| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Samsara BioCapital, LLC | 0 | 11,448,081 | +11,448,081 | 0.00 | 16.39 | +16.39 | buy |
| GILEAD SCIENCES, INC. | 0 | 723,273 | +723,273 | 0.00 | 0.49 | +0.49 | buy |
| Octagon Capital Advisors LP | 0 | 481,000 | +481,000 | 0.00 | 0.53 | +0.53 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 309,221 | +309,221 | 0.00 | 0.14 | +0.14 | buy |
| Siren, L.L.C. | 0 | 282,586 | +282,586 | 0.00 | 0.13 | +0.13 | buy |
| EcoR1 Capital, LLC | 0 | 201,718 | +201,718 | 0.00 | 0.10 | +0.10 | buy |
| VANGUARD GROUP INC | 0 | 115,086 | +115,086 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 0 | 82,955 | +82,955 | 0.00 | 0.06 | +0.06 | buy |
| BlackRock, Inc. | 0 | 27,514 | +27,514 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 26,787 | +26,787 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 21,581 | +21,581 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 21,519 | +21,519 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 19,251 | +19,251 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 0 | 17,391 | +17,391 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 16,582 | +16,582 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 14,587 | +14,587 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 14,115 | +14,115 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 10,710 | +10,710 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 7,806 | +7,806 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,434 | +1,434 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 634 | +634 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 208 | +208 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 127 | +127 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |