| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 933,541 | +933,541 | 0.00 | 1.32 | +1.32 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 854,000 | +854,000 | 0.00 | 1.31 | +1.31 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 693,179 | +693,179 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 619,874 | +619,874 | 0.00 | 0.32 | +0.32 | buy |
| JANUS HENDERSON GROUP PLC | 3,022,784 | 3,585,849 | +563,065 | 0.01 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 850,454 | 1,249,727 | +399,273 | 0.02 | 0.06 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,585 | 299,619 | +293,034 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 245,418 | +245,418 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 278,430 | 437,179 | +158,749 | 0.44 | 1.05 | +0.61 | buy |
| BlackRock, Inc. | 4,605,109 | 4,726,394 | +121,285 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,437,407 | 1,555,887 | +118,480 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 724,582 | 803,881 | +79,299 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,756 | 58,995 | +46,239 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 79,929 | 124,634 | +44,705 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,051,967 | 1,093,574 | +41,607 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 40,330 | +40,330 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 134,000 | 174,000 | +40,000 | 0.57 | 1.29 | +0.72 | buy |
| ADAR1 Capital Management, LLC | 0 | 36,200 | +36,200 | 0.00 | 0.04 | +0.04 | buy |
| Creative Planning | 19,521 | 55,310 | +35,789 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 58,800 | 90,100 | +31,300 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 117,804 | 148,337 | +30,533 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 66,645 | 96,675 | +30,030 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 6,764,172 | 6,794,172 | +30,000 | 1.23 | 1.97 | +0.74 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 29,048 | +29,048 | 0.00 | 0.02 | +0.02 | buy |
| Deep Track Capital, LP | 3,442,833 | 3,470,172 | +27,339 | 0.47 | 0.95 | +0.48 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 27,334 | +27,334 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 25,692 | +25,692 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 70,000 | +20,000 | 0.01 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,095 | 112,277 | +19,182 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 18,751 | +18,751 | 0.00 | 0.04 | +0.04 | buy |
| ZACKS INVESTMENT MANAGEMENT | 12,940 | 30,803 | +17,863 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 92,501 | 109,526 | +17,025 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 16,291 | +16,291 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 32,390 | 45,842 | +13,452 | 0.02 | 0.02 | +0.00 | buy |
| Sender Co & Partners, Inc. | 0 | 10,793 | +10,793 | 0.00 | 0.04 | +0.04 | buy |
| Corient Private Wealth LLC | 0 | 10,299 | +10,299 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,215 | 45,661 | +7,446 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 54,110 | 61,092 | +6,982 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 5,399 | +5,399 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 164,292 | 169,197 | +4,905 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 23,161 | 28,026 | +4,865 | 0.03 | 0.08 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 799,502 | 802,304 | +2,802 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,608 | 4,109 | +2,501 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 14,195 | 16,640 | +2,445 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,861 | 31,781 | +1,920 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 28,241 | 29,422 | +1,181 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 935 | 1,423 | +488 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 466 | +466 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 404 | +404 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 236 | +236 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 231 | +231 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 5,118 | 5,275 | +157 | 0.00 | 0.01 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 236 | 391 | +155 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 6,202 | 6,313 | +111 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,215 | 3,287 | +72 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,422 | 1,477 | +55 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 9 | 61 | +52 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,716 | 3,728 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,643 | 2,653 | +10 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BVF INC/IL | 5,295,893 | 5,295,893 | 0 | 0.81 | 2.10 | +1.30 | hold |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | 50,000 | 0 | 0.07 | 0.13 | +0.07 | hold |
| ALLIANCEBERNSTEIN L.P. | 76,660 | 76,660 | 0 | 0.00 | 0.00 | +0.00 | hold |
| J. Goldman & Co LP | 13,500 | 13,500 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Parkside Financial Bank & Trust | 135 | 135 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 224 | 224 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 37,620 | 37,620 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 1,505,862 | 1,505,862 | 0 | 0.66 | 1.19 | +0.53 | hold |
| Lightspeed Management Company, L.L.C. | 1,930,894 | 1,930,894 | 0 | 3.44 | 5.87 | +2.43 | hold |
| Bain Capital Life Sciences Investors, LLC | 6,843,954 | 6,843,954 | 0 | 3.65 | 4.45 | +0.80 | hold |
| EverSource Wealth Advisors, LLC | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 838 | 838 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.16 | 0.23 | +0.07 | hold |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 1.83 | 3.10 | +1.28 | hold |
| WOLFF WIESE MAGANA LLC | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 51 | 51 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 128,220 | 128,220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AlphaQuest LLC | 898 | 898 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 16 | 16 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TITLEIST ASSET MANAGEMENT, LLC | 15,000 | 15,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Federation des caisses Desjardins du Quebec | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONWAY CAPITAL MANAGEMENT, INC. | 10,000 | 10,000 | 0 | 0.02 | 0.04 | +0.02 | hold |
| FRANKLIN RESOURCES INC | 3,011,969 | 3,011,969 | 0 | 0.00 | 0.01 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 5,422 | 5,422 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,868 | 8,868 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 225 | 225 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,411 | 1,411 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SWAN Capital LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 30 | 0 | -30 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 88,450 | 88,150 | -300 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 6,080 | 4,975 | -1,105 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 82,875 | 81,181 | -1,694 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,742 | 12,031 | -1,711 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 86,027 | 84,289 | -1,738 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,442 | 20,541 | -1,901 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 14,766 | 12,627 | -2,139 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 32,479 | 30,131 | -2,348 | 0.00 | 0.00 | +0.00 | sell |