| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Samsara BioCapital, LLC | 11,448,081 | 11,448,081 | 0 | 6.25 | 8.64 | +2.39 | hold |
| TANG CAPITAL MANAGEMENT LLC | 360,859 | 418,241 | +57,382 | 0.05 | 0.09 | +0.04 | buy |
| Siren, L.L.C. | 282,586 | 318,264 | +35,678 | 0.04 | 0.07 | +0.03 | buy |
| Woodline Partners LP | 0 | 241,102 | +241,102 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 129,839 | 203,051 | +73,212 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 96,751 | 112,751 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 82,955 | 82,955 | 0 | 0.02 | 0.05 | +0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 25,476 | 64,551 | +39,075 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 38,156 | 40,379 | +2,223 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 59,095 | 40,173 | -18,922 | 0.00 | 0.00 | +0.00 | sell |
| Belpointe Asset Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.01 | +0.01 | buy |
| Fortis Capital Advisors, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 54,092 | 24,923 | -29,169 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 10,710 | 22,610 | +11,900 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 22,500 | +22,500 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 22,465 | +22,465 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 17,391 | 17,391 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 14,115 | 14,115 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Johnson Financial Group, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,806 | 7,806 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 634 | 578 | -56 | 0.00 | 0.00 | +0.00 | sell |
| Strengthening Families & Communities, LLC | 0 | 268 | +268 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 141 | 141 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 49 | 49 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 33 | 33 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 10 | 8 | -2 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 20,281 | 0 | -20,281 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,153 | 0 | -2,153 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 24,234 | 0 | -24,234 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 360,000 | 0 | -360,000 | 0.21 | 0.00 | -0.21 | sell |
| GILEAD SCIENCES, INC. | 317,789 | 0 | -317,789 | 0.07 | 0.00 | -0.07 | sell |