| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAR1 Capital Management, LLC | 10,000 | 246,128 | +236,128 | 0.02 | 0.46 | +0.44 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,602,323 | 4,834,813 | +232,490 | 0.01 | 0.01 | +0.00 | buy |
| Checkpoint Capital L.P. | 232,200 | 380,000 | +147,800 | 1.50 | 2.11 | +0.61 | buy |
| Polar Asset Management Partners Inc. | 46,600 | 170,200 | +123,600 | 0.01 | 0.04 | +0.03 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 27,557 | 91,979 | +64,422 | 0.02 | 0.04 | 0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 258,554 | 297,362 | +38,808 | 0.38 | 0.53 | +0.15 | buy |
| ALGERT GLOBAL LLC | 69,842 | 106,562 | +36,720 | 0.03 | 0.03 | 0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 127,634 | 157,217 | +29,583 | 0.08 | 0.10 | +0.01 | buy |
| Exome Asset Management LLC | 124,000 | 149,600 | +25,600 | 1.19 | 1.13 | -0.05 | buy |
| Hennion & Walsh Asset Management, Inc. | 68,289 | 91,974 | +23,685 | 0.04 | 0.05 | +0.01 | buy |
| Woodline Partners LP | 103,623 | 111,660 | +8,037 | 0.01 | 0.01 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 77,000 | 84,885 | +7,885 | 0.05 | 0.07 | 0.00 | buy |
| AlphaQuest LLC | 32,175 | 25,571 | +6,604 | 0.05 | 0.03 | 0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 38,200 | 44,400 | +6,200 | 0.03 | 0.04 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,087 | 11,694 | +4,607 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 47,074 | 48,238 | +1,164 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,563 | 7,697 | +134 | 0.04 | 0.04 | +0.00 | buy |
| BESSEMER GROUP INC | 532,079 | 532,174 | +95 | 0.01 | 0.01 | -0.00 | buy |
| Redmile Group, LLC | 3,209,591 | 3,197,491 | -12,100 | 2.09 | 2.11 | +0.03 | sell |
| Granahan Investment Management, LLC | 982,049 | 738,252 | -243,797 | 0.42 | 0.33 | -0.10 | sell |
| GREAT POINT PARTNERS LLC | 2,636,864 | 1,910,121 | -726,743 | 5.43 | 6.30 | +0.87 | sell |
| First Light Asset Management, LLC | 3,401,213 | 2,575,546 | -825,667 | 3.21 | 2.40 | -0.80 | sell |