| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 464,252 | 2,340,118 | +1,875,866 | 0.09 | 0.64 | 0.00 | buy |
| Redmile Group, LLC | 274,252 | 1,370,299 | +1,096,047 | 0.10 | 0.68 | +0.58 | buy |
| PERCEPTIVE ADVISORS LLC | 724,777 | 1,545,000 | +820,223 | 0.16 | 0.58 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,541,645 | 3,266,645 | +725,000 | 0.05 | 0.09 | 0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,344,000 | 1,594,000 | +250,000 | 0.06 | 0.12 | 0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 175,951 | 50,621 | +125,330 | 0.04 | 0.02 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 45,000 | 81,332 | +36,332 | 0.02 | 0.04 | 0.00 | buy |