| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 2,395,930 | 2,889,288 | +493,358 | 1.05 | 1.08 | +0.03 | buy |
| Nikko Asset Management Americas, Inc. | 4,270,020 | 4,726,799 | +456,779 | 1.07 | 0.80 | -0.27 | buy |
| ARK Investment Management LLC | 8,480,089 | 8,847,841 | +367,752 | 1.66 | 1.10 | -0.55 | buy |
| TWO SIGMA INVESTMENTS, LP | 369,201 | 561,521 | +192,320 | 0.02 | 0.02 | 0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 154,521 | 323,000 | +168,479 | 0.08 | 0.08 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 205,000 | +155,000 | 0.05 | 0.18 | +0.12 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 65,252 | 195,288 | +130,036 | 0.15 | 0.30 | +0.15 | buy |
| PEREGRINE INVESTMENT MANAGEMENT INC | 224,260 | 264,260 | +40,000 | 3.27 | 2.87 | -0.40 | buy |
| Casdin Capital, LLC | 1,425,562 | 1,450,000 | +24,438 | 2.27 | 2.25 | -0.03 | buy |
| D.A. DAVIDSON & CO. | 70,857 | 85,681 | +14,824 | 0.01 | 0.01 | -0.00 | buy |
| Scientech Research LLC | 19,850 | 31,875 | +12,025 | 0.10 | 0.13 | +0.03 | buy |
| BRANDYWINE MANAGERS, LLC | 11,306 | 18,606 | +7,300 | 0.26 | 0.31 | +0.05 | buy |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 45,000 | 51,000 | +6,000 | 0.56 | 0.45 | -0.11 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 38,031 | 41,731 | +3,700 | 0.01 | 0.00 | -0.00 | buy |
| Quarry LP | 4,500 | 8,000 | +3,500 | 0.02 | 0.03 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,022 | 20,197 | +3,175 | 0.03 | 0.03 | +0.00 | buy |
| Rafferty Asset Management, LLC | 119,871 | 122,832 | +2,961 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 11,203 | 13,675 | +2,472 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 760,611 | 761,498 | +887 | 0.10 | 0.07 | -0.03 | buy |
| PROFUND ADVISORS LLC | 25,425 | 26,183 | +758 | 0.02 | 0.02 | -0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 54,779 | 55,465 | +686 | 0.00 | 0.00 | -0.00 | buy |
| Kestra Investment Management, LLC | 71 | 165 | +94 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 5,856 | 5,392 | -464 | 0.03 | 0.03 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 302,734 | 300,137 | -2,597 | 0.01 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 15,771 | 3,603 | -12,168 | 0.03 | 0.00 | -0.02 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 73,858 | 37,605 | -36,253 | 0.02 | 0.02 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 211,780 | 155,380 | -56,400 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 2,518,170 | 2,417,647 | -100,523 | 4.21 | 4.43 | +0.22 | sell |
| Redmile Group, LLC | 1,610,329 | 1,423,411 | -186,918 | 2.97 | 2.58 | -0.40 | sell |
| TWINBEECH CAPITAL LP | 238,913 | 47,836 | -191,077 | 0.08 | 0.02 | -0.07 | sell |
| Avidity Partners Management LP | 709,517 | 409,400 | -300,117 | 2.86 | 1.40 | -1.46 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,026,701 | 2,442,876 | -583,825 | 0.01 | 0.00 | -0.00 | sell |