| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 3,422,984 | 5,546,467 | +2,123,483 | 0.04 | 0.03 | -0.01 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 500,000 | 2,618,000 | +2,118,000 | 0.05 | 0.10 | +0.05 | buy |
| T. Rowe Price Investment Management, Inc. | 2,470,493 | 3,878,210 | +1,407,717 | 0.03 | 0.02 | -0.01 | buy |
| JPMORGAN CHASE & CO | 23,655 | 956,689 | +933,034 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 429,746 | 1,220,400 | +790,654 | 0.43 | 0.58 | +0.14 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,921 | 403,136 | +390,215 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 36,674 | 395,437 | +358,763 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 319,546 | +319,546 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 300,200 | +300,200 | 0.00 | 2.00 | +2.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 299,801 | +299,801 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 42,431 | 315,379 | +272,948 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 16,749 | 286,424 | +269,675 | 0.02 | 0.12 | +0.10 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 371,623 | 634,217 | +262,594 | 0.01 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 50,719 | 296,615 | +245,896 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 459,367 | 698,317 | +238,950 | 0.01 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 69,220 | 286,810 | +217,590 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 773,090 | 970,573 | +197,483 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 189,957 | +189,957 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 182,135 | +182,135 | 0.00 | 0.03 | +0.03 | buy |
| STEMPOINT CAPITAL LP | 1,003,916 | 1,178,105 | +174,189 | 4.58 | 2.59 | -1.98 | buy |
| MARSHALL WACE, LLP | 171,187 | 330,187 | +159,000 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 95,200 | +95,200 | 0.00 | 0.06 | +0.06 | buy |
| AXA S.A. | 178,162 | 270,778 | +92,616 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 2,276,222 | 2,366,057 | +89,835 | 0.00 | 0.00 | -0.00 | buy |
| WESTWOOD HOLDINGS GROUP INC | 82,228 | 170,129 | +87,901 | 0.01 | 0.01 | -0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 72,500 | +72,500 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 57,626 | +57,626 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 146,061 | 190,217 | +44,156 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 14,963 | 56,828 | +41,865 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,310 | 64,630 | +33,320 | 0.00 | 0.00 | -0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,617,364 | 1,649,964 | +32,600 | 2.22 | 1.35 | -0.86 | buy |
| Corton Capital Inc. | 0 | 31,931 | +31,931 | 0.00 | 0.13 | +0.13 | buy |
| Aquatic Capital Management LLC | 0 | 31,100 | +31,100 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,525 | 118,327 | +24,802 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 23,057 | +23,057 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 20,669 | +20,669 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 85,000 | 104,705 | +19,705 | 0.14 | 0.06 | -0.08 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 18,727 | +18,727 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 17,245 | +17,245 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 45,606 | 61,880 | +16,274 | 0.00 | 0.00 | -0.00 | buy |
| Bridgefront Capital, LLC | 0 | 11,876 | +11,876 | 0.00 | 0.04 | +0.04 | buy |
| Tower Research Capital LLC (TRC) | 453 | 11,603 | +11,150 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,315 | 27,714 | +9,399 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 11,187 | 20,583 | +9,396 | 0.02 | 0.02 | -0.00 | buy |
| Swiss National Bank | 59,200 | 66,500 | +7,300 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 127,030 | 134,030 | +7,000 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,204 | +6,204 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,375 | 19,309 | +5,934 | 0.00 | 0.00 | -0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 15,894 | 21,506 | +5,612 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,233 | 56,424 | +4,191 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 1,250,000 | 1,253,500 | +3,500 | 0.11 | 0.06 | -0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,428 | 33,825 | +3,397 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 23,418 | 26,720 | +3,302 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,215 | 7,207 | +2,992 | 0.04 | 0.03 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,099 | 66,973 | +2,874 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 16,123 | 18,904 | +2,781 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 304,161 | 306,408 | +2,247 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 38 | 1,562 | +1,524 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 13,827 | 14,817 | +990 | 0.03 | 0.01 | -0.02 | buy |
| FMR LLC | 487 | 1,077 | +590 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 9,200 | 9,600 | +400 | 0.04 | 0.02 | -0.02 | buy |
| Woodline Partners LP | 242,663 | 242,981 | +318 | 0.04 | 0.02 | -0.02 | buy |
| Quarry LP | 0 | 207 | +207 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 31 | 224 | +193 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 274 | 417 | +143 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 33,427 | 33,548 | +121 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 72 | +72 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 3 | 12 | +9 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1 | 5 | +4 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,452 | 3,452 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,036,645 | 3,036,645 | 0 | 0.10 | 0.04 | -0.06 | hold |
| PRIVATE TRUST CO NA | 538 | 538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 22,208 | 22,208 | 0 | 0.14 | 0.06 | -0.07 | hold |
| Redmile Group, LLC | 442,826 | 442,826 | 0 | 0.28 | 0.20 | -0.08 | hold |
| Daiwa Securities Group Inc. | 175 | 175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 49,563 | 49,563 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 1,131 | 1,131 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Capital Advisors, Ltd. LLC | 81 | 81 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 1,563,952 | 1,563,952 | 0 | 1.27 | 0.75 | -0.52 | hold |
| Birchview Capital, LP | 10,000 | 10,000 | 0 | 0.14 | 0.07 | -0.07 | hold |
| Bogart Wealth, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Integral Health Asset Management, LLC | 425,000 | 425,000 | 0 | 0.71 | 0.32 | -0.40 | hold |
| Nan Fung Group Holdings Ltd | 47,150 | 47,150 | 0 | 0.75 | 0.38 | -0.37 | hold |
| Commodore Capital LP | 1,100,000 | 1,100,000 | 0 | 1.25 | 0.56 | -0.69 | hold |
| TCG Crossover Management, LLC | 86,795 | 86,795 | 0 | 0.12 | 0.07 | -0.05 | hold |
| Beaird Harris Wealth Management, LLC | 79 | 79 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 4 | 4 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Federation des caisses Desjardins du Quebec | 340 | 340 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 1,175 | 1,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 19,578 | 19,400 | -178 | 0.00 | 0.00 | -0.00 | sell |
| CIBC Private Wealth Group LLC | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 82,386 | 82,160 | -226 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 262 | 0 | -262 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| Harvest Investment Services, LLC | 16,402 | 15,871 | -531 | 0.11 | 0.05 | -0.07 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,740 | 20,191 | -549 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 1,955 | 997 | -958 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 1,653 | 589 | -1,064 | 0.00 | 0.00 | -0.00 | sell |