| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 6,531,099 | 7,068,029 | +536,930 | 1.46 | 1.46 | -0.00 | buy |
| Casdin Capital, LLC | 775,000 | 1,250,000 | +475,000 | 1.27 | 2.06 | +0.80 | buy |
| Kynam Capital Management, LP | 1,302,085 | 1,756,158 | +454,073 | 2.47 | 2.87 | +0.40 | buy |
| Nikko Asset Management Americas, Inc. | 3,552,829 | 3,957,611 | +404,782 | 0.99 | 1.06 | +0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,486,308 | 1,753,142 | +266,834 | 0.00 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 20,800 | 208,255 | +187,455 | 0.01 | 0.06 | +0.05 | buy |
| TWINBEECH CAPITAL LP | 58,208 | 127,664 | +69,456 | 0.03 | 0.05 | +0.03 | buy |
| Crestline Management, LP | 17,415 | 62,969 | +45,554 | 0.02 | 0.05 | +0.03 | buy |
| Vestmark Advisory Solutions, Inc. | 133,902 | 173,152 | +39,250 | 0.12 | 0.15 | +0.03 | buy |
| Liontrust Investment Partners LLP | 80,000 | 110,180 | +30,180 | 0.03 | 0.04 | +0.01 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 13,118 | 32,198 | +19,080 | 0.03 | 0.09 | +0.06 | buy |
| PROFUND ADVISORS LLC | 36,987 | 22,111 | +14,876 | 0.03 | 0.02 | 0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 156,279 | 162,407 | +6,128 | 0.01 | 0.01 | -0.00 | buy |
| Scientech Research LLC | 17,671 | 22,863 | +5,192 | 0.09 | 0.16 | +0.07 | buy |
| Quarry LP | 6,000 | 1,500 | +4,500 | 0.05 | 0.01 | 0.00 | sell |
| Rock Springs Capital Management LP | 249,923 | 252,223 | +2,300 | 0.20 | 0.24 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 16,087 | 17,794 | +1,707 | 0.04 | 0.04 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 10,529 | 11,438 | +909 | 0.01 | 0.01 | +0.00 | buy |
| CI INVESTMENTS INC. | 4,840 | 4,360 | +480 | 0.00 | 0.00 | 0.00 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 9,194 | 9,597 | +403 | 0.00 | 0.00 | -0.00 | buy |
| Fairfield Financial Advisors, LTD | 1,025 | 780 | -245 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,653 | 2,534 | -1,119 | 0.04 | 0.03 | -0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 57,698 | 56,027 | -1,671 | 0.00 | 0.00 | +0.00 | sell |
| Green Alpha Advisors, LLC | 12,475 | 10,192 | -2,283 | 0.24 | 0.20 | -0.04 | sell |
| D.A. DAVIDSON & CO. | 53,847 | 51,409 | -2,438 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 43,900 | 38,312 | -5,588 | 0.18 | 0.20 | +0.02 | sell |
| Hudson Bay Capital Management LP | 115,000 | 100,000 | -15,000 | 0.01 | 0.01 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 357,698 | 308,236 | -49,462 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 187,091 | 111,100 | -75,991 | 0.02 | 0.01 | -0.01 | sell |
| Redmile Group, LLC | 1,611,013 | 1,528,567 | -82,446 | 2.33 | 2.64 | +0.32 | sell |
| TANG CAPITAL MANAGEMENT LLC | 170,000 | 50,000 | -120,000 | 0.30 | 0.08 | -0.22 | sell |
| ARCH Venture Management, LLC | 4,834,653 | 4,540,132 | -294,521 | 45.46 | 48.91 | +3.45 | sell |
| Yiheng Capital Management, L.P. | 763,760 | 426,102 | -337,658 | 0.96 | 0.41 | -0.55 | sell |