 | 15,429 | +15,429 | 0.00 | 0.08 | +0.08 | buy |
| Gotham Asset Management, LLC | 0 | 14,932 | +14,932 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 57,001 | 71,741 | +14,740 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 17,064 | 30,196 | +13,132 | 0.05 | 0.11 | +0.06 | buy |
| Creative Planning | 0 | 12,061 | +12,061 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 20,916 | 32,953 | +12,037 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 11,864 | +11,864 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 8,532 | 19,407 | +10,875 | 0.23 | 0.34 | +0.11 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 10,734 | +10,734 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| Krilogy Financial LLC | 23,617 | 33,602 | +9,985 | 0.05 | 0.09 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 36,946 | 46,873 | +9,927 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 14,094 | 23,166 | +9,072 | 0.01 | 0.02 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 8,803 | +8,803 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 0 | 8,475 | +8,475 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 571,236 | 579,272 | +8,036 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 7,900 | +7,900 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 7,894 | +7,894 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 7,630 | +7,630 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 0 | 7,626 | +7,626 | 0.00 | 0.00 | +0.00 | buy |
| SteelPeak Wealth, LLC | 0 | 7,505 | +7,505 | 0.00 | 0.01 | +0.01 | buy |
| DLK Investment Management, LLC | 0 | 7,225 | +7,225 | 0.00 | 0.10 | +0.10 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 15,860 | 23,036 | +7,176 | 0.01 | 0.01 | +0.00 | buy |
| Thrive Wealth Management, LLC | 0 | 6,925 | +6,925 | 0.00 | 0.05 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 6,524 | +6,524 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,667 | 15,919 | +6,252 | 0.05 | 0.07 | +0.02 | buy |
| McGuire Investment Group, LLC | 0 | 6,250 | +6,250 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 137,726 | 143,828 | +6,102 | 0.01 | 0.01 | +0.00 | buy |
| Reynders McVeigh Capital Management, LLC | 0 | 6,055 | +6,055 | 0.00 | 0.01 | +0.01 | buy |
| D.A. DAVIDSON & CO. | 38,277 | 43,953 | +5,676 | 0.01 | 0.01 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 12,239 | 17,275 | +5,036 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 4,953 | +4,953 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 104,212 | 109,004 | +4,792 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 132,600 | 136,700 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 4,071 | +4,071 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 84,230 | 88,110 | +3,880 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 56,955 | 60,755 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 2,358,091 | 2,361,817 | +3,726 | 0.05 | 0.05 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 2,358,091 | 2,361,817 | +3,726 | 0.62 | 0.77 | +0.16 | buy |
| Vident Advisory, LLC | 15,992 | 19,400 | +3,408 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 70,548 | 73,558 | +3,010 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 2,800 | +2,800 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 2,453 | +2,453 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,626 | 30,996 | +2,370 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 21,764 | 23,896 | +2,132 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 17,638 | 19,511 | +1,873 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,134 | +1,134 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 800 | +800 | 0.00 | 0.01 | +0.01 | buy |
| Riverview Trust Co | 0 | 796 | +796 | 0.00 | 0.02 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 17,629 | 18,418 | +789 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 36,028 | 36,760 | +732 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 7,626 | 8,155 | +529 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 7,429 | 7,825 | +396 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,725 | 21,101 | +376 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 10,323 | 10,612 | +289 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,017 | 2,244 | +227 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 18,819 | 19,039 | +220 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,564 | 1,772 | +208 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF VERMONT | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |