| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 3,422,984 | 5,546,467 | +2,123,483 | 0.04 | 0.03 | -0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 2,470,493 | 3,878,210 | +1,407,717 | 0.03 | 0.02 | -0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,036,645 | 3,036,645 | 0 | 0.10 | 0.04 | -0.06 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 500,000 | 2,618,000 | +2,118,000 | 0.05 | 0.10 | +0.05 | buy |
| FRED ALGER MANAGEMENT, LLC | 3,110,314 | 2,522,882 | -587,432 | 0.26 | 0.09 | -0.17 | sell |
| VANGUARD GROUP INC | 2,276,222 | 2,366,057 | +89,835 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 3,741,460 | 2,005,801 | -1,735,659 | 0.00 | 0.00 | -0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,617,364 | 1,649,964 | +32,600 | 2.22 | 1.35 | -0.86 | buy |
| VR Adviser, LLC | 1,563,952 | 1,563,952 | 0 | 1.27 | 0.75 | -0.52 | hold |
| Polar Capital Holdings Plc | 1,250,000 | 1,253,500 | +3,500 | 0.11 | 0.06 | -0.06 | buy |
| Sofinnova Investments, Inc. | 429,746 | 1,220,400 | +790,654 | 0.43 | 0.58 | +0.14 | buy |
| STEMPOINT CAPITAL LP | 1,003,916 | 1,178,105 | +174,189 | 4.58 | 2.59 | -1.98 | buy |
| Commodore Capital LP | 1,100,000 | 1,100,000 | 0 | 1.25 | 0.56 | -0.69 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 773,090 | 970,573 | +197,483 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 23,655 | 956,689 | +933,034 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 459,367 | 698,317 | +238,950 | 0.01 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 371,623 | 634,217 | +262,594 | 0.01 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,716,660 | 585,045 | -1,131,615 | 0.52 | 0.11 | -0.41 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 612,398 | 582,275 | -30,123 | 0.00 | 0.00 | -0.00 | sell |
| Lynx1 Capital Management LP | 2,082,973 | 492,103 | -1,590,870 | 9.15 | 1.33 | -7.82 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,258,650 | 464,252 | -794,398 | 0.37 | 0.06 | -0.32 | sell |
| Redmile Group, LLC | 442,826 | 442,826 | 0 | 0.28 | 0.20 | -0.08 | hold |
| Integral Health Asset Management, LLC | 425,000 | 425,000 | 0 | 0.71 | 0.32 | -0.40 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,921 | 403,136 | +390,215 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 425,174 | 395,823 | -29,351 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 36,674 | 395,437 | +358,763 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 171,187 | 330,187 | +159,000 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 334,813 | 327,397 | -7,416 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 319,546 | +319,546 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 42,431 | 315,379 | +272,948 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 304,161 | 306,408 | +2,247 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 434,500 | 303,326 | -131,174 | 0.01 | 0.00 | -0.01 | sell |
| Exome Asset Management LLC | 0 | 300,200 | +300,200 | 0.00 | 2.00 | +2.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 299,801 | +299,801 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 50,719 | 296,615 | +245,896 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 885,704 | 295,509 | -590,195 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 69,220 | 286,810 | +217,590 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 16,749 | 286,424 | +269,675 | 0.02 | 0.12 | +0.10 | buy |
| AXA S.A. | 178,162 | 270,778 | +92,616 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 242,663 | 242,981 | +318 | 0.04 | 0.02 | -0.02 | buy |
| Schonfeld Strategic Advisors LLC | 317,520 | 194,037 | -123,483 | 0.04 | 0.01 | -0.03 | sell |
| Bank of New York Mellon Corp | 146,061 | 190,217 | +44,156 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 189,957 | +189,957 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 182,135 | +182,135 | 0.00 | 0.03 | +0.03 | buy |
| WESTWOOD HOLDINGS GROUP INC | 82,228 | 170,129 | +87,901 | 0.01 | 0.01 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 238,103 | 169,105 | -68,998 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,008,259 | 158,809 | -849,450 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 290,797 | 139,895 | -150,902 | 3.28 | 1.32 | -1.96 | sell |
| TD ASSET MANAGEMENT INC | 127,030 | 134,030 | +7,000 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,525 | 118,327 | +24,802 | 0.00 | 0.00 | -0.00 | buy |
| Crestline Management, LP | 85,000 | 104,705 | +19,705 | 0.14 | 0.06 | -0.08 | buy |
| Rafferty Asset Management, LLC | 354,424 | 103,582 | -250,842 | 0.02 | 0.00 | -0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 95,200 | +95,200 | 0.00 | 0.06 | +0.06 | buy |
| TCG Crossover Management, LLC | 86,795 | 86,795 | 0 | 0.12 | 0.07 | -0.05 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 82,386 | 82,160 | -226 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 278,123 | 76,513 | -201,610 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 72,500 | +72,500 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 209,476 | 68,573 | -140,903 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 77,245 | 67,062 | -10,183 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,099 | 66,973 | +2,874 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 59,200 | 66,500 | +7,300 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,310 | 64,630 | +33,320 | 0.00 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 77,540 | 64,321 | -13,219 | 0.80 | 0.29 | -0.51 | sell |
| RHUMBLINE ADVISERS | 45,606 | 61,880 | +16,274 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 57,626 | +57,626 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 14,963 | 56,828 | +41,865 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,233 | 56,424 | +4,191 | 0.00 | 0.00 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 49,563 | 49,563 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 47,150 | 47,150 | 0 | 0.75 | 0.38 | -0.37 | hold |
| BARCLAYS PLC | 48,968 | 41,239 | -7,729 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,428 | 33,825 | +3,397 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 33,427 | 33,548 | +121 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 0 | 31,931 | +31,931 | 0.00 | 0.13 | +0.13 | buy |
| Aquatic Capital Management LLC | 0 | 31,100 | +31,100 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 32,564 | 30,026 | -2,538 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 34,933 | 29,441 | -5,492 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 69,417 | 28,233 | -41,184 | 0.02 | 0.00 | -0.02 | sell |
| MetLife Investment Management, LLC | 18,315 | 27,714 | +9,399 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 23,418 | 26,720 | +3,302 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 23,057 | +23,057 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,287 | 22,969 | -3,318 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 301,886 | 22,894 | -278,992 | 0.01 | 0.00 | -0.01 | sell |
| HighVista Strategies LLC | 22,208 | 22,208 | 0 | 0.14 | 0.06 | -0.07 | hold |
| KEYBANK NATIONAL ASSOCIATION/OH | 15,894 | 21,506 | +5,612 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 20,669 | +20,669 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 11,187 | 20,583 | +9,396 | 0.02 | 0.02 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,740 | 20,191 | -549 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 19,578 | 19,400 | -178 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 330,925 | 19,373 | -311,552 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 13,375 | 19,309 | +5,934 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 54,427 | 19,250 | -35,177 | 0.04 | 0.01 | -0.03 | sell |
| FRANKLIN RESOURCES INC | 16,123 | 18,904 | +2,781 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 18,727 | +18,727 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 31,174 | 17,966 | -13,208 | 0.02 | 0.00 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 25,375 | 17,516 | -7,859 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 17,245 | +17,245 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 16,402 | 15,871 | -531 | 0.11 | 0.05 | -0.07 | sell |
| Invesco Ltd. | 744,777 | 15,324 | -729,453 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 13,827 | 14,817 | +990 | 0.03 | 0.01 | -0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 59,498 | 14,293 | -45,205 | 0.00 | 0.00 | -0.00 | sell |