| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 7,068,029 | 8,480,089 | +1,412,060 | 1.46 | 1.66 | +0.20 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,753,142 | 3,026,701 | +1,273,559 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 1,518,121 | 2,395,930 | +877,809 | 0.72 | 1.05 | +0.32 | buy |
| Kynam Capital Management, LP | 1,756,158 | 2,518,170 | +762,012 | 2.87 | 4.21 | +1.34 | buy |
| Woodline Partners LP | 282,120 | 760,611 | +478,491 | 0.05 | 0.10 | +0.05 | buy |
| Nikko Asset Management Americas, Inc. | 3,957,611 | 4,270,020 | +312,409 | 1.06 | 1.07 | +0.01 | buy |
| Casdin Capital, LLC | 1,250,000 | 1,425,562 | +175,562 | 2.06 | 2.27 | +0.21 | buy |
| TWINBEECH CAPITAL LP | 127,664 | 238,913 | +111,249 | 0.05 | 0.08 | +0.03 | buy |
| Redmile Group, LLC | 1,528,567 | 1,610,329 | +81,762 | 2.64 | 2.97 | +0.33 | buy |
| PEREGRINE INVESTMENT MANAGEMENT INC | 158,550 | 224,260 | +65,710 | 2.28 | 3.27 | +0.99 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 32,198 | 65,252 | +33,054 | 0.09 | 0.15 | +0.06 | buy |
| TD ASSET MANAGEMENT INC | 184,306 | 211,780 | +27,474 | 0.00 | 0.00 | -0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 16,600 | 38,031 | +21,431 | 0.00 | 0.01 | 0.00 | buy |
| D.A. DAVIDSON & CO. | 51,409 | 70,857 | +19,448 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 111,100 | 119,871 | +8,771 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 162,407 | 167,014 | +4,607 | 0.01 | 0.01 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 35,827 | 39,649 | +3,822 | 0.01 | 0.01 | 0.00 | buy |
| PROFUND ADVISORS LLC | 22,111 | 25,425 | +3,314 | 0.02 | 0.02 | +0.00 | buy |
| Quarry LP | 1,500 | 4,500 | +3,000 | 0.01 | 0.02 | 0.00 | buy |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 42,000 | 45,000 | +3,000 | 0.60 | 0.56 | -0.05 | buy |
| Avanza Fonder AB | 50,285 | 51,077 | +792 | 0.04 | 0.03 | -0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 11,438 | 12,038 | +600 | 0.01 | 0.01 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,739 | 2,120 | +381 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 4,360 | 4,340 | +20 | 0.00 | 0.00 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 17,794 | 17,022 | -772 | 0.04 | 0.03 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 56,027 | 54,779 | -1,248 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 22,863 | 19,850 | -3,013 | 0.16 | 0.10 | -0.06 | sell |
| BAILLIE GIFFORD & CO | 308,236 | 302,734 | -5,502 | 0.01 | 0.01 | -0.00 | sell |
| Raiffeisen Bank International AG | 50,000 | 35,000 | -15,000 | 0.02 | 0.01 | -0.01 | sell |
| Liontrust Investment Partners LLP | 110,180 | 93,890 | -16,290 | 0.04 | 0.03 | -0.01 | sell |
| Vestmark Advisory Solutions, Inc. | 173,152 | 154,521 | -18,631 | 0.15 | 0.08 | -0.08 | sell |
| BIT Capital GmbH | 35,414 | 15,771 | -19,643 | 0.07 | 0.03 | -0.04 | sell |
| Rock Springs Capital Management LP | 252,223 | 150,020 | -102,203 | 0.24 | 0.17 | -0.07 | sell |
| Yiheng Capital Management, L.P. | 426,102 | 69,058 | -357,044 | 0.41 | 0.13 | -0.28 | sell |