| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 3,731,046 | 7,803,600 | +4,072,554 | 2.73 | 6.57 | +3.85 | buy |
| BVF INC/IL | 7,611,503 | 9,135,893 | +1,524,390 | 1.92 | 3.04 | +1.13 | buy |
| Cormorant Asset Management, LP | 3,082,000 | 4,504,764 | +1,422,764 | 1.59 | 3.25 | +1.66 | buy |
| MPM BioImpact LLC | 462,500 | 1,857,681 | +1,395,181 | 0.84 | 6.12 | +5.28 | buy |
| Vivo Capital, LLC | 1,339,271 | 1,873,704 | +534,433 | 0.83 | 2.54 | +1.70 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 74,919 | 244,472 | +169,553 | 0.00 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 231,433 | 388,982 | +157,549 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 588,052 | 717,332 | +129,280 | 0.06 | 0.10 | +0.04 | buy |
| Informed Momentum Co LLC | 169,730 | 243,290 | +73,560 | 0.28 | 0.58 | +0.30 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 105,814 | 153,007 | +47,193 | 0.65 | 1.37 | +0.73 | buy |
| GSA CAPITAL PARTNERS LLP | 101,840 | 59,773 | +42,067 | 0.10 | 0.07 | 0.00 | sell |
| EP Wealth Advisors, LLC | 4,967 | 46,248 | +41,281 | 0.01 | 0.01 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,687 | 86,487 | +29,200 | 0.03 | 0.03 | 0.00 | sell |
| Altium Capital Management LLC | 310,000 | 335,000 | +25,000 | 2.19 | 2.39 | +0.21 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 390,466 | 407,801 | +17,335 | 1.19 | 1.88 | +0.69 | buy |
| ALGERT GLOBAL LLC | 58,090 | 47,630 | +10,460 | 0.02 | 0.03 | 0.00 | sell |
| Dorsey Wright & Associates | 2,957 | 2,858 | -99 | 0.01 | 0.01 | +0.00 | sell |
| Newtyn Management, LLC | 175,000 | 150,000 | -25,000 | 0.37 | 0.46 | +0.08 | sell |
| HighVista Strategies LLC | 292,276 | 247,880 | -44,396 | 1.21 | 1.42 | +0.21 | sell |
| J. Goldman & Co LP | 108,390 | 31,332 | -77,058 | 0.06 | 0.02 | -0.04 | sell |
| Aquilo Capital Management, LLC | 250,000 | 88,875 | -161,125 | 1.48 | 0.99 | -0.49 | sell |
| SECTORAL ASSET MANAGEMENT INC | 648,353 | 437,652 | -210,701 | 0.98 | 1.05 | +0.08 | sell |
| Kynam Capital Management, LP | 1,304,332 | 235,176 | -1,069,156 | 1.81 | 0.48 | -1.32 | sell |