| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Propel Bio Management, LLC | 42,053 | 295,771 | +253,718 | 0.30 | 1.08 | +0.78 | buy |
| Alyeska Investment Group, L.P. | 403,551 | 572,687 | +169,136 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 34,303 | 110,503 | +76,200 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 20,074 | 87,426 | +67,352 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 59,534 | +59,534 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 88,436 | 118,887 | +30,451 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 20,400 | +20,400 | 0.00 | 0.10 | +0.10 | buy |
| Velan Capital Investment Management LP | 0 | 18,000 | +18,000 | 0.00 | 0.07 | +0.07 | buy |
| Squarepoint Ops LLC | 25,367 | 39,773 | +14,406 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 0 | 14,230 | +14,230 | 0.00 | 0.00 | +0.00 | buy |
| WealthTrust Asset Management, LLC | 0 | 12,416 | +12,416 | 0.00 | 0.04 | +0.04 | buy |
| HRT FINANCIAL LP | 0 | 11,617 | +11,617 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 11,103 | +11,103 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1 | 8,703 | +8,702 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 82,647 | 87,545 | +4,898 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 10,159 | 13,655 | +3,496 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 27,759 | 30,650 | +2,891 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 2,215 | +2,215 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 25,410 | 26,510 | +1,100 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 13,654 | 14,449 | +795 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 52 | 652 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Strengthening Families & Communities, LLC | 0 | 268 | +268 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 22,500 | 22,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 17,391 | 17,391 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Johnson Financial Group, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,300,000 | 1,300,000 | 0 | 0.11 | 0.07 | -0.04 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 92,261 | 92,261 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Parallel Advisors, LLC | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Belpointe Asset Management LLC | 40,000 | 40,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Samsara BioCapital, LLC | 12,948,081 | 12,948,081 | 0 | 11.27 | 7.26 | -4.02 | hold |
| Ikarian Capital, LLC | 360,000 | 360,000 | 0 | 0.39 | 0.30 | -0.10 | hold |
| Woodline Partners LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Paradigm Biocapital Advisors LP | 700,000 | 700,000 | 0 | 0.16 | 0.08 | -0.08 | hold |
| ADAR1 Capital Management, LLC | 100,000 | 100,000 | 0 | 0.06 | 0.03 | -0.03 | hold |
| Fortitude Family Office, LLC | 114 | 114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fortis Capital Advisors, LLC | 40,000 | 40,000 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Siren, L.L.C. | 435,798 | 435,798 | 0 | 0.11 | 0.07 | -0.04 | hold |
| FMR LLC | 7,806 | 7,806 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 6,065 | 5,280 | -785 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 38,454 | 36,043 | -2,411 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 72,876 | 67,879 | -4,997 | 0.00 | 0.00 | -0.00 | sell |
| Keel Point, LLC | 10,225 | 0 | -10,225 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 10,897 | 0 | -10,897 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 11,225 | 0 | -11,225 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 87,751 | 66,151 | -21,600 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 33,114 | 0 | -33,114 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 80,590 | 45,000 | -35,590 | 0.06 | 0.02 | -0.03 | sell |
| Redmile Group, LLC | 82,955 | 0 | -82,955 | 0.05 | 0.00 | -0.05 | sell |