| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sands Capital Alternatives, LLC | 0 | 10,950,000 | +10,950,000 | 0.00 | 7.74 | +7.74 | buy |
| Soleus Capital Management, L.P. | 0 | 6,325,000 | +6,325,000 | 0.00 | 1.56 | +1.56 | buy |
| Fairmount Funds Management LLC | 0 | 6,125,000 | +6,125,000 | 0.00 | 1.98 | +1.98 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 5,925,000 | +5,925,000 | 0.00 | 0.54 | +0.54 | buy |
| Commodore Capital LP | 0 | 5,925,000 | +5,925,000 | 0.00 | 1.41 | +1.41 | buy |
| ADAR1 Capital Management, LLC | 0 | 5,103,005 | +5,103,005 | 0.00 | 3.42 | +3.42 | buy |
| VANGUARD GROUP INC | 16,724 | 2,838,645 | +2,821,921 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 2,190,000 | +2,190,000 | 0.00 | 0.50 | +0.50 | buy |
| Blackstone Inc. | 0 | 2,070,684 | +2,070,684 | 0.00 | 0.03 | +0.03 | buy |
| Stonepine Capital Management, LLC | 0 | 1,132,388 | +1,132,388 | 0.00 | 2.97 | +2.97 | buy |
| BlackRock, Inc. | 0 | 335,460 | +335,460 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 50,065 | 322,878 | +272,813 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 142,209 | +142,209 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 84,000 | +84,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 77,100 | +77,100 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 64,011 | +64,011 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 54,600 | +54,600 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 46,416 | +46,416 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 43,952 | +43,952 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 10,084 | 41,884 | +31,800 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 28,411 | +28,411 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 0 | 16,393 | +16,393 | 0.00 | 0.32 | +0.32 | buy |
| Alpine Global Management, LLC | 0 | 14,842 | +14,842 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 14,800 | +14,800 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 13,129 | +13,129 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 126,120 | 134,953 | +8,833 | 0.00 | 0.00 | +0.00 | buy |
| Synergy Asset Management, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,057 | 0 | -4,057 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 19,922 | 0 | -19,922 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 626,500 | 0 | -626,500 | 0.02 | 0.00 | -0.02 | sell |