| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,315,601 | +1,315,601 | 0.00 | 3.87 | +3.87 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,120,803 | +1,120,803 | 0.00 | 0.61 | +0.61 | buy |
| DEUTSCHE BANK AG\ | 1,534,365 | 2,551,865 | +1,017,500 | 0.01 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 750,000 | +750,000 | 0.00 | 1.16 | +1.16 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 649,660 | +649,660 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 230,308 | 628,281 | +397,973 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 35,054 | 401,689 | +366,635 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 380,000 | 535,494 | +155,494 | 2.11 | 3.59 | +1.48 | buy |
| JPMORGAN CHASE & CO | 49,212 | 197,251 | +148,039 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 142,404 | +142,404 | 0.00 | 0.08 | +0.08 | buy |
| Atom Investors LP | 0 | 130,448 | +130,448 | 0.00 | 0.21 | +0.21 | buy |
| GOLDMAN SACHS GROUP INC | 347,397 | 446,700 | +99,303 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 3,104,486 | 3,197,050 | +92,564 | 1.22 | 1.46 | +0.25 | buy |
| DIMENSIONAL FUND ADVISORS LP | 456,166 | 547,297 | +91,131 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 833,216 | 900,104 | +66,888 | 0.05 | 0.07 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 53,880 | +53,880 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 502,016 | 555,600 | +53,584 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,638 | 68,574 | +21,936 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 117,937 | 139,574 | +21,637 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 384,996 | 404,796 | +19,800 | 0.14 | 0.20 | +0.06 | buy |
| Jump Financial, LLC | 0 | 19,402 | +19,402 | 0.00 | 0.01 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 84,885 | 103,563 | +18,678 | 0.02 | 0.03 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 91,974 | 108,608 | +16,634 | 0.05 | 0.06 | +0.02 | buy |
| Woodline Partners LP | 111,660 | 127,295 | +15,635 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,407 | 47,867 | +13,460 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 40,712 | 52,961 | +12,249 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 11,755 | +11,755 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 10,497 | +10,497 | 0.00 | 0.08 | +0.08 | buy |
| AMERICAN CENTURY COMPANIES INC | 90,905 | 100,849 | +9,944 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 12,913 | 22,517 | +9,604 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 7,512 | +7,512 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 67,500 | 75,000 | +7,500 | 0.41 | 0.57 | +0.15 | buy |
| ROYAL BANK OF CANADA | 105,570 | 112,517 | +6,947 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 24,150 | 30,729 | +6,579 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,039,904 | 1,045,577 | +5,673 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 400 | 5,596 | +5,196 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 14,361 | 18,931 | +4,570 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 32,863 | 36,788 | +3,925 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 91,979 | 95,801 | +3,822 | 0.04 | 0.06 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 157,217 | 160,522 | +3,305 | 0.10 | 0.12 | +0.02 | buy |
| CITIGROUP INC | 49,540 | 52,581 | +3,041 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 456,663 | 459,384 | +2,721 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 15,911 | 18,323 | +2,412 | 0.10 | 0.10 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,104 | 14,451 | +2,347 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 46,332 | 48,514 | +2,182 | 0.00 | 0.00 | +0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 10,009 | 11,889 | +1,880 | 0.02 | 0.03 | +0.01 | buy |
| Atria Investments, Inc | 10,009 | 11,821 | +1,812 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,858 | 4,578 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 204 | 1,826 | +1,622 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 529 | 2,036 | +1,507 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 94,200 | 95,700 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 9,113 | 10,509 | +1,396 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 2,209 | 3,572 | +1,363 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,694 | 12,903 | +1,209 | 0.01 | 0.02 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,290 | 32,431 | +1,141 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 106,562 | 107,603 | +1,041 | 0.03 | 0.03 | +0.00 | buy |
| ALPS ADVISORS INC | 48,238 | 49,210 | +972 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 233 | 775 | +542 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 262 | 672 | +410 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,047 | 1,341 | +294 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 13,896 | 14,096 | +200 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 479 | 607 | +128 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 109 | +109 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 102 | 181 | +79 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 5 | 6 | +1 | 0.00 | 0.00 | 0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,486 | 5,486 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BESSEMER GROUP INC | 532,174 | 532,174 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,614 | 5,614 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 78,034 | 78,034 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 59,080 | 59,080 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 17,251 | 17,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 10,400 | 10,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,281,000 | 1,281,000 | 0 | 0.17 | 0.22 | +0.06 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,030 | 8,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blackstone Inc. | 22,206 | 22,206 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 42,768 | 42,768 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 124 | 124 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 196 | 196 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 281,189 | 281,189 | 0 | 0.04 | 0.05 | +0.01 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 297,362 | 297,362 | 0 | 0.55 | 0.72 | +0.18 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 65,582 | 65,582 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allianz Asset Management GmbH | 14,600 | 14,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 13 | 13 | 0 | 0.00 | 0.00 | 0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRV GP IV, LLC | 2,132,867 | 2,132,867 | 0 | 14.75 | 35.03 | +20.28 | hold |
| Global Retirement Partners, LLC | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 167 | 167 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Integral Health Asset Management, LLC | 300,000 | 300,000 | 0 | 0.40 | 0.35 | -0.05 | hold |
| Polar Capital Holdings Plc | 2,015,000 | 2,015,000 | 0 | 0.11 | 0.15 | +0.04 | hold |
| Bond & Devick Financial Network, Inc. | 100,160 | 100,160 | 0 | 0.48 | 0.48 | 0.00 | hold |
| Deep Track Capital, LP | 5,972,257 | 5,972,257 | 0 | 2.14 | 2.95 | +0.81 | hold |
| Washington Trust Advisors, Inc. | 65 | 65 | 0 | 0.00 | 0.00 | +0.00 | hold |