| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,023,092 | 10,386,845 | +5,363,753 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,884,399 | 3,937,831 | +2,053,432 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 3,300,700 | 4,756,949 | +1,456,249 | 2.46 | 1.97 | -0.50 | buy |
| Cormorant Asset Management, LP | 2,750,000 | 3,900,000 | +1,150,000 | 3.90 | 2.93 | -0.97 | buy |
| Duquesne Family Office LLC | 0 | 986,827 | +986,827 | 0.00 | 0.50 | +0.50 | buy |
| JENNISON ASSOCIATES LLC | 963,997 | 1,822,123 | +858,126 | 0.01 | 0.02 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 393,658 | 1,169,421 | +775,763 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 665,803 | 1,215,690 | +549,887 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 7,544,172 | 8,020,576 | +476,404 | 5.05 | 2.44 | -2.61 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 220,971 | 664,679 | +443,708 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 328,680 | 738,552 | +409,872 | 0.02 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 6,710,194 | 7,108,488 | +398,294 | 0.08 | 0.05 | -0.02 | buy |
| Jump Financial, LLC | 100,274 | 452,966 | +352,692 | 0.03 | 0.10 | +0.07 | buy |
| Qube Research & Technologies Ltd | 0 | 312,812 | +312,812 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 0 | 299,756 | +299,756 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,257,441 | 1,544,417 | +286,976 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 49,754 | 325,173 | +275,419 | 0.01 | 0.04 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,224 | 285,882 | +274,658 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 238,914 | 508,706 | +269,792 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 817,889 | 1,045,589 | +227,700 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 1,380,450 | 1,602,970 | +222,520 | 0.16 | 0.10 | -0.05 | buy |
| Blue Owl Capital Holdings LP | 0 | 200,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 154,770 | +154,770 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 617,714 | 768,662 | +150,948 | 1.76 | 1.28 | -0.48 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.12 | +0.12 | buy |
| NORTHERN TRUST CORP | 445,327 | 569,956 | +124,629 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 958,644 | 1,082,434 | +123,790 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 123,218 | +123,218 | 0.00 | 0.03 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 86,100 | 203,959 | +117,859 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 110,150 | +110,150 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 63,067 | 161,396 | +98,329 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 96,782 | +96,782 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 15,314 | 111,186 | +95,872 | 0.01 | 0.05 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 25,991 | 121,494 | +95,503 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 293,560 | 385,061 | +91,501 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 5,563,260 | 5,652,135 | +88,875 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,096,035 | 1,182,836 | +86,801 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 45,005 | 131,520 | +86,515 | 0.00 | 0.01 | +0.00 | buy |
| Tidal Investments LLC | 0 | 85,151 | +85,151 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 679,484 | 759,513 | +80,029 | 0.08 | 0.06 | -0.03 | buy |
| Swiss National Bank | 0 | 74,600 | +74,600 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 98,240 | 170,378 | +72,138 | 0.13 | 0.15 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 70,711 | +70,711 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 210,000 | 275,000 | +65,000 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 407,141 | 466,546 | +59,405 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 59,374 | +59,374 | 0.00 | 0.10 | +0.10 | buy |
| Y-Intercept (Hong Kong) Ltd | 37,199 | 90,375 | +53,176 | 0.02 | 0.03 | +0.00 | buy |
| Nuveen, LLC | 229,469 | 278,990 | +49,521 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 47,012 | +47,012 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,207 | 70,471 | +44,264 | 0.01 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 41,960 | +41,960 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 17,381 | 58,577 | +41,196 | 0.01 | 0.03 | +0.02 | buy |
| Erste Asset Management GmbH | 0 | 38,000 | +38,000 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 37,994 | +37,994 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,940 | 72,703 | +37,763 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 37,180 | +37,180 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 0 | 35,880 | +35,880 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,666 | 39,079 | +35,413 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.02 | +0.02 | buy |
| TEMA ETFS LLC | 44,505 | 79,243 | +34,738 | 0.09 | 0.08 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 447,046 | 481,485 | +34,439 | 0.39 | 0.24 | -0.14 | buy |
| Quantinno Capital Management LP | 61,306 | 95,336 | +34,030 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 9,954 | 39,230 | +29,276 | 0.00 | 0.00 | +0.00 | buy |
| Aristotle Atlantic Partners, LLC | 0 | 24,953 | +24,953 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 412 | 25,025 | +24,613 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 21,247 | +21,247 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 20,567 | +20,567 | 0.00 | 0.15 | +0.15 | buy |
| Bank of New York Mellon Corp | 176,201 | 193,483 | +17,282 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 16,710 | +16,710 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 0 | 16,533 | +16,533 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 14,086 | +14,086 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 13,376 | +13,376 | 0.00 | 0.01 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 0 | 12,901 | +12,901 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 3,902 | 16,443 | +12,541 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,268 | 42,074 | +11,806 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,362 | 21,670 | +11,308 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 11,305 | +11,305 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 20,490 | 31,665 | +11,175 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 0 | 10,368 | +10,368 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 74,379 | 84,350 | +9,971 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 81,167 | 89,562 | +8,395 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 8,300 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 64,654 | 72,234 | +7,580 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 102,322 | 109,582 | +7,260 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 5,970 | +5,970 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 5,321 | 11,127 | +5,806 | 0.00 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,500 | 38,520 | +5,020 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 3,000 | 7,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,640 | 19,191 | +2,551 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,764 | 5,864 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 4,735 | 6,579 | +1,844 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 1,191 | 2,455 | +1,264 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 56,195 | 57,405 | +1,210 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,018 | 14,225 | +1,207 | 0.02 | 0.02 | -0.01 | buy |
| KBC Group NV | 0 | 1,164 | +1,164 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,198 | 26,266 | +1,068 | 0.01 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,975 | 5,716 | +741 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 654 | +654 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 150 | 746 | +596 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,822 | 4,181 | +359 | 0.00 | 0.00 | -0.00 | buy |