| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 0 | 7,470,214 | +7,470,214 | 0.00 | 5.12 | +5.12 | buy |
| Paradigm Biocapital Advisors LP | 5,503,600 | 7,304,970 | +1,801,370 | 2.30 | 1.48 | -0.82 | buy |
| BVF INC/IL | 9,135,893 | 5,715,893 | -3,420,000 | 3.19 | 1.13 | -2.06 | sell |
| BlackRock, Inc. | 3,847,471 | 3,789,832 | -57,639 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 3,687,374 | 3,670,826 | -16,548 | 0.15 | 0.06 | -0.09 | sell |
| Deep Track Capital, LP | 4,000,000 | 3,442,833 | -557,167 | 1.52 | 0.75 | -0.77 | sell |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 4.29 | 2.19 | -2.10 | hold |
| MPM BioImpact LLC | 2,680,596 | 2,912,550 | +231,954 | 4.80 | 2.41 | -2.39 | buy |
| VANGUARD GROUP INC | 2,532,892 | 2,685,009 | +152,117 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,667,459 | 1,883,354 | +215,895 | 0.02 | 0.01 | -0.01 | buy |
| STATE STREET CORP | 1,969,963 | 1,857,527 | -112,436 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,252,745 | 1,683,207 | +430,462 | 0.02 | 0.01 | -0.01 | buy |
| Avoro Capital Advisors LLC | 0 | 1,651,982 | +1,651,982 | 0.00 | 0.14 | +0.14 | buy |
| Candriam S.C.A. | 1,506,764 | 1,551,562 | +44,798 | 0.10 | 0.05 | -0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,002,685 | 1,525,484 | +522,799 | 0.00 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 1,505,862 | 1,505,862 | 0 | 1.49 | 0.98 | -0.50 | hold |
| Woodline Partners LP | 1,354,186 | 1,357,479 | +3,293 | 0.14 | 0.05 | -0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,376,924 | 1,332,792 | -44,132 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 709,097 | 1,127,589 | +418,492 | 0.02 | 0.02 | -0.01 | buy |
| MORGAN STANLEY | 249,601 | 1,024,477 | +774,876 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 78,060 | 979,219 | +901,159 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 934,929 | 926,162 | -8,767 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 410,939 | 865,339 | +454,400 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 77,547 | 560,506 | +482,959 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 82,187 | 533,111 | +450,924 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 461,926 | 505,400 | +43,474 | 0.04 | 0.02 | -0.03 | buy |
| AMERIPRISE FINANCIAL INC | 463,124 | 449,698 | -13,426 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 389,734 | 423,787 | +34,053 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 462,347 | 382,917 | -79,430 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 365,198 | -34,802 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 330,761 | 332,950 | +2,189 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 176,663 | 313,982 | +137,319 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 15,081 | 273,706 | +258,625 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 0 | 272,372 | +272,372 | 0.00 | 0.23 | +0.23 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 455,082 | 233,281 | -221,801 | 1.22 | 0.30 | -0.92 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 220,264 | +220,264 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 117,595 | 212,246 | +94,651 | 0.07 | 0.06 | -0.01 | buy |
| HighVista Strategies LLC | 212,185 | 212,185 | 0 | 0.87 | 0.46 | -0.41 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 193,748 | +193,748 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 240,387 | 192,943 | -47,444 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 181,032 | 160,751 | -20,281 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 29,400 | 157,300 | +127,900 | 0.00 | 0.00 | +0.00 | buy |
| Newtyn Management, LLC | 140,000 | 140,000 | 0 | 0.26 | 0.14 | -0.11 | hold |
| Bank of New York Mellon Corp | 132,182 | 128,666 | -3,516 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 94,915 | 114,879 | +19,964 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,974 | 93,979 | +18,005 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 851,512 | 93,100 | -758,412 | 0.01 | 0.00 | -0.01 | sell |
| Dana Investment Advisors, Inc. | 85,807 | 92,039 | +6,232 | 0.03 | 0.02 | -0.02 | buy |
| Ikarian Capital, LLC | 92,000 | 91,994 | -6 | 0.34 | 0.15 | -0.19 | sell |
| ExodusPoint Capital Management, LP | 69,841 | 91,298 | +21,457 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 101,200 | 89,000 | -12,200 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 0 | 87,476 | +87,476 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 90,475 | 81,424 | -9,051 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 74,919 | 74,919 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 100,047 | 72,877 | -27,170 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 34,544 | 69,526 | +34,982 | 0.23 | 0.17 | -0.06 | buy |
| CITIGROUP INC | 30,097 | 67,996 | +37,899 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 67,007 | +67,007 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,268 | 66,220 | +19,952 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 66,000 | 66,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 65,980 | 61,650 | -4,330 | 0.47 | 0.24 | -0.23 | sell |
| RHUMBLINE ADVISERS | 57,861 | 58,433 | +572 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 21,955 | 51,908 | +29,953 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 49,786 | 50,062 | +276 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 15,969 | 48,829 | +32,860 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 48,655 | 48,655 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XTX Topco Ltd | 25,332 | 48,032 | +22,700 | 0.02 | 0.02 | +0.00 | buy |
| ALPS ADVISORS INC | 45,691 | 46,335 | +644 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,901 | 45,828 | +43,927 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 47,706 | 43,737 | -3,969 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 108,852 | 41,198 | -67,654 | 0.01 | 0.00 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 27,132 | 39,331 | +12,199 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,136 | 32,687 | +551 | 0.00 | 0.00 | -0.00 | buy |
| Aristides Capital LLC | 0 | 32,500 | +32,500 | 0.00 | 0.06 | +0.06 | buy |
| Aquatic Capital Management LLC | 0 | 31,565 | +31,565 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 28,170 | 31,226 | +3,056 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 29,716 | 29,716 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Verition Fund Management LLC | 0 | 29,640 | +29,640 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,492 | 26,216 | +724 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,458 | 26,112 | -5,346 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 25,987 | +25,987 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 25,268 | +25,268 | 0.00 | 0.01 | +0.01 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 12,000 | 25,000 | +13,000 | 0.05 | 0.04 | -0.01 | buy |
| Monaco Asset Management SAM | 0 | 25,000 | +25,000 | 0.00 | 0.06 | +0.06 | buy |
| PITCAIRN CO | 24,546 | 24,028 | -518 | 0.02 | 0.01 | -0.01 | sell |
| MetLife Investment Management, LLC | 23,695 | 23,695 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 23,603 | 23,118 | -485 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 16,767 | 22,725 | +5,958 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,478 | 22,714 | +21,236 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 20,400 | +20,400 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 21,349 | 20,322 | -1,027 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 19,001 | +19,001 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 18,849 | 18,849 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 1,903 | 18,414 | +16,511 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 17,800 | 17,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 13,686 | 17,742 | +4,056 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 17,600 | 17,600 | 0 | 0.02 | 0.00 | -0.02 | hold |
| SG Americas Securities, LLC | 13,056 | 17,475 | +4,419 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 19,146 | 17,308 | -1,838 | 0.11 | 0.06 | -0.05 | sell |
| Invesco Ltd. | 15,155 | 16,448 | +1,293 | 0.00 | 0.00 | -0.00 | buy |