| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,961,459 | 11,692,853 | -1,268,606 | 0.01 | 0.01 | +0.00 | sell |
| ARK Investment Management LLC | 8,847,841 | 11,038,834 | +2,190,993 | 1.10 | 1.59 | +0.49 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 10,013,111 | 10,063,111 | +50,000 | 0.78 | 1.38 | +0.60 | buy |
| VANGUARD GROUP INC | 9,706,224 | 9,250,784 | -455,440 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 8,002,689 | 8,148,205 | +145,516 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 4,729,444 | 4,830,738 | +101,294 | 0.05 | 0.07 | +0.02 | buy |
| Nikko Asset Management Americas, Inc. | 4,726,799 | 4,830,738 | +103,939 | 0.80 | 1.14 | +0.33 | buy |
| ARCH Venture Management, LLC | 4,540,132 | 4,540,132 | 0 | 25.82 | 22.38 | -3.44 | hold |
| STATE STREET CORP | 3,638,266 | 4,008,658 | +370,392 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 2,889,288 | 2,889,288 | 0 | 1.08 | 1.46 | +0.37 | hold |
| Kynam Capital Management, LP | 2,417,647 | 2,517,647 | +100,000 | 4.43 | 4.55 | +0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,254,261 | 2,390,943 | +136,682 | 0.00 | 0.00 | +0.00 | buy |
| MWG Management Ltd. | 2,266,934 | 2,266,934 | 0 | 74.30 | 67.66 | -6.64 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,442,876 | 2,263,149 | -179,727 | 0.00 | 0.01 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,758,669 | 1,720,290 | -38,379 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 493,408 | 1,665,385 | +1,171,977 | 0.00 | 0.01 | +0.01 | buy |
| Casdin Capital, LLC | 1,450,000 | 1,600,000 | +150,000 | 2.25 | 3.24 | +0.99 | buy |
| Contrarius Group Holdings Ltd | 0 | 1,533,269 | +1,533,269 | 0.00 | 1.68 | +1.68 | buy |
| Redmile Group, LLC | 1,423,411 | 1,387,559 | -35,852 | 2.58 | 3.28 | +0.70 | sell |
| GOLDMAN SACHS GROUP INC | 1,283,123 | 1,318,653 | +35,530 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,131,793 | 1,260,011 | +128,218 | 0.07 | 0.10 | +0.03 | buy |
| UBS Group AG | 1,163,894 | 1,137,633 | -26,261 | 0.00 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 828,508 | 854,344 | +25,836 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 774,851 | 841,210 | +66,359 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 851,336 | 779,024 | -72,312 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 1,307,156 | 644,760 | -662,396 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 761,498 | 546,559 | -214,939 | 0.07 | 0.06 | -0.01 | sell |
| JPMORGAN CHASE & CO | 580,299 | 541,303 | -38,996 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 558,061 | 416,255 | -141,806 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 321,117 | 409,442 | +88,325 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 500,000 | 400,000 | -100,000 | 0.79 | 0.71 | -0.09 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 195,288 | 383,531 | +188,243 | 0.30 | 0.63 | +0.34 | buy |
| TWO SIGMA INVESTMENTS, LP | 561,521 | 379,044 | -182,477 | 0.02 | 0.01 | -0.00 | sell |
| Pictet Asset Management Holding SA | 319,680 | 337,514 | +17,834 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 553,100 | 333,000 | -220,100 | 0.02 | 0.02 | -0.00 | sell |
| Alphabet Inc. | 321,604 | 321,604 | 0 | 0.26 | 0.32 | +0.07 | hold |
| BARCLAYS PLC | 684,599 | 313,627 | -370,972 | 0.00 | 0.00 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 300,137 | 297,803 | -2,334 | 0.00 | 0.01 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 228,862 | 296,090 | +67,228 | 0.03 | 0.05 | +0.02 | buy |
| PEREGRINE INVESTMENT MANAGEMENT INC | 264,260 | 267,930 | +3,670 | 2.87 | 3.19 | +0.32 | buy |
| TANG CAPITAL MANAGEMENT LLC | 205,000 | 255,000 | +50,000 | 0.18 | 0.24 | +0.06 | buy |
| Nuveen, LLC | 231,900 | 237,340 | +5,440 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 128,874 | 176,864 | +47,990 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 172,600 | 175,400 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 175,000 | +175,000 | 0.00 | 0.01 | +0.01 | buy |
| Vestmark Advisory Solutions, Inc. | 323,000 | 166,297 | -156,703 | 0.08 | 0.08 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 162,711 | +162,711 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 150,027 | 145,388 | -4,639 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 155,380 | 145,180 | -10,200 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 0 | 144,500 | +144,500 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 151,372 | 143,828 | -7,544 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 123,491 | 138,132 | +14,641 | 0.05 | 0.05 | +0.01 | buy |
| Rafferty Asset Management, LLC | 122,832 | 137,152 | +14,320 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 587,977 | 125,146 | -462,831 | 0.02 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 83,411 | 117,323 | +33,912 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 409,400 | 112,000 | -297,400 | 1.40 | 0.62 | -0.78 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 117,446 | 108,681 | -8,765 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 99,420 | 100,720 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 102,646 | 99,568 | -3,078 | 0.00 | 0.00 | +0.00 | sell |
| D.A. DAVIDSON & CO. | 85,681 | 94,630 | +8,949 | 0.01 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 93,930 | +93,930 | 0.00 | 0.11 | +0.11 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 88,732 | +88,732 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,033 | 83,053 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 31,888 | 75,294 | +43,406 | 0.01 | 0.05 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 64,788 | 72,915 | +8,127 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 71,720 | +71,720 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 593,815 | 70,431 | -523,384 | 0.01 | 0.00 | -0.01 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,215 | 70,280 | +33,065 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 45,000 | 70,000 | +25,000 | 0.01 | 0.01 | +0.01 | buy |
| Yiheng Capital Management, L.P. | 69,058 | 69,058 | 0 | 0.43 | 0.55 | +0.13 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 68,515 | +68,515 | 0.00 | 0.04 | +0.04 | buy |
| Privium Fund Management B.V. | 0 | 61,000 | +61,000 | 0.00 | 0.27 | +0.27 | buy |
| Clarius Group, LLC | 60,615 | 60,615 | 0 | 0.06 | 0.09 | +0.03 | hold |
| MetLife Investment Management, LLC | 56,576 | 56,576 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CITIGROUP INC | 109,420 | 51,301 | -58,119 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 28,900 | 51,123 | +22,223 | 0.00 | 0.00 | +0.00 | buy |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 51,000 | 51,000 | 0 | 0.45 | 0.66 | +0.20 | hold |
| AMERICAN CENTURY COMPANIES INC | 13,659 | 50,193 | +36,534 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 49,811 | +49,811 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,272 | 47,273 | +1 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 36,233 | 43,747 | +7,514 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 43,648 | +43,648 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 7,216 | 43,220 | +36,004 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 35,000 | 43,000 | +8,000 | 0.01 | 0.01 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 41,731 | 41,831 | +100 | 0.00 | 0.01 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 41,664 | +41,664 | 0.00 | 0.03 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 39,501 | 39,501 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 34,848 | 39,267 | +4,419 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 37,267 | 37,988 | +721 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 32,534 | 37,427 | +4,893 | 0.00 | 0.00 | +0.00 | buy |
| BENJAMIN EDWARDS INC | 31,656 | 32,728 | +1,072 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 31,043 | 30,876 | -167 | 0.00 | 0.00 | +0.00 | sell |
| AlphaQuest LLC | 35,469 | 30,660 | -4,809 | 0.06 | 0.05 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,629 | 30,629 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PROFUND ADVISORS LLC | 26,183 | 30,046 | +3,863 | 0.02 | 0.02 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 28,160 | 29,762 | +1,602 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 58,204 | 29,750 | -28,454 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 29,165 | 29,250 | +85 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 33,731 | 28,476 | -5,255 | 0.00 | 0.01 | +0.00 | sell |