| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 9,135,893 | 9,135,893 | 0 | 2.77 | 3.19 | +0.42 | hold |
| Paradigm Biocapital Advisors LP | 7,903,600 | 5,503,600 | -2,400,000 | 3.27 | 2.30 | -0.97 | sell |
| Deep Track Capital, LP | 4,000,000 | 4,000,000 | 0 | 1.29 | 1.52 | +0.23 | hold |
| Point72 Asset Management, L.P. | 3,211,927 | 3,687,374 | +475,447 | 0.11 | 0.15 | +0.04 | buy |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 4.00 | 4.29 | +0.29 | hold |
| MPM BioImpact LLC | 2,654,867 | 2,680,596 | +25,729 | 4.46 | 4.80 | +0.34 | buy |
| VANGUARD GROUP INC | 2,742,664 | 2,532,892 | -209,772 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,947,977 | 1,969,963 | +21,986 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 1,667,459 | +1,667,459 | 0.00 | 0.02 | +0.02 | buy |
| Candriam S.C.A. | 1,058,673 | 1,506,764 | +448,091 | 0.07 | 0.10 | +0.03 | buy |
| Vivo Capital, LLC | 1,873,704 | 1,505,862 | -367,842 | 1.87 | 1.49 | -0.38 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,684,924 | 1,376,924 | -308,000 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 852,554 | 1,354,186 | +501,632 | 0.09 | 0.14 | +0.05 | buy |
| CITADEL ADVISORS LLC | 132,253 | 1,252,745 | +1,120,492 | 0.00 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 905,257 | 1,002,685 | +97,428 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 796,880 | 1,000,000 | +203,120 | 1.65 | 3.60 | +1.95 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,060,099 | 934,929 | -125,170 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 774,792 | 851,512 | +76,720 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 709,097 | +709,097 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 441,066 | 463,124 | +22,058 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 401,105 | 462,347 | +61,242 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 116,926 | 461,926 | +345,000 | 0.01 | 0.04 | +0.03 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 546,863 | 455,082 | -91,781 | 1.46 | 1.22 | -0.24 | sell |
| BANK OF AMERICA CORP /DE/ | 133,395 | 410,939 | +277,544 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 325,000 | 400,000 | +75,000 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 344,082 | 389,734 | +45,652 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,196 | 330,761 | +207,565 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 335,571 | 249,601 | -85,970 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 588,996 | 240,387 | -348,609 | 0.01 | 0.00 | -0.01 | sell |
| HighVista Strategies LLC | 247,880 | 212,185 | -35,695 | 0.98 | 0.87 | -0.11 | sell |
| JPMORGAN CHASE & CO | 0 | 181,032 | +181,032 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 208,583 | 176,663 | -31,920 | 0.00 | 0.00 | -0.00 | sell |
| Newtyn Management, LLC | 140,000 | 140,000 | 0 | 0.28 | 0.26 | -0.03 | hold |
| Bank of New York Mellon Corp | 139,923 | 132,182 | -7,741 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 114,642 | 120,093 | +5,451 | 0.02 | 0.02 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 87,312 | 117,595 | +30,283 | 0.05 | 0.07 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 108,852 | +108,852 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 216,500 | 103,500 | -113,000 | 0.21 | 0.10 | -0.10 | sell |
| TWO SIGMA ADVISERS, LP | 129,500 | 101,200 | -28,300 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 182,120 | 100,047 | -82,073 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 46,301 | 94,915 | +48,614 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 92,000 | +92,000 | 0.00 | 0.34 | +0.34 | buy |
| Rafferty Asset Management, LLC | 102,006 | 90,475 | -11,531 | 0.00 | 0.00 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 74,657 | 85,807 | +11,150 | 0.03 | 0.03 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 159,739 | 82,187 | -77,552 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 78,060 | +78,060 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 158,625 | 77,547 | -81,078 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 83,590 | 75,974 | -7,616 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 87,397 | 74,919 | -12,478 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 69,841 | +69,841 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 66,000 | 66,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 118,480 | 65,980 | -52,500 | 0.52 | 0.47 | -0.06 | sell |
| Jump Financial, LLC | 30,592 | 63,041 | +32,449 | 0.01 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 59,261 | 57,861 | -1,400 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 31,472 | 52,218 | +20,746 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 49,220 | 49,786 | +566 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 46,248 | 48,655 | +2,407 | 0.01 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 52,661 | 47,706 | -4,955 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 66,138 | 46,268 | -19,870 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 43,652 | 45,691 | +2,039 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 39,727 | 34,544 | -5,183 | 0.20 | 0.23 | +0.03 | sell |
| J. Goldman & Co LP | 0 | 33,750 | +33,750 | 0.00 | 0.02 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 31,405 | 33,296 | +1,891 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,293 | 32,136 | -1,157 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,242 | 31,458 | +216 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 23,752 | 30,097 | +6,345 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 29,409 | 29,716 | +307 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 53,200 | 29,400 | -23,800 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 11,832 | 29,029 | +17,197 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 28,170 | +28,170 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 253,874 | 27,132 | -226,742 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 21,059 | 25,593 | +4,534 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,856 | 25,492 | +8,636 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 12,454 | 25,332 | +12,878 | 0.01 | 0.02 | +0.01 | buy |
| PITCAIRN CO | 27,013 | 24,546 | -2,467 | 0.02 | 0.02 | -0.00 | sell |
| MetLife Investment Management, LLC | 23,695 | 23,695 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROYAL BANK OF CANADA | 12,631 | 23,603 | +10,972 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 61,369 | 21,955 | -39,414 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 21,480 | 21,349 | -131 | 0.00 | 0.00 | +0.00 | sell |
| Dynamic Technology Lab Private Ltd | 0 | 19,894 | +19,894 | 0.00 | 0.03 | +0.03 | buy |
| Corton Capital Inc. | 14,377 | 19,146 | +4,769 | 0.08 | 0.11 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 14,849 | 18,849 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 18,908 | 17,947 | -961 | 0.01 | 0.01 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 56,000 | 17,800 | -38,200 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 17,600 | +17,600 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 16,310 | 16,767 | +457 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 57,070 | 15,969 | -41,101 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,888 | 15,461 | -427 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 15,482 | 15,155 | -327 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 15,081 | 15,081 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,686 | +13,686 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,056 | +13,056 | 0.00 | 0.00 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 0 | 12,000 | +12,000 | 0.00 | 0.05 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 6,572 | 11,014 | +4,442 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,928 | +10,928 | 0.00 | 0.00 | +0.00 | buy |
| CONWAY CAPITAL MANAGEMENT, INC. | 10,000 | 10,000 | 0 | 0.05 | 0.06 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,282 | 9,282 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,990 | 8,868 | -8,122 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 7,265 | 7,394 | +129 | 0.04 | 0.04 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,912 | 3,912 | 0 | 0.00 | 0.00 | +0.00 | hold |