| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 2,594,470 | 3,741,460 | +1,146,990 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,626,628 | 3,422,984 | +1,796,356 | 0.03 | 0.04 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 3,327,132 | 3,110,314 | -216,818 | 0.41 | 0.26 | -0.14 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,266,645 | 3,036,645 | -230,000 | 0.15 | 0.10 | -0.06 | sell |
| T. Rowe Price Investment Management, Inc. | 1,832,854 | 2,470,493 | +637,639 | 0.03 | 0.03 | -0.00 | buy |
| VANGUARD GROUP INC | 2,131,931 | 2,276,222 | +144,291 | 0.00 | 0.00 | -0.00 | buy |
| Lynx1 Capital Management LP | 2,110,401 | 2,082,973 | -27,428 | 18.84 | 9.15 | -9.68 | sell |
| PERCEPTIVE ADVISORS LLC | 2,003,058 | 1,716,660 | -286,398 | 1.02 | 0.52 | -0.50 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,000,000 | 1,617,364 | -382,636 | 4.35 | 2.22 | -2.13 | sell |
| VR Adviser, LLC | 2,563,952 | 1,563,952 | -1,000,000 | 3.99 | 1.27 | -2.72 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,007,729 | 1,258,650 | -749,079 | 0.84 | 0.37 | -0.47 | sell |
| Polar Capital Holdings Plc | 1,250,000 | 1,250,000 | 0 | 0.17 | 0.11 | -0.06 | hold |
| Cormorant Asset Management, LP | 0 | 1,100,000 | +1,100,000 | 0.00 | 0.83 | +0.83 | buy |
| Commodore Capital LP | 1,900,000 | 1,100,000 | -800,000 | 3.77 | 1.25 | -2.51 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 539,876 | 1,008,259 | +468,383 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 450,706 | 1,003,916 | +553,210 | 2.76 | 4.58 | +1.82 | buy |
| MORGAN STANLEY | 387,383 | 885,704 | +498,321 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 753,176 | 773,090 | +19,914 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 1,397,942 | 744,777 | -653,165 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 527,765 | 612,398 | +84,633 | 0.00 | 0.00 | -0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 360,000 | 500,000 | +140,000 | 0.05 | 0.05 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 459,367 | +459,367 | 0.00 | 0.01 | +0.01 | buy |
| Redmile Group, LLC | 1,374,189 | 442,826 | -931,363 | 1.12 | 0.28 | -0.84 | sell |
| Qube Research & Technologies Ltd | 52,199 | 434,500 | +382,301 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 429,395 | 429,746 | +351 | 0.55 | 0.43 | -0.11 | buy |
| GOLDMAN SACHS GROUP INC | 238,137 | 425,174 | +187,037 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 520,000 | 425,000 | -95,000 | 1.70 | 0.71 | -0.99 | sell |
| Duquesne Family Office LLC | 0 | 417,000 | +417,000 | 0.00 | 0.19 | +0.19 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 403,927 | 371,623 | -32,304 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 209,263 | 354,424 | +145,161 | 0.02 | 0.02 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 334,813 | +334,813 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 118,002 | 330,925 | +212,923 | 0.01 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 251,615 | 317,520 | +65,905 | 0.05 | 0.04 | -0.00 | buy |
| NORTHERN TRUST CORP | 310,672 | 304,161 | -6,511 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 86,546 | 301,886 | +215,340 | 0.00 | 0.01 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 290,797 | +290,797 | 0.00 | 3.28 | +3.28 | buy |
| Point72 Asset Management, L.P. | 284,666 | 282,651 | -2,015 | 0.02 | 0.01 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 236,400 | 278,123 | +41,723 | 0.02 | 0.02 | -0.00 | buy |
| Woodline Partners LP | 241,453 | 242,663 | +1,210 | 0.06 | 0.04 | -0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 160,520 | 238,103 | +77,583 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 138,645 | 209,476 | +70,831 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 0 | 200,000 | +200,000 | 0.00 | 0.02 | +0.02 | buy |
| AXA S.A. | 0 | 178,162 | +178,162 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 0 | 173,173 | +173,173 | 0.00 | 1.18 | +1.18 | buy |
| MARSHALL WACE, LLP | 0 | 171,187 | +171,187 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 164,605 | +164,605 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 38,300 | 160,000 | +121,700 | 0.09 | 0.30 | +0.21 | buy |
