| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 6,843,954 | 6,843,954 | 0 | 3.65 | 4.45 | +0.80 | hold |
| Paradigm Biocapital Advisors LP | 6,764,172 | 6,794,172 | +30,000 | 1.23 | 1.97 | +0.74 | buy |
| BVF INC/IL | 5,295,893 | 5,295,893 | 0 | 0.81 | 2.10 | +1.30 | hold |
| BlackRock, Inc. | 4,605,109 | 4,726,394 | +121,285 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 3,022,784 | 3,585,849 | +563,065 | 0.01 | 0.02 | +0.01 | buy |
| Deep Track Capital, LP | 3,442,833 | 3,470,172 | +27,339 | 0.47 | 0.95 | +0.48 | buy |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 1.83 | 3.10 | +1.28 | hold |
| VANGUARD GROUP INC | 3,266,999 | 3,197,320 | -69,679 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 3,011,969 | 3,011,969 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Woodline Partners LP | 3,505,893 | 2,217,893 | -1,288,000 | 0.08 | 0.10 | +0.02 | sell |
| Lightspeed Management Company, L.L.C. | 1,930,894 | 1,930,894 | 0 | 3.44 | 5.87 | +2.43 | hold |
| Pictet Asset Management Holding SA | 1,879,013 | 1,636,372 | -242,641 | 0.01 | 0.02 | +0.01 | sell |
| MORGAN STANLEY | 1,437,407 | 1,555,887 | +118,480 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 1,505,862 | 1,505,862 | 0 | 0.66 | 1.19 | +0.53 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,326,123 | 1,276,005 | -50,118 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 850,454 | 1,249,727 | +399,273 | 0.02 | 0.06 | +0.04 | buy |
| CITADEL ADVISORS LLC | 1,708,134 | 1,236,915 | -471,219 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 1,412,099 | 1,190,654 | -221,445 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 1,172,863 | 1,147,068 | -25,795 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 1,051,967 | 1,093,574 | +41,607 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,207,150 | 1,064,549 | -142,601 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 933,541 | +933,541 | 0.00 | 1.32 | +1.32 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 854,000 | +854,000 | 0.00 | 1.31 | +1.31 | buy |
| GOLDMAN SACHS GROUP INC | 724,582 | 803,881 | +79,299 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 799,502 | 802,304 | +2,802 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 693,179 | +693,179 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 619,874 | +619,874 | 0.00 | 0.32 | +0.32 | buy |
| Pier Capital, LLC | 771,072 | 524,249 | -246,823 | 0.50 | 0.80 | +0.30 | sell |
| NORTHERN TRUST CORP | 499,424 | 483,032 | -16,392 | 0.00 | 0.00 | +0.00 | sell |
| HighVista Strategies LLC | 278,430 | 437,179 | +158,749 | 0.44 | 1.05 | +0.61 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 430,522 | 395,127 | -35,395 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,271,090 | 331,454 | -939,636 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,585 | 299,619 | +293,034 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.16 | 0.23 | +0.07 | hold |
| Point72 Asset Management, L.P. | 0 | 245,418 | +245,418 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 248,542 | 244,076 | -4,466 | 0.04 | 0.09 | +0.04 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 228,021 | 204,207 | -23,814 | 0.00 | 0.00 | +0.00 | sell |
| Birchview Capital, LP | 134,000 | 174,000 | +40,000 | 0.57 | 1.29 | +0.72 | buy |
| Bank of New York Mellon Corp | 164,292 | 169,197 | +4,905 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 117,804 | 148,337 | +30,533 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 128,220 | 128,220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 79,929 | 124,634 | +44,705 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 130,342 | 121,342 | -9,000 | 0.01 | 0.02 | +0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,095 | 112,277 | +19,182 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 92,501 | 109,526 | +17,025 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 155,840 | 104,624 | -51,216 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 66,645 | 96,675 | +30,030 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 113,492 | 94,883 | -18,609 | 0.01 | 0.04 | +0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 58,800 | 90,100 | +31,300 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 88,450 | 88,150 | -300 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 86,027 | 84,289 | -1,738 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 82,875 | 81,181 | -1,694 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 76,660 | 76,660 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 70,000 | +20,000 | 0.01 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 54,110 | 61,092 | +6,982 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 12,756 | 58,995 | +46,239 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 19,521 | 55,310 | +35,789 | 0.00 | 0.00 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | 50,000 | 0 | 0.07 | 0.13 | +0.07 | hold |
| Brooklyn Investment Group | 32,390 | 45,842 | +13,452 | 0.02 | 0.02 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,215 | 45,661 | +7,446 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 40,330 | +40,330 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 37,620 | 37,620 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 0 | 36,200 | +36,200 | 0.00 | 0.04 | +0.04 | buy |
| HSBC HOLDINGS PLC | 37,633 | 35,179 | -2,454 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 36,910 | 32,510 | -4,400 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,861 | 31,781 | +1,920 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 12,940 | 30,803 | +17,863 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 32,479 | 30,131 | -2,348 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 28,241 | 29,422 | +1,181 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 29,048 | +29,048 | 0.00 | 0.02 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 23,161 | 28,026 | +4,865 | 0.03 | 0.08 | +0.05 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 27,334 | +27,334 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 25,692 | +25,692 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 144,400 | 21,100 | -123,300 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,442 | 20,541 | -1,901 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 70,331 | 20,446 | -49,885 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 0 | 18,751 | +18,751 | 0.00 | 0.04 | +0.04 | buy |
| Police & Firemen's Retirement System of New Jersey | 14,195 | 16,640 | +2,445 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 16,291 | +16,291 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 28,337 | 15,301 | -13,036 | 0.01 | 0.01 | +0.00 | sell |
| TITLEIST ASSET MANAGEMENT, LLC | 15,000 | 15,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Squarepoint Ops LLC | 43,606 | 14,091 | -29,515 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 38,609 | 13,567 | -25,042 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 13,500 | 13,500 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ProShare Advisors LLC | 14,766 | 12,627 | -2,139 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,742 | 12,031 | -1,711 | 0.01 | 0.01 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 16,580 | 11,082 | -5,498 | 0.00 | 0.00 | +0.00 | sell |
| Sender Co & Partners, Inc. | 0 | 10,793 | +10,793 | 0.00 | 0.04 | +0.04 | buy |
| Corient Private Wealth LLC | 0 | 10,299 | +10,299 | 0.00 | 0.00 | +0.00 | buy |
| CONWAY CAPITAL MANAGEMENT, INC. | 10,000 | 10,000 | 0 | 0.02 | 0.04 | +0.02 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,868 | 8,868 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 6,202 | 6,313 | +111 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,422 | 5,422 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 0 | 5,399 | +5,399 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 5,118 | 5,275 | +157 | 0.00 | 0.01 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,080 | 4,975 | -1,105 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 1,608 | 4,109 | +2,501 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,716 | 3,728 | +12 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3,215 | 3,287 | +72 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,643 | 2,653 | +10 | 0.00 | 0.00 | +0.00 | buy |