| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,452,199 | 12,609,002 | +156,803 | 0.02 | 0.02 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 10,134,696 | 10,236,396 | +101,700 | 1.43 | 2.06 | +0.62 | buy |
| ARK Investment Management LLC | 12,133,433 | 10,234,862 | -1,898,571 | 2.25 | 2.28 | +0.03 | sell |
| BlackRock, Inc. | 8,487,569 | 8,997,542 | +509,973 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 5,699,265 | 5,827,122 | +127,857 | 0.00 | 0.01 | +0.00 | buy |
| ARCH Venture Management, LLC | 4,540,132 | 4,540,132 | 0 | 15.98 | 14.16 | -1.82 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 3,825,585 | 3,455,043 | -370,542 | 0.06 | 0.07 | +0.01 | sell |
| Nikko Asset Management Americas, Inc. | 3,825,585 | 3,455,043 | -370,542 | 1.29 | 1.53 | +0.24 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,713,230 | 3,415,239 | +702,009 | 0.01 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 3,682,185 | 2,840,792 | -841,393 | 5.57 | 5.39 | -0.18 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,418,592 | 2,596,963 | +178,371 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,154,575 | 2,225,844 | +71,269 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 648,264 | 1,950,969 | +1,302,705 | 0.00 | 0.00 | +0.00 | buy |
| Contrarius Group Holdings Ltd | 533,443 | 1,614,538 | +1,081,095 | 0.72 | 2.55 | +1.83 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,653,714 | 1,551,781 | -101,933 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,210,853 | 1,388,227 | +177,374 | 0.02 | 0.04 | +0.01 | buy |
| Casdin Capital, LLC | 1,350,000 | 1,350,000 | 0 | 2.44 | 2.32 | -0.12 | hold |
| GOLDMAN SACHS GROUP INC | 1,005,743 | 1,310,059 | +304,316 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 1,237,659 | 1,164,259 | -73,400 | 1.95 | 2.68 | +0.73 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 700,647 | 1,067,883 | +367,236 | 0.01 | 0.02 | +0.01 | buy |
| Deep Track Capital, LP | 820,765 | 1,000,000 | +179,235 | 0.40 | 0.51 | +0.10 | buy |
| NORTHERN TRUST CORP | 825,580 | 933,481 | +107,901 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 885,902 | +885,902 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 808,436 | 885,902 | +77,466 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 538,290 | 720,648 | +182,358 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 826,061 | 574,814 | -251,247 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 570,394 | 570,394 | 0 | 0.14 | 0.17 | +0.03 | hold |
| JPMORGAN CHASE & CO | 551,355 | 514,767 | -36,588 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 139,241 | 478,980 | +339,739 | 0.00 | 0.01 | +0.01 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 488,417 | 455,954 | -32,463 | 0.88 | 1.00 | +0.11 | sell |
| JUPITER ASSET MANAGEMENT LTD | 24,060 | 445,718 | +421,658 | 0.00 | 0.08 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 513,578 | 445,000 | -68,578 | 0.02 | 0.02 | +0.00 | sell |
| Bank of New York Mellon Corp | 344,486 | 362,800 | +18,314 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management VI LLC | 0 | 330,000 | +330,000 | 0.00 | 1.76 | +1.76 | buy |
| Alphabet Inc. | 321,604 | 321,604 | 0 | 0.19 | 0.01 | -0.18 | hold |
| BAILLIE GIFFORD & CO | 385,891 | 314,228 | -71,663 | 0.01 | 0.01 | +0.00 | sell |
| Integral Health Asset Management, LLC | 300,000 | 300,000 | 0 | 0.38 | 0.42 | +0.04 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 296,294 | +296,294 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 297,504 | 250,797 | -46,707 | 0.01 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 232,596 | 245,283 | +12,687 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 168,673 | 204,697 | +36,024 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 219,961 | 194,171 | -25,790 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,084,768 | 194,083 | -890,685 | 0.04 | 0.01 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 132,249 | 189,389 | +57,140 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 185,499 | +185,499 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 135,166 | 178,945 | +43,779 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 180,600 | 178,900 | -1,700 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 0 | 166,289 | +166,289 | 0.00 | 0.31 | +0.31 | buy |
