| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GREAT POINT PARTNERS LLC | 1,851,864 | 2,636,864 | +785,000 | 4.30 | 5.43 | +1.13 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,959,088 | 4,602,323 | +643,235 | 0.01 | 0.01 | -0.00 | buy |
| Candriam S.C.A. | 548,000 | 833,216 | +285,216 | 0.05 | 0.05 | +0.00 | buy |
| Deep Track Capital, LP | 5,750,000 | 5,972,257 | +222,257 | 2.46 | 1.92 | -0.55 | buy |
| Redmile Group, LLC | 3,097,220 | 3,209,591 | +112,371 | 1.69 | 2.09 | +0.39 | buy |
| ALGERT GLOBAL LLC | 16,930 | 69,842 | +52,912 | 0.01 | 0.03 | 0.00 | buy |
| Hudson Bay Capital Management LP | 69,400 | 100,000 | +30,600 | 0.01 | 0.01 | -0.00 | buy |
| HighMark Wealth Management LLC | 42,500 | 67,500 | +25,000 | 0.39 | 0.44 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 8,580 | 27,557 | +18,977 | 0.02 | 0.02 | +0.01 | buy |
| AlphaQuest LLC | 18,298 | 32,175 | +13,877 | 0.05 | 0.05 | 0.00 | buy |
| Nebula Research & Development LLC | 17,650 | 24,904 | +7,254 | 0.06 | 0.04 | -0.01 | buy |
| Corton Capital Inc. | 11,291 | 15,996 | +4,705 | 0.06 | 0.09 | +0.03 | buy |
| ALPS ADVISORS INC | 42,485 | 47,074 | +4,589 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 100,143 | 103,623 | +3,480 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,167 | 7,563 | +2,396 | 0.04 | 0.04 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,581 | 7,087 | -4,494 | 0.02 | 0.01 | -0.01 | sell |
| Polar Asset Management Partners Inc. | 65,300 | 46,600 | -18,700 | 0.02 | 0.01 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 145,250 | 120,250 | -25,000 | 0.21 | 0.12 | -0.08 | sell |
| Artia Global Partners LP | 100,000 | 50,000 | -50,000 | 0.37 | 0.14 | -0.23 | sell |
| Granahan Investment Management, LLC | 1,046,845 | 982,049 | -64,796 | 0.55 | 0.42 | -0.13 | sell |
| First Light Asset Management, LLC | 3,534,993 | 3,401,213 | -133,780 | 4.03 | 3.21 | -0.83 | sell |
| Laurion Capital Management LP | 3,474,744 | 2,498,920 | -975,824 | 0.44 | 0.32 | -0.12 | sell |
| Capital International Investors | 1,377,327 | 224,997 | -1,152,330 | 0.00 | 0.00 | -0.00 | sell |