| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 19,251 | 96,751 | +77,500 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 309,221 | 360,859 | +51,638 | 0.14 | 0.05 | -0.09 | buy |
| Squarepoint Ops LLC | 14,587 | 59,095 | +44,508 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 16,582 | 54,092 | +37,510 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 24,234 | +24,234 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 115,086 | 129,839 | +14,753 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 27,514 | 38,156 | +10,642 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,434 | 2,153 | +719 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 127 | 141 | +14 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 634 | 634 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 17,391 | 17,391 | 0 | 0.01 | 0.00 | -0.01 | hold |
| MARSHALL WACE, LLP | 14,115 | 14,115 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Redmile Group, LLC | 82,955 | 82,955 | 0 | 0.06 | 0.02 | -0.04 | hold |
| Parallel Advisors, LLC | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 11,448,081 | 11,448,081 | 0 | 16.39 | 6.25 | -10.14 | hold |
| Farther Finance Advisors, LLC | 33 | 33 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 282,586 | 282,586 | 0 | 0.13 | 0.04 | -0.09 | hold |
| FMR LLC | 7,806 | 7,806 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 10,710 | 10,710 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 30 | 0 | -30 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 208 | 0 | -208 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 21,581 | 20,281 | -1,300 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 26,787 | 25,476 | -1,311 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 21,519 | 0 | -21,519 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 481,000 | 360,000 | -121,000 | 0.53 | 0.21 | -0.32 | sell |
| EcoR1 Capital, LLC | 201,718 | 0 | -201,718 | 0.10 | 0.00 | -0.10 | sell |
| GILEAD SCIENCES, INC. | 723,273 | 317,789 | -405,484 | 0.49 | 0.07 | -0.43 | sell |