| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 8,208,123 | 8,239,123 | +31,000 | 1.10 | 1.08 | -0.03 | buy |
| BlackRock, Inc. | 7,748,264 | 7,671,939 | -76,325 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 7,844,606 | 7,621,989 | -222,617 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 6,531,099 | 7,068,029 | +536,930 | 1.46 | 1.46 | -0.00 | buy |
| ARCH Venture Management, LLC | 4,834,653 | 4,540,132 | -294,521 | 45.46 | 48.91 | +3.45 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 3,552,829 | 3,957,611 | +404,782 | 0.06 | 0.07 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 3,552,829 | 3,957,611 | +404,782 | 0.99 | 1.06 | +0.08 | buy |
| FMR LLC | 4,211,517 | 3,317,294 | -894,223 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 3,929,557 | 3,077,377 | -852,180 | 0.00 | 0.00 | -0.00 | sell |
| MWG Management Ltd. | 2,266,934 | 2,266,934 | 0 | 61.51 | 75.61 | +14.10 | hold |
| CITADEL ADVISORS LLC | 1,496,195 | 2,062,246 | +566,051 | 0.04 | 0.05 | +0.01 | buy |
| UBS Group AG | 189,194 | 1,819,636 | +1,630,442 | 0.00 | 0.01 | +0.01 | buy |
| Temasek Holdings (Private) Ltd | 1,812,972 | 1,812,972 | 0 | 0.18 | 0.18 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,807,683 | 1,804,374 | -3,309 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 1,302,085 | 1,756,158 | +454,073 | 2.47 | 2.87 | +0.40 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,486,308 | 1,753,142 | +266,834 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,240,331 | 1,538,398 | +298,067 | 0.01 | 0.01 | +0.00 | buy |
| Redmile Group, LLC | 1,611,013 | 1,528,567 | -82,446 | 2.33 | 2.64 | +0.32 | sell |
| Bellevue Group AG | 1,518,121 | 1,518,121 | 0 | 0.60 | 0.72 | +0.12 | hold |
| Casdin Capital, LLC | 775,000 | 1,250,000 | +475,000 | 1.27 | 2.07 | +0.81 | buy |
| MORGAN STANLEY | 1,207,757 | 795,319 | -412,438 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 691,091 | 740,506 | +49,415 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 680,848 | 719,864 | +39,016 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 629,492 | 648,945 | +19,453 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 639,238 | 513,671 | -125,567 | 0.00 | 0.00 | -0.00 | sell |
| Yiheng Capital Management, L.P. | 763,760 | 426,102 | -337,658 | 3.46 | 2.34 | -1.12 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 463,662 | 413,409 | -50,253 | 0.04 | 0.04 | -0.01 | sell |
| JANE STREET GROUP, LLC | 188,091 | 402,012 | +213,921 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 401,286 | 395,920 | -5,366 | 0.00 | 0.00 | -0.00 | sell |
| Alphabet Inc. | 321,604 | 321,604 | 0 | 0.43 | 0.46 | +0.04 | hold |
| BAILLIE GIFFORD & CO | 357,698 | 308,236 | -49,462 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 0 | 282,120 | +282,120 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 183,214 | 278,019 | +94,805 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 227,545 | 276,917 | +49,372 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 249,923 | 252,223 | +2,300 | 0.20 | 0.24 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 85,310 | 212,804 | +127,494 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 20,800 | 208,255 | +187,455 | 0.01 | 0.08 | +0.06 | buy |
| Point72 Asset Management, L.P. | 0 | 193,356 | +193,356 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 184,306 | 184,306 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 187,845 | 176,181 | -11,664 | 0.01 | 0.01 | -0.00 | sell |
| Vestmark Advisory Solutions, Inc. | 133,902 | 173,152 | +39,250 | 0.12 | 0.15 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 156,279 | 162,407 | +6,128 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 155,278 | +155,278 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 107,384 | 154,726 | +47,342 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 145,851 | 143,502 | -2,349 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 136,700 | 137,800 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 539,987 | 136,933 | -403,054 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 119,606 | 135,380 | +15,774 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 85,647 | 130,436 | +44,789 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 108,844 | 128,002 | +19,158 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 58,208 | 127,664 | +69,456 | 0.03 | 0.05 | +0.03 | buy |