| Vestmark Advisory Solutions, Inc. | 176,865 | 164,164 | -12,701 | 0.05 | 0.05 | +0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 118,018 | 156,997 | +38,979 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 144,722 | 156,478 | +11,756 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 153,600 | +153,600 | 0.00 | 0.12 | +0.12 | buy |
| Susquehanna Portfolio Strategies, LLC | 138,132 | 151,216 | +13,084 | 0.05 | 0.08 | +0.03 | buy |
| CITIGROUP INC | 66,858 | 138,866 | +72,008 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 176,024 | 137,038 | -38,986 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,391 | 134,679 | -43,712 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 112,239 | 132,227 | +19,988 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 130,577 | +130,577 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 231,994 | 129,820 | -102,174 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 105,120 | 127,630 | +22,510 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 24 | 124,826 | +124,802 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 151,403 | 123,425 | -27,978 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 164,292 | 111,900 | -52,392 | 0.06 | 0.05 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 107,741 | 104,505 | -3,236 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 87,141 | 104,091 | +16,950 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 98,992 | 100,628 | +1,636 | 0.01 | 0.02 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 102,129 | 99,526 | -2,603 | 0.01 | 0.01 | +0.00 | sell |
| Edgestream Partners, L.P. | 0 | 96,651 | +96,651 | 0.00 | 0.10 | +0.10 | buy |
| Rafferty Asset Management, LLC | 172,948 | 93,606 | -79,342 | 0.02 | 0.01 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 0 | 89,939 | +89,939 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 81,912 | 79,179 | -2,733 | 0.00 | 0.00 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 69,013 | 70,464 | +1,451 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 63,982 | 70,282 | +6,300 | 0.32 | 0.44 | +0.13 | buy |
| BARCLAYS PLC | 47,638 | 70,219 | +22,581 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE INVESTMENT MANAGEMENT INC | 260,050 | 70,000 | -190,050 | 4.87 | 1.02 | -3.85 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 41,493 | 69,375 | +27,882 | 0.00 | 0.00 | +0.00 | buy |
| Concurrent Investment Advisors, LLC | 11,641 | 63,879 | +52,238 | 0.00 | 0.02 | +0.02 | buy |
| Clearstead Advisors, LLC | 121,230 | 60,620 | -60,610 | 0.03 | 0.02 | -0.01 | sell |
| Liontrust Investment Partners LLP | 80,764 | 60,025 | -20,739 | 0.03 | 0.03 | -0.00 | sell |
| MetLife Investment Management, LLC | 52,994 | 57,723 | +4,729 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 66,933 | 56,646 | -10,287 | 0.00 | 0.00 | +0.00 | sell |
| WCG Wealth Advisors LLC | 50,119 | 56,172 | +6,053 | 0.03 | 0.05 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 53,722 | +53,722 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,217 | 50,456 | -6,761 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 47,310 | 49,092 | +1,782 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 77,095 | 47,584 | -29,511 | 0.07 | 0.04 | -0.02 | sell |
| XTX Topco Ltd | 52,061 | 45,755 | -6,306 | 0.02 | 0.02 | -0.00 | sell |
| Raiffeisen Bank International AG | 45,000 | 45,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 41,792 | +41,792 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 41,000 | +41,000 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 33,623 | 39,823 | +6,200 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 32,563 | 38,746 | +6,183 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 60,180 | 38,287 | -21,893 | 0.00 | 0.00 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 37,331 | 38,131 | +800 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 42,194 | 37,289 | -4,905 | 0.00 | 0.00 | +0.00 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 62,089 | 36,419 | -25,670 | 0.11 | 0.08 | -0.04 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 38,824 | 36,311 | -2,513 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,629 | 35,502 | +4,873 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 22,234 | 34,260 | +12,026 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 35,884 | 34,091 | -1,793 | 0.01 | 0.01 | +0.00 | sell |