| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 1,626,628 | 3,422,984 | +1,796,356 | 0.03 | 0.04 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 1,832,854 | 2,470,493 | +637,639 | 0.03 | 0.03 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 450,706 | 1,003,916 | +553,210 | 2.76 | 4.58 | +1.82 | buy |
| Rafferty Asset Management, LLC | 209,263 | 354,424 | +145,161 | 0.02 | 0.02 | +0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 360,000 | 500,000 | +140,000 | 0.02 | 0.01 | -0.00 | buy |
| Atle Fund Management AB | 21,000 | 77,540 | +56,540 | 0.37 | 0.80 | +0.43 | buy |
| TD ASSET MANAGEMENT INC | 93,630 | 127,030 | +33,400 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 33,858 | 54,427 | +20,569 | 0.03 | 0.04 | 0.00 | buy |
| E Fund Management Co., Ltd. | 11,239 | 16,749 | +5,510 | 0.02 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,962 | 8,206 | +3,244 | 0.02 | 0.02 | -0.00 | buy |
| Woodline Partners LP | 241,453 | 242,663 | +1,210 | 0.06 | 0.04 | -0.02 | buy |
| Sofinnova Investments, Inc. | 429,395 | 429,746 | +351 | 0.55 | 0.41 | -0.14 | buy |
| VIRTUS ADVISERS, LLC | 4,507 | 4,215 | -292 | 0.06 | 0.04 | -0.03 | sell |
| CHURCHILL MANAGEMENT Corp | 49,356 | 46,606 | -2,750 | 0.02 | 0.01 | -0.01 | sell |
| Cutter Capital Management, LP | 230,000 | 157,964 | -72,036 | 2.50 | 1.04 | -1.46 | sell |
| Integral Health Asset Management, LLC | 520,000 | 425,000 | -95,000 | 1.70 | 0.71 | -0.99 | sell |
| FRED ALGER MANAGEMENT, LLC | 3,327,132 | 3,110,314 | -216,818 | 0.41 | 0.26 | -0.14 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,266,645 | 3,036,645 | -230,000 | 0.15 | 0.10 | -0.06 | sell |
| PERCEPTIVE ADVISORS LLC | 2,003,058 | 1,716,660 | -286,398 | 1.01 | 0.51 | -0.50 | sell |
| Blackstone Inc. | 347,494 | 46,780 | -300,714 | 0.04 | 0.00 | -0.03 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,000,000 | 1,617,364 | -382,636 | 4.35 | 2.22 | -2.13 | sell |
| TCG Crossover Management, LLC | 486,795 | 86,795 | -400,000 | 1.23 | 0.12 | -1.11 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,007,729 | 1,258,650 | -749,079 | 0.84 | 0.37 | -0.47 | sell |
| Commodore Capital LP | 1,900,000 | 1,100,000 | -800,000 | 3.77 | 1.25 | -2.51 | sell |
| Redmile Group, LLC | 1,374,189 | 442,826 | -931,363 | 1.12 | 0.28 | -0.84 | sell |
| VR Adviser, LLC | 2,563,952 | 1,563,952 | -1,000,000 | 3.99 | 1.27 | -2.72 | sell |