| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 1,710,307 | 2,705,895 | +995,588 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 700,100 | +700,100 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 659,035 | +659,035 | 0.00 | 5.51 | +5.51 | buy |
| Logos Global Management LP | 3,743,875 | 4,383,875 | +640,000 | 6.60 | 6.05 | -0.55 | buy |
| First Light Asset Management, LLC | 0 | 631,064 | +631,064 | 0.00 | 0.71 | +0.71 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 63,450 | 621,527 | +558,077 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 539,831 | +539,831 | 0.00 | 0.17 | +0.17 | buy |
| MORGAN STANLEY | 0 | 497,844 | +497,844 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,518 | 248,661 | +234,143 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 93,935 | 315,478 | +221,543 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 215,008 | +215,008 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 86,734 | 290,721 | +203,987 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 655,754 | 824,833 | +169,079 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 407,801 | 573,830 | +166,029 | 1.88 | 2.48 | +0.61 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,993 | 151,867 | +116,874 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 559,117 | 673,170 | +114,053 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 388,982 | 500,000 | +111,018 | 0.01 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 7,803,600 | 7,903,600 | +100,000 | 6.57 | 5.20 | -1.38 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 210,000 | 300,000 | +90,000 | 0.47 | 0.80 | +0.33 | buy |
| Altium Capital Management LLC | 335,000 | 413,607 | +78,607 | 2.39 | 4.00 | +1.61 | buy |
| Swiss National Bank | 0 | 64,600 | +64,600 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 62,500 | +62,500 | 0.00 | 0.01 | +0.01 | buy |
| Atom Investors LP | 0 | 58,870 | +58,870 | 0.00 | 0.15 | +0.15 | buy |
| NORTHERN TRUST CORP | 301,325 | 352,818 | +51,493 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 45,757 | +45,757 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 39,584 | +39,584 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 4,657 | 43,396 | +38,739 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 14,003 | 52,498 | +38,495 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 38,163 | +38,163 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 36,150 | +36,150 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 35,989 | +35,989 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 131,842 | 165,709 | +33,867 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 717,332 | 750,279 | +32,947 | 0.10 | 0.11 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,924 | 33,563 | +27,639 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 27,462 | +27,462 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 26,904 | +26,904 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 25,913 | +25,913 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,427 | 24,533 | +22,106 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,694,000 | 1,715,420 | +21,420 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 21,378 | +21,378 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 19,866 | +19,866 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 31,332 | 50,766 | +19,434 | 0.02 | 0.04 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 0 | 18,651 | +18,651 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,299 | 45,209 | +15,910 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 11,889 | +11,889 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,319 | +11,319 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 18,373 | 28,576 | +10,203 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,152 | 10,522 | +9,370 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 9,282 | +9,282 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,952 | 89,210 | +9,258 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 91,807 | 101,042 | +9,235 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 7,515 | +7,515 | 0.00 | 0.07 | +0.07 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 6,341 | +6,341 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,900 | 15,860 | +4,960 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15 | 4,807 | +4,792 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 11,495 | 15,874 | +4,379 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 37,840 | 40,176 | +2,336 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 37,883 | 40,110 | +2,227 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,725 | 8,458 | +1,733 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 14,584 | 15,951 | +1,367 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,053 | 10,781 | +728 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 99,121 | 99,413 | +292 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,843 | 11,101 | +258 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 224 | +224 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 143 | +143 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,217 | 2,217 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 9,135,893 | 9,135,893 | 0 | 3.04 | 3.21 | +0.17 | hold |
| HighVista Strategies LLC | 247,880 | 247,880 | 0 | 1.42 | 1.26 | -0.15 | hold |
| MetLife Investment Management, LLC | 14,905 | 14,905 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 1,020 | 1,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EP Wealth Advisors, LLC | 46,248 | 46,248 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Newtyn Management, LLC | 150,000 | 150,000 | 0 | 0.46 | 0.41 | -0.04 | hold |
| VR Adviser, LLC | 77,042 | 77,042 | 0 | 0.10 | 0.07 | -0.03 | hold |
| Vivo Capital, LLC | 1,873,704 | 1,873,704 | 0 | 2.54 | 2.15 | -0.38 | hold |
| Truvestments Capital LLC | 1,323 | 1,323 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Polar Capital Holdings Plc | 750,000 | 750,000 | 0 | 0.07 | 0.06 | -0.00 | hold |
| Deep Track Capital, LP | 1,930,894 | 1,930,894 | 0 | 0.92 | 0.95 | +0.02 | hold |
| CONWAY CAPITAL MANAGEMENT, INC. | 26,500 | 26,500 | 0 | 0.24 | 0.24 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 12,871 | 12,871 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,545 | 1,545 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,399 | 13,345 | -54 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,590 | 6,518 | -72 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 2,612 | 2,343 | -269 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 1,857,681 | 1,857,136 | -545 | 6.12 | 6.10 | -0.03 | sell |
| FMR LLC | 1,636 | 908 | -728 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,822 | 10,926 | -896 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 1,035 | 0 | -1,035 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 2,850 | 0 | -2,850 | 0.00 | 0.00 | -0.00 | sell |
| Dorsey Wright & Associates | 2,858 | 0 | -2,858 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 11,151 | 0 | -11,151 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 14,903 | 2,193 | -12,710 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,846 | 24,765 | -14,081 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 243,290 | 228,139 | -15,151 | 0.58 | 0.57 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 59,773 | 44,240 | -15,533 | 0.06 | 0.05 | -0.01 | sell |
| ALGERT GLOBAL LLC | 47,630 | 0 | -47,630 | 0.03 | 0.00 | -0.03 | sell |
| TWO SIGMA ADVISERS, LP | 239,800 | 180,800 | -59,000 | 0.01 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 72,369 | 0 | -72,369 | 0.01 | 0.00 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 86,487 | 0 | -86,487 | 0.03 | 0.00 | -0.03 | sell |