| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 912,467 | 1,377,327 | +464,860 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 2,696,648 | 3,097,220 | +400,572 | 1.75 | 1.69 | -0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,785,916 | 3,959,088 | +173,172 | 0.01 | 0.01 | -0.00 | buy |
| Candriam S.C.A. | 453,000 | 548,000 | +95,000 | 0.06 | 0.05 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 193,554 | 258,554 | +65,000 | 0.56 | 0.54 | -0.02 | buy |
| Rhenman & Partners Asset Management AB | 112,741 | 145,250 | +32,509 | 0.20 | 0.21 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,823,184 | 1,851,864 | +28,680 | 5.63 | 4.30 | -1.33 | buy |
| Hudson Bay Capital Management LP | 45,000 | 69,400 | +24,400 | 0.01 | 0.01 | +0.00 | buy |
| HighMark Wealth Management LLC | 23,500 | 42,500 | +19,000 | 0.31 | 0.39 | +0.08 | buy |
| AlphaQuest LLC | 2,051 | 18,298 | +16,247 | 0.01 | 0.05 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,929 | 11,581 | +4,652 | 0.02 | 0.02 | -0.00 | buy |
| ALPS ADVISORS INC | 41,062 | 42,485 | +1,423 | 0.01 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,521 | 5,167 | -354 | 0.06 | 0.04 | -0.02 | sell |
| Corton Capital Inc. | 18,548 | 11,291 | -7,257 | 0.11 | 0.06 | -0.04 | sell |
| Atom Investors LP | 66,361 | 58,064 | -8,297 | 0.21 | 0.11 | -0.10 | sell |
| Woodline Partners LP | 124,090 | 100,143 | -23,947 | 0.02 | 0.01 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 121,787 | 97,082 | -24,705 | 0.01 | 0.01 | -0.00 | sell |
| First Light Asset Management, LLC | 3,591,776 | 3,534,993 | -56,783 | 5.23 | 4.03 | -1.20 | sell |
| Granahan Investment Management, LLC | 1,150,766 | 1,046,845 | -103,921 | 0.69 | 0.55 | -0.14 | sell |
| Laurion Capital Management LP | 3,583,567 | 3,474,744 | -108,823 | 0.55 | 0.44 | -0.11 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 318,524 | 183,392 | -135,132 | 1.78 | 0.77 | -1.01 | sell |
| Casdin Capital, LLC | 1,577,108 | 1,000,000 | -577,108 | 2.80 | 1.11 | -1.70 | sell |