| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 5,972,257 | 5,972,257 | 0 | 2.14 | 2.95 | +0.81 | hold |
| BlackRock, Inc. | 5,218,965 | 5,179,977 | -38,988 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,834,813 | 4,634,486 | -200,327 | 0.01 | 0.01 | +0.00 | sell |
| FMR LLC | 3,899,481 | 3,876,598 | -22,883 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 3,526,514 | 3,228,755 | -297,759 | 0.00 | 0.00 | +0.00 | sell |
| Paradigm Biocapital Advisors LP | 3,104,486 | 3,197,050 | +92,564 | 1.22 | 1.46 | +0.25 | buy |
| Redmile Group, LLC | 3,197,491 | 2,895,478 | -302,013 | 2.11 | 2.66 | +0.55 | sell |
| Blue Owl Capital Holdings LP | 3,004,199 | 2,769,199 | -235,000 | 6.53 | 8.40 | +1.87 | sell |
| DEUTSCHE BANK AG\ | 1,534,365 | 2,551,865 | +1,017,500 | 0.01 | 0.01 | +0.01 | buy |
| TRV GP IV, LLC | 2,132,867 | 2,132,867 | 0 | 14.75 | 35.03 | +20.28 | hold |
| Polar Capital Holdings Plc | 2,015,000 | 2,015,000 | 0 | 0.11 | 0.15 | +0.04 | hold |
| First Light Asset Management, LLC | 2,575,546 | 1,681,110 | -894,436 | 2.40 | 2.12 | -0.28 | sell |
| STATE STREET CORP | 1,402,730 | 1,385,236 | -17,494 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,318,308 | 1,316,648 | -1,660 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,315,601 | +1,315,601 | 0.00 | 3.87 | +3.87 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,281,000 | 1,281,000 | 0 | 0.17 | 0.22 | +0.06 | hold |
| Pictet Asset Management Holding SA | 1,279,717 | 1,266,030 | -13,687 | 0.02 | 0.02 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 0 | 1,120,803 | +1,120,803 | 0.00 | 0.61 | +0.61 | buy |
| GREAT POINT PARTNERS LLC | 1,910,121 | 1,055,000 | -855,121 | 6.46 | 6.55 | +0.09 | sell |
| FRANKLIN RESOURCES INC | 1,039,904 | 1,045,577 | +5,673 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 833,216 | 900,104 | +66,888 | 0.05 | 0.07 | +0.01 | buy |
| MORGAN STANLEY | 817,123 | 782,004 | -35,119 | 0.00 | 0.00 | +0.00 | sell |
| Logos Global Management LP | 0 | 750,000 | +750,000 | 0.00 | 1.16 | +1.16 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 649,660 | +649,660 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 230,308 | 628,281 | +397,973 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 502,016 | 555,600 | +53,584 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 456,166 | 547,297 | +91,131 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 380,000 | 535,494 | +155,494 | 2.11 | 3.59 | +1.48 | buy |
| BESSEMER GROUP INC | 532,174 | 532,174 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Granahan Investment Management, LLC | 738,252 | 527,147 | -211,105 | 0.33 | 0.29 | -0.04 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 456,663 | 459,384 | +2,721 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 347,397 | 446,700 | +99,303 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 384,996 | 404,796 | +19,800 | 0.14 | 0.20 | +0.06 | buy |
| CITADEL ADVISORS LLC | 35,054 | 401,689 | +366,635 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 347,487 | 346,941 | -546 | 0.01 | 0.01 | +0.00 | sell |
| Integral Health Asset Management, LLC | 300,000 | 300,000 | 0 | 0.40 | 0.35 | -0.05 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 297,362 | 297,362 | 0 | 0.55 | 0.72 | +0.18 | hold |
| ArrowMark Colorado Holdings LLC | 281,189 | 281,189 | 0 | 0.04 | 0.05 | +0.01 | hold |
| JPMORGAN CHASE & CO | 49,212 | 197,251 | +148,039 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 184,554 | 184,382 | -172 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 186,726 | 182,015 | -4,711 | 0.00 | 0.00 | +0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 157,217 | 160,522 | +3,305 | 0.10 | 0.12 | +0.02 | buy |
| Caption Management, LLC | 0 | 142,404 | +142,404 | 0.00 | 0.08 | +0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 117,937 | 139,574 | +21,637 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 157,800 | 135,700 | -22,100 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 246,128 | 134,798 | -111,330 | 0.46 | 0.37 | -0.10 | sell |
| Atom Investors LP | 0 | 130,448 | +130,448 | 0.00 | 0.21 | +0.21 | buy |
