| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 5,750,000 | 5,750,000 | 0 | 3.65 | 2.46 | -1.19 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,785,916 | 3,959,088 | +173,172 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 3,963,418 | 3,946,497 | -16,921 | 0.01 | 0.00 | -0.00 | sell |
| First Light Asset Management, LLC | 3,591,776 | 3,534,993 | -56,783 | 5.23 | 4.03 | -1.20 | sell |
| VANGUARD GROUP INC | 3,065,869 | 3,478,355 | +412,486 | 0.00 | 0.00 | -0.00 | buy |
| Laurion Capital Management LP | 3,583,567 | 3,474,744 | -108,823 | 2.33 | 1.44 | -0.89 | sell |
| Redmile Group, LLC | 2,696,648 | 3,097,220 | +400,572 | 1.75 | 1.69 | -0.05 | buy |
| Blue Owl Capital Holdings LP | 3,004,199 | 3,004,199 | 0 | 13.01 | 8.94 | -4.06 | hold |
| TRV GP IV, LLC | 2,132,867 | 2,132,867 | 0 | 15.69 | 15.40 | -0.29 | hold |
| Polar Capital Holdings Plc | 2,015,000 | 2,015,000 | 0 | 0.22 | 0.16 | -0.07 | hold |
| GREAT POINT PARTNERS LLC | 1,823,184 | 1,851,864 | +28,680 | 5.63 | 4.30 | -1.33 | buy |
| CITADEL ADVISORS LLC | 1,578,514 | 1,701,746 | +123,232 | 0.03 | 0.02 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 1,579,572 | 1,536,850 | -42,722 | 0.01 | 0.01 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 984,992 | 1,485,793 | +500,801 | 0.01 | 0.01 | +0.00 | buy |
| Capital International Investors | 912,467 | 1,377,327 | +464,860 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,335,278 | 1,318,767 | -16,511 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 1,318,804 | 1,307,611 | -11,193 | 0.03 | 0.02 | -0.01 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,281,000 | 1,281,000 | 0 | 0.36 | 0.24 | -0.12 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,187,198 | 1,214,883 | +27,685 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 1,150,766 | 1,046,845 | -103,921 | 0.69 | 0.55 | -0.14 | sell |
| Casdin Capital, LLC | 1,577,108 | 1,000,000 | -577,108 | 2.82 | 1.11 | -1.71 | sell |
| Candriam S.C.A. | 453,000 | 548,000 | +95,000 | 0.06 | 0.05 | -0.00 | buy |
| BESSEMER GROUP INC | 532,079 | 532,079 | 0 | 0.02 | 0.01 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 387,246 | 502,571 | +115,325 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 78,330 | 497,814 | +419,484 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 505,326 | 495,289 | -10,037 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 424,196 | 430,286 | +6,090 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 384,996 | 384,996 | 0 | 0.17 | 0.15 | -0.03 | hold |
| MORGAN STANLEY | 405,023 | 384,102 | -20,921 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 369,801 | 371,126 | +1,325 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 342,173 | 365,064 | +22,891 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 352,897 | 360,145 | +7,248 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 347,100 | 347,194 | +94 | 0.02 | 0.02 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 154,072 | 300,170 | +146,098 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 281,189 | 281,189 | 0 | 0.06 | 0.05 | -0.01 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 193,554 | 258,554 | +65,000 | 0.65 | 0.62 | -0.03 | buy |
| CITIGROUP INC | 71,475 | 213,305 | +141,830 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 210,640 | 199,064 | -11,576 | 0.00 | 0.00 | -0.00 | sell |
| Cutter Capital Management, LP | 0 | 194,119 | +194,119 | 0.00 | 1.12 | +1.12 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 318,524 | 183,392 | -135,132 | 1.78 | 0.77 | -1.01 | sell |
| TWO SIGMA ADVISERS, LP | 92,600 | 149,500 | +56,900 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 112,741 | 145,250 | +32,509 | 0.20 | 0.21 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 130,935 | +130,935 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 89,144 | 128,912 | +39,768 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 112,248 | 112,248 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 107,024 | +107,024 | 0.00 | 0.00 | +0.00 | buy |
| Bond & Devick Financial Network, Inc. | 100,160 | 100,160 | 0 | 1.03 | 0.81 | -0.22 | hold |
