| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 2,000,000 | 4,974,906 | +2,974,906 | 0.85 | 1.95 | +1.10 | buy |
| Point72 Asset Management, L.P. | 0 | 956,221 | +956,221 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 502,601 | 1,429,101 | +926,500 | 0.30 | 1.12 | +0.82 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 658,971 | 1,470,407 | +811,436 | 0.08 | 0.19 | +0.11 | buy |
| Deep Track Capital, LP | 490,000 | 1,222,453 | +732,453 | 0.05 | 0.14 | +0.09 | buy |
| HighVista Strategies LLC | 0 | 615,666 | +615,666 | 0.00 | 0.94 | +0.94 | buy |
| MARSHALL WACE, LLP | 172,093 | 654,211 | +482,118 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.12 | +0.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,652,570 | 2,987,613 | +335,043 | 0.01 | 0.01 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 323,006 | +323,006 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 615,473 | 844,215 | +228,742 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 205,639 | +205,639 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 57,417 | 226,406 | +168,989 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 145,459 | +145,459 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,998,880 | 2,132,138 | +133,258 | 0.04 | 0.05 | +0.01 | buy |
| MORGAN STANLEY | 507,701 | 613,357 | +105,656 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 69,434 | +69,434 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 64,950 | +64,950 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 18,053 | 66,121 | +48,068 | 0.00 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 38,256 | +38,256 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 31,482 | +31,482 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 27,836 | +27,836 | 0.00 | 0.00 | +0.00 | buy |
| Quaker Wealth Management, LLC | 0 | 24,960 | +24,960 | 0.00 | 0.04 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 24,467 | +24,467 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,854 | +18,854 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 334,251 | 352,399 | +18,148 | 0.93 | 0.80 | -0.13 | buy |
| Quadrature Capital Ltd | 66,929 | 84,323 | +17,394 | 0.00 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 16,000 | +16,000 | 0.00 | 0.01 | +0.01 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 12,869 | 18,729 | +5,860 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,780 | 4,515 | +2,735 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 25,770 | 26,685 | +915 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 881 | +881 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 604 | +604 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 2,632 | 2,862 | +230 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Western Wealth Management, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,298,701 | 1,298,702 | +1 | 0.06 | 0.07 | +0.01 | buy |
| BVF INC/IL | 686,040 | 686,040 | 0 | 0.11 | 0.12 | +0.01 | hold |
| NEA Management Company, LLC | 1,462,586 | 1,462,586 | 0 | 0.35 | 0.46 | +0.11 | hold |
| Cerity Partners LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Yu Fan | 1,500,000 | 1,500,000 | 0 | 7.56 | 8.58 | +1.02 | hold |
| Samsara BioCapital, LLC | 5,194,805 | 5,194,805 | 0 | 2.49 | 2.80 | +0.31 | hold |
| Paradigm Biocapital Advisors LP | 4,000,000 | 4,000,000 | 0 | 0.50 | 0.45 | -0.04 | hold |
| Covestor Ltd | 402 | 402 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 77,561 | 77,561 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Atlantic Union Bankshares Corp | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 129,711 | 128,099 | -1,612 | 0.29 | 0.28 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 2,500,141 | 2,461,565 | -38,576 | 0.00 | 0.00 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 100,000 | 0 | -100,000 | 0.25 | 0.00 | -0.25 | sell |
| Simplify Asset Management Inc. | 337,662 | 227,923 | -109,739 | 0.03 | 0.02 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 429,595 | 184,907 | -244,688 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | 0 | -250,000 | 0.02 | 0.00 | -0.02 | sell |
| Yiheng Capital Management, L.P. | 255,915 | 0 | -255,915 | 0.52 | 0.00 | -0.52 | sell |
| Propel Bio Management, LLC | 1,000,000 | 724,678 | -275,322 | 3.97 | 2.52 | -1.45 | sell |
| Saturn V Capital Management LP | 283,166 | 0 | -283,166 | 0.24 | 0.00 | -0.24 | sell |
| UBS Group AG | 2,643,702 | 2,318,693 | -325,009 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 516,445 | 103,518 | -412,927 | 0.09 | 0.03 | -0.07 | sell |
| STEMPOINT CAPITAL LP | 467,242 | 0 | -467,242 | 0.37 | 0.00 | -0.37 | sell |
| Alyeska Investment Group, L.P. | 500,000 | 0 | -500,000 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 2,709,846 | 2,174,398 | -535,448 | 0.94 | 0.73 | -0.22 | sell |
| Ally Bridge Group (NY) LLC | 1,500,000 | 745,300 | -754,700 | 11.07 | 4.11 | -6.96 | sell |