| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Samsara BioCapital, LLC | 11,448,081 | 12,948,081 | +1,500,000 | 8.64 | 11.27 | +2.64 | buy |
| RTW INVESTMENTS, LP | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.11 | +0.11 | buy |
| Paradigm Biocapital Advisors LP | 0 | 700,000 | +700,000 | 0.00 | 0.16 | +0.16 | buy |
| Alyeska Investment Group, L.P. | 0 | 403,551 | +403,551 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 360,000 | +360,000 | 0.00 | 0.39 | +0.39 | buy |
| Siren, L.L.C. | 318,264 | 435,798 | +117,534 | 0.07 | 0.11 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.06 | +0.06 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 92,261 | +92,261 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 203,051 | 292,790 | +89,739 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 88,436 | +88,436 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 80,590 | +80,590 | 0.00 | 0.06 | +0.06 | buy |
| MARSHALL WACE, LLP | 14,115 | 72,876 | +58,761 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 42,053 | +42,053 | 0.00 | 0.30 | +0.30 | buy |
| JANE STREET GROUP, LLC | 0 | 33,114 | +33,114 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 27,759 | +27,759 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 20,074 | +20,074 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 64,551 | 82,647 | +18,096 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 13,654 | +13,654 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 22,465 | 34,303 | +11,838 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 11,225 | +11,225 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,897 | +10,897 | 0.00 | 0.00 | +0.00 | buy |
| Keel Point, LLC | 0 | 10,225 | +10,225 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 10,159 | +10,159 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 6,065 | +6,065 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 22,610 | 25,410 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 114 | +114 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 22,500 | 22,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 17,391 | 17,391 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Redmile Group, LLC | 82,955 | 82,955 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Johnson Financial Group, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 49 | 49 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Belpointe Asset Management LLC | 40,000 | 40,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Fortis Capital Advisors, LLC | 40,000 | 40,000 | 0 | 0.04 | 0.05 | +0.01 | hold |
| FMR LLC | 7,806 | 7,806 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 8 | 5 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 33 | 0 | -33 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 141 | 52 | -89 | 0.00 | 0.00 | -0.00 | sell |
| Strengthening Families & Communities, LLC | 268 | 0 | -268 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 578 | 0 | -578 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 40,379 | 38,454 | -1,925 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 40,173 | 25,367 | -14,806 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 24,923 | 0 | -24,923 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 112,751 | 87,751 | -25,000 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 241,102 | 100,000 | -141,102 | 0.01 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 418,241 | 0 | -418,241 | 0.09 | 0.00 | -0.09 | sell |