| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,317,294 | 7,920,053 | +4,602,759 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 32,501 | 1,752,402 | +1,719,901 | 0.00 | 0.02 | +0.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 8,239,123 | 9,928,111 | +1,688,988 | 1.08 | 1.05 | -0.03 | buy |
| ARK Investment Management LLC | 7,068,029 | 8,480,089 | +1,412,060 | 1.46 | 1.66 | +0.20 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,753,142 | 3,026,701 | +1,273,559 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 7,621,989 | 8,871,292 | +1,249,303 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 877,809 | +877,809 | 0.00 | 0.34 | +0.34 | buy |
| Bellevue Group AG | 1,518,121 | 2,395,930 | +877,809 | 0.72 | 1.05 | +0.32 | buy |
| Kynam Capital Management, LP | 1,756,158 | 2,518,170 | +762,012 | 2.87 | 4.21 | +1.34 | buy |
| Avidity Partners Management LP | 0 | 709,517 | +709,517 | 0.00 | 2.86 | +2.86 | buy |
| BANK OF AMERICA CORP /DE/ | 136,933 | 673,780 | +536,847 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 526,685 | +526,685 | 0.00 | 0.61 | +0.61 | buy |
| Woodline Partners LP | 282,120 | 760,611 | +478,491 | 0.05 | 0.10 | +0.05 | buy |
| RTW INVESTMENTS, LP | 0 | 438,659 | +438,659 | 0.00 | 0.13 | +0.13 | buy |
| CITADEL ADVISORS LLC | 2,062,246 | 2,500,347 | +438,101 | 0.05 | 0.05 | +0.00 | buy |
| BlackRock, Inc. | 7,671,939 | 8,102,656 | +430,717 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,804,374 | 2,199,455 | +395,081 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 3,077,377 | 3,440,119 | +362,742 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 315,765 | +315,765 | 0.00 | 0.20 | +0.20 | buy |
| Nikko Asset Management Americas, Inc. | 3,957,611 | 4,270,020 | +312,409 | 1.06 | 1.07 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 3,957,611 | 4,266,871 | +309,260 | 0.07 | 0.06 | -0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 117,088 | 369,201 | +252,113 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 513,671 | 755,321 | +241,650 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 55,000 | 269,129 | +214,129 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 0 | 175,562 | +175,562 | 0.00 | 1.86 | +1.86 | buy |
| Casdin Capital, LLC | 1,250,000 | 1,425,562 | +175,562 | 2.07 | 2.27 | +0.20 | buy |
| Pictet Asset Management Holding SA | 8,378 | 174,844 | +166,466 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 648,945 | 776,445 | +127,500 | 0.00 | 0.00 | -0.00 | buy |
| Contrarius Group Holdings Ltd | 0 | 126,470 | +126,470 | 0.00 | 0.17 | +0.17 | buy |
| NORTHERN TRUST CORP | 740,506 | 853,549 | +113,043 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 127,664 | 238,913 | +111,249 | 0.05 | 0.08 | +0.03 | buy |
| Allostery Investments LP | 0 | 92,754 | +92,754 | 0.00 | 2.61 | +2.61 | buy |
| TWO SIGMA ADVISERS, LP | 19,000 | 104,900 | +85,900 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 1,528,567 | 1,610,329 | +81,762 | 2.64 | 2.97 | +0.33 | buy |
| FIRST TRUST ADVISORS LP | 25,595 | 99,084 | +73,489 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE INVESTMENT MANAGEMENT INC | 158,550 | 224,260 | +65,710 | 2.28 | 3.27 | +0.99 | buy |
| CITIGROUP INC | 154,726 | 220,196 | +65,470 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 62,829 | +62,829 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 130,436 | 192,421 | +61,985 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 61,602 | +61,602 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,538,398 | 1,596,052 | +57,654 | 0.01 | 0.01 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 43,199 | +43,199 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 395,920 | 438,529 | +42,609 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 276,917 | 318,026 | +41,109 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 36,707 | +36,707 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 137,800 | 172,600 | +34,800 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 32,198 | 65,252 | +33,054 | 0.09 | 0.15 | +0.06 | buy |
| Engineers Gate Manager LP | 29,810 | 62,305 | +32,495 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 795,319 | 822,961 | +27,642 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 184,306 | 211,780 | +27,474 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 143,502 | 170,608 | +27,106 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 66,265 | 88,291 | +22,026 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 16,600 | 38,031 | +21,431 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 73,342 | 94,623 | +21,281 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 52,725 | 73,858 | +21,133 | 0.02 | 0.02 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 20,295 | +20,295 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 51,409 | 70,857 | +19,448 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,552 | 28,801 | +19,249 | 0.00 | 0.00 | +0.00 | buy |
| Concurrent Investment Advisors, LLC | 0 | 19,000 | +19,000 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,962 | 82,802 | +16,840 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 29,401 | 44,675 | +15,274 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 126,233 | 141,204 | +14,971 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,372 | 14,953 | +13,581 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 23,015 | 35,117 | +12,102 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 11,203 | +11,203 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 5,896 | 16,467 | +10,571 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 128,002 | 136,873 | +8,871 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 67,508 | 76,311 | +8,803 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 111,100 | 119,871 | +8,771 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 46,900 | 55,008 | +8,108 | 0.01 | 0.01 | -0.00 | buy |
| Corebridge Financial, Inc. | 38,013 | 44,808 | +6,795 | 0.01 | 0.01 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 13,400 | 19,500 | +6,100 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 5,856 | +5,856 | 0.00 | 0.03 | +0.03 | buy |
| AlphaQuest LLC | 2,610 | 8,262 | +5,652 | 0.01 | 0.02 | +0.01 | buy |
| Arizona State Retirement System | 20,337 | 25,534 | +5,197 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 162,407 | 167,014 | +4,607 | 0.01 | 0.01 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 4,430 | +4,430 | 0.00 | 0.06 | +0.06 | buy |
| SG Americas Securities, LLC | 12,118 | 16,038 | +3,920 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 35,827 | 39,649 | +3,822 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 22,111 | 25,425 | +3,314 | 0.02 | 0.02 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 22,629 | 25,937 | +3,308 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,729 | 26,029 | +3,300 | 0.00 | 0.00 | -0.00 | buy |
| Parallax Volatility Advisers, L.P. | 0 | 3,259 | +3,259 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,476 | 19,697 | +3,221 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 20,767 | 23,794 | +3,027 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,500 | 4,500 | +3,000 | 0.01 | 0.02 | +0.01 | buy |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 42,000 | 45,000 | +3,000 | 0.60 | 0.56 | -0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 44,445 | 47,380 | +2,935 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 7,200 | 9,900 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| BENJAMIN EDWARDS INC | 24,358 | 26,314 | +1,956 | 0.01 | 0.01 | -0.00 | buy |
| LPL Financial LLC | 27,698 | 29,457 | +1,759 | 0.00 | 0.00 | -0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 1,714 | +1,714 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 8,994 | 10,612 | +1,618 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 4,442 | 6,056 | +1,614 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,999 | 9,349 | +1,350 | 0.01 | 0.01 | -0.00 | buy |
| CWM, LLC | 1,493 | 2,684 | +1,191 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,190 | +1,190 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 9,613 | 10,492 | +879 | 0.00 | 0.00 | -0.00 | buy |
| Avanza Fonder AB | 50,285 | 51,077 | +792 | 0.04 | 0.03 | -0.01 | buy |