| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 11,038,834 | 12,467,189 | +1,428,355 | 1.59 | 2.29 | +0.70 | buy |
| FMR LLC | 11,692,853 | 11,909,138 | +216,285 | 0.01 | 0.02 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 10,063,111 | 10,063,111 | 0 | 1.38 | 1.45 | +0.07 | hold |
| VANGUARD GROUP INC | 9,250,784 | 9,193,474 | -57,310 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 8,148,205 | 8,450,182 | +301,977 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,008,658 | 5,228,529 | +1,219,871 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 4,540,132 | 4,540,132 | 0 | 22.38 | 19.31 | -3.07 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 4,830,738 | 4,409,300 | -421,438 | 0.07 | 0.07 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 4,830,738 | 4,409,300 | -421,438 | 1.14 | 1.41 | +0.28 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,263,149 | 2,730,282 | +467,133 | 0.01 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 2,517,647 | 2,440,214 | -77,433 | 4.55 | 4.40 | -0.15 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,390,943 | 2,351,908 | -39,035 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,720,290 | 1,947,879 | +227,589 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,665,385 | 1,712,359 | +46,974 | 0.01 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 1,600,000 | 1,600,000 | 0 | 3.24 | 2.75 | -0.48 | hold |
| Redmile Group, LLC | 1,387,559 | 1,285,859 | -101,700 | 3.28 | 2.62 | -0.65 | sell |
| TWO SIGMA INVESTMENTS, LP | 379,044 | 1,120,389 | +741,345 | 0.01 | 0.05 | +0.03 | buy |
| Woodline Partners LP | 546,559 | 993,066 | +446,507 | 0.06 | 0.11 | +0.04 | buy |
| UBS Group AG | 1,137,633 | 973,843 | -163,790 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 945,829 | +945,829 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 841,210 | 834,795 | -6,415 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 854,344 | 808,947 | -45,397 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 644,760 | 729,400 | +84,640 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 541,303 | 619,241 | +77,938 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 570,394 | +570,394 | 0.00 | 0.16 | +0.16 | buy |
| Integral Health Asset Management, LLC | 400,000 | 550,000 | +150,000 | 0.71 | 0.77 | +0.07 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 383,531 | 533,563 | +150,032 | 0.63 | 1.02 | +0.39 | buy |
| TWO SIGMA ADVISERS, LP | 333,000 | 527,802 | +194,802 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,318,653 | 522,636 | -796,017 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,260,011 | 492,430 | -767,581 | 0.10 | 0.05 | -0.05 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 23,970 | 468,910 | +444,940 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 779,024 | 427,328 | -351,696 | 0.00 | 0.00 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 297,803 | 416,224 | +118,421 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 70,431 | 399,659 | +329,228 | 0.00 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 409,442 | 357,671 | -51,771 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 313,627 | 326,178 | +12,551 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 337,514 | 325,654 | -11,860 | 0.01 | 0.01 | +0.00 | sell |
| Alphabet Inc. | 321,604 | 321,604 | 0 | 0.32 | 0.35 | +0.02 | hold |
| MILLENNIUM MANAGEMENT LLC | 29,750 | 301,650 | +271,900 | 0.00 | 0.01 | +0.01 | buy |
| PEREGRINE INVESTMENT MANAGEMENT INC | 267,930 | 257,280 | -10,650 | 3.19 | 4.43 | +1.23 | sell |
| CITADEL ADVISORS LLC | 0 | 255,710 | +255,710 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 237,340 | 233,065 | -4,275 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 176,864 | 213,185 | +36,321 | 0.00 | 0.00 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 166,297 | 196,036 | +29,739 | 0.08 | 0.07 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 145,180 | 191,248 | +46,068 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 175,400 | 179,500 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 178,352 | +178,352 | 0.00 | 0.22 | +0.22 | buy |
| Rafferty Asset Management, LLC | 137,152 | 176,859 | +39,707 | 0.01 | 0.02 | +0.01 | buy |
| Liontrust Investment Partners LLP | 0 | 170,404 | +170,404 | 0.00 | 0.07 | +0.07 | buy |
| ExodusPoint Capital Management, LP | 0 | 163,316 | +163,316 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 117,323 | 159,188 | +41,865 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 145,388 | 157,030 | +11,642 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 156,500 | +156,500 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 162,711 | 151,183 | -11,528 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 50,193 | 148,303 | +98,110 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 138,132 | 138,132 | 0 | 0.05 | 0.06 | +0.01 | hold |
| SummitTX Capital, L.P. | 16,209 | 137,946 | +121,737 | 0.02 | 0.12 | +0.10 | buy |
| RHUMBLINE ADVISERS | 143,828 | 131,199 | -12,629 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 296,090 | 128,360 | -167,730 | 0.05 | 0.02 | -0.03 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 108,681 | 112,771 | +4,090 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 2,889,288 | 111,510 | -2,777,778 | 1.46 | 0.06 | -1.40 | sell |
| SG Americas Securities, LLC | 43,220 | 103,469 | +60,249 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,720 | 100,720 | 0 | 0.00 | 0.00 | +0.00 | hold |
| D.A. DAVIDSON & CO. | 94,630 | 98,883 | +4,253 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,146 | 98,511 | -26,635 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 99,568 | 92,078 | -7,490 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,053 | 87,265 | +4,212 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 72,915 | 77,564 | +4,649 | 0.00 | 0.00 | +0.00 | buy |
| Concurrent Investment Advisors, LLC | 0 | 76,825 | +76,825 | 0.00 | 0.02 | +0.02 | buy |
| Privium Fund Management B.V. | 61,000 | 71,500 | +10,500 | 0.27 | 0.36 | +0.10 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,280 | 69,964 | -316 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 30,046 | 65,617 | +35,571 | 0.02 | 0.06 | +0.03 | buy |
| FIRST TRUST ADVISORS LP | 0 | 64,056 | +64,056 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 68,515 | 60,759 | -7,756 | 0.04 | 0.04 | +0.00 | sell |
| Clarius Group, LLC | 60,615 | 60,615 | 0 | 0.09 | 0.10 | +0.01 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,273 | 58,526 | +11,253 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 17,166 | 56,091 | +38,925 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 43,747 | 55,619 | +11,872 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 56,576 | 54,523 | -2,053 | 0.01 | 0.01 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 51,000 | 45,000 | -6,000 | 0.66 | 0.61 | -0.05 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 37,427 | 43,781 | +6,354 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 43,000 | 43,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| WCG Wealth Advisors LLC | 24,162 | 39,917 | +15,755 | 0.04 | 0.03 | -0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 41,831 | 39,531 | -2,300 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 39,501 | 39,501 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 27,825 | 38,053 | +10,228 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 37,988 | 36,902 | -1,086 | 0.00 | 0.00 | +0.00 | sell |
| BENJAMIN EDWARDS INC | 32,728 | 35,802 | +3,074 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 34,290 | +34,290 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 51,123 | 33,623 | -17,500 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 32,711 | +32,711 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 39,267 | 31,532 | -7,735 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 0 | 31,076 | +31,076 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 30,876 | 30,982 | +106 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,629 | 30,629 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GUGGENHEIM CAPITAL LLC | 28,476 | 29,508 | +1,032 | 0.01 | 0.01 | +0.00 | buy |
| AlphaQuest LLC | 30,660 | 28,549 | -2,111 | 0.05 | 0.04 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 27,327 | 28,115 | +788 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 27,935 | +27,935 | 0.00 | 0.00 | +0.00 | buy |