| Cutter Capital Management, LP | 230,000 | 157,964 | -72,036 | 2.50 | 1.04 | -1.46 | sell |
| Bank of New York Mellon Corp | 156,953 | 146,061 | -10,892 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 29,241 | 137,538 | +108,297 | 0.01 | 0.03 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 93,630 | 127,030 | +33,400 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 96,310 | 93,525 | -2,785 | 0.00 | 0.00 | -0.00 | sell |
| TCG Crossover Management, LLC | 486,795 | 86,795 | -400,000 | 1.23 | 0.12 | -1.11 | sell |
| Crestline Management, LP | 0 | 85,000 | +85,000 | 0.00 | 0.14 | +0.14 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 25,191 | 82,386 | +57,195 | 0.00 | 0.00 | +0.00 | buy |
| WESTWOOD HOLDINGS GROUP INC | 0 | 82,228 | +82,228 | 0.00 | 0.01 | +0.01 | buy |
| Atle Fund Management AB | 21,000 | 77,540 | +56,540 | 0.37 | 0.80 | +0.43 | buy |
| ROYAL BANK OF CANADA | 96,956 | 77,245 | -19,711 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 69,417 | +69,417 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 69,220 | 69,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,054 | 64,099 | +42,045 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,929 | 59,498 | +45,569 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 51,000 | 59,200 | +8,200 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 59,000 | +59,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 33,858 | 54,427 | +20,569 | 0.03 | 0.04 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 53,342 | +53,342 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,677 | 52,233 | -444 | 0.00 | 0.00 | +0.00 | sell |
| Octagon Capital Advisors LP | 0 | 52,000 | +52,000 | 0.00 | 0.11 | +0.11 | buy |
| JANE STREET GROUP, LLC | 88,409 | 50,719 | -37,690 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 49,563 | +49,563 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 129,072 | 48,968 | -80,104 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 47,150 | 47,150 | 0 | 0.67 | 0.75 | +0.08 | hold |
| Blackstone Inc. | 347,494 | 46,780 | -300,714 | 0.04 | 0.00 | -0.03 | sell |
| CHURCHILL MANAGEMENT Corp | 49,356 | 46,606 | -2,750 | 0.02 | 0.01 | -0.01 | sell |
| RHUMBLINE ADVISERS | 44,147 | 45,606 | +1,459 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 23,633 | 42,431 | +18,798 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 74,791 | 36,674 | -38,117 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 37,638 | 34,933 | -2,705 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 0 | 34,592 | +34,592 | 0.00 | 0.03 | +0.03 | buy |
| OSAIC HOLDINGS, INC. | 27,680 | 33,427 | +5,747 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 33,081 | 32,564 | -517 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 93,332 | 31,310 | -62,022 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 31,174 | +31,174 | 0.00 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 0 | 30,876 | +30,876 | 0.00 | 0.09 | +0.09 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,717 | 30,428 | +1,711 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 27,900 | +27,900 | 0.00 | 0.01 | +0.01 | buy |
| BLAIR WILLIAM & CO/IL | 18,538 | 27,300 | +8,762 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 26,287 | +26,287 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 25,375 | 25,375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HAP Trading, LLC | 0 | 24,070 | +24,070 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 44,840 | 23,655 | -21,185 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 25,611 | 23,418 | -2,193 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 22,208 | +22,208 | 0.00 | 0.14 | +0.14 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 21,314 | +21,314 | 0.00 | 0.00 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 20,956 | +20,956 | 0.00 | 0.20 | +0.20 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 23,053 | 20,740 | -2,313 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 19,559 | 19,578 | +19 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 18,315 | 18,315 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 17,905 | +17,905 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 17,329 | 17,810 | +481 | 0.00 | 0.00 | -0.00 | buy |