| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,909,138 | 12,452,199 | +543,061 | 0.02 | 0.02 | -0.00 | buy |
| ARK Investment Management LLC | 12,467,189 | 12,133,433 | -333,756 | 2.29 | 2.25 | -0.05 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 10,063,111 | 10,134,696 | +71,585 | 1.45 | 1.43 | -0.02 | buy |
| BlackRock, Inc. | 8,450,182 | 8,487,569 | +37,387 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 5,228,529 | 5,699,265 | +470,736 | 0.00 | 0.00 | -0.00 | buy |
| ARCH Venture Management, LLC | 4,540,132 | 4,540,132 | 0 | 19.31 | 15.98 | -3.33 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 4,409,300 | 3,825,585 | -583,715 | 0.07 | 0.06 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 4,409,300 | 3,825,585 | -583,715 | 1.41 | 1.29 | -0.12 | sell |
| Kynam Capital Management, LP | 2,440,214 | 3,682,185 | +1,241,971 | 4.40 | 5.57 | +1.17 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,730,282 | 2,713,230 | -17,052 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,351,908 | 2,418,592 | +66,684 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,947,879 | 2,154,575 | +206,696 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,712,359 | 1,653,714 | -58,645 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 1,446,375 | +1,446,375 | 0.00 | 2.07 | +2.07 | buy |
| Casdin Capital, LLC | 1,600,000 | 1,350,000 | -250,000 | 2.75 | 2.44 | -0.32 | sell |
| Redmile Group, LLC | 1,285,859 | 1,237,659 | -48,200 | 2.62 | 1.95 | -0.67 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,120,389 | 1,210,853 | +90,464 | 0.05 | 0.02 | -0.02 | buy |
| Qube Research & Technologies Ltd | 399,659 | 1,084,768 | +685,109 | 0.02 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 522,636 | 1,005,743 | +483,107 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 973,843 | 826,061 | -147,782 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 808,947 | 825,580 | +16,633 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 820,765 | +820,765 | 0.00 | 0.40 | +0.40 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 834,795 | 808,436 | -26,359 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 468,910 | 700,647 | +231,737 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 729,400 | 648,264 | -81,136 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 570,394 | 570,394 | 0 | 0.16 | 0.14 | -0.02 | hold |
| JPMORGAN CHASE & CO | 619,241 | 551,355 | -67,886 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 427,328 | 538,290 | +110,962 | 0.00 | 0.00 | +0.00 | buy |
| Contrarius Group Holdings Ltd | 0 | 533,443 | +533,443 | 0.00 | 0.72 | +0.72 | buy |
| CITADEL ADVISORS LLC | 255,710 | 528,970 | +273,260 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 156,500 | 513,578 | +357,078 | 0.01 | 0.02 | +0.01 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 533,563 | 488,417 | -45,146 | 1.02 | 0.88 | -0.14 | sell |
| BAILLIE GIFFORD & CO | 416,224 | 385,891 | -30,333 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 357,671 | 344,486 | -13,185 | 0.00 | 0.00 | -0.00 | sell |
| Alphabet Inc. | 321,604 | 321,604 | 0 | 0.35 | 0.19 | -0.15 | hold |
| Integral Health Asset Management, LLC | 550,000 | 300,000 | -250,000 | 0.77 | 0.38 | -0.39 | sell |
| Pictet Asset Management Holding SA | 325,654 | 297,504 | -28,150 | 0.01 | 0.01 | -0.00 | sell |
| PEREGRINE INVESTMENT MANAGEMENT INC | 257,280 | 260,050 | +2,770 | 4.43 | 4.87 | +0.44 | buy |
| Nuveen, LLC | 233,065 | 232,596 | -469 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 231,994 | +231,994 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 213,185 | 219,961 | +6,776 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 151,183 | 219,426 | +68,243 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 179,500 | 180,600 | +1,100 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,511 | 178,391 | +79,880 | 0.00 | 0.01 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 196,036 | 176,865 | -19,171 | 0.07 | 0.05 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 191,248 | 176,024 | -15,224 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 176,859 | 172,948 | -3,911 | 0.02 | 0.02 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 148,303 | 168,673 | +20,370 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 34,290 | 164,292 | +130,002 | 0.01 | 0.06 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 157,030 | 151,403 | -5,627 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 22,128 | 144,722 | +122,594 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 945,829 | 139,241 | -806,588 | 0.03 | 0.00 | -0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 138,132 | 138,132 | 0 | 0.06 | 0.05 | -0.01 | hold |
