| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 2,736,912 | 5,903,281 | +3,166,369 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 331,225 | 1,934,990 | +1,603,765 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 9,858,257 | 11,080,005 | +1,221,748 | 0.01 | 0.02 | +0.01 | buy |
| MARSHALL WACE, LLP | 959,076 | 2,179,818 | +1,220,742 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 4,400,000 | 5,500,000 | +1,100,000 | 0.55 | 0.75 | +0.20 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 765,000 | +765,000 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,839,799 | 2,497,917 | +658,118 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,522,583 | 2,036,663 | +514,080 | 0.01 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 900,000 | 1,380,000 | +480,000 | 0.26 | 0.49 | +0.23 | buy |
| GOLDMAN SACHS GROUP INC | 430,674 | 783,220 | +352,546 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 452,039 | 740,648 | +288,609 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 269,257 | +269,257 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 262,831 | +262,831 | 0.00 | 0.19 | +0.19 | buy |
| GSA CAPITAL PARTNERS LLP | 303,992 | 561,726 | +257,734 | 0.06 | 0.09 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 247,659 | +247,659 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 415,677 | 606,664 | +190,987 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 56,648 | 246,615 | +189,967 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 189,412 | +189,412 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 149,721 | +149,721 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 130,675 | 267,372 | +136,697 | 0.01 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 105,985 | +105,985 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 98,500 | +98,500 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 95,512 | +95,512 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 8,905,699 | 8,970,578 | +64,879 | 0.01 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 1,343,708 | 1,408,152 | +64,444 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 58,777 | 108,319 | +49,542 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,085,816 | 1,133,245 | +47,429 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,328,470 | 2,373,003 | +44,533 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 425,478 | 469,978 | +44,500 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 43,416 | +43,416 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 38,703 | +38,703 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 33,104 | +33,104 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 28,938 | +28,938 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 138,729 | 161,726 | +22,997 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 21,300 | +21,300 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 66,377 | 87,060 | +20,683 | 0.00 | 0.00 | +0.00 | buy |
| GSB Wealth Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 17,595 | +17,595 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 16,700 | +16,700 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 15,300 | +15,300 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 12,522 | +12,522 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 11,750 | +11,750 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 6,495 | +6,495 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 14,725 | 18,025 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 189,195 | 192,383 | +3,188 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,686 | 17,083 | +1,397 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1,322 | +1,322 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,678 | 5,021 | +343 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,891 | 2,149 | +258 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 54,047 | 54,299 | +252 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 163 | +163 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 756,637 | 756,637 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 60 | 60 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,829,758 | 8,829,758 | 0 | 0.03 | 0.04 | +0.01 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 90,475 | 90,475 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clear Harbor Asset Management, LLC | 19,500 | 19,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 243,445 | 243,445 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Russell Investments Group, Ltd. | 939 | 939 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 9,677,125 | 9,677,125 | 0 | 1.62 | 2.35 | +0.72 | hold |
| CRA Financial Services, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Ikarian Capital, LLC | 900,000 | 900,000 | 0 | 0.26 | 0.35 | +0.09 | hold |
| Woodline Partners LP | 1,250,242 | 1,250,242 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SBI Securities Co., Ltd. | 316 | 316 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Burkehill Global Management, LP | 700,000 | 700,000 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Federation des caisses Desjardins du Quebec | 340 | 340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Raiffeisen Bank International AG | 450,000 | 450,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| MATAURO, LLC | 55,108 | 55,108 | 0 | 0.02 | 0.02 | +0.00 | hold |
| NORTHERN TRUST CORP | 238,442 | 238,442 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 26,510 | 26,510 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 50,824 | 50,824 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 811 | 811 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 10 | 2 | -8 | 0.00 | 0.00 | +0.00 | sell |
| Optiver Holding B.V. | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Covestor Ltd | 34 | 0 | -34 | 0.00 | 0.00 | 0.00 | sell |
| FMR LLC | 13,045 | 12,991 | -54 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,640 | 1,569 | -71 | 0.00 | 0.00 | +0.00 | sell |
| Truvestments Capital LLC | 680 | 0 | -680 | 0.00 | 0.00 | -0.00 | sell |
| FLAGSHIP HARBOR ADVISORS, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 22,384 | 19,390 | -2,994 | 0.00 | 0.00 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 3,500 | 0 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 149,094 | 144,681 | -4,413 | 0.00 | 0.00 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 28,021 | 23,157 | -4,864 | 0.00 | 0.00 | +0.00 | sell |
| Callan Family Office, LLC | 22,575 | 17,434 | -5,141 | 0.00 | 0.00 | +0.00 | sell |
| HB Wealth Management, LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| ANTIPODES PARTNERS Ltd | 17,187 | 5,616 | -11,571 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 45,125 | 33,442 | -11,683 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,011 | 0 | -13,011 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 20,660 | 653 | -20,007 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 88,600 | 66,924 | -21,676 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 30,345 | 5,784 | -24,561 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 30,629 | 0 | -30,629 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 38,880 | 0 | -38,880 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 51,552 | 11,154 | -40,398 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 95,400 | 54,100 | -41,300 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 73,774 | 27,473 | -46,301 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 151,451 | 101,688 | -49,763 | 0.01 | 0.01 | -0.00 | sell |
| Almitas Capital LLC | 387,491 | 337,391 | -50,100 | 0.19 | 0.21 | +0.02 | sell |
| Dynamic Technology Lab Private Ltd | 66,789 | 10,777 | -56,012 | 0.03 | 0.00 | -0.03 | sell |
| Stonepine Capital Management, LLC | 171,100 | 50,000 | -121,100 | 0.30 | 0.12 | -0.18 | sell |