| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 7,913,123 | 8,208,123 | +295,000 | 1.09 | 1.10 | +0.01 | buy |
| VANGUARD GROUP INC | 7,900,379 | 7,844,606 | -55,773 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 7,626,139 | 6,531,099 | -1,095,040 | 1.59 | 1.46 | -0.12 | sell |
| ARCH Venture Management, LLC | 5,443,039 | 4,834,653 | -608,386 | 47.94 | 45.46 | -2.48 | sell |
| FMR LLC | 4,407,695 | 4,211,517 | -196,178 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 3,492,155 | 3,929,557 | +437,402 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 2,224,415 | 3,552,829 | +1,328,414 | 0.04 | 0.06 | +0.02 | buy |
| Nikko Asset Management Americas, Inc. | 2,224,415 | 3,552,829 | +1,328,414 | 0.60 | 0.99 | +0.38 | buy |
| MWG Management Ltd. | 2,266,934 | 2,266,934 | 0 | 58.01 | 61.51 | +3.50 | hold |
| Temasek Holdings (Private) Ltd | 1,812,972 | 1,812,972 | 0 | 0.20 | 0.18 | -0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,729,581 | 1,807,683 | +78,102 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 1,703,061 | 1,611,013 | -92,048 | 2.41 | 2.33 | -0.09 | sell |
| Bellevue Group AG | 1,418,121 | 1,518,121 | +100,000 | 0.54 | 0.60 | +0.06 | buy |
| CITADEL ADVISORS LLC | 769,154 | 1,496,195 | +727,041 | 0.02 | 0.04 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,393,673 | 1,486,308 | +92,635 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 0 | 1,302,085 | +1,302,085 | 0.00 | 2.47 | +2.47 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,049,360 | 1,240,331 | +190,971 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 803,829 | 1,207,757 | +403,928 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 675,000 | 775,000 | +100,000 | 1.21 | 1.27 | +0.06 | buy |
| Yiheng Capital Management, L.P. | 845,500 | 763,760 | -81,740 | 2.79 | 3.46 | +0.66 | sell |
| NORTHERN TRUST CORP | 657,382 | 691,091 | +33,709 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 784,563 | 680,848 | -103,715 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 690,065 | 639,238 | -50,827 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 593,266 | 629,492 | +36,226 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 362,137 | 539,987 | +177,850 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 1.37 | +1.37 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 382,995 | 463,662 | +80,667 | 0.03 | 0.04 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 419,569 | 401,286 | -18,283 | 0.00 | 0.00 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 623,640 | 357,698 | -265,942 | 0.01 | 0.01 | -0.00 | sell |
| Alphabet Inc. | 321,604 | 321,604 | 0 | 0.38 | 0.43 | +0.05 | hold |
| Rock Springs Capital Management LP | 249,923 | 249,923 | 0 | 0.18 | 0.20 | +0.02 | hold |
| Bank of New York Mellon Corp | 287,569 | 227,545 | -60,024 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 162,577 | 189,194 | +26,617 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 450,216 | 188,091 | -262,125 | 0.01 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 169,561 | 187,845 | +18,284 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 165,264 | 187,091 | +21,827 | 0.01 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 175,892 | 184,306 | +8,414 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 81,827 | 183,214 | +101,387 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 270,000 | 170,000 | -100,000 | 0.64 | 0.30 | -0.35 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 174,180 | 156,279 | -17,901 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 137,089 | 145,851 | +8,762 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 136,700 | 136,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vestmark Advisory Solutions, Inc. | 83,579 | 133,902 | +50,323 | 0.08 | 0.12 | +0.04 | buy |
| Walleye Capital LLC | 104,924 | 127,588 | +22,664 | 0.03 | 0.03 | +0.01 | buy |
| RHUMBLINE ADVISERS | 132,569 | 127,105 | -5,464 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 144,554 | 126,710 | -17,844 | 0.14 | 0.21 | +0.07 | sell |
| AMERICAN CENTURY COMPANIES INC | 95,578 | 119,606 | +24,028 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 37,500 | 115,000 | +77,500 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 61,753 | 108,844 | +47,091 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 90,335 | 107,384 | +17,049 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 165,763 | 85,647 | -80,116 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 88,110 | 85,310 | -2,800 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 80,844 | 81,717 | +873 | 0.00 | 0.00 | +0.00 | buy |
| Liontrust Investment Partners LLP | 80,000 | 80,000 | 0 | 0.03 | 0.03 | 0.00 | hold |
| Legal & General Group Plc | 70,639 | 71,756 | +1,117 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 120,765 | 66,817 | -53,948 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,295 | 66,660 | -1,635 | 0.00 | 0.00 | -0.00 | sell |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 64,313 | +64,313 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 64,692 | 63,564 | -1,128 | 0.00 | 0.00 | -0.00 | sell |
| Clarius Group, LLC | 60,615 | 60,615 | 0 | 0.10 | 0.10 | +0.00 | hold |
| TWINBEECH CAPITAL LP | 0 | 58,208 | +58,208 | 0.00 | 0.03 | +0.03 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 59,095 | 57,698 | -1,397 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 46,916 | 54,575 | +7,659 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 49,625 | 53,847 | +4,222 | 0.01 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 46,738 | 45,603 | -1,135 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 151,066 | 45,045 | -106,021 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 72,800 | 43,900 | -28,900 | 0.34 | 0.18 | -0.16 | sell |
| DEUTSCHE BANK AG\ | 861,993 | 43,637 | -818,356 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 43,534 | 43,534 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALGERT GLOBAL LLC | 11,393 | 43,523 | +32,130 | 0.01 | 0.03 | +0.02 | buy |
| Jump Financial, LLC | 0 | 43,099 | +43,099 | 0.00 | 0.02 | +0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 47,079 | 42,645 | -4,434 | 0.01 | 0.01 | -0.00 | sell |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 42,000 | 42,000 | 0 | 0.64 | 0.65 | +0.01 | hold |
| Corebridge Financial, Inc. | 41,134 | 40,883 | -251 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 43,108 | 38,996 | -4,112 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 46,648 | 38,120 | -8,528 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 20,839 | 37,501 | +16,662 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 37,001 | 37,001 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 31,810 | 37,001 | +5,191 | 0.06 | 0.07 | +0.00 | buy |
| PROFUND ADVISORS LLC | 30,868 | 36,987 | +6,119 | 0.03 | 0.03 | +0.01 | buy |
| AlphaQuest LLC | 7,085 | 36,193 | +29,108 | 0.02 | 0.08 | +0.06 | buy |
| TUDOR INVESTMENT CORP ET AL | 49,022 | 32,817 | -16,205 | 0.01 | 0.01 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 77,698 | 31,025 | -46,673 | 0.02 | 0.01 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 29,111 | 29,111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 17,600 | 28,500 | +10,900 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 20,538 | 28,171 | +7,633 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 26,432 | 26,236 | -196 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 44,173 | 24,743 | -19,430 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,870 | 23,870 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 23,500 | 23,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,529 | 22,729 | -8,800 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 21,700 | 21,700 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,880 | 21,396 | +516 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 20,892 | +20,892 | 0.00 | 0.01 | +0.01 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 21,230 | 20,808 | -422 | 0.01 | 0.01 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 0 | 20,800 | +20,800 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 0 | 20,799 | +20,799 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 19,431 | 20,146 | +715 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,072 | 19,319 | +4,247 | 0.00 | 0.00 | +0.00 | buy |