| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,023,092 | 10,386,845 | +5,363,753 | 0.01 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 7,544,172 | 8,020,576 | +476,404 | 5.05 | 2.44 | -2.61 | buy |
| Bain Capital Life Sciences Investors, LLC | 8,508,641 | 7,473,238 | -1,035,403 | 16.29 | 10.05 | -6.24 | sell |
| JANUS HENDERSON GROUP PLC | 6,710,194 | 7,108,488 | +398,294 | 0.08 | 0.05 | -0.02 | buy |
| BlackRock, Inc. | 5,563,260 | 5,652,135 | +88,875 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 5,295,893 | 5,295,893 | 0 | 4.46 | 2.52 | -1.94 | hold |
| Siren, L.L.C. | 3,300,700 | 4,756,949 | +1,456,249 | 2.46 | 1.97 | -0.50 | buy |
| STATE STREET CORP | 1,884,399 | 3,937,831 | +2,053,432 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 2,750,000 | 3,900,000 | +1,150,000 | 3.90 | 2.93 | -0.97 | buy |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 5.35 | 2.46 | -2.88 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 2,600,000 | 2,600,000 | 0 | 0.67 | 0.41 | -0.26 | hold |
| JENNISON ASSOCIATES LLC | 963,997 | 1,822,123 | +858,126 | 0.01 | 0.02 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,380,450 | 1,602,970 | +222,520 | 0.16 | 0.10 | -0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,257,441 | 1,544,417 | +286,976 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 1,481,930 | 1,482,030 | +100 | 0.14 | 0.08 | -0.06 | buy |
| Lightspeed Management Company, L.L.C. | 1,930,894 | 1,355,299 | -575,595 | 3.46 | 2.05 | -1.41 | sell |
| FRANKLIN RESOURCES INC | 2,476,665 | 1,218,957 | -1,257,708 | 0.02 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 665,803 | 1,215,690 | +549,887 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,096,035 | 1,182,836 | +86,801 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 393,658 | 1,169,421 | +775,763 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 958,644 | 1,082,434 | +123,790 | 0.01 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 817,889 | 1,045,589 | +227,700 | 0.00 | 0.00 | -0.00 | buy |
| Duquesne Family Office LLC | 0 | 986,827 | +986,827 | 0.00 | 0.50 | +0.50 | buy |
| CITADEL ADVISORS LLC | 1,200,307 | 905,332 | -294,975 | 0.02 | 0.01 | -0.01 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 953,600 | 855,000 | -98,600 | 3.65 | 2.13 | -1.51 | sell |
| First Turn Management, LLC | 617,714 | 768,662 | +150,948 | 1.76 | 1.28 | -0.48 | buy |
| Candriam S.C.A. | 679,484 | 759,513 | +80,029 | 0.08 | 0.06 | -0.03 | buy |
| Squarepoint Ops LLC | 328,680 | 738,552 | +409,872 | 0.02 | 0.02 | +0.01 | buy |
| Vivo Capital, LLC | 671,843 | 671,843 | 0 | 1.09 | 0.83 | -0.25 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 220,971 | 664,679 | +443,708 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 758,654 | 598,281 | -160,373 | 2.45 | 1.28 | -1.18 | sell |
| NORTHERN TRUST CORP | 445,327 | 569,956 | +124,629 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 238,914 | 508,706 | +269,792 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 447,046 | 481,485 | +34,439 | 0.39 | 0.24 | -0.14 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 407,141 | 466,546 | +59,405 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 100,274 | 452,966 | +352,692 | 0.03 | 0.10 | +0.07 | buy |
| Vestal Point Capital, LP | 1,650,000 | 428,551 | -1,221,449 | 1.51 | 0.18 | -1.33 | sell |
| UBS Group AG | 293,560 | 385,061 | +91,501 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 49,754 | 325,173 | +275,419 | 0.01 | 0.04 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 312,812 | +312,812 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 0 | 299,756 | +299,756 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,224 | 285,882 | +274,658 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 229,469 | 278,990 | +49,521 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 210,000 | 275,000 | +65,000 | 0.01 | 0.01 | -0.00 | buy |
| Birchview Capital, LP | 269,000 | 219,000 | -50,000 | 3.94 | 1.86 | -2.08 | sell |