| Woodline Partners LP | 124,090 | 100,143 | -23,947 | 0.02 | 0.01 | -0.01 | sell |
| Artia Global Partners LP | 100,000 | 100,000 | 0 | 0.72 | 0.37 | -0.35 | hold |
| FRED ALGER MANAGEMENT, LLC | 121,787 | 97,082 | -24,705 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 88,400 | 88,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 74,875 | 82,292 | +7,417 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 80,614 | 81,826 | +1,212 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 18,105 | 77,576 | +59,471 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 75,900 | +75,900 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 63,719 | 72,119 | +8,400 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 69,170 | 71,350 | +2,180 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 45,000 | 69,400 | +24,400 | 0.01 | 0.01 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 65,582 | 65,582 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Polar Asset Management Partners Inc. | 0 | 65,300 | +65,300 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 30,895 | 62,762 | +31,867 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 55,748 | 59,670 | +3,922 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 59,080 | 59,080 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 85,593 | 58,328 | -27,265 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 66,361 | 58,064 | -8,297 | 0.21 | 0.11 | -0.10 | sell |
| HARBOURVEST PARTNERS LLC | 49,434 | 49,434 | 0 | 0.30 | 0.34 | +0.04 | hold |
| Invesco Ltd. | 27,524 | 47,782 | +20,258 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 65,887 | 47,306 | -18,581 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 60,001 | 46,614 | -13,387 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,368 | 46,141 | -3,227 | 0.00 | 0.00 | -0.00 | sell |
| HighMark Wealth Management LLC | 23,500 | 42,500 | +19,000 | 0.31 | 0.39 | +0.08 | buy |
| ALPS ADVISORS INC | 41,062 | 42,485 | +1,423 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 41,734 | 41,625 | -109 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 42,318 | 38,691 | -3,627 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 34,039 | 34,039 | 0 | 0.22 | 0.18 | -0.04 | hold |
| MILLENNIUM MANAGEMENT LLC | 0 | 30,539 | +30,539 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 29,814 | 29,814 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 28,407 | 28,165 | -242 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 26,897 | +26,897 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 30,375 | 26,861 | -3,514 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 26,700 | 25,418 | -1,282 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,607 | 22,745 | -54,862 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 22,206 | 22,206 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 10,014 | 20,006 | +9,992 | 0.17 | 0.27 | +0.09 | buy |
| AlphaQuest LLC | 2,051 | 18,298 | +16,247 | 0.01 | 0.05 | +0.04 | buy |
| Nebula Research & Development LLC | 0 | 17,650 | +17,650 | 0.00 | 0.06 | +0.06 | buy |
| JANUS HENDERSON GROUP PLC | 17,525 | 17,526 | +1 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 16,930 | 16,930 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ProShare Advisors LLC | 13,286 | 14,489 | +1,203 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 12,545 | 12,346 | -199 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 12,897 | 11,863 | -1,034 | 0.01 | 0.01 | -0.00 | sell |
| Rathbones Group PLC | 11,700 | 11,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIDUCIARY TRUST CO | 11,620 | 11,620 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 6,929 | 11,581 | +4,652 | 0.02 | 0.02 | -0.00 | buy |
| Corton Capital Inc. | 18,548 | 11,291 | -7,257 | 0.11 | 0.06 | -0.04 | sell |
| HSBC HOLDINGS PLC | 0 | 10,507 | +10,507 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 8,580 | +8,580 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,600 | 8,030 | +2,430 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 7,212 | +7,212 | 0.00 | 0.00 | +0.00 | buy |