| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 4,974,906 | 8,163,191 | +3,188,285 | 1.95 | 1.49 | -0.46 | buy |
| Nantahala Capital Management, LLC | 0 | 2,686,393 | +2,686,393 | 0.00 | 0.61 | +0.61 | buy |
| Woodline Partners LP | 0 | 2,323,149 | +2,323,149 | 0.00 | 0.03 | +0.03 | buy |
| Aberdeen Group plc | 0 | 2,307,773 | +2,307,773 | 0.00 | 0.01 | +0.01 | buy |
| Patient Square Capital LP | 0 | 1,967,171 | +1,967,171 | 0.00 | 1.15 | +1.15 | buy |
| CITADEL ADVISORS LLC | 64,950 | 1,784,566 | +1,719,616 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 2,174,398 | 3,606,656 | +1,432,258 | 0.73 | 0.64 | -0.08 | buy |
| STEMPOINT CAPITAL LP | 0 | 1,426,320 | +1,426,320 | 0.00 | 0.93 | +0.93 | buy |
| JPMORGAN CHASE & CO | 0 | 1,309,100 | +1,309,100 | 0.00 | 0.00 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 1,270,000 | +1,270,000 | 0.00 | 0.65 | +0.65 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,120,000 | +1,120,000 | 0.00 | 0.01 | +0.01 | buy |
| Samsara BioCapital, LLC | 5,194,805 | 6,314,805 | +1,120,000 | 2.80 | 1.96 | -0.84 | buy |
| Integral Health Asset Management, LLC | 400,000 | 1,520,000 | +1,120,000 | 0.12 | 0.24 | +0.12 | buy |
| SYQUANT CAPITAL SAS | 0 | 913,135 | +913,135 | 0.00 | 0.77 | +0.77 | buy |
| Alyeska Investment Group, L.P. | 0 | 909,000 | +909,000 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 844,215 | 1,697,148 | +852,933 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 69,434 | 901,369 | +831,935 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 956,221 | 1,683,012 | +726,791 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 0 | 685,400 | +685,400 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 724,678 | 1,281,212 | +556,534 | 2.52 | 2.53 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,470,407 | 2,003,782 | +533,375 | 0.19 | 0.14 | -0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,987,613 | 3,512,174 | +524,561 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 226,406 | 728,111 | +501,705 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 397,558 | +397,558 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 352,399 | 740,786 | +388,387 | 0.80 | 0.96 | +0.16 | buy |
| MARSHALL WACE, LLP | 654,211 | 965,907 | +311,696 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 613,357 | 901,640 | +288,283 | 0.00 | 0.00 | -0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 250,000 | +250,000 | 0.00 | 0.02 | +0.02 | buy |
| J. Goldman & Co LP | 103,518 | 337,500 | +233,982 | 0.03 | 0.04 | +0.02 | buy |
| Burkehill Global Management, LP | 0 | 225,000 | +225,000 | 0.00 | 0.03 | +0.03 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 225,000 | +225,000 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 615,666 | 831,442 | +215,776 | 0.94 | 0.72 | -0.23 | buy |
| FRANKLIN RESOURCES INC | 2,461,565 | 2,642,611 | +181,046 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 151,917 | +151,917 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 66,121 | 214,282 | +148,161 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 144,181 | +144,181 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 135,648 | +135,648 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 84,323 | 207,182 | +122,859 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 18,854 | 123,953 | +105,099 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 227,923 | 313,483 | +85,560 | 0.02 | 0.02 | -0.00 | buy |
| Persistent Asset Partners Ltd | 128,099 | 209,182 | +81,083 | 0.28 | 0.25 | -0.03 | buy |
| Engineers Gate Manager LP | 27,836 | 71,116 | +43,280 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 184,907 | 224,499 | +39,592 | 0.00 | 0.00 | -0.00 | buy |
| R Squared Ltd | 0 | 29,918 | +29,918 | 0.00 | 0.06 | +0.06 | buy |
| Shay Capital LLC | 0 | 21,871 | +21,871 | 0.00 | 0.01 | +0.01 | buy |
| Ground Swell Capital, LLC | 0 | 12,803 | +12,803 | 0.00 | 0.05 | +0.05 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 26,685 | 36,726 | +10,041 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 0 | 6,612 | +6,612 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 77,561 | 83,996 | +6,435 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,000 | 21,600 | +5,600 | 0.01 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 31,482 | 34,355 | +2,873 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 2,862 | 4,672 | +1,810 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1,781 | +1,781 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 0 | 1,463 | +1,463 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 4,515 | 5,020 | +505 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 225 | +225 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 2 | 155 | +153 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 20,000 | 20,078 | +78 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 686,040 | 686,040 | 0 | 0.12 | 0.07 | -0.05 | hold |
| NEA Management Company, LLC | 1,462,586 | 1,462,586 | 0 | 0.46 | 0.35 | -0.11 | hold |
| Cerity Partners LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Yu Fan | 1,500,000 | 1,500,000 | 0 | 8.58 | 5.25 | -3.33 | hold |
| Quaker Wealth Management, LLC | 24,960 | 24,960 | 0 | 0.04 | 0.03 | -0.02 | hold |
| Paradigm Biocapital Advisors LP | 4,000,000 | 4,000,000 | 0 | 0.45 | 0.28 | -0.17 | hold |
| Bell Investment Advisors, Inc | 76 | 76 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 402 | 402 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,467 | 24,467 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atlantic Union Bankshares Corp | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BLAIR WILLIAM & CO/IL | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Western Wealth Management, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 604 | 0 | -604 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 881 | 0 | -881 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 2,318,693 | 2,305,192 | -13,501 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 18,729 | 0 | -18,729 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 145,459 | 115,000 | -30,459 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 38,256 | 0 | -38,256 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 40,000 | 0 | -40,000 | 0.02 | 0.00 | -0.02 | sell |
| Artisan Partners Limited Partnership | 323,006 | 263,538 | -59,468 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 745,300 | 634,800 | -110,500 | 4.11 | 3.09 | -1.02 | sell |
| Russell Investments Group, Ltd. | 205,639 | 0 | -205,639 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 1,429,101 | 1,129,101 | -300,000 | 1.12 | 0.68 | -0.44 | sell |
| Deep Track Capital, LP | 1,222,453 | 800,000 | -422,453 | 0.14 | 0.04 | -0.10 | sell |
| Polar Capital Holdings Plc | 2,132,138 | 1,074,214 | -1,057,924 | 0.05 | 0.01 | -0.04 | sell |
| RTW INVESTMENTS, LP | 1,298,702 | 0 | -1,298,702 | 0.07 | 0.00 | -0.07 | sell |