| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 3,211,927 | +3,211,927 | 0.00 | 0.11 | +0.11 | buy |
| GREAT POINT PARTNERS LLC | 0 | 796,880 | +796,880 | 0.00 | 1.65 | +1.65 | buy |
| Deep Track Capital, LP | 3,225,419 | 4,000,000 | +774,581 | 1.05 | 1.29 | +0.24 | buy |
| Candriam S.C.A. | 353,018 | 1,058,673 | +705,655 | 0.03 | 0.07 | +0.04 | buy |
| MPM BioImpact LLC | 1,953,690 | 2,654,867 | +701,177 | 3.56 | 4.46 | +0.91 | buy |
| VANGUARD GROUP INC | 2,407,688 | 2,742,664 | +334,976 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 275,000 | +275,000 | 0.00 | 0.47 | +0.47 | buy |
| Polar Capital Holdings Plc | 750,000 | 1,000,000 | +250,000 | 0.04 | 0.06 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 839,345 | 1,060,099 | +220,754 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 25,090 | 208,583 | +183,493 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 610,649 | 774,792 | +164,143 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 159,739 | +159,739 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 313,246 | 441,066 | +127,820 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 114,642 | +114,642 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 750,279 | 852,554 | +102,275 | 0.08 | 0.09 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 87,312 | +87,312 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 95,814 | 182,120 | +86,306 | 0.00 | 0.00 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 0 | 74,657 | +74,657 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 835,613 | 905,257 | +69,644 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 81,301 | 139,923 | +58,622 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 28,790 | 83,590 | +54,800 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 53,200 | +53,200 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 49,220 | +49,220 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 547,803 | 588,996 | +41,193 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,134 | 61,369 | +37,235 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 86,957 | 123,196 | +36,239 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 515,317 | 546,863 | +31,546 | 1.64 | 1.46 | -0.17 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 31,405 | +31,405 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 30,592 | +30,592 | 0.00 | 0.01 | +0.01 | buy |
| PITCAIRN CO | 0 | 27,013 | +27,013 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 14,530 | 39,727 | +25,197 | 0.15 | 0.20 | +0.05 | buy |
| Brevan Howard Capital Management LP | 0 | 22,328 | +22,328 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 0 | 20,076 | +20,076 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,036 | 66,138 | +18,102 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,308 | 59,261 | +17,953 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 35,654 | 52,661 | +17,007 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 15,857 | +15,857 | 0.00 | 0.03 | +0.03 | buy |
| Corton Capital Inc. | 0 | 14,377 | +14,377 | 0.00 | 0.08 | +0.08 | buy |
| Cubist Systematic Strategies, LLC | 0 | 13,416 | +13,416 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 12,631 | +12,631 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 74,919 | 87,397 | +12,478 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 12,129 | +12,129 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 10,100 | 21,059 | +10,959 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,954 | 16,990 | +10,036 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,905 | 23,695 | +8,790 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,616 | 9,200 | +7,584 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,680 | 16,310 | +6,630 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,439 | 15,888 | +5,449 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,251 | 31,242 | +4,991 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 249,030 | 253,874 | +4,844 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 38,861 | 43,652 | +4,791 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 42,810 | 46,301 | +3,491 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 12,871 | 15,081 | +2,210 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 27,294 | 29,409 | +2,115 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 1,839 | +1,839 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,217 | 3,912 | +1,695 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 1,414 | +1,414 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 1,248 | +1,248 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 0 | 1,025 | +1,025 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 37 | 1,018 | +981 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 13,999 | 14,849 | +850 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,421 | 12,125 | +704 | 0.00 | 0.00 | -0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 644 | +644 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 14,991 | 15,482 | +491 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,030 | 7,265 | +235 | 0.04 | 0.04 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 162 | +162 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,020 | 1,083 | +63 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 7 | 58 | +51 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 14 | 56 | +42 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 996 | 1,036 | +40 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 9,135,893 | 9,135,893 | 0 | 2.84 | 2.77 | -0.07 | hold |
| HighVista Strategies LLC | 247,880 | 247,880 | 0 | 1.00 | 0.98 | -0.02 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,282 | 9,282 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 224 | 224 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EP Wealth Advisors, LLC | 46,248 | 46,248 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Vivo Capital, LLC | 1,873,704 | 1,873,704 | 0 | 1.67 | 1.87 | +0.21 | hold |
| WOLFF WIESE MAGANA LLC | 600 | 600 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Paradigm Biocapital Advisors LP | 7,903,600 | 7,903,600 | 0 | 3.15 | 3.27 | +0.12 | hold |
| Covestor Ltd | 7 | 7 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Fortitude Family Office, LLC | 319 | 319 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONWAY CAPITAL MANAGEMENT, INC. | 10,000 | 10,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| AMALGAMATED BANK | 906 | 906 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 157 | 0 | -157 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 354 | 0 | -354 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 1,369 | 580 | -789 | 0.00 | 0.00 | -0.00 | sell |
| Truvestments Capital LLC | 1,323 | 0 | -1,323 | 0.01 | 0.00 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,695 | 33,293 | -1,402 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,154 | 736 | -1,418 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,545 | 0 | -1,545 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,562 | 6,572 | -3,990 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 70,300 | 66,000 | -4,300 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 349,157 | 344,082 | -5,075 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 8,327 | 1,900 | -6,427 | 0.03 | 0.01 | -0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 34,608 | 26,549 | -8,059 | 0.01 | 0.01 | +0.00 | sell |
| AlphaQuest LLC | 8,215 | 0 | -8,215 | 0.02 | 0.00 | -0.02 | sell |
| Mirae Asset Global Investments Co., Ltd. | 10,539 | 1,670 | -8,869 | 0.00 | 0.00 | -0.00 | sell |
| Newtyn Management, LLC | 150,000 | 140,000 | -10,000 | 0.34 | 0.28 | -0.05 | sell |