| Woodline Partners LP | 111,660 | 127,295 | +15,635 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 627,696 | 120,977 | -506,719 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 120,250 | 116,250 | -4,000 | 0.11 | 0.16 | +0.05 | sell |
| ROYAL BANK OF CANADA | 105,570 | 112,517 | +6,947 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 91,974 | 108,608 | +16,634 | 0.05 | 0.06 | +0.02 | buy |
| ALGERT GLOBAL LLC | 106,562 | 107,603 | +1,041 | 0.03 | 0.03 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 84,885 | 103,563 | +18,678 | 0.02 | 0.03 | +0.01 | buy |
| Exome Asset Management LLC | 149,600 | 103,504 | -46,096 | 1.13 | 1.03 | -0.11 | sell |
| BARCLAYS PLC | 421,499 | 101,823 | -319,676 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 90,905 | 100,849 | +9,944 | 0.00 | 0.00 | +0.00 | buy |
| Bond & Devick Financial Network, Inc. | 100,160 | 100,160 | 0 | 0.48 | 0.48 | 0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 135,122 | 97,078 | -38,044 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 91,979 | 95,801 | +3,822 | 0.04 | 0.06 | +0.01 | buy |
| Swiss National Bank | 94,200 | 95,700 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 105,476 | 93,804 | -11,672 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 94,697 | 92,580 | -2,117 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 93,232 | 85,880 | -7,352 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 78,034 | 78,034 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 67,500 | 75,000 | +7,500 | 0.41 | 0.57 | +0.15 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,268 | 74,826 | -442 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,638 | 68,574 | +21,936 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 65,582 | 65,582 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Polar Asset Management Partners Inc. | 170,200 | 62,600 | -107,600 | 0.05 | 0.01 | -0.03 | sell |
| Trexquant Investment LP | 86,852 | 62,477 | -24,375 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 59,080 | 59,080 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hudson Bay Capital Management LP | 100,000 | 57,500 | -42,500 | 0.01 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 53,880 | +53,880 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 40,712 | 52,961 | +12,249 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 49,540 | 52,581 | +3,041 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 48,238 | 49,210 | +972 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 46,332 | 48,514 | +2,182 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,407 | 47,867 | +13,460 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,257 | 46,051 | -206 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 42,768 | 42,768 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 32,863 | 36,788 | +3,925 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 36,438 | 34,823 | -1,615 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,290 | 32,431 | +1,141 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 44,400 | 30,782 | -13,618 | 0.04 | 0.03 | -0.00 | sell |
| SG Americas Securities, LLC | 24,150 | 30,729 | +6,579 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 30,467 | 28,329 | -2,138 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 101,200 | 27,800 | -73,400 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 26,382 | 23,432 | -2,950 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 12,913 | 22,517 | +9,604 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 22,206 | 22,206 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atria Wealth Solutions, Inc. | 21,574 | 21,574 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jump Financial, LLC | 0 | 19,402 | +19,402 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 14,361 | 18,931 | +4,570 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 15,911 | 18,323 | +2,412 | 0.10 | 0.10 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 17,251 | 17,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,180 | 16,180 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allianz Asset Management GmbH | 14,600 | 14,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,104 | 14,451 | +2,347 | 0.00 | 0.00 | +0.00 | buy |