| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,920,053 | 12,961,459 | +5,041,406 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 9,928,111 | 10,013,111 | +85,000 | 1.05 | 0.78 | -0.27 | buy |
| VANGUARD GROUP INC | 8,871,292 | 9,706,224 | +834,932 | 0.00 | 0.00 | -0.00 | buy |
| ARK Investment Management LLC | 8,480,089 | 8,847,841 | +367,752 | 1.66 | 1.10 | -0.55 | buy |
| BlackRock, Inc. | 8,102,656 | 8,002,689 | -99,967 | 0.00 | 0.00 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 4,266,871 | 4,729,444 | +462,573 | 0.06 | 0.05 | -0.01 | buy |
| Nikko Asset Management Americas, Inc. | 4,270,020 | 4,726,799 | +456,779 | 1.07 | 0.80 | -0.27 | buy |
| ARCH Venture Management, LLC | 4,540,132 | 4,540,132 | 0 | 43.00 | 25.82 | -17.18 | hold |
| STATE STREET CORP | 3,440,119 | 3,638,266 | +198,147 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 2,395,930 | 2,889,288 | +493,358 | 1.05 | 1.08 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,026,701 | 2,442,876 | -583,825 | 0.01 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 2,518,170 | 2,417,647 | -100,523 | 4.21 | 4.43 | +0.22 | sell |
| CITADEL ADVISORS LLC | 2,500,347 | 2,337,517 | -162,830 | 0.05 | 0.03 | -0.01 | sell |
| MWG Management Ltd. | 2,266,934 | 2,266,934 | 0 | 75.44 | 74.30 | -1.14 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,199,455 | 2,254,261 | +54,806 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,596,052 | 1,758,669 | +162,617 | 0.01 | 0.01 | -0.00 | buy |
| Casdin Capital, LLC | 1,425,562 | 1,450,000 | +24,438 | 2.27 | 2.25 | -0.03 | buy |
| Redmile Group, LLC | 1,610,329 | 1,423,411 | -186,918 | 2.97 | 2.58 | -0.40 | sell |
| MORGAN STANLEY | 822,961 | 1,307,156 | +484,195 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 677,162 | 1,283,123 | +605,961 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,461,789 | 1,163,894 | -297,895 | 0.01 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 315,436 | 1,131,793 | +816,357 | 0.02 | 0.07 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 673,780 | 851,336 | +177,556 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 853,549 | 828,508 | -25,041 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 776,445 | 774,851 | -1,594 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 760,611 | 761,498 | +887 | 0.10 | 0.07 | -0.03 | buy |
| BARCLAYS PLC | 160,046 | 684,599 | +524,553 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 593,815 | +593,815 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 192,421 | 587,977 | +395,556 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 755,321 | 580,299 | -175,022 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 369,201 | 561,521 | +192,320 | 0.02 | 0.02 | +0.00 | buy |
| ROYAL BANK OF CANADA | 8,183 | 558,061 | +549,878 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 104,900 | 553,100 | +448,200 | 0.00 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.79 | +0.79 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 438,529 | 493,408 | +54,879 | 0.00 | 0.00 | -0.00 | buy |
| Avidity Partners Management LP | 709,517 | 409,400 | -300,117 | 2.86 | 1.40 | -1.46 | sell |
| Caption Management, LLC | 0 | 348,435 | +348,435 | 0.00 | 0.54 | +0.54 | buy |
| Vestmark Advisory Solutions, Inc. | 154,521 | 323,000 | +168,479 | 0.08 | 0.08 | +0.00 | buy |
| Alphabet Inc. | 321,604 | 321,604 | 0 | 0.40 | 0.26 | -0.14 | hold |
| Bank of New York Mellon Corp | 318,026 | 321,117 | +3,091 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 174,844 | 319,680 | +144,836 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 124,167 | 310,010 | +185,843 | 0.00 | 0.01 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 302,734 | 300,137 | -2,597 | 0.01 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 28,801 | 265,008 | +236,207 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE INVESTMENT MANAGEMENT INC | 224,260 | 264,260 | +40,000 | 3.27 | 2.87 | -0.40 | buy |
| Nuveen, LLC | 199,880 | 231,900 | +32,020 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 228,862 | +228,862 | 0.00 | 0.03 | +0.03 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 226,744 | +226,744 | 0.00 | 0.24 | +0.24 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 205,000 | +155,000 | 0.05 | 0.18 | +0.12 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 65,252 | 195,288 | +130,036 | 0.15 | 0.30 | +0.15 | buy |
| Swiss National Bank | 172,600 | 172,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 166,055 | +166,055 | 0.00 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 211,780 | 155,380 | -56,400 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 141,204 | 151,372 | +10,168 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 170,608 | 150,027 | -20,581 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 149,052 | +149,052 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 24,416 | 138,765 | +114,349 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 88,291 | 128,874 | +40,583 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 123,491 | +123,491 | 0.00 | 0.05 | +0.05 | buy |
| Rafferty Asset Management, LLC | 119,871 | 122,832 | +2,961 | 0.01 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 167,014 | 117,446 | -49,568 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 220,196 | 109,420 | -110,776 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 94,623 | 102,646 | +8,023 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 269,129 | 99,959 | -169,170 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 86,610 | 99,420 | +12,810 | 0.00 | 0.00 | -0.00 | buy |
| D.A. DAVIDSON & CO. | 70,857 | 85,681 | +14,824 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 136,873 | 83,411 | -53,462 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,802 | 83,033 | +231 | 0.00 | 0.00 | -0.00 | buy |
| Yiheng Capital Management, L.P. | 69,058 | 69,058 | 0 | 0.47 | 0.43 | -0.05 | hold |
| DEUTSCHE BANK AG\ | 76,311 | 64,788 | -11,523 | 0.00 | 0.00 | -0.00 | sell |
| Clarius Group, LLC | 60,615 | 60,615 | 0 | 0.07 | 0.06 | -0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 36,480 | 58,204 | +21,724 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 55,008 | 56,576 | +1,568 | 0.01 | 0.01 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 16,467 | 56,570 | +40,103 | 0.01 | 0.03 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 54,779 | 55,465 | +686 | 0.00 | 0.00 | -0.00 | buy |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 45,000 | 51,000 | +6,000 | 0.56 | 0.45 | -0.11 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWINBEECH CAPITAL LP | 238,913 | 47,836 | -191,077 | 0.08 | 0.02 | -0.07 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,380 | 47,272 | -108 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 46,378 | +46,378 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 44,675 | 46,205 | +1,530 | 0.01 | 0.01 | -0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 45,000 | +45,000 | 0.00 | 0.01 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 38,031 | 41,731 | +3,700 | 0.01 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,752,402 | 39,501 | -1,712,901 | 0.02 | 0.00 | -0.02 | sell |
| GROUP ONE TRADING LLC | 1,190 | 39,323 | +38,133 | 0.00 | 0.02 | +0.02 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 38,438 | +38,438 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 73,858 | 37,605 | -36,253 | 0.02 | 0.02 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 33,631 | 37,267 | +3,636 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 36,707 | 37,215 | +508 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 29,457 | 36,233 | +6,776 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 8,262 | 35,469 | +27,207 | 0.02 | 0.06 | +0.04 | buy |
| Raiffeisen Bank International AG | 35,000 | 35,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 29,682 | 34,848 | +5,166 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 39,649 | 33,731 | -5,918 | 0.01 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 43,199 | 32,645 | -10,554 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25,937 | 32,534 | +6,597 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 14,953 | 31,888 | +16,935 | 0.01 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 19,850 | 31,875 | +12,025 | 0.10 | 0.13 | +0.03 | buy |
| BENJAMIN EDWARDS INC | 26,314 | 31,656 | +5,342 | 0.01 | 0.01 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,612 | 31,043 | +20,431 | 0.00 | 0.00 | +0.00 | buy |