| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 9,135,893 | 9,135,893 | 0 | 3.21 | 2.84 | -0.36 | hold |
| Paradigm Biocapital Advisors LP | 7,903,600 | 7,903,600 | 0 | 5.20 | 3.15 | -2.05 | hold |
| Logos Global Management LP | 4,383,875 | 4,383,875 | 0 | 6.05 | 5.22 | -0.82 | hold |
| Deep Track Capital, LP | 1,930,894 | 3,225,419 | +1,294,525 | 0.95 | 1.05 | +0.10 | buy |
| STATE STREET CORP | 673,170 | 3,178,427 | +2,505,257 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,705,895 | 2,407,688 | -298,207 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 1,857,136 | 1,953,690 | +96,554 | 6.10 | 3.56 | -2.54 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,715,420 | 1,936,157 | +220,737 | 0.01 | 0.01 | -0.00 | buy |
| Vivo Capital, LLC | 1,873,704 | 1,873,704 | 0 | 2.15 | 1.67 | -0.49 | hold |
| JANUS HENDERSON GROUP PLC | 700,100 | 1,221,662 | +521,562 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 824,833 | 839,345 | +14,512 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 99,413 | 835,613 | +736,200 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 283,952 | 780,660 | +496,708 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 750,279 | 750,279 | 0 | 0.11 | 0.08 | -0.04 | hold |
| Polar Capital Holdings Plc | 750,000 | 750,000 | 0 | 0.06 | 0.04 | -0.02 | hold |
| BRAIDWELL LP | 0 | 704,344 | +704,344 | 0.00 | 0.26 | +0.26 | buy |
| Soleus Capital Management, L.P. | 0 | 658,000 | +658,000 | 0.00 | 0.65 | +0.65 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 621,527 | 610,649 | -10,878 | 0.01 | 0.01 | -0.00 | sell |
| Altium Capital Management LLC | 413,607 | 605,000 | +191,393 | 4.00 | 3.06 | -0.94 | buy |
| Ally Bridge Group (NY) LLC | 659,035 | 559,035 | -100,000 | 5.51 | 3.52 | -1.99 | sell |
| MARSHALL WACE, LLP | 290,721 | 547,803 | +257,082 | 0.01 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 573,830 | 515,317 | -58,513 | 2.48 | 1.64 | -0.85 | sell |
| MORGAN STANLEY | 497,844 | 498,126 | +282 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 460,000 | -40,000 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 315,478 | 437,031 | +121,553 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 215,008 | 353,018 | +138,010 | 0.02 | 0.03 | +0.00 | buy |
| NORTHERN TRUST CORP | 352,818 | 349,157 | -3,661 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 40,110 | 326,819 | +286,709 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 260,357 | 313,246 | +52,889 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 294,719 | +294,719 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 4,807 | 249,982 | +245,175 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 248,661 | 249,030 | +369 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 247,880 | 247,880 | 0 | 1.26 | 1.00 | -0.26 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 203,825 | +203,825 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 52,498 | 173,161 | +120,663 | 0.00 | 0.00 | +0.00 | buy |
| Newtyn Management, LLC | 150,000 | 150,000 | 0 | 0.41 | 0.34 | -0.07 | hold |
| TWO SIGMA ADVISERS, LP | 180,800 | 148,500 | -32,300 | 0.01 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 143,400 | +143,400 | 0.00 | 1.39 | +1.39 | buy |
| SECTORAL ASSET MANAGEMENT INC | 19,230 | 139,980 | +120,750 | 0.12 | 0.62 | +0.51 | buy |
| Monashee Investment Management LLC | 0 | 135,000 | +135,000 | 0.00 | 0.18 | +0.18 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,101 | 129,587 | +118,486 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 122,178 | +122,178 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 255,925 | 103,179 | -152,746 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 165,709 | 95,814 | -69,895 | 0.01 | 0.00 | -0.00 | sell |
| Atom Investors LP | 58,870 | 94,321 | +35,451 | 0.15 | 0.13 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 87,252 | 88,257 | +1,005 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 89,210 | 86,957 | -2,253 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 101,042 | 81,301 | -19,741 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 77,042 | 77,042 | 0 | 0.07 | 0.04 | -0.03 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 149,659 | 74,919 | -74,740 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 45,757 | 73,589 | +27,832 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 64,600 | 70,300 | +5,700 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 62,500 | 67,507 | +5,007 | 0.01 | 0.01 | -0.00 | buy |
| Cinctive Capital Management LP | 0 | 56,518 | +56,518 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 51,922 | +51,922 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,867 | 48,036 | -103,831 | 0.00 | 0.00 | -0.00 | sell |
| EP Wealth Advisors, LLC | 46,248 | 46,248 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PROFUND ADVISORS LLC | 0 | 45,218 | +45,218 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 43,396 | 42,810 | -586 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 40,176 | 41,308 | +1,132 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 45,209 | 39,984 | -5,225 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 38,163 | 38,861 | +698 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 36,150 | 35,654 | -496 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,563 | 34,695 | +1,132 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 36,408 | 34,608 | -1,800 | 0.01 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 33,580 | +33,580 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 32,700 | +32,700 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 21,378 | 28,790 | +7,412 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 24,533 | 27,294 | +2,761 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 44,240 | 27,013 | -17,227 | 0.05 | 0.02 | -0.03 | sell |
| XTX Topco Ltd | 0 | 26,959 | +26,959 | 0.00 | 0.04 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,765 | 26,251 | +1,486 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 15,860 | 25,090 | +9,230 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,904 | 24,134 | -2,770 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 28,576 | 22,885 | -5,691 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 15,565 | +15,565 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 25,800 | 14,991 | -10,809 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 14,905 | 14,905 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 1,384 | 14,530 | +13,146 | 0.02 | 0.15 | +0.13 | buy |
| Entropy Technologies, LP | 0 | 14,246 | +14,246 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 0 | 13,999 | +13,999 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 13,927 | +13,927 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,345 | 13,231 | -114 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 12,871 | 12,871 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 12,144 | 11,966 | -178 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 10,781 | 11,421 | +640 | 0.00 | 0.00 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 11,212 | +11,212 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 6,341 | 10,562 | +4,221 | 0.02 | 0.02 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 15,951 | 10,539 | -5,412 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,926 | 10,439 | -487 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 11,889 | 10,100 | -1,789 | 0.00 | 0.00 | -0.00 | sell |
| CONWAY CAPITAL MANAGEMENT, INC. | 26,500 | 10,000 | -16,500 | 0.24 | 0.06 | -0.18 | sell |
| WELLS FARGO & COMPANY/MN | 8,458 | 9,680 | +1,222 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,282 | 9,282 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 0 | 8,215 | +8,215 | 0.00 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 7,515 | 7,030 | -485 | 0.07 | 0.04 | -0.02 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,518 | 6,954 | +436 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,217 | 2,217 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 18,651 | 2,154 | -16,497 | 0.01 | 0.00 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 10,522 | 1,616 | -8,906 | 0.00 | 0.00 | -0.00 | sell |