| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,386,845 | 12,143,062 | +1,756,217 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.28 | +0.28 | buy |
| FRANKLIN RESOURCES INC | 1,218,957 | 2,349,586 | +1,130,629 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 5,652,135 | 6,714,691 | +1,062,556 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 71,107 | 1,070,949 | +999,842 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 57,362 | 840,646 | +783,284 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 8,020,576 | 8,670,576 | +650,000 | 2.44 | 2.03 | -0.41 | buy |
| MORGAN STANLEY | 1,215,690 | 1,832,269 | +616,579 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 593,829 | +593,829 | 0.00 | 0.30 | +0.30 | buy |
| GOLDMAN SACHS GROUP INC | 1,045,589 | 1,567,979 | +522,390 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 518,342 | +518,342 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 154,770 | 566,400 | +411,630 | 0.01 | 0.03 | +0.02 | buy |
| STATE STREET CORP | 3,937,831 | 4,316,058 | +378,227 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 312,812 | 663,319 | +350,507 | 0.01 | 0.01 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 855,000 | 1,200,000 | +345,000 | 2.13 | 2.02 | -0.11 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,082,434 | 1,416,533 | +334,099 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,544,417 | 1,819,029 | +274,612 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 114,192 | +114,192 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 569,956 | 674,945 | +104,989 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 4,756,949 | 4,856,949 | +100,000 | 1.97 | 1.23 | -0.73 | buy |
| CITIGROUP INC | 27,578 | 125,561 | +97,983 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 136,108 | 220,699 | +84,591 | 0.33 | 0.37 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 0 | 70,142 | +70,142 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 170,378 | 235,178 | +64,800 | 0.15 | 0.14 | -0.01 | buy |
| FEDERATED HERMES, INC. | 14,086 | 77,266 | +63,180 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,703 | 133,155 | +60,452 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 55,121 | +55,121 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 466,546 | 518,342 | +51,796 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 35,880 | 80,928 | +45,048 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 57,840 | 102,670 | +44,830 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 117,601 | 160,167 | +42,566 | 0.48 | 0.46 | -0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 113,842 | 147,669 | +33,827 | 0.03 | 0.03 | +0.00 | buy |
| Russell Investments Group, Ltd. | 6,579 | 39,237 | +32,658 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 74,600 | 105,000 | +30,400 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 193,483 | 222,177 | +28,694 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 27,885 | +27,885 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,250 | 33,150 | +24,900 | 0.03 | 0.10 | +0.06 | buy |
| ALPS ADVISORS INC | 64,035 | 88,649 | +24,614 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 25,025 | 49,136 | +24,111 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 22,100 | +22,100 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 46,433 | 67,667 | +21,234 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,079 | 58,536 | +19,457 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 19,324 | +19,324 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 17,600 | +17,600 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 39,230 | 55,519 | +16,289 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,305 | 26,603 | +15,298 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 84,350 | 99,530 | +15,180 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 14,454 | +14,454 | 0.00 | 0.04 | +0.04 | buy |
| Aristotle Atlantic Partners, LLC | 24,953 | 36,509 | +11,556 | 0.02 | 0.02 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 11,500 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 654 | 11,834 | +11,180 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 13,998 | 22,366 | +8,368 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,868 | 27,168 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 38,520 | 46,500 | +7,980 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 6,116 | +6,116 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 31,665 | 37,540 | +5,875 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 10,368 | 14,430 | +4,062 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 19,191 | 23,213 | +4,022 | 0.00 | 0.00 | -0.00 | buy |
| DRW Securities, LLC | 13,376 | 17,396 | +4,020 | 0.01 | 0.01 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 12,901 | 16,909 | +4,008 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 7,000 | 11,000 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 8,300 | 11,900 | +3,600 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 3,295 | +3,295 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,074 | 44,871 | +2,797 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 10,500 | 12,800 | +2,300 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 57,405 | 58,941 | +1,536 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 1,445 | +1,445 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,716 | 7,115 | +1,399 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,261 | +1,261 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 2,455 | 3,275 | +820 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 550 | +550 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 142,762 | 143,279 | +517 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 79,243 | 79,759 | +516 | 0.08 | 0.03 | -0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 121,494 | 121,927 | +433 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 273 | 559 | +286 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 365 | 485 | +120 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 20,600 | 20,700 | +100 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 654 | 736 | +82 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 225 | 280 | +55 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 55 | 103 | +48 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 26 | +26 | 0.00 | 0.00 | 0.00 | buy |
| US BANCORP \DE\ | 511 | 530 | +19 | 0.00 | 0.00 | -0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 10 | 26 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 5 | 19 | +14 | 0.00 | 0.00 | 0.00 | buy |
| GAMMA Investing LLC | 588 | 596 | +8 | 0.00 | 0.00 | -0.00 | buy |
| TORONTO DOMINION BANK | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 106,214 | 106,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,295,893 | 5,295,893 | 0 | 2.52 | 1.69 | -0.82 | hold |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | 50,000 | 0 | 0.24 | 0.17 | -0.06 | hold |
| Duquesne Family Office LLC | 986,827 | 986,827 | 0 | 0.50 | 0.28 | -0.22 | hold |
| Hurley Capital, LLC | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wealthspire Advisors, LLC | 10,172 | 10,172 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 671,843 | 671,843 | 0 | 0.83 | 0.77 | -0.07 | hold |
| Lightspeed Management Company, L.L.C. | 1,355,299 | 1,355,299 | 0 | 2.05 | 0.71 | -1.34 | hold |
| Truvestments Capital LLC | 838 | 838 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Inscription Capital, LLC | 15,273 | 15,273 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 2.46 | 1.73 | -0.74 | hold |
| Physician Wealth Advisors, Inc. | 391 | 391 | 0 | 0.00 | 0.00 | -0.00 | hold |