| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 5,750,000 | 5,972,257 | +222,257 | 2.46 | 1.92 | -0.55 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,959,088 | 4,602,323 | +643,235 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 3,946,497 | 3,911,759 | -34,738 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 3,478,355 | 3,437,160 | -41,195 | 0.00 | 0.00 | -0.00 | sell |
| First Light Asset Management, LLC | 3,534,993 | 3,401,213 | -133,780 | 4.03 | 3.21 | -0.83 | sell |
| Redmile Group, LLC | 3,097,220 | 3,209,591 | +112,371 | 1.69 | 2.09 | +0.39 | buy |
| Blue Owl Capital Holdings LP | 3,004,199 | 3,004,199 | 0 | 8.94 | 8.98 | +0.04 | hold |
| GREAT POINT PARTNERS LLC | 1,851,864 | 2,636,864 | +785,000 | 4.30 | 5.43 | +1.13 | buy |
| Laurion Capital Management LP | 3,474,744 | 2,498,920 | -975,824 | 1.44 | 0.88 | -0.56 | sell |
| TRV GP IV, LLC | 2,132,867 | 2,132,867 | 0 | 15.40 | 11.34 | -4.06 | hold |
| Polar Capital Holdings Plc | 2,015,000 | 2,015,000 | 0 | 0.16 | 0.13 | -0.03 | hold |
| DEUTSCHE BANK AG\ | 1,485,793 | 1,526,164 | +40,371 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 1,318,767 | 1,376,120 | +57,353 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,214,883 | 1,287,087 | +72,204 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,281,000 | 1,281,000 | 0 | 0.24 | 0.18 | -0.06 | hold |
| Pictet Asset Management Holding SA | 1,307,611 | 1,195,779 | -111,832 | 0.02 | 0.01 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 1,536,850 | 1,024,991 | -511,859 | 0.01 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 1,000,000 | 1,000,000 | 0 | 1.11 | 0.82 | -0.29 | hold |
| Granahan Investment Management, LLC | 1,046,845 | 982,049 | -64,796 | 0.55 | 0.42 | -0.13 | sell |
| Candriam S.C.A. | 548,000 | 833,216 | +285,216 | 0.05 | 0.05 | +0.00 | buy |
| MORGAN STANLEY | 384,102 | 673,847 | +289,745 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 497,814 | 604,245 | +106,431 | 0.00 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 532,079 | 532,079 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHERN TRUST CORP | 495,289 | 477,165 | -18,124 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 430,286 | 437,382 | +7,096 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,701,746 | 430,712 | -1,271,034 | 0.02 | 0.00 | -0.02 | sell |
| Rock Springs Capital Management LP | 384,996 | 384,996 | 0 | 0.15 | 0.12 | -0.02 | hold |
| AXA S.A. | 347,194 | 347,389 | +195 | 0.02 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 360,145 | 342,924 | -17,221 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 300,170 | 305,322 | +5,152 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 281,189 | 281,189 | 0 | 0.05 | 0.04 | -0.01 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 258,554 | 258,554 | 0 | 0.62 | 0.45 | -0.17 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 75,900 | 253,369 | +177,469 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 107,024 | 245,572 | +138,548 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 128,912 | 237,498 | +108,586 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 232,200 | +232,200 | 0.00 | 1.50 | +1.50 | buy |
| Bank of New York Mellon Corp | 199,064 | 228,693 | +29,629 | 0.00 | 0.00 | -0.00 | buy |
| Capital International Investors | 1,377,327 | 224,997 | -1,152,330 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 502,571 | 213,238 | -289,333 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 149,500 | 189,700 | +40,200 | 0.01 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 158,700 | +158,700 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 365,064 | 152,202 | -212,862 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 127,634 | +127,634 | 0.00 | 0.08 | +0.08 | buy |
| Exome Asset Management LLC | 0 | 124,000 | +124,000 | 0.00 | 1.19 | +1.19 | buy |
| Rhenman & Partners Asset Management AB | 145,250 | 120,250 | -25,000 | 0.21 | 0.12 | -0.08 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 72,119 | 117,482 | +45,363 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 112,248 | 112,248 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 100,143 | 103,623 | +3,480 | 0.01 | 0.01 | -0.00 | buy |
| Bond & Devick Financial Network, Inc. | 100,160 | 100,160 | 0 | 0.81 | 0.58 | -0.23 | hold |
| Hudson Bay Capital Management LP | 69,400 | 100,000 | +30,600 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 81,826 | 96,488 | +14,662 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 77,576 | 93,244 | +15,668 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 88,400 | 88,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 82,292 | 83,483 | +1,191 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 80,475 | +80,475 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 71,350 | 80,226 | +8,876 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 77,000 | +77,000 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 62,762 | 74,113 | +11,351 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 30,539 | 73,290 | +42,751 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 16,930 | 69,842 | +52,912 | 0.01 | 0.02 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 68,289 | +68,289 | 0.00 | 0.04 | +0.04 | buy |
| HighMark Wealth Management LLC | 42,500 | 67,500 | +25,000 | 0.39 | 0.44 | +0.04 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 65,582 | 65,582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDT Partners, LLC | 0 | 63,352 | +63,352 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 59,080 | 59,080 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Verition Fund Management LLC | 0 | 56,501 | +56,501 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,861 | 54,332 | +27,471 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 47,306 | 52,040 | +4,734 | 0.00 | 0.00 | -0.00 | buy |
| Artia Global Partners LP | 100,000 | 50,000 | -50,000 | 0.37 | 0.14 | -0.23 | sell |
| HARBOURVEST PARTNERS LLC | 49,434 | 49,434 | 0 | 0.34 | 0.28 | -0.05 | hold |
| JPMORGAN CHASE & CO | 58,328 | 49,190 | -9,138 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 47,782 | 47,155 | -627 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 42,485 | 47,074 | +4,589 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 65,300 | 46,600 | -18,700 | 0.03 | 0.01 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 46,200 | +46,200 | 0.00 | 0.42 | +0.42 | buy |
| SG Americas Securities, LLC | 7,212 | 45,891 | +38,679 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,141 | 44,924 | -1,217 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 41,625 | 40,379 | -1,246 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 38,200 | +38,200 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 38,691 | 36,730 | -1,961 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 25,418 | 35,368 | +9,950 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 29,814 | 32,863 | +3,049 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 26,897 | 32,246 | +5,349 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 18,298 | 32,175 | +13,877 | 0.05 | 0.05 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 31,910 | +31,910 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 20,006 | 30,238 | +10,232 | 0.27 | 0.15 | -0.12 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,745 | 29,436 | +6,691 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 8,580 | 27,557 | +18,977 | 0.02 | 0.02 | +0.01 | buy |
| Nebula Research & Development LLC | 17,650 | 24,904 | +7,254 | 0.06 | 0.04 | -0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 59,670 | 22,282 | -37,388 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 22,206 | 22,206 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 213,305 | 17,549 | -195,756 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 0 | 17,487 | +17,487 | 0.00 | 0.02 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 17,526 | 17,251 | -275 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 16,180 | +16,180 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 11,291 | 15,996 | +4,705 | 0.06 | 0.09 | +0.03 | buy |
| Quantbot Technologies LP | 277 | 15,261 | +14,984 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 15,022 | +15,022 | 0.00 | 0.01 | +0.01 | buy |
| Arizona State Retirement System | 12,346 | 12,647 | +301 | 0.00 | 0.00 | -0.00 | buy |