| FIRST TRUST ADVISORS LP | 64,056 | 135,166 | +71,110 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 159,188 | 132,249 | -26,939 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 1,500 | 121,230 | +119,730 | 0.00 | 0.03 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 112,771 | 118,018 | +5,247 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 131,199 | 112,239 | -18,960 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,265 | 107,741 | +20,476 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,720 | 105,120 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,781 | 102,129 | +58,348 | 0.00 | 0.01 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 98,883 | 98,992 | +109 | 0.02 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 39,501 | 93,253 | +53,752 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 89,386 | +89,386 | 0.00 | 0.03 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 77,564 | 87,141 | +9,577 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 92,078 | 81,912 | -10,166 | 0.00 | 0.00 | -0.00 | sell |
| Liontrust Investment Partners LLP | 170,404 | 80,764 | -89,640 | 0.07 | 0.03 | -0.04 | sell |
| PROFUND ADVISORS LLC | 65,617 | 77,095 | +11,478 | 0.06 | 0.07 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 69,964 | 69,013 | -951 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 55,619 | 66,933 | +11,314 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 26,757 | 66,858 | +40,101 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 71,500 | 63,982 | -7,518 | 0.36 | 0.32 | -0.05 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 0 | 62,089 | +62,089 | 0.00 | 0.11 | +0.11 | buy |
| SG Americas Securities, LLC | 103,469 | 60,180 | -43,289 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,526 | 57,217 | -1,309 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 54,953 | +54,953 | 0.00 | 0.04 | +0.04 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 53,164 | +53,164 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 54,523 | 52,994 | -1,529 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 52,825 | +52,825 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 15,357 | 52,061 | +36,704 | 0.01 | 0.02 | +0.01 | buy |
| WCG Wealth Advisors LLC | 39,917 | 50,119 | +10,202 | 0.03 | 0.03 | +0.00 | buy |
| BARCLAYS PLC | 326,178 | 47,638 | -278,540 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 16,207 | 47,310 | +31,103 | 0.00 | 0.01 | +0.00 | buy |
| Raiffeisen Bank International AG | 43,000 | 45,000 | +2,000 | 0.02 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 31,532 | 42,194 | +10,662 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 56,091 | 41,493 | -14,598 | 0.00 | 0.00 | -0.00 | sell |
| Canal Insurance CO | 0 | 40,000 | +40,000 | 0.00 | 0.20 | +0.20 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 36,902 | 38,824 | +1,922 | 0.00 | 0.00 | -0.00 | buy |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 45,000 | 38,000 | -7,000 | 0.61 | 0.47 | -0.14 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 39,531 | 37,331 | -2,200 | 0.01 | 0.01 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 29,508 | 35,884 | +6,376 | 0.01 | 0.01 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 34,018 | +34,018 | 0.00 | 0.20 | +0.20 | buy |
| Handelsbanken Fonder AB | 33,623 | 33,623 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 28,115 | 32,563 | +4,448 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 38,053 | 32,120 | -5,933 | 0.01 | 0.01 | -0.00 | sell |
| BENJAMIN EDWARDS INC | 35,802 | 31,652 | -4,150 | 0.01 | 0.01 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 31,076 | 31,212 | +136 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 30,982 | 31,099 | +117 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,629 | 30,629 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SteelPeak Wealth, LLC | 16,287 | 29,704 | +13,417 | 0.01 | 0.02 | +0.01 | buy |