| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 852,554 | 1,354,186 | +501,632 | 0.09 | 0.14 | +0.05 | buy |
| Candriam S.C.A. | 1,058,673 | 1,506,764 | +448,091 | 0.07 | 0.10 | +0.03 | buy |
| GREAT POINT PARTNERS LLC | 796,880 | 1,000,000 | +203,120 | 1.65 | 3.51 | +1.86 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 325,000 | 400,000 | +75,000 | 0.01 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 87,312 | 117,595 | +30,283 | 0.05 | 0.07 | +0.02 | buy |
| MPM BioImpact LLC | 2,654,867 | 2,680,596 | +25,729 | 4.46 | 4.80 | +0.34 | buy |
| Dana Investment Advisors, Inc. | 74,657 | 85,807 | +11,150 | 0.03 | 0.03 | +0.01 | buy |
| Corton Capital Inc. | 14,377 | 19,146 | +4,769 | 0.08 | 0.11 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 6,572 | 11,014 | +4,442 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 43,652 | 45,691 | +2,039 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 31,405 | 33,296 | +1,891 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,265 | 7,394 | +129 | 0.04 | 0.04 | +0.00 | buy |
| PITCAIRN CO | 27,013 | 24,546 | -2,467 | 0.02 | 0.02 | -0.00 | sell |
| Rafferty Asset Management, LLC | 102,006 | 90,475 | -11,531 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 87,397 | 74,919 | -12,478 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 247,880 | 212,185 | -35,695 | 0.98 | 0.87 | -0.11 | sell |
| SECTORAL ASSET MANAGEMENT INC | 118,480 | 65,980 | -52,500 | 0.52 | 0.47 | -0.06 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 546,863 | 455,082 | -91,781 | 1.46 | 1.22 | -0.24 | sell |
| Soleus Capital Management, L.P. | 216,500 | 103,500 | -113,000 | 0.21 | 0.10 | -0.10 | sell |
| Vivo Capital, LLC | 1,873,704 | 1,505,862 | -367,842 | 1.87 | 1.49 | -0.38 | sell |
| Paradigm Biocapital Advisors LP | 7,903,600 | 5,503,600 | -2,400,000 | 3.27 | 2.30 | -0.97 | sell |