| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Samsara BioCapital, LLC | 0 | 5,194,805 | +5,194,805 | 0.00 | 2.49 | +2.49 | buy |
| Paradigm Biocapital Advisors LP | 0 | 4,000,000 | +4,000,000 | 0.00 | 0.50 | +0.50 | buy |
| ADAR1 Capital Management, LLC | 0 | 2,709,846 | +2,709,846 | 0.00 | 0.94 | +0.94 | buy |
| UBS Group AG | 0 | 2,643,702 | +2,643,702 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 112,030 | 2,652,570 | +2,540,540 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 2,500,141 | +2,500,141 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.85 | +0.85 | buy |
| Polar Capital Holdings Plc | 0 | 1,998,880 | +1,998,880 | 0.00 | 0.04 | +0.04 | buy |
| Yu Fan | 0 | 1,500,000 | +1,500,000 | 0.00 | 7.56 | +7.56 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 11.07 | +11.07 | buy |
| RTW INVESTMENTS, LP | 0 | 1,298,701 | +1,298,701 | 0.00 | 0.06 | +0.06 | buy |
| Propel Bio Management, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 3.97 | +3.97 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 658,971 | +658,971 | 0.00 | 0.08 | +0.08 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 615,473 | +615,473 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 516,445 | +516,445 | 0.00 | 0.09 | +0.09 | buy |
| MORGAN STANLEY | 0 | 507,701 | +507,701 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 502,601 | +502,601 | 0.00 | 0.30 | +0.30 | buy |
| Alyeska Investment Group, L.P. | 0 | 500,000 | +500,000 | 0.00 | 0.01 | +0.01 | buy |
| Deep Track Capital, LP | 0 | 490,000 | +490,000 | 0.00 | 0.05 | +0.05 | buy |
| STEMPOINT CAPITAL LP | 30,824 | 467,242 | +436,418 | 0.04 | 0.37 | +0.34 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 429,595 | +429,595 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 337,662 | +337,662 | 0.00 | 0.03 | +0.03 | buy |
| DIADEMA PARTNERS LP | 0 | 334,251 | +334,251 | 0.00 | 0.93 | +0.93 | buy |
| Saturn V Capital Management LP | 0 | 283,166 | +283,166 | 0.00 | 0.24 | +0.24 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 0 | 172,093 | +172,093 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 129,711 | +129,711 | 0.00 | 0.29 | +0.29 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 100,000 | +100,000 | 0.00 | 0.25 | +0.25 | buy |
| Quadrature Capital Ltd | 0 | 66,929 | +66,929 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 57,417 | +57,417 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,053 | +18,053 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,869 | +12,869 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 64,857 | 77,561 | +12,704 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 150 | 2,632 | +2,482 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 1,780 | +1,780 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 686,040 | 686,040 | 0 | 0.16 | 0.11 | -0.05 | hold |
| AQR CAPITAL MANAGEMENT LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 1,462,586 | 1,462,586 | 0 | 0.46 | 0.35 | -0.11 | hold |
| Creative Planning | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 25,770 | 25,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 402 | 402 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atlantic Union Bankshares Corp | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Yiheng Capital Management, L.P. | 2,644,926 | 255,915 | -2,389,011 | 5.07 | 0.52 | -4.55 | sell |