| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 6,843,954 | 8,508,641 | +1,664,687 | 4.45 | 16.29 | +11.84 | buy |
| Paradigm Biocapital Advisors LP | 6,794,172 | 7,544,172 | +750,000 | 1.97 | 5.05 | +3.08 | buy |
| JANUS HENDERSON GROUP PLC | 3,585,849 | 6,710,194 | +3,124,345 | 0.02 | 0.08 | +0.06 | buy |
| BlackRock, Inc. | 4,726,394 | 5,563,260 | +836,866 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 5,295,893 | 5,295,893 | 0 | 2.10 | 4.46 | +2.36 | hold |
| FMR LLC | 29,422 | 5,023,092 | +4,993,670 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 3,197,320 | 3,561,355 | +364,035 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 3,300,700 | +3,300,700 | 0.00 | 2.46 | +2.46 | buy |
| Logos Global Management LP | 3,208,875 | 3,208,875 | 0 | 3.10 | 5.35 | +2.24 | hold |
| Cormorant Asset Management, LP | 0 | 2,750,000 | +2,750,000 | 0.00 | 3.90 | +3.90 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,600,000 | +2,600,000 | 0.00 | 0.67 | +0.67 | buy |
| FRANKLIN RESOURCES INC | 3,011,969 | 2,476,665 | -535,304 | 0.01 | 0.02 | +0.01 | sell |
| Lightspeed Management Company, L.L.C. | 1,930,894 | 1,930,894 | 0 | 5.87 | 3.46 | -2.41 | hold |
| STATE STREET CORP | 1,093,574 | 1,884,399 | +790,825 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 1,650,000 | +1,650,000 | 0.00 | 1.51 | +1.51 | buy |
| Woodline Partners LP | 2,217,893 | 1,481,930 | -735,963 | 0.10 | 0.14 | +0.04 | sell |
| Polar Capital Holdings Plc | 0 | 1,380,450 | +1,380,450 | 0.00 | 0.16 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,276,005 | 1,257,441 | -18,564 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 1,236,915 | 1,200,307 | -36,608 | 0.01 | 0.02 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,781 | 1,096,035 | +1,064,254 | 0.00 | 0.00 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 0 | 1,069,543 | +1,069,543 | 0.00 | 0.43 | +0.43 | buy |
| JENNISON ASSOCIATES LLC | 0 | 963,997 | +963,997 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,064,549 | 958,644 | -105,905 | 0.00 | 0.01 | +0.00 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 854,000 | 953,600 | +99,600 | 1.31 | 3.65 | +2.34 | buy |
| GOLDMAN SACHS GROUP INC | 803,881 | 817,889 | +14,008 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 758,654 | +758,654 | 0.00 | 2.45 | +2.45 | buy |
| Candriam S.C.A. | 1,249,727 | 679,484 | -570,243 | 0.06 | 0.08 | +0.02 | sell |
| Vivo Capital, LLC | 1,505,862 | 671,843 | -834,019 | 1.19 | 1.09 | -0.10 | sell |
| MORGAN STANLEY | 1,555,887 | 665,803 | -890,084 | 0.00 | 0.00 | +0.00 | sell |
| First Turn Management, LLC | 0 | 617,714 | +617,714 | 0.00 | 1.76 | +1.76 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 569,000 | +569,000 | 0.00 | 0.22 | +0.22 | buy |
| Holocene Advisors, LP | 0 | 506,001 | +506,001 | 0.00 | 0.03 | +0.03 | buy |
| Pictet Asset Management Holding SA | 1,636,372 | 502,568 | -1,133,804 | 0.02 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 331,454 | 498,490 | +167,036 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 244,076 | 447,046 | +202,970 | 0.09 | 0.39 | +0.30 | buy |
| NORTHERN TRUST CORP | 483,032 | 445,327 | -37,705 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 395,127 | 407,141 | +12,014 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 109,526 | 393,658 | +284,132 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 360,394 | +360,394 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 14,091 | 328,680 | +314,589 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 245,418 | 307,890 | +62,472 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 1,190,654 | 293,560 | -897,094 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 281,687 | +281,687 | 0.00 | 0.03 | +0.03 | buy |
| Birchview Capital, LP | 174,000 | 269,000 | +95,000 | 1.29 | 3.94 | +2.65 | buy |
| JPMORGAN CHASE & CO | 30,131 | 268,471 | +238,340 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 267,058 | +267,058 | 0.00 | 1.18 | +1.18 | buy |
| HighVista Strategies LLC | 437,179 | 241,489 | -195,690 | 1.05 | 1.55 | +0.51 | sell |
| BANK OF AMERICA CORP /DE/ | 802,304 | 238,914 | -563,390 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 128,220 | 229,469 | +101,249 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 204,207 | 220,971 | +16,764 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 219,086 | +219,086 | 0.00 | 0.14 | +0.14 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 210,000 | +210,000 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 933,541 | 206,280 | -727,261 | 1.32 | 0.75 | -0.58 | sell |
| AMERIPRISE FINANCIAL INC | 1,147,068 | 204,629 | -942,439 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 169,197 | 176,201 | +7,004 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 693,179 | 167,308 | -525,871 | 0.01 | 0.01 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 0 | 165,713 | +165,713 | 0.00 | 0.08 | +0.08 | buy |
| Invesco Ltd. | 124,634 | 155,732 | +31,098 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 150,670 | +150,670 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 20,446 | 147,363 | +126,917 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 524,249 | 140,101 | -384,148 | 0.80 | 0.56 | -0.24 | sell |
| TD ASSET MANAGEMENT INC | 0 | 136,400 | +136,400 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 104,624 | 133,125 | +28,501 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 125,000 | +125,000 | 0.00 | 0.21 | +0.21 | buy |
| Susquehanna Portfolio Strategies, LLC | 121,342 | 121,342 | 0 | 0.02 | 0.05 | +0.03 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 113,978 | +113,978 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 107,950 | +107,950 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,541 | 102,322 | +81,781 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 100,274 | +100,274 | 0.00 | 0.03 | +0.03 | buy |
| Rock Springs Capital Management LP | 0 | 98,240 | +98,240 | 0.00 | 0.13 | +0.13 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 94,883 | 94,883 | 0 | 0.04 | 0.08 | +0.04 | hold |
| AMERICAN CENTURY COMPANIES INC | 58,995 | 93,900 | +34,905 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 88,150 | 86,100 | -2,050 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 45,661 | 84,130 | +38,469 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 36,200 | 81,399 | +45,199 | 0.04 | 0.15 | +0.12 | buy |
| AQR CAPITAL MANAGEMENT LLC | 81,181 | 81,167 | -14 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 84,289 | 74,379 | -9,910 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 619,874 | 69,874 | -550,000 | 0.32 | 0.07 | -0.25 | sell |
| SG Americas Securities, LLC | 0 | 69,382 | +69,382 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 68,723 | +68,723 | 0.00 | 0.32 | +0.32 | buy |
| Nicholas Investment Partners, LP | 0 | 64,757 | +64,757 | 0.00 | 0.12 | +0.12 | buy |
| Creative Planning | 55,310 | 64,654 | +9,344 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 32,510 | 64,592 | +32,082 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 64,484 | +64,484 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 61,092 | 63,067 | +1,975 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 76,660 | 62,610 | -14,050 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 40,330 | 61,306 | +20,976 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 96,675 | 56,195 | -40,480 | 0.00 | 0.00 | +0.00 | sell |
| Swedbank AB | 0 | 55,100 | +55,100 | 0.00 | 0.00 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 50,000 | 50,000 | 0 | 0.13 | 0.38 | +0.24 | hold |
| Trexquant Investment LP | 0 | 49,754 | +49,754 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 0 | 45,170 | +45,170 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 0 | 45,005 | +45,005 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 44,505 | +44,505 | 0.00 | 0.09 | +0.09 | buy |
| Virtu Financial LLC | 0 | 42,437 | +42,437 | 0.00 | 0.04 | +0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 40,647 | +40,647 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 70,000 | 40,500 | -29,500 | 0.01 | 0.02 | +0.01 | sell |
| HRT FINANCIAL LP | 16,291 | 40,266 | +23,975 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 38,078 | +38,078 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 37,199 | +37,199 | 0.00 | 0.02 | +0.02 | buy |