| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,386,845 | 12,143,062 | +1,756,217 | 0.01 | 0.01 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 8,020,576 | 8,670,576 | +650,000 | 2.44 | 2.03 | -0.41 | buy |
| Bain Capital Life Sciences Investors, LLC | 7,473,238 | 7,085,249 | -387,989 | 10.05 | 5.27 | -4.78 | sell |
| BlackRock, Inc. | 5,652,135 | 6,714,691 | +1,062,556 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 5,295,893 | 5,295,893 | 0 | 2.52 | 1.69 | -0.82 | hold |
| Siren, L.L.C. | 4,756,949 | 4,856,949 | +100,000 | 1.97 | 1.23 | -0.73 | buy |
| STATE STREET CORP | 3,937,831 | 4,316,058 | +378,227 | 0.00 | 0.00 | -0.00 | buy |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 2.46 | 1.73 | -0.74 | hold |
| FRANKLIN RESOURCES INC | 1,218,957 | 2,349,586 | +1,130,629 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 3,900,000 | 2,150,000 | -1,750,000 | 2.93 | 1.38 | -1.55 | sell |
| MORGAN STANLEY | 1,215,690 | 1,832,269 | +616,579 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,544,417 | 1,819,029 | +274,612 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,045,589 | 1,567,979 | +522,390 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.28 | +0.28 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,082,434 | 1,416,533 | +334,099 | 0.00 | 0.00 | -0.00 | buy |
| Lightspeed Management Company, L.L.C. | 1,355,299 | 1,355,299 | 0 | 2.05 | 0.71 | -1.34 | hold |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 855,000 | 1,200,000 | +345,000 | 2.13 | 2.02 | -0.11 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,169,421 | 1,131,434 | -37,987 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 71,107 | 1,070,949 | +999,842 | 0.00 | 0.02 | +0.02 | buy |
| Duquesne Family Office LLC | 986,827 | 986,827 | 0 | 0.50 | 0.28 | -0.22 | hold |
| AMERIPRISE FINANCIAL INC | 57,362 | 840,646 | +783,284 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,182,836 | 826,569 | -356,267 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 759,513 | 751,133 | -8,380 | 0.06 | 0.04 | -0.02 | sell |
| Woodline Partners LP | 1,482,030 | 751,030 | -731,000 | 0.08 | 0.03 | -0.05 | sell |
| NORTHERN TRUST CORP | 569,956 | 674,945 | +104,989 | 0.00 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 671,843 | 671,843 | 0 | 0.83 | 0.77 | -0.07 | hold |
| Qube Research & Technologies Ltd | 312,812 | 663,319 | +350,507 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 905,332 | 641,828 | -263,504 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 738,552 | 615,470 | -123,082 | 0.02 | 0.01 | -0.01 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 593,829 | +593,829 | 0.00 | 0.30 | +0.30 | buy |
| Hudson Bay Capital Management LP | 154,770 | 566,400 | +411,630 | 0.01 | 0.03 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 664,679 | 526,446 | -138,233 | 0.00 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 518,342 | +518,342 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 466,546 | 518,342 | +51,796 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 481,485 | 420,211 | -61,274 | 0.24 | 0.15 | -0.09 | sell |
| Vestal Point Capital, LP | 428,551 | 418,551 | -10,000 | 0.18 | 0.12 | -0.06 | sell |
| Ikarian Capital, LLC | 598,281 | 383,281 | -215,000 | 1.28 | 0.78 | -0.49 | sell |
| BANK OF AMERICA CORP /DE/ | 508,706 | 334,875 | -173,831 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 299,756 | 296,724 | -3,032 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 170,378 | 235,178 | +64,800 | 0.15 | 0.14 | -0.01 | buy |
| UBS Group AG | 385,061 | 222,873 | -162,188 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 193,483 | 222,177 | +28,694 | 0.00 | 0.00 | -0.00 | buy |
| Pier Capital, LLC | 136,108 | 220,699 | +84,591 | 0.33 | 0.37 | +0.03 | buy |
| Birchview Capital, LP | 219,000 | 199,000 | -20,000 | 1.86 | 1.16 | -0.69 | sell |
| Jump Financial, LLC | 452,966 | 181,672 | -271,294 | 0.10 | 0.02 | -0.08 | sell |
| Nuveen, LLC | 278,990 | 161,090 | -117,900 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 117,601 | 160,167 | +42,566 | 0.48 | 0.46 | -0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 113,842 | 147,669 | +33,827 | 0.03 | 0.03 | +0.00 | buy |
