| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 3,104,486 | +3,104,486 | 0.00 | 1.22 | +1.22 | buy |
| Integral Health Asset Management, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.40 | +0.40 | buy |
| ADAR1 Capital Management, LLC | 10,000 | 246,128 | +236,128 | 0.02 | 0.46 | +0.44 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,602,323 | 4,834,813 | +232,490 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 73,290 | 244,640 | +171,350 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 305,322 | 456,166 | +150,844 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 232,200 | 380,000 | +147,800 | 1.50 | 2.11 | +0.61 | buy |
| MORGAN STANLEY | 673,847 | 817,123 | +143,276 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 213,238 | 347,397 | +134,159 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 46,600 | 170,200 | +123,600 | 0.01 | 0.05 | +0.03 | buy |
| VANGUARD GROUP INC | 3,437,160 | 3,526,514 | +89,354 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,195,779 | 1,279,717 | +83,938 | 0.01 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 342,924 | 421,499 | +78,575 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 152,202 | 230,308 | +78,106 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 27,557 | 91,979 | +64,422 | 0.02 | 0.04 | +0.02 | buy |
| NATIXIS | 0 | 55,000 | +55,000 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 52,040 | 105,570 | +53,530 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 258,554 | 297,362 | +38,808 | 0.45 | 0.55 | +0.09 | buy |
| ALGERT GLOBAL LLC | 69,842 | 106,562 | +36,720 | 0.02 | 0.03 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 34,611 | +34,611 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 17,549 | 49,540 | +31,991 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,287,087 | 1,318,308 | +31,221 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 30,471 | +30,471 | 0.00 | 0.02 | +0.02 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 127,634 | 157,217 | +29,583 | 0.08 | 0.10 | +0.01 | buy |
| STATE STREET CORP | 1,376,120 | 1,402,730 | +26,610 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 124,000 | 149,600 | +25,600 | 1.19 | 1.13 | -0.05 | buy |
| NORTHERN TRUST CORP | 477,165 | 502,016 | +24,851 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 68,289 | 91,974 | +23,685 | 0.04 | 0.05 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 604,245 | 627,696 | +23,451 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 437,382 | 456,663 | +19,281 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,436 | 46,638 | +17,202 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 74,113 | 90,905 | +16,792 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,024,991 | 1,039,904 | +14,913 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 14,600 | +14,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 80,226 | 93,232 | +13,006 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 12,913 | +12,913 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 93,244 | 105,476 | +12,232 | 0.01 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 12,229 | +12,229 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 12,104 | +12,104 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 0 | 10,400 | +10,400 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 10,260 | +10,260 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 10,077 | +10,077 | 0.00 | 0.00 | +0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 0 | 10,009 | +10,009 | 0.00 | 0.02 | +0.02 | buy |
| Atria Investments, Inc | 0 | 10,009 | +10,009 | 0.00 | 0.00 | +0.00 | buy |
| Atria Wealth Solutions, Inc. | 11,715 | 21,574 | +9,859 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,526,164 | 1,534,365 | +8,201 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 103,623 | 111,660 | +8,037 | 0.01 | 0.01 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 77,000 | 84,885 | +7,885 | 0.02 | 0.02 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 35,368 | 42,768 | +7,400 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 38,200 | 44,400 | +6,200 | 0.03 | 0.04 | +0.00 | buy |
| Swiss National Bank | 88,400 | 94,200 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,087 | 11,694 | +4,607 | 0.01 | 0.01 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 4,422 | +4,422 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,379 | 14,361 | +2,982 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 2,209 | +2,209 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,286 | 31,290 | +2,004 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,924 | 46,257 | +1,333 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,647 | 13,896 | +1,249 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,693 | 2,858 | +1,165 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 47,074 | 48,238 | +1,164 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 29 | 1,047 | +1,018 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 479 | +479 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 117,482 | 117,937 | +455 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,801 | 2,199 | +398 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 40,379 | 40,712 | +333 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 262 | +262 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 344 | 529 | +185 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 167 | +167 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 98 | 233 | +135 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,563 | 7,697 | +134 | 0.04 | 0.04 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 124 | +124 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 347,389 | 347,487 | +98 | 0.01 | 0.01 | +0.00 | buy |
| BESSEMER GROUP INC | 532,079 | 532,174 | +95 | 0.01 | 0.01 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 80 | +40 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 79 | 102 | +23 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 49,190 | 49,212 | +22 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,486 | 5,486 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,614 | 5,614 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 59,080 | 59,080 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOURVEST PARTNERS LLC | 49,434 | 49,434 | 0 | 0.28 | 0.29 | +0.01 | hold |
| JANUS HENDERSON GROUP PLC | 17,251 | 17,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,281,000 | 1,281,000 | 0 | 0.18 | 0.17 | -0.02 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,030 | 8,030 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blackstone Inc. | 22,206 | 22,206 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hudson Bay Capital Management LP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 196 | 196 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 281,189 | 281,189 | 0 | 0.04 | 0.04 | +0.00 | hold |
| MetLife Investment Management, LLC | 32,863 | 32,863 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 65,582 | 65,582 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Candriam S.C.A. | 833,216 | 833,216 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Capital International Investors | 224,997 | 224,997 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rock Springs Capital Management LP | 384,996 | 384,996 | 0 | 0.12 | 0.14 | +0.02 | hold |
| Capital Advisors, Ltd. LLC | 13 | 13 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Rhenman & Partners Asset Management AB | 120,250 | 120,250 | 0 | 0.12 | 0.11 | -0.01 | hold |
| TRV GP IV, LLC | 2,132,867 | 2,132,867 | 0 | 11.34 | 14.75 | +3.41 | hold |
| Global Retirement Partners, LLC | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |