| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 29,422 | 5,023,092 | +4,993,670 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 0 | 3,300,700 | +3,300,700 | 0.00 | 2.46 | +2.46 | buy |
| JANUS HENDERSON GROUP PLC | 3,585,849 | 6,710,194 | +3,124,345 | 0.02 | 0.08 | +0.06 | buy |
| Cormorant Asset Management, LP | 0 | 2,750,000 | +2,750,000 | 0.00 | 3.90 | +3.90 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,600,000 | +2,600,000 | 0.00 | 0.67 | +0.67 | buy |
| Bain Capital Life Sciences Investors, LLC | 6,843,954 | 8,508,641 | +1,664,687 | 4.45 | 16.29 | +11.84 | buy |
| Vestal Point Capital, LP | 0 | 1,650,000 | +1,650,000 | 0.00 | 1.51 | +1.51 | buy |
| Polar Capital Holdings Plc | 0 | 1,380,450 | +1,380,450 | 0.00 | 0.16 | +0.16 | buy |
| SAMLYN CAPITAL, LLC | 0 | 1,069,543 | +1,069,543 | 0.00 | 0.43 | +0.43 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,781 | 1,096,035 | +1,064,254 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 963,997 | +963,997 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 4,726,394 | 5,563,260 | +836,866 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,093,574 | 1,884,399 | +790,825 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 758,654 | +758,654 | 0.00 | 2.45 | +2.45 | buy |
| Paradigm Biocapital Advisors LP | 6,794,172 | 7,544,172 | +750,000 | 1.97 | 5.05 | +3.08 | buy |
| First Turn Management, LLC | 0 | 617,714 | +617,714 | 0.00 | 1.76 | +1.76 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 569,000 | +569,000 | 0.00 | 0.22 | +0.22 | buy |
| Holocene Advisors, LP | 0 | 506,001 | +506,001 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 3,197,320 | 3,561,355 | +364,035 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 360,394 | +360,394 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 14,091 | 328,680 | +314,589 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 109,526 | 393,658 | +284,132 | 0.00 | 0.01 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 281,687 | +281,687 | 0.00 | 0.03 | +0.03 | buy |
| Catalio Capital Management, LP | 0 | 267,058 | +267,058 | 0.00 | 1.18 | +1.18 | buy |
| JPMORGAN CHASE & CO | 30,131 | 268,471 | +238,340 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 219,086 | +219,086 | 0.00 | 0.14 | +0.14 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 210,000 | +210,000 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 244,076 | 447,046 | +202,970 | 0.09 | 0.39 | +0.30 | buy |
| MILLENNIUM MANAGEMENT LLC | 331,454 | 498,490 | +167,036 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 165,713 | +165,713 | 0.00 | 0.08 | +0.08 | buy |
| ExodusPoint Capital Management, LP | 0 | 150,670 | +150,670 | 0.00 | 0.04 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 0 | 136,400 | +136,400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 20,446 | 147,363 | +126,917 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 125,000 | +125,000 | 0.00 | 0.21 | +0.21 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 113,978 | +113,978 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 107,950 | +107,950 | 0.00 | 0.05 | +0.05 | buy |
| Nuveen, LLC | 128,220 | 229,469 | +101,249 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 100,274 | +100,274 | 0.00 | 0.03 | +0.03 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 854,000 | 953,600 | +99,600 | 1.31 | 3.65 | +2.34 | buy |
| Rock Springs Capital Management LP | 0 | 98,240 | +98,240 | 0.00 | 0.13 | +0.13 | buy |
| Birchview Capital, LP | 174,000 | 269,000 | +95,000 | 1.29 | 3.94 | +2.65 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,541 | 102,322 | +81,781 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 69,382 | +69,382 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 68,723 | +68,723 | 0.00 | 0.32 | +0.32 | buy |
| Nicholas Investment Partners, LP | 0 | 64,757 | +64,757 | 0.00 | 0.12 | +0.12 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 64,484 | +64,484 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 245,418 | 307,890 | +62,472 | 0.01 | 0.01 | +0.01 | buy |
| Swedbank AB | 0 | 55,100 | +55,100 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 49,754 | +49,754 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 36,200 | 81,399 | +45,199 | 0.04 | 0.15 | +0.12 | buy |
| NEOS Investment Management LLC | 0 | 45,170 | +45,170 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 0 | 45,005 | +45,005 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 44,505 | +44,505 | 0.00 | 0.09 | +0.09 | buy |
| Virtu Financial LLC | 0 | 42,437 | +42,437 | 0.00 | 0.04 | +0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 40,647 | +40,647 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 45,661 | 84,130 | +38,469 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 38,078 | +38,078 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 37,199 | +37,199 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 34,940 | +34,940 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 58,995 | 93,900 | +34,905 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 33,382 | +33,382 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 32,510 | 64,592 | +32,082 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 124,634 | 155,732 | +31,098 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 30,160 | +30,160 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 104,624 | 133,125 | +28,501 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 26,207 | +26,207 | 0.00 | 0.01 | +0.01 | buy |
| Empire Financial Management Company, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.14 | +0.14 | buy |
| HRT FINANCIAL LP | 16,291 | 40,266 | +23,975 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 21,323 | +21,323 | 0.00 | 0.12 | +0.12 | buy |
| Shay Capital LLC | 0 | 21,000 | +21,000 | 0.00 | 0.08 | +0.08 | buy |
| Quantinno Capital Management LP | 40,330 | 61,306 | +20,976 | 0.00 | 0.00 | +0.00 | buy |
| Huntleigh Advisors, Inc. | 0 | 20,130 | +20,130 | 0.00 | 0.08 | +0.08 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,868 | 28,234 | +19,366 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 19,088 | +19,088 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 17,474 | +17,474 | 0.00 | 0.27 | +0.27 | buy |
| PROFUND ADVISORS LLC | 0 | 17,381 | +17,381 | 0.00 | 0.01 | +0.01 | buy |
| Entropy Technologies, LP | 0 | 17,304 | +17,304 | 0.00 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 204,207 | 220,971 | +16,764 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 15,314 | +15,314 | 0.00 | 0.01 | +0.01 | buy |
| Inscription Capital, LLC | 0 | 15,273 | +15,273 | 0.00 | 0.04 | +0.04 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 15,206 | +15,206 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,422 | 20,490 | +15,068 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,082 | 25,991 | +14,909 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 803,881 | 817,889 | +14,008 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 15,301 | 27,368 | +12,067 | 0.01 | 0.04 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 395,127 | 407,141 | +12,014 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 13,567 | 25,198 | +11,631 | 0.00 | 0.01 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| Blueshift Asset Management, LLC | 0 | 10,237 | +10,237 | 0.00 | 0.07 | +0.07 | buy |
| Wealthspire Advisors, LLC | 0 | 10,172 | +10,172 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 9,954 | +9,954 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 9,500 | +9,500 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 55,310 | 64,654 | +9,344 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 9,069 | +9,069 | 0.00 | 0.11 | +0.11 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 8,880 | +8,880 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 8,259 | +8,259 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 8,046 | +8,046 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 2,525 | 9,938 | +7,413 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 169,197 | 176,201 | +7,004 | 0.00 | 0.00 | +0.00 | buy |