| JPMORGAN CHASE & CO | 142,762 | 143,279 | +517 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 174,603 | 142,610 | -31,993 | 0.06 | 0.03 | -0.03 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,703 | 133,155 | +60,452 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 27,578 | 125,561 | +97,983 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 285,882 | 124,952 | -160,930 | 0.01 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 121,494 | 121,927 | +433 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 130,933 | 117,412 | -13,521 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 114,192 | +114,192 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 106,214 | 106,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 74,600 | 105,000 | +30,400 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 57,840 | 102,670 | +44,830 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 150,000 | 100,000 | -50,000 | 0.12 | 0.05 | -0.07 | sell |
| RHUMBLINE ADVISERS | 84,350 | 99,530 | +15,180 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 161,396 | 95,834 | -65,562 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 325,173 | 92,412 | -232,761 | 0.04 | 0.01 | -0.03 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 109,582 | 89,990 | -19,592 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 123,218 | 89,525 | -33,693 | 0.03 | 0.01 | -0.02 | sell |
| ALPS ADVISORS INC | 64,035 | 88,649 | +24,614 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 203,959 | 82,030 | -121,929 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 35,880 | 80,928 | +45,048 | 0.01 | 0.01 | +0.00 | buy |
| Tidal Investments LLC | 85,151 | 79,759 | -5,392 | 0.00 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 79,243 | 79,759 | +516 | 0.08 | 0.03 | -0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 89,562 | 78,161 | -11,401 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 14,086 | 77,266 | +63,180 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 131,520 | 75,522 | -55,998 | 0.01 | 0.00 | -0.01 | sell |
| Creative Planning | 72,234 | 70,263 | -1,971 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 70,142 | +70,142 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 46,433 | 67,667 | +21,234 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 70,711 | 66,163 | -4,548 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 110,150 | 60,060 | -50,090 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 57,405 | 58,941 | +1,536 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,079 | 58,536 | +19,457 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 95,336 | 55,879 | -39,457 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 39,230 | 55,519 | +16,289 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 55,121 | +55,121 | 0.00 | 0.01 | +0.01 | buy |
| Swedbank AB | 55,100 | 55,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 70,471 | 53,554 | -16,917 | 0.01 | 0.01 | -0.00 | sell |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | 50,000 | 0 | 0.24 | 0.17 | -0.06 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 25,025 | 49,136 | +24,111 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 38,520 | 46,500 | +7,980 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 47,012 | 45,211 | -1,801 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,074 | 44,871 | +2,797 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 59,374 | 41,242 | -18,132 | 0.10 | 0.05 | -0.05 | sell |
| Russell Investments Group, Ltd. | 6,579 | 39,237 | +32,658 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 58,577 | 38,359 | -20,218 | 0.03 | 0.01 | -0.02 | sell |
| Legal & General Group Plc | 31,665 | 37,540 | +5,875 | 0.00 | 0.00 | -0.00 | buy |
| Aristotle Atlantic Partners, LLC | 24,953 | 36,509 | +11,556 | 0.02 | 0.02 | +0.00 | buy |
| NOMURA HOLDINGS INC | 41,960 | 33,856 | -8,104 | 0.01 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 8,250 | 33,150 | +24,900 | 0.03 | 0.10 | +0.06 | buy |
| SG Americas Securities, LLC | 0 | 27,885 | +27,885 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,868 | 27,168 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,305 | 26,603 | +15,298 | 0.00 | 0.00 | +0.00 | buy |