| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Checkpoint Capital L.P. | 380,000 | 535,494 | +155,494 | 2.11 | 3.59 | +1.48 | buy |
| Paradigm Biocapital Advisors LP | 3,104,486 | 3,197,050 | +92,564 | 1.22 | 1.46 | +0.25 | buy |
| Candriam S.C.A. | 833,216 | 900,104 | +66,888 | 0.05 | 0.07 | +0.01 | buy |
| Rock Springs Capital Management LP | 384,996 | 404,796 | +19,800 | 0.14 | 0.20 | +0.06 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 84,885 | 103,563 | +18,678 | 0.07 | 0.11 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 91,974 | 108,608 | +16,634 | 0.05 | 0.06 | +0.02 | buy |
| Woodline Partners LP | 111,660 | 127,295 | +15,635 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 105,476 | 93,804 | +11,672 | 0.01 | 0.01 | 0.00 | sell |
| HighMark Wealth Management LLC | 67,500 | 75,000 | +7,500 | 0.41 | 0.57 | +0.15 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 91,979 | 95,801 | +3,822 | 0.04 | 0.06 | 0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 157,217 | 160,522 | +3,305 | 0.10 | 0.12 | +0.02 | buy |
| EntryPoint Capital, LLC | 15,911 | 18,323 | +2,412 | 0.10 | 0.10 | -0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 10,009 | 11,889 | +1,880 | 0.02 | 0.03 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 11,694 | 12,903 | +1,209 | 0.01 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 106,562 | 107,603 | +1,041 | 0.03 | 0.03 | 0.00 | buy |
| ALPS ADVISORS INC | 48,238 | 49,210 | +972 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,697 | 5,133 | -2,564 | 0.04 | 0.03 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 120,250 | 116,250 | -4,000 | 0.11 | 0.16 | +0.05 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 44,400 | 30,782 | -13,618 | 0.04 | 0.03 | -0.00 | sell |
| Hudson Bay Capital Management LP | 100,000 | 57,500 | -42,500 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 149,600 | 103,504 | -46,096 | 1.13 | 1.03 | -0.11 | sell |
| Polar Asset Management Partners Inc. | 170,200 | 62,600 | -107,600 | 0.04 | 0.01 | -0.03 | sell |
| ADAR1 Capital Management, LLC | 246,128 | 134,798 | -111,330 | 0.46 | 0.37 | -0.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,834,813 | 4,634,486 | -200,327 | 0.01 | 0.01 | +0.00 | sell |
| Granahan Investment Management, LLC | 738,252 | 527,147 | -211,105 | 0.33 | 0.29 | -0.04 | sell |
| Blue Owl Capital Holdings LP | 3,004,199 | 2,769,199 | -235,000 | 6.53 | 8.40 | +1.87 | sell |
| Redmile Group, LLC | 3,197,491 | 2,895,478 | -302,013 | 2.11 | 2.66 | +0.55 | sell |
| GREAT POINT PARTNERS LLC | 1,910,121 | 1,055,000 | -855,121 | 6.30 | 6.55 | +0.25 | sell |
| First Light Asset Management, LLC | 2,575,546 | 1,681,110 | -894,436 | 2.40 | 2.12 | -0.28 | sell |