| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 3,422,984 | 5,546,467 | +2,123,483 | 0.04 | 0.03 | -0.01 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 500,000 | 2,618,000 | +2,118,000 | 0.01 | 0.03 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 2,470,493 | 3,878,210 | +1,407,717 | 0.03 | 0.02 | -0.01 | buy |
| Sofinnova Investments, Inc. | 429,746 | 1,220,400 | +790,654 | 0.41 | 0.47 | +0.07 | buy |
| E Fund Management Co., Ltd. | 16,749 | 286,424 | +269,675 | 0.02 | 0.12 | +0.10 | buy |
| STEMPOINT CAPITAL LP | 1,003,916 | 1,178,105 | +174,189 | 4.58 | 2.59 | -1.98 | buy |
| WESTWOOD HOLDINGS GROUP INC | 82,228 | 170,129 | +87,901 | 0.01 | 0.01 | -0.01 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,617,364 | 1,649,964 | +32,600 | 2.22 | 1.35 | -0.86 | buy |
| Crestline Management, LP | 85,000 | 104,705 | +19,705 | 0.13 | 0.06 | -0.07 | buy |
| Bayesian Capital Management, LP | 11,187 | 20,583 | +9,396 | 0.02 | 0.02 | -0.00 | buy |
| Polar Capital Holdings Plc | 1,250,000 | 1,253,500 | +3,500 | 0.11 | 0.06 | -0.06 | buy |
| VIRTUS ADVISERS, LLC | 4,215 | 7,207 | +2,992 | 0.04 | 0.03 | -0.01 | buy |
| Woodline Partners LP | 242,663 | 242,981 | +318 | 0.04 | 0.02 | -0.02 | buy |
| Harvest Investment Services, LLC | 16,402 | 15,871 | -531 | 0.11 | 0.05 | -0.07 | sell |
| China Universal Asset Management Co., Ltd. | 8,206 | 5,671 | -2,535 | 0.02 | 0.01 | -0.01 | sell |
| Artisan Partners Limited Partnership | 334,813 | 327,397 | -7,416 | 0.01 | 0.00 | -0.00 | sell |
| Atle Fund Management AB | 77,540 | 64,321 | -13,219 | 0.80 | 0.29 | -0.51 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 290,797 | 139,895 | -150,902 | 3.28 | 1.32 | -1.96 | sell |
| Rafferty Asset Management, LLC | 354,424 | 103,582 | -250,842 | 0.02 | 0.00 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 3,110,314 | 2,522,882 | -587,432 | 0.26 | 0.09 | -0.17 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,258,650 | 464,252 | -794,398 | 0.37 | 0.06 | -0.32 | sell |
| PERCEPTIVE ADVISORS LLC | 1,716,660 | 585,045 | -1,131,615 | 0.51 | 0.11 | -0.41 | sell |