| RHUMBLINE ADVISERS | 127,105 | 126,233 | -872 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 66,817 | 117,088 | +50,271 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 187,091 | 111,100 | -75,991 | 0.02 | 0.01 | -0.01 | sell |
| Liontrust Investment Partners LLP | 80,000 | 110,180 | +30,180 | 0.03 | 0.04 | +0.01 | buy |
| Hudson Bay Capital Management LP | 115,000 | 100,000 | -15,000 | 0.02 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 127,588 | 90,061 | -37,527 | 0.03 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 81,717 | 75,353 | -6,364 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 71,756 | 73,342 | +1,586 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 43,637 | 67,508 | +23,871 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 63,564 | 66,265 | +2,701 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,660 | 65,962 | -698 | 0.00 | 0.00 | +0.00 | sell |
| Cinctive Capital Management LP | 0 | 65,242 | +65,242 | 0.00 | 0.09 | +0.09 | buy |
| Crestline Management, LP | 17,415 | 62,969 | +45,554 | 0.02 | 0.05 | +0.03 | buy |
| Clarius Group, LLC | 60,615 | 60,615 | 0 | 0.10 | 0.10 | -0.00 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 57,698 | 56,027 | -1,671 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 0 | 55,000 | +55,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 52,725 | +52,725 | 0.00 | 0.02 | +0.02 | buy |
| D.A. DAVIDSON & CO. | 53,847 | 51,409 | -2,438 | 0.01 | 0.01 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 170,000 | 50,000 | -120,000 | 0.30 | 0.08 | -0.22 | sell |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 43,534 | 46,900 | +3,366 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,603 | 44,445 | -1,158 | 0.00 | 0.00 | +0.00 | sell |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 42,000 | 42,000 | 0 | 0.65 | 0.60 | -0.05 | hold |
| ADAR1 Capital Management, LLC | 43,900 | 38,312 | -5,588 | 0.18 | 0.20 | +0.02 | sell |
| Corebridge Financial, Inc. | 40,883 | 38,013 | -2,870 | 0.01 | 0.01 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 42,645 | 35,827 | -6,818 | 0.01 | 0.01 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 38,996 | 35,569 | -3,427 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 0 | 35,414 | +35,414 | 0.00 | 0.08 | +0.08 | buy |
| Jump Financial, LLC | 43,099 | 34,498 | -8,601 | 0.02 | 0.02 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 37,001 | 32,501 | -4,500 | 0.00 | 0.00 | -0.00 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 13,118 | 32,198 | +19,080 | 0.03 | 0.09 | +0.06 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 28,171 | 30,467 | +2,296 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 15,006 | 29,810 | +14,804 | 0.01 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 37,501 | 29,709 | -7,792 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 20,892 | 29,401 | +8,509 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 15,024 | 29,375 | +14,351 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 29,111 | 29,111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LPL Financial LLC | 26,236 | 27,698 | +1,462 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 28,500 | 27,500 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 38,120 | 27,470 | -10,650 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 15,187 | 26,514 | +11,327 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 26,177 | +26,177 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 17,972 | 25,595 | +7,623 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 19,319 | 25,446 | +6,127 | 0.00 | 0.00 | +0.00 | buy |
| BENJAMIN EDWARDS INC | 16,315 | 24,358 | +8,043 | 0.01 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,870 | 23,870 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 23,500 | 23,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 24,743 | 23,015 | -1,728 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 22,907 | +22,907 | 0.00 | 0.00 | +0.00 | buy |