| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 5,503,600 | 7,304,970 | +1,801,370 | 2.30 | 1.48 | -0.82 | buy |
| Candriam S.C.A. | 1,058,673 | 1,551,562 | +492,889 | 0.07 | 0.05 | -0.02 | buy |
| MPM BioImpact LLC | 2,680,596 | 2,912,550 | +231,954 | 4.80 | 2.41 | -2.39 | buy |
| Hennion & Walsh Asset Management, Inc. | 117,595 | 212,246 | +94,651 | 0.07 | 0.06 | -0.01 | buy |
| EntryPoint Capital, LLC | 34,544 | 69,526 | +34,982 | 0.23 | 0.17 | -0.06 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 12,000 | 25,000 | +13,000 | 0.05 | 0.04 | -0.01 | buy |
| Dana Investment Advisors, Inc. | 85,807 | 92,039 | +6,232 | 0.03 | 0.02 | -0.02 | buy |
| Woodline Partners LP | 1,354,186 | 1,357,479 | +3,293 | 0.14 | 0.05 | -0.08 | buy |
| VIRTUS ADVISERS, LLC | 7,394 | 10,579 | +3,185 | 0.04 | 0.03 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 11,014 | 12,149 | +1,135 | 0.01 | 0.01 | -0.01 | buy |
| ALPS ADVISORS INC | 45,691 | 46,335 | +644 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 92,000 | 91,994 | -6 | 0.34 | 0.15 | -0.19 | sell |
| PITCAIRN CO | 24,546 | 24,028 | -518 | 0.02 | 0.01 | -0.01 | sell |
| Corton Capital Inc. | 19,146 | 17,308 | -1,838 | 0.11 | 0.06 | -0.05 | sell |
| SECTORAL ASSET MANAGEMENT INC | 65,980 | 61,650 | -4,330 | 0.47 | 0.24 | -0.23 | sell |
| Rafferty Asset Management, LLC | 90,475 | 81,424 | -9,051 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 33,750 | 13,500 | -20,250 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 365,198 | -34,802 | 0.01 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 455,082 | 233,281 | -221,801 | 1.22 | 0.30 | -0.92 | sell |
| Deep Track Capital, LP | 4,000,000 | 3,442,833 | -557,167 | 1.52 | 0.75 | -0.77 | sell |
| BVF INC/IL | 9,135,893 | 5,715,893 | -3,420,000 | 3.19 | 1.13 | -2.06 | sell |