| Pictet Asset Management Holding SA | 502,568 | 217,023 | -285,545 | 0.01 | 0.00 | -0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 86,100 | 203,959 | +117,859 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 200,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 176,201 | 193,483 | +17,282 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 498,490 | 182,935 | -315,555 | 0.01 | 0.00 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 219,086 | 174,603 | -44,483 | 0.14 | 0.06 | -0.08 | sell |
| Rock Springs Capital Management LP | 98,240 | 170,378 | +72,138 | 0.13 | 0.15 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 63,067 | 161,396 | +98,329 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 154,770 | +154,770 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.12 | +0.12 | buy |
| JPMORGAN CHASE & CO | 268,471 | 142,762 | -125,709 | 0.00 | 0.00 | -0.00 | sell |
| Pier Capital, LLC | 140,101 | 136,108 | -3,993 | 0.56 | 0.33 | -0.22 | sell |
| Rafferty Asset Management, LLC | 45,005 | 131,520 | +86,515 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 155,732 | 130,933 | -24,799 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 125,000 | 125,000 | 0 | 0.21 | 0.09 | -0.11 | hold |
| XTX Topco Ltd | 0 | 123,218 | +123,218 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 25,991 | 121,494 | +95,503 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 241,489 | 117,601 | -123,888 | 1.55 | 0.48 | -1.07 | sell |
| Susquehanna Portfolio Strategies, LLC | 121,342 | 113,842 | -7,500 | 0.05 | 0.03 | -0.02 | sell |
| Aquatic Capital Management LLC | 15,314 | 111,186 | +95,872 | 0.01 | 0.05 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 110,150 | +110,150 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 102,322 | 109,582 | +7,260 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 136,400 | 106,214 | -30,186 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 0 | 96,782 | +96,782 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 61,306 | 95,336 | +34,030 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 37,199 | 90,375 | +53,176 | 0.02 | 0.03 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 167,308 | 89,671 | -77,637 | 0.01 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 81,167 | 89,562 | +8,395 | 0.00 | 0.00 | -0.00 | buy |
| Tidal Investments LLC | 0 | 85,151 | +85,151 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 74,379 | 84,350 | +9,971 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 93,900 | 81,734 | -12,166 | 0.00 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 44,505 | 79,243 | +34,738 | 0.09 | 0.08 | -0.01 | buy |
| Swiss National Bank | 0 | 74,600 | +74,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,940 | 72,703 | +37,763 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 64,654 | 72,234 | +7,580 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 307,890 | 71,107 | -236,783 | 0.01 | 0.00 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 70,711 | +70,711 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,207 | 70,471 | +44,264 | 0.01 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 64,592 | 64,035 | -557 | 0.01 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 0 | 59,374 | +59,374 | 0.00 | 0.10 | +0.10 | buy |
| PROFUND ADVISORS LLC | 17,381 | 58,577 | +41,196 | 0.01 | 0.03 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 62,610 | 57,840 | -4,770 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 56,195 | 57,405 | +1,210 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 204,629 | 57,362 | -147,267 | 0.00 | 0.00 | -0.00 | sell |
| Swedbank AB | 55,100 | 55,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | 50,000 | 0 | 0.38 | 0.24 | -0.14 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 47,012 | +47,012 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 84,130 | 46,433 | -37,697 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,268 | 42,074 | +11,806 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 41,960 | +41,960 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 9,954 | 39,230 | +29,276 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,666 | 39,079 | +35,413 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,500 | 38,520 | +5,020 | 0.00 | 0.00 | -0.00 | buy |
| Erste Asset Management GmbH | 0 | 38,000 | +38,000 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 37,994 | +37,994 | 0.00 | 0.00 | +0.00 | buy |