| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 3,022,784 | +3,022,784 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 1,477,907 | 3,505,893 | +2,027,986 | 0.04 | 0.08 | +0.04 | buy |
| MORGAN STANLEY | 451,691 | 1,437,407 | +985,716 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 3,822,342 | 4,605,109 | +782,767 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 399,799 | 1,172,863 | +773,064 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,871,613 | 3,266,999 | +395,386 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 978,848 | 1,271,090 | +292,242 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,151,147 | 1,412,099 | +260,952 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,083,126 | 1,326,123 | +242,997 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 865,556 | 1,051,967 | +186,411 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 100,000 | 253,657 | +153,657 | 0.30 | 0.67 | +0.37 | buy |
| Birchview Capital, LP | 0 | 134,000 | +134,000 | 0.00 | 0.57 | +0.57 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 74,919 | 194,450 | +119,531 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 14,125 | 130,342 | +116,217 | 0.02 | 0.01 | -0.01 | buy |
| ROYAL BANK OF CANADA | 21,939 | 117,804 | +95,865 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 93,095 | +93,095 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 533,111 | 618,184 | +85,073 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 349,023 | 430,522 | +81,499 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 418,085 | 499,424 | +81,339 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 80,414 | +80,414 | 0.00 | 0.01 | +0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 72,455 | +72,455 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 212,185 | 278,430 | +66,245 | 0.31 | 0.44 | +0.13 | buy |
| ExodusPoint Capital Management, LP | 0 | 58,980 | +58,980 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 54,177 | +54,177 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 30,991 | 70,331 | +39,340 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 45,661 | 82,875 | +37,214 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 22,988 | 58,333 | +35,345 | 0.08 | 0.22 | +0.14 | buy |
| Bank of New York Mellon Corp | 131,994 | 164,292 | +32,298 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 44,620 | 76,660 | +32,040 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 62,926 | 92,501 | +29,575 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 50,810 | 79,929 | +29,119 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 58,055 | 86,027 | +27,972 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,815 | 28,241 | +26,426 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 6,741,172 | 6,764,172 | +23,000 | 1.17 | 1.23 | +0.06 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 22,133 | +22,133 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 15,698 | 37,633 | +21,935 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 22,933 | 43,606 | +20,673 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 17,675 | 37,620 | +19,945 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 19,521 | +19,521 | 0.00 | 0.00 | +0.00 | buy |
| TITLEIST ASSET MANAGEMENT, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 23,239 | 38,215 | +14,976 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 24,312 | 38,609 | +14,297 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 18,915 | 32,390 | +13,475 | 0.02 | 0.02 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 12,940 | +12,940 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 12,756 | +12,756 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,536 | 29,861 | +12,325 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 55,959 | 66,645 | +10,686 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,296 | 22,442 | +7,146 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 138,000 | 144,400 | +6,400 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 8,054 | 14,195 | +6,141 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 242,486 | 248,542 | +6,056 | 0.04 | 0.04 | +0.00 | buy |
| Farther Finance Advisors, LLC | 973 | 6,839 | +5,866 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 5,118 | +5,118 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 5,000 | 10,000 | +5,000 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,779 | 16,580 | +4,801 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 3,215 | +3,215 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 153,104 | 155,840 | +2,736 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,394 | 8,004 | +2,610 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,197 | 14,766 | +2,569 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 12,199 | 14,699 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,912 | 6,080 | +2,168 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 4,180 | 6,202 | +2,022 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,005 | 5,422 | +1,417 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 555 | 1,608 | +1,053 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,064 | 3,716 | +652 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 225 | +205 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,484 | 2,643 | +159 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 35 | 51 | +16 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 9 | 13 | +4 | 0.00 | 0.00 | +0.00 | buy |
| SWAN Capital LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BVF INC/IL | 5,295,893 | 5,295,893 | 0 | 0.81 | 0.81 | -0.01 | hold |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | 50,000 | 0 | 0.06 | 0.07 | +0.01 | hold |
| J. Goldman & Co LP | 13,500 | 13,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 224 | 224 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 1,505,862 | 1,505,862 | 0 | 0.75 | 0.66 | -0.09 | hold |
| Lightspeed Management Company, L.L.C. | 1,930,894 | 1,930,894 | 0 | 5.32 | 3.44 | -1.87 | hold |
| Bain Capital Life Sciences Investors, LLC | 6,843,954 | 6,843,954 | 0 | 3.81 | 3.65 | -0.16 | hold |
| Truvestments Capital LLC | 838 | 838 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 2.14 | 1.83 | -0.32 | hold |
| Physician Wealth Advisors, Inc. | 236 | 236 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLFF WIESE MAGANA LLC | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Deep Track Capital, LP | 3,442,833 | 3,442,833 | 0 | 0.42 | 0.47 | +0.05 | hold |
| AlphaQuest LLC | 898 | 898 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pictet Asset Management Holding SA | 1,879,013 | 1,879,013 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONWAY CAPITAL MANAGEMENT, INC. | 10,000 | 10,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,422 | 1,422 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 3,011,969 | 3,011,969 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,868 | 8,868 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,411 | 1,411 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 17 | 16 | -1 | 0.00 | 0.00 | 0.00 | sell |
| True Wealth Design, LLC | 41 | 9 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 850,517 | 850,454 | -63 | 0.02 | 0.02 | +0.00 | sell |
| First Horizon Advisors, Inc. | 87 | 0 | -87 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 54,329 | 54,110 | -219 | 0.00 | 0.00 | +0.